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Bryan Briney, Ph.D.

Assistant Professor of Ims
Department of Immunology and Microbiology
California Campus
Scripps VIVO Scientific Profile
(858) 784-2902


Ph.D. (Microbiology and Immunology), Vanderbilt University 2012
B.S. (Biochemistry and Cell Biology), University of California, San Diego 2007

Professional Experience

2015-2017 Assistant Professor of IMS, Immunology and Microbial Science (IMS), The Scripps Research Institute
2012-2015 Postdoctoral Fellow, The Scripps Research Institute

Selected References

All Publications

Havenar-Daughton, C., Carnathan, D. G., Torrents de la Peña, A., Pauthner, M., Briney, B., Reiss, S. M., Wood, J. S., Kaushik, K., van Gils, M. J., Rosales, S. L., van der Woude, P., Locci, M., et al. Direct probing of germinal center responses reveals immunological features and bottlenecks for neutralizing antibody responses to HIV Env trimer. (2016). Cell Reports, 17(9), 2195-2209. PMCID: PMC5142765.

Steichen, J. M., Kulp, D. W., Tokatlian, T., Escolano, A., Dosenovic, P., Stanfield, R. L., McCoy, L. E., Ozorowski, G., Hu, X., Kalyuzhniy, O., Briney, B., Schiffner, T., et al. HIV vaccine design to target germline precursors of glycan-dependent broadly neutralizing antibodies. (2016). Immunity, 45(3), 483-496. PMCID: PMC5040827.

Jardine, J. G., Kulp, D. W., Havenar-Daughton, C., Sarkar, A., Briney, B., Sok, D., Sesterhenn, F., Ereno-Orbea, J., Kalyuzhniy, O., Deresa, I., Hu, X., Spencer, S., et al. HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogene. (2016). Science, 351(6280), 1458-1463. PMCID: PMC4872700.

Stapleton, J. A., Kim, J., Hamilton, J. P., Wu, M., Irber, L. C., Maddamsetti, R., Briney, B., Newton, L., Burton, D. R., Brown, C. T., Chan, C., Buell, C. R., et al. Haplotype-phased synthetic long reads from short-read sequencing. (2016). PLoS One, 11. PMCID: PMC4720449.

McCoy, L. E., van Gils, M. J., Ozorowski, G., Messmer, T., Briney, B., Voss, J. E., Kulp, D. W., Macauley, M. S., Sok, D., Pauthner, M., Menis, S., Cottrell, C. A., et al. Holes in the glycan shield of the native HIV Envelope are a target of trimer-elicited neutralizing antibodies. (2016). Cell Reports, 16(9), 2327-2338. PMCID: PMC5007210.

Andrabi, R., Voss, J. E., Liang, C. H., Briney, B., McCoy, L. E., Wu, C. Y., Wong, C. H., Poignard, P. & Burton, D. R. Identification of common features in prototype broadly neutralizing antibodies to HIV envelope V2 apex to facilitate vaccine design. (2015). Immunity, 43(5), 959-973. PMCID: PMC4654981.

Jardine, J. G., Ota, T., Sok, D., Pauthner, M., Kulp, D. W., Kalyuzhniy, O., Skog, P. D., Thinnes, T. C., Bhullar, D., Briney, B., Menis, S., Jones, M., et al. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen. (2015). Science, 349(6244), 156-161. PMCID: PMC4669217.

Sok, D., Doores, K. J., Briney, B., Le, K. M., Saye-Francisco, K. L., Ramos, A., Kulp, D. W., Julien, J. P., Menis, S., Wickramasinghe, L., Seaman, M. S., Schief, W. R., et al. Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV. (2014). Science Translational Medicine, 6, 236ra63. PMCID: PMC4095976.

Sok, D., van Gils, M. J., Pauthner, M., Julien, J. P., Saye-Francisco, K. L., Hsueh, J., Briney, B., Lee, J. H., Le, K. M., Lee, P. S., Hua, Y., Seaman, M. S., et al. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex. (2014). Proceedings of the National Academy of Sciences of the United States of America, 111(49), 17624-17629. PMCID: PMC4267403.

Briney, B. S., Willis, J. R., Finn, J. A., McKinney, B. A. & Crowe Jr., J. E. Tissue-specific expressed antibody variable gene repertoires. (2014). PLoS One, 9, e100839. PMCID: PMC4067404.