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Lars Hangartner, PhD

Associate Professor of Ims
Department of Immunology and Microbiology
California Campus
Scripps VIVO Scientific Profile
lhangart@scripps.edu
(858) 784-9876

Education

Ph.D., Eidgenössische Technische Hochschule 2002
Diploma (Molecular Biology), University of Zurich 1997

Professional Experience

2015-2017 Associate Professor, Immunology and Microbial Science (IMS), The Scripps Research Institute
2009-2015 Professor SNSF, Institute of Medical Virology, University of Zurich
2008-2009 Staff Scientist, University of Zurich
2005-2008 Senior Research Associate, The Scripps Research Institute
2002-2005 Postdoctoral Fellow, University Hospital Zurich

Selected References

All Publications

Maurer, M. A., Meyer, L., Bianchi, M., Turner, H. L., Le, N. P. L., Steck, M., Wyrzucki, A., Orlowski, V., Ward, A. B., Crispin, M. & Hangartner, L. Glycosylation of human IgA directly inhibits influenza A and other sialic-acid-binding viruses. (2018). Cell Reports, 23(1), 90-99.

Burton, D. R. & Hangartner, L. Broadly neutralizing antibodies to HIV and their role in vaccine design. (2016). Annual Review of Immunology, 34, 635.

Wyrzucki, A., Bianchi, M., Kohler, I., Steck, M. & Hangartner, L. Heterosubtypic antibodies to influenza A virus have limited activity against cell-bound virus but are not impaired by strain-specific serum antibodies. (2015). Journal of Virology, 89(6), 3136-3144. PMCID: PMC4337524.

Kohler, I., Kouyos, R., Bianchi, M., Grube, C., Wyrzucki, A., Gunthard, H. F. & Hangartner, L. The impact of vaccination on the breadth and magnitude of the antibody response to influenza A viruses in HIV-infected individuals. (2015). AIDS, 29(14), 1803-1810.

Wyrzucki, A., Dreyfus, C., Kohler, I., Steck, M., Wilson, I. A. & Hangartner, L. Alternative recognition of the conserved stem epitope in influenza A virus hemagglutinin by a VH3-30-encoded heterosubtypic antibody. (2014). Journal of Virology, 88(12), 7083-7092. PMCID: PMC4054347.

Kohler, I., Scherrer, A. U., Zagordi, O., Bianchi, M., Wyrzucki, A., Steck, M., Ledergerber, B., Gunthard, H. F. & Hangartner, L. Prevalence and predictors for homo- and heterosubtypic antibodies against influenza A virus.. (2014). Clinical Infectious Diseases, 59(10), 1386-1393.

Hoot, S., McGuire, A. T., Cohen, K. W., Strong, R. K., Hangartner, L., Klein, F., Diskin, R., Scheid, J. F., Sather, D. N., Burton, D. R. & Stamatatos, L. Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs.. (2013). PLoS Pathogens, 9, e1003106. PMCID: PMC3536657.

Ota, T., Doyle-Cooper, C., Cooper, A. B., Huber, M., Falkowska, E., Doores, K. J., Hangartner, L., Le, K., Sok, D., Jardine, J., Lifson, J., Wu, X. L., et al. Anti-HIV B Cell lines as candidate vaccine biosensors. (2012). Journal of Immunology, 189(10), 4816-4824. PMCID: PMC3626558.

Hessell, A. J., Rakasz, E. G., Poignard, P., Hangartner, L., Landucci, G., Forthal, D. N., Koff, W. C., Watkins, D. I. & Burton, D. R. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. (2009). PLoS Pathogens, 5, e1000433. PMCID: PMC2674935.

Hessell, A. J., Poignard, P., Hunter, M., Tehrani, D. M., Bleeker, W. K., Parren, Pwhi, Marx, P. A., Burton, D. R. & Hangartner, L. Effective, low-titer antibody protection against low-dose repeated mucosal shiv challenge in macaques. (2009). Nature Medicine, 15(8), 951-954. PMCID: PMC4334439.