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Edward Roberts, PhD

Department of Molecular Medicine
California Campus
Scripps VIVO Scientific Profile
(858) 784-7770

Scripps Research Joint Appointments

Professor, Department of Chemistry


B.S., Biochemistry, University of Sussex, 1979
Ph.D., Organic Chemistry, Newcastle University, 1982

Professional Experience

2003-2004 Senior Vice President and Chief Scientific Officer, F. Hoffmann-La Roche Ltd.
1999-2002 Senior Vice President and Head of Discovery Chemistry, F. Hoffmann-La Roche Ltd.
1994-1999 Director, Research and Development, AstraZeneca
1986-1993 Neuroscience Research Centre at Addenbrookes Hospital, Parke-Davis
1983-1985 Assistant Professor, University of Wales, Cardiff

Selected References

All Publications

Burkert, K., Zellmann, T., Meier, R., Kaiser, A., Stichel, J., Meiler, J., Mittapalli, G. K., Roberts, E. & Beck-Sickinger, A. G. A deep hydrophobic binding cavity is the main interaction for different Y2R antagonists. (2017). ChemMedChem, 12(1), 75-85.

Harris, R. A., Bajo, M., Bell, R. L., Blednov, Y. A., Varodayan, F. P., Truitt, J. M., de Guglielmo, G., Lasek, A. W., Logrip, M. L. & Vendruscolo, L. F. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents. (2017). Journal of Neuroscience, 37(5), 1139-1155. PMCID: PMC5296793.

Xie, J. Y., De Felice, M., Kopruszinski, C. M., Eyde, N., LaVigne, J., Remeniuk, B., Hernandez, P., Yue, X., Goshima, N., Ossipov, M., King, T., Streicher, J. M., et al. Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention. (2017). Cephalalgia, 37(8), 780-794.

Scott, F. L., Clemons, B., Brooks, J., Brahmachary, E., Powell, R., Dedman, H., Desale, H. G., Timony, G. A., Martinborough, E., Rosen, H., Roberts, E., Boehm, M. F., et al. Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P(1)) and receptor-5 (S1P(5)) agonist with autoimmune disease-modifying activity. (2016). British Journal of Pharmacology, 173(11), 1778-1792. PMCID: PMC4867749.

Dillmann, C., Ringel, C., Ringleb, J., Mora, J., Olesch, C., Fink, A. F., Roberts, E., Brüne, B. & Weigert, A. S1PR4 signaling attenuates ILT 7 internalization to limit IFN-α production by human plasmacytoid dendritic cells. (2016). Journal of Immunology, 196(4), 1579-1590.

Guerrero, M., Urbano, M. & Roberts, E. Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013-2015). (2016). Expert Opinion on Therapeutic Patents, 26(4), 455-470.

Schreiber, S. L., Kotz, J. D., Li, M., Aube, J., Austin, C. P., Reed, J. C., Rosen, H., White, E. L., Sklar, L. A., Lindsley, C. W., Alexander, B. R., Bittker, J. A., et al. Advancing biological understanding and therapeutics discovery with small-molecule probes. (2015). Cell, 161(6), 1252-1265. PMCID: PMC4564295.

Urbano, M., Guerrero, M., Rosen, H. & Roberts, E. Antagonists of the kappa opioid receptor. (2014). Bioorganic & Medicinal Chemistry Letters, 24(9), 2021-2032.

Mittapalli, G. K. & Roberts, E. Ligands of the neuropeptide Y Y2 receptor. (2014). Bioorganic & Medicinal Chemistry Letters, 24(2), 430-441. PMCID: PMC4672871.

Mittapalli, G. K. & Roberts, E. Structure activity relationships of novel antiepileptic drugs. (2014). Current Medicinal Chemistry, 21(6), 722-754.