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News and Publications


Staff Awards and Activities

Benard, V.--Postdoctoral Fellowship, Arthritis Foundation.

Beutler, E.--Member, Advisory Council, National Heart, Lung and Blood Institute; Robert Hettig Lecturer in Hematology, Baylor College of Medicine, Houston, Texas; Editor-in-Chief, Blood Cells, Molecules and Diseases; Associate Editor, Acta Haematologica, Clinical and Laboratory Hematology, Hematologic Pathology, Journal of Clinical Investigation, Molecular Medicine.

Bloom, F.E.--Honorary Doctor of Science, Thomas Jefferson University, Philadelphia, and Washington University, St. Louis; Member, National Academy of Sciences, Institute of Medicine, American Academy of Arts and Sciences, American Philosophical Society, Royal Swedish Academy; Editor-in-Chief, Science Magazine.

Boger, D.L.--Councilor, American Chemical Society, Division of Medicinal Chemistry; Editor, Bioorganic and Medicinal Chemistry Letters; Editorial Boards, Tetrahedron Publications, Drug Discovery Today, Progress in Heterocyclic Chemistry, Current Opinion in Drug Discovery and Development, Journal of Heterocyclic Chemistry.

Bokoch, G.M.--Editorial Board, Journal of Immunology.

Brooks, C.L. III--Member, Molecular and Cellular Biophysics Panel, National Science Foundation; work on protein folding selected for permanent display in Smithsonian Institute Archives; Editorial Boards, Proteins: Structure, Function, and Genetics, Journal of Molecular Graphics and Modeling.

Buchmeier, M.J.--Fellow, American Association for the Advancement of Science; Councilor, American Society for Microbiology; Editorial Boards, Virology, Journal of Neurovirology.

Case, D.A.--Associate Editor, Biopolymers; Editorial Boards, Journal of Biological and Inorganic Chemistry, Theoretical Chemistry Accounts.

Chan, E.K.L.--Member, General Medicine A1 Study Section, National Institutes of Health; Editorial Boards, Molecular Biology Reports, Electronic Journal of Biotechnology.

Chazin, W.J.--American Cancer Society Faculty Research Award; Visiting Professor, Università di Napoli, Italy.

Cheresh, D.A.--Myron Karon Memorial Award, University of Southern California; Visiting Professor in Oncology, McGill University and The University of Montreal, Montreal, Quebec.

Chisari, F.V.--Distinguished Scientific Achievement Award, American Liver Foundation; Shipley Symposium Lectureship, Harvard Medical School; Editorial Boards, Journal of Clinical Investigation, Virology, Microbial Pathogenesis, Viral Immunology, Transgenic Research, Journal of Experimental Pathology.

Chuang, T.H.--Investigator Award, Arthritis Foundation.

Curtiss, L.K.--Member, National Institutes of Health Reviewers Reserve; Editorial Boards, Arteriosclerosis, Thrombosis and Vascular Biology, Journal of Lipid Research; Consulting Editor, Journal of Clinical Investigation.

DerMardirossian, C.--Postdoctoral Fellowship, Association Pour la Recherche Sur le Cancer, France.

Dyson, H.J.--Member, Molecular and Cellular Biophysics Study Section, National Institutes of Health; Editorial Board, Folding and Design.

Edgington, T.S.--Member, Institute of Medicine, U.S. National Academy of Sciences; Fellow, Council on Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association; Chairman, Scientific Subcommittee on Thrombosis and Vascular Biology, American Society for Hematology; Advisor, The Netherlands National Organization for Scientific Research.

Elder, J.H.--Editorial Boards, Journal of Cellular Biochemistry, Journal of Virology, Virology.

Evans, C.F.--J.D. and Iva Leiper Scholar.

Feeney, A.J.--Member, Allergy, Immunology, and Transplantation Review Committee, National Institutes of Health; Section Editor, Journal of Immunology.

Gardner, H.A.R.--Shannon Award, National Institutes of Health.

Ghadiri, M.R.--Member, Astrobiology Institute, National Aeronautics and Space Administration.

Giacchino, J.L.--Research Scientist Development Award, National Institutes of Health.

Gilula, N.B.--Visiting Professor, University College, London, England; Editor-in-Chief, Journal of Cell Biology.

Ginsberg, M.H.--Scientific Advisory Board, Gladstone Institutes, University of California, San Francisco; Editorial Boards, Journal of Biological Chemistry, Molecular Biology of the Cell.

Gottlieb, R.A.--Pew Scholar, Program in the Biomedical Sciences; Junior Faculty Scholar, American Society for Hematology.

Grynszpan, F.--Michael Landau Research Prize, Israeli Mifal Hapais Foundation.

Havran, W.L.--Associate Editor, Journal of Immunology.

Henriksen, S.J.--Secretary/Treasurer, The Sleep Research Society; Editorial Board, Peptide Research.

Heyworth, P.G.--Associate Editor, Journal of Immunology.

Holz, A.--Swiss National Science Foundation Advanced Fellowship.

Hugli, T.E.--Member, Public Affairs Advisory Committee, Federation of American Societies for Experimental Biology; Editorial Boards, Journal of Biological Chemistry, Analytical Biochemistry, Biochemistry, Immunopharmacology, Inflammation, Complement and Inflammation, Journal of Clinical Laboratory Analysis, Protein Science.

Johnson, E.F.--Merit Award, National Institute of Child Health and Human Development; Reviewing Editor, Science; Editorial Boards, Journal of Biological Chemistry, Molecular Pharmacology, Archives of Biochemistry and Biophysics, Drug Metabolism and Disposition.

Johnson, J.E.--Board of Scientific Counselors, National Cancer Institute and National Institute of Arthritis and Musculoskeletal and Skin Disorders; Board of Governors, Consortium for Advanced Radiation Sources, University of Chicago; Member, International Committee on Taxonomy of Viruses; Associate Editor, Biophysical Journal; Editorial Boards, Virology, Journal of General Virology.

Joyce, G.F.--Hans Sigrist Award, Universität Bern, Switzerland; T.Y. Shen Visiting Lecturer in Biological Chemistry, Massachusetts Institute of Technology, Boston; Cynthia Ann Chan Memorial Lecture, Department of Chemistry, University of California, Berkeley; Associate Editor, Chemistry and Biology, Evolutionary Computation.

King, C.C.--Postdoctoral Fellowship, Arthritis Foundation.

Koob, G.F.--Daniel H. Efron Award for Excellence in Research in Neuropsychopharmacology, American College of Neuropsychopharmacology; Merit Award, National Institute on Alcohol Abuse and Alcoholism; Member, National Advisory Council, National Institute on Drug Abuse; U.S. Editor-in-Chief, Pharmacology, Biochemistry and Behavior.

Lane, T.E.--Advanced Postdoctoral Fellowship, National Multiple Sclerosis Society.

Lerner, R.A.--Distinguished Lecturer in Chemistry, Zeneca Pharmaceuticals, Wilmington, Delaware; Member, Academic Committee, Board of Governors, Technion-Israel Institute of Technology, Haifa, Israel; Editorial Boards, Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters, Catalysis Technology, Chemistry and Biology, Drug Targeting and Delivery, In Vivo, Journal of Virology, Molecular Biology and Medicine, Molecular Medicine, Journal of Peptide Research, Vaccine, Accounts of Chemical Research Journal.

Loskutoff, D.J.--Editorial Board, Journal of Clinical Investigation.

Lotz, M.--Editorial Boards, Arthritis and Rheumatism, Biotherapy, Osteoarthritis and Cartilage, Revue de Rhumatisme.

Maruyama, I.--Editorial Board, Biotechnology et alia.

McLachlan, A.--Editorial Board, Journal of Virology.

Naniche, D.--World Health Organization Fellowship Award.

Nemerow, G.R.--Lecturer, Foundation for Microbiology; Editorial Boards, Trends in Microbiology, Immunopharmacology, Gene Therapy and Molecular Biology.

Nicolaou, K.C.-- Honorary Ph.D. (honoris causa), University of Cyprus, Nicosia, Cyprus; C.S. Hamilton Award, University of Nebraska, Lincoln; John Gustavus Esselen Award for Chemistry in the Public Interest, American Chemical Society; Decoration of the Order of the Commander of Honor Medal, Greece; Backer Lecturer, VanLeusen Symposium, University of Groningen, the Netherlands; Mahler Lecturer, University of Texas, Austin, Texas; Barton Lecturer, Texas A&M University, College Station, Texas; Co-Editor-in-Chief, Chemistry and Biology; Editorial Boards, Tetrahedron Publications, Synthesis, Carbohydrate Letters, Chemistry: A European Journal, Perspectives in Drug Discovery and Design, Indian Journal of Chemistry, Section B, Combinatorial Chemistry High Throughput Screening, Current Opinion in Bioorganic Chemistry, Current Organic Chemistry.

Novella, I.--Theodore and Vada Stanley Foundation Research Award.

Oldstone, M.B.A.--J. Allyn Taylor International Prize in Medicine; Member, Institute of Medicine, National Academy of Sciences; Scandinavian Society of Immunology; and World Health Organization Committee for the Eradication of Poliomyelitis and Measles Virus; Editor, Virology; Editorial Boards, Journal of Experimental Medicine, Current Topics in Microbiology and Immunology.

Polich, J.--Board of Directors, Society for Psychophysiological Research; Editorial Boards, Electroencephalography and Clinical Neurophysiology, International Journal of Psychophysiology.

Rebeck, J., Jr.--James Flack Norris Award in Physical Organic Chemistry, American Chemical Society; Watkins Lectureship, Wichita State University; Hirschman Lecturer, Oberlin College; Gary Griffin Memorial Lecture, University of New Orleans; Editorial Boards, Tetrahedron Publications, Accounts of Chemical Research, Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters, Chemistry and Biology, Chemtracts, Current Opinion in Drug Discovery and Development, Journal of the Chemical Society, Perkin Transactions, Journal of Molecular Recognition, Journal of Organic Chemistry, Progress in Physical Organic Chemistry.

Reed, S.--Advisor, HED-2 Study Section, National Institutes of Health; Associate Editor, Journal of Molecular Biology; Editorial Boards, Molecular and Cellular Biology, Molecular Biology of the Cell.

Reisfeld, R.A.--Outstanding Investigator Award, National Cancer Institute; Visiting Professor, University of Texas Health Science Center, Houston, TX; Medical Advisory Board, Pediatric Brain Tumor Foundation; Coeditor, Journal of Clinical Laboratory Analysis; Editorial Boards, Bioconjugate Chemistry, Cancer Immunology and Immunotherapy, Clinical and Experimental Immunology, Clinical Cancer Research, Hybridoma, International Journal of Oncology.

Salomon, D.R.--Editorial Boards, Transplantation, Journal of Heart and Lung Transplantation, Graft.

Sanders, L.C.--Postdoctoral Fellowship, Department of Defense, Breast Cancer Research Program.

Satterthwait, A.C.--Committee Member, Innovative Program for Approaches in HIV Vaccine Research and Integrated Preclinical/Clinical AIDS Vaccine Development, National Institute of Allergy and Infectious Diseases; Organizing Committee, Chinese Peptide Symposium.

Schmid, S.L.--American Heart Association Established Investigator; Editorial Boards, Journal of Cell Biology, Trends in Cell Biology, FASEB Journal.

Sevilla, N.--Fundacion Ramon Areces Fellowship Award.

Sharpless, K.B.--Named one of the Top 75 Contributors to the Chemical Enterprise by Chemical and Engineering News; Richards Medal, American Chemical Society, Northeastern Section; Honorary Fellow of the Royal Society of Chemistry (Great Britain); Harvey Prize in Science and Technology, Technion-Israel Institute of Technology; Max Tishler Lecture, The Kitasato Institute, Tokyo; Wyeth-Ayerst Lecture, Princeton University; Editorial Boards, Tetrahedron Publications, Acta Chemica Scandinavica, Catalysis Technology, Enantiomer, Chirality, Topics in Stereochemistry, Current Opinion in Drug Discovery and Development, Molecules Online, Synlett.

Shattil, S.J.--Councilor, American Society of Hematology; Associate Editor, Blood; Editorial Boards, Trends in Cardiovascular Medicine, American Journal of Physiology: Cell Physiology.

Siggins, G.R.--Chairman, Initial Review Group, National Institute on Drug Abuse.

Siuzdak, G.--Environmental Protection Agency Distinguished Lecturer.

Skolnick, J.--Editorial Board, Biophysical Journal.

Sprent, J.--President, American Association of Immunologists; Fellow, Royal Society, United Kingdom.

Sutcliffe, J.G.--Grass Traveling Lecturer, Society for Neuroscience; Editorial Boards, DNA and Cell Biology, Molecular Neurobiology Reviews, Journal of Neuroscience Research, Journal of Molecular Neuroscience, Advances in Neuroscience, Journal of Neurochemistry.

Theofilopoulos, A.N.--Member, American Association of Physicians.

Vogt, P.R.--Member, German Academy Leopoldina; Board of Scientific Advisors, National Cancer Institute; Board of Cell Biology Reviewers, Howard Hughes Medical Institute; Editorial Boards, Virology, Journal of Virology, Current Topics in Microbiology and Immunology, Cancer Research, Cell Growth and Differentiation, Archives of Biochemistry and Biophysics, Blood Cells, Molecules and Diseases.

von Herrath, M.G.--Junior Faculty Award, Juvenile Diabetes Association.

Whitton, J.L.--Chair, Special Study Section on Vaccine Development, National Institutes of Health; Member, Virology Study Section, National Institutes of Health; Editorial Boards, Journal of Virology, Virology, FEMS Medical Microbiology and Immunology, Journal of General Virology.

Wilson, C.B.--Editorial Boards, Clinical Nephrology, American Journal of Nephrology.

Wong, C.-H.--Taiwanese-American Foundation Prize in Science and Engineering; Visiting Professor, Academia Sinica, Taipei, and University of Florida; C.-H. Li Memorial Lecturer, Academia Sinica, Taipei; Allelix Lecturer, Department of Chemistry, University of Toronto; Member, Bioorganic and Natural Products Chemistry Study Section, National Institutes of Health; Editor-in-Chief, Bioorganic and Medicinal Chemistry; Editorial Boards, Tetrahedron Publications, Current Opinion in Chemical Biology, Biocatalysis, Drug Discovery Today.

Wright, P.E.--Fellow, American Association for the Advancement of Science; Member, Medical Advisory Board, Howard Hughes Medical Institute, and IUPAC-IUBMB-IUPAB Interunion Task Group on the Standardization of Data Bases on Protein Structures Determined by NMR in Solution; Editor-in-Chief, Journal of Molecular Biology; Editorial Boards, Biochemistry, Current Opinion in Structural Biology, Macromolecular Structures, Journal of Biomolecular NMR, Encyclopedia of Molecular Biology.

Yagi, T.--Member, Physical Biochemistry Study Section, National Institutes of Health.

Yeager, M.--Health Hero Award, Combined Health Agencies of San Diego.

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Graduate Studies Program

Norton B. Gilula, Ph.D.

The Scripps Research Institute's Graduate Studies Program continues to grow in scope and stature as it fulfills its objective to provide a unique education and training opportunity for a small group of talented students. The program was established in 1989, drawing on the Institute's unique strength in the integration of such disciplines as cell and molecular biology, structure, and chemistry. Three years later, a doctoral degree program in chemistry was initiated in an effort to use the talent of the recently assembled chemistry department.

All aspects of the program stress its multidisciplinary nature. Course work is designed to focus on the interplay of diverse fields of study. Our faculty members encourage the students to take advantage of the opportunity to participate in numerous ongoing research activities throughout the Institute that provide a tangible representation of the integration of biology with chemistry and structure.

This year, TSRI celebrated the conferral of doctoral degrees on 20 students. At commencement ceremonies held in May, Thomas D. Clark, Scott R. Conley, Martin Hendrix, Karen L. Laslo, Jean E. Patterson, Shuichi Takayama, Krista L. Witte, and Guofu Zhong received a degree in Chemistry, and Steven Joel Bark, Xiaohua Gong, James D. Jontes, David H. Lee, Gavin MacBeath, Jeanne K. McAdara, Alexander B. Niculescu, Eric B. Peterson, Greg R. Phillips, Andrew C. Saphire, Christopher A. Scott, and Felix B. Sheinerman received a degree in Macromolecular and Cellular Structure and Chemistry. In addition, Nobel Laureate Robert Bruce Merrifield, Ph.D., Professor, The Rockefeller University, and philanthropist L.S. Skaggs received honorary doctor of science degrees. Professor Julius Rebek, Jr., Ph.D., Director, The Skaggs Institute for Chemical Biology, gave the commencement address.

As has been the case each year, an increasing number of students obtained financial support from a broad range of highly competitive and prestigious sources. Students have received fellowships from government agencies, private foundations, and corporations, including the National Science Foundation, Howard Hughes Medical Institute, National Science and Engineering Research Council, Fletcher Jones Foundation, American Cancer Society, American Heart Association, Medical Research Council of Canada, FCAR, Parsons Foundation, Computational Science Graduate Fellowship Program, Boehringer Ingelheim Fonds, La Jolla Interfaces in Science, Heiwa Nakajima Foundation, Roche Foundation, Achievement Rewards for College Scientists, The Ellen Browning Scripps Foundation, National Defense Science and Engineering Graduate Fellowship, and The American Chemical Society.

A number of specially planned activities for the students provide them with the opportunity to interact with TSRI faculty as well as eminent scientists from throughout the United States.

The Distinguished Lecturer Series hosts several prominent researchers at the forefront of the biological and chemical sciences at the Institute each year. In addition to attending a formal presentation, students meet with the scientists on an informal basis in a small group setting. Speakers who participated in the series this past year included Dr. Paul A. Bartlett, University of California, Berkeley; Dr. Thomas C. Bruice, University of California, Santa Barbara; Dr. Dennis P. Curran, University of Pittsburgh; Dr. Stephen J. Lippard, Massachusetts Institute of Technology; and Dr. Gary A. Molander, University of Colorado at Boulder.

Open Forum Luncheons, held on a monthly basis, provide an informal setting for a general discussion of the students' scientific interests and progress, as well as a discussion of topics relevant to their experiences in the Graduate Program. This activity is part of the program's emphasis on individualized attention to the needs of the students and the desire to create a meaningful dialogue between students, administrators, and faculty.

The fall student-faculty retreat was held at the San Diego Princess Resort on Mission Bay. The program primarily focused on students' presentations of their research activities and poster sessions. This annual event was established to provide an interactive educational experience for faculty and students in a relaxed environment.

The Graduate Studies Program is accredited by the Accrediting Commission for Senior Colleges and Universities of the Western Association of Schools and Colleges, an institutional accrediting body recognized by the Council for Higher Education Accreditation and the U.S. Department of Education.

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General Clinical Research Center

E. Beutler, F.V. Chisari, B.L. Zuraw, D.R. Salomon, J.A. Koziol, S. Mirkis, E.E. Jensen, E.A. Bieger, K.H. Cox

Established in 1974 with a generous gift from Mrs. William H. Black and Mr. and Mrs. William F. Black, and later supplemented by a donation from the Stein Endowment Fund, the General Clinical Research Center (GCRC) is in its 24th year of continuous operation. Financed by a $14 million grant from the National Center for Research Resources, National Institutes of Health, to provide facilities for investigator-initiated, peer-reviewed research with human subjects, the GCRC is the only one of 76 such centers in the United States that is not affiliated with a university or a medical school. The Center aims to augment investigative collaborations among the clinicians and researchers at Scripps to facilitate the transfer of basic knowledge generated in research laboratories to the clinical arena, elucidate pathogenetic mechanisms of disease, and evaluate new modes of patient management.

The GCRC provides inpatient and outpatient environments in which investigators conduct human studies; the protocols followed are approved for safety by the Human Subjects Committee and for scientific merit by the GCRC Scientific Advisory Committee. The GCRC grant pays many of the costs of this research. GCRC facilities include a highly trained research nursing staff in a discrete nursing unit in the Scripps Green Hospital. A fully staffed core laboratory provides technical support for specialized research assays; preparation and storage of specimens; samples of normal blood for the laboratories of TSRI; and a DNA/RNA tissue bank, established in cooperation with the Department of Surgery.

In addition, the GCRC operates a computer center with a Unix workstation environment for the management of clinical data, genetic sequencing, and other statistical needs. Additional staff include a biostatistician for consultation on study design and statistical analysis and professional and administrative personnel to help with study design, preparation of protocols, and budgetary matters.

Last year, the GCRC provided these services for about 7000 outpatient visits, processed about 12,500 specimens, and supported 51 computer-based research protocols from TSRI and the Scripps Clinic Medical Group. Fifty-two patient-related research protocols were carried out in the GCRC; the titles and principal investigators of most of them are listed at the end of this report. Many of these projects are described under the names of the individual investigators elsewhere in this volume. A total of 97 investigators made use of the GCRC's facilities, and 90 peer-reviewed papers and abstracts resulting from GCRC-assisted research were published last year.

PRINCIPAL INVESTIGATOR PROTOCOL TITLE
Ernest Beutler, MD Normal Blood-Drawing for TSRI Labs
Ernest Beutler, MD Studies and Enzyme Replacement Therapy in Gaucher Disease
Dennis R. Burton, PhD Human Antibodies to Infectious Agents
Francis Chisari, MD Immunobiology and Pathogenesis of Hepatitis B Virus
Clifford Colwell, MD Comparison of DVT-Prevention Therapies Following Joint Replacement
Denis Darko, MD Fatigue and Sleep Abnormalities in HIV Infection: Identification of Therapies
Denis Darko, MD Mechanism of HIV-Related Fatigue and Disability
Arthur Dawson, MD Alcohol and Respiration During Sleep
Arthur Dawson, MD Hypoxemia and Pulmonary Hypertension in Gaucher Disease
Cindy Ehlers, PhD EEG Markers of Alcoholism Risk
Cindy Ehlers, PhD Fetal Alcohol Syndrome Studies
Cindy Ehlers, PhD Response to Ethanol in Asian-, African-, and Native Americans
Ann Feeney, PhD Molecular Analysis of H. influenzae Response
Robert Fox, MD, PhD CdA in Pathogenetic Autoantibodies
Robert Fox, MD, PhD Measurement of EBV DNA in Patients with Sjögren's Syndrome
Lawrence Kline, DO DPAP for Obstructive Sleep Apnea
John McHutchison, MD Intron A and Alferon-N for Hepatitis C
Robert McMillan, MD Studies in Idiopathic Thrombocytopenic Purpura (ITP)
Lindsey Miles, PhD Prothrombotic Effects in Lipoprotein(a)
Merrill Mitler, PhD Narcolepsy: Human Genetics and HLA Correlates
Donald Mosier, MD, PhD T-Cell Changes in HIV-1 Infection
Paul Pockros, MD Studies of Interferon in Hepatitis B and Hepatitis C
Steven Reed, PhD Cell-Cycle Control in Normal Human B Lymphocytes
Vance Rodgers, MD 2-CdA for Crohn's Disease and Ulcerative Colitis
Deborah Schiff, MD Recombinant IFN-/gammapub/ in Normal Subjects
Jack Sipe, MD Cladribine (2-CdA) Treatment of Multiple Sclerosis
Donald Stevenson, MD Analgesic Desensitization in Aspirin-Sensitive Asthma
Donald Stevenson, MD MSG Sensitivity in Asthma
Bruce Torbett, PhD Disruption of Human Hematopoiesis by HIV-1
Mark Yeager, MD, PhD Relationship Between Membrane Density of 2ß1 Integrin and CAD
John Yu, MD, PhD Effects of New Cytokines on Hematopoietic Stem/Progenitor Cells
Bruce Zuraw, MD Angioedema and Hageman Factor
Bruce Zuraw, MD Studies in Interstitial Cystitis

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Scripps Reference Laboratory

David J. Bylund, M.D.

The Scripps Reference Laboratory (SRL), located at 11107 Roselle Street in San Diego, California, is a division of TSRI. Its core mission is to support TSRI's biomedical research through validation and verification of new, medically useful laboratory assays. Most new assays are based on innovative research discoveries made at TSRI or elsewhere. New assays are introduced to the medical community only after careful validation or verification of the performance characteristics of the assays. Data and clinical samples from new assays performed for U.S. clients are made available to TSRI investigators in support of the investigators' applied research work.

SRL made steady technical progress during 1997-1998. We are working with John Griffin to validate a molecular assay to detect a mutation in the gene that encodes prothrombin; this mutation predisposes individuals to an increased risk of venous thrombosis. We also remain committed to supporting Dr. Griffin's research on genetic and molecular studies of activated protein C resistance and factor V--Gln506Arg.

The past year saw the introduction of a functional flow cytometric assay that uses dihydrorhodamine 123 to measure the ability of a person's stimulated granulocytes to produce reactive oxygen intermediates. The assay was validated in collaboration with John Curnutte and his associates, and we are extremely pleased with the medical utility of this state-of-the-art test. In our opinion, this assay should be considered one of the best laboratory methods available as an aid in diagnosing chronic granulomatous disease. Additionally, the likelihood is high of introducing molecular DNA sequencing assays that will detect the most common genetic alteration in chronic granulomatous disease, thereby confirming diagnosis of the disease or establishing that a patient is a carrier of the disease. This work is also being done with Dr. Curnutte.

Jerry Ware is assisting David Carney, SRL's staff scientist, with validation of an assay to help diagnose the hemophilia A carrier state. This assay is based on the principle of detecting restriction fragment length polymorphisms in families with a known hemophilia A proband.

An enzyme-linked immunoassay to detect specific autoantibodies to mitochondria in patients with primary biliary cirrhosis has been verified for use in the laboratory.

In addition to validation of new assays, numerous improvements in or conversions of assays have been implemented this past year.

SRL has assembled specialized medical assays in the areas of diagnostic immunopathology, coagulation and thrombosis, and molecular pathology that set the stage for our long-term growth. Despite the impact of managed care in the United States, we remain cautiously optimistic. We continue to face the challenges of working in an industry characterized by highly competitive economics, excess capacity, and consolidation and regionalization of laboratory services. Government and other third-party health care regulations continue to encourage a rather parsimonious approach to use of medical laboratory tests and motivate the entire laboratory industry to proactively address medical usefulness, cost containment, and managed care issues.

SRL remains committed to its role as a close partner with SmithKline Beecham Clinical Laboratories, Inc., in the United States and as a reference laboratory for Special Reference Laboratories, our affiliate based in Tokyo, Japan.

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Society of Fellows

In its 36th year, the Society of Fellows continued its mission of enhancing the postdoctoral experience at TSRI by promoting interactions between the Scripps postdoctoral fellows and the TSRI and greater scientific communities. A lecture series, 2 research symposia, and many social functions were sponsored by the Society this year.

The Society hosted a number of speakers as part of the Distinguished Lecture Series. Professor Peter Kollman, University of California, San Francisco, presented his recent work in "Some of the Major Challenges in Applying Computational Chemistry to Systems of Biological Interest Addressed With Molecular Dynamics Simulations and Quantum Mechanical Calculations." Visiting from the University Hospital of Zurich, Switzerland, Professor Rolf Zinkernagel presented "Antiviral Immunity: A Biased View." Professor Kendal Houk, University of California, Los Angeles, described his research in "Pericyclic Reactions: Computational Investigation of Rates, Mechanisms, and Catalysis of Chemical and Biological Systems." Professor Barbara Imperiali presented recent results from her group at the California Institute of Technology in "Chemistry and Biology of Asparagine-Linked Protein Glycosylation."

Our spring lectures began with 2 speakers from industry. Dr. Stephen Fesik of Abbott Laboratories, described work on important apoptosis proteins in "Solution Structure of Two Signaling Modules: Sec7 and Death Effector Domains." Dr. William Rastetter, chief executive officer, IDEC Pharmaceuticals, presented "Therapeutic Uses of Antilymphocyte Antibodies" and provided valuable insights into the biotechnology industry in a small group discussion after the seminar. Professor Francisco Ayala of the University of California, Irvine, presented "The Molecular Clock of Evolution: Power and Limitation." In our final seminar, Professor Lee Smolin of Pennsylvania State University presented "Common Themes on the Frontiers of Physics and Biology." The seminar series remains the highlight of our activities, and we look forward to continuing this successful program.

This past year was the inaugural year of a fall research symposium. The symposium was an all-day event with sessions in chemistry, structural biology, immunology, and cell biology. Each of the sessions began with a presentation given by an invited speaker. After the keynote seminars, members of the Society had the opportunity to give a talk on their research and compete for travel awards. Our invited speakers were Professors Robert Grubbs and Doug Rees from the California Institute of Technology, Professor Eli Sercarz from the La Jolla Institute of Allergy and Immunology, and Professor David Meyer from the University of California, Los Angeles. Travel awards, which help defray cost of travel to a professional meeting, were presented to David Lee (chemistry), Ulrich Genick (structural biology), Bee-Cheng Sim (immunology), and John F. Reilly (cell biology).

Another major event sponsored by the Society this spring was the Tenth Annual Research Symposium and Vendor Show. In this symposium, members of the Society were invited to present their work through poster presentations and again compete for travel awards. Award winners were Bryann Coon and Dirk Homann from the Department of Immunology and Brendan Duggan, Junko Konah, Andria Lee, and Elizabeth Thomas from the Department of Molecular Biology. Honorable mentions went to Pere Constans and Jayashree Srinivasan of the Department of Molecular Biology. At the vendor exposition, 65 chemical, biotechnical, and instrumentation companies displayed their latest scientific equipment and technology. Both the fall and spring symposia were extremely successful events and will be continued in the coming years.

This past year, the Society also embarked on efforts to help provide members with opportunities for career development. Society members met with BIOCOM, a trade organization of local biotechnology companies, and we are working on events to promote interactions between the Society of Fellows and local industry. As always, the Society sponsored several social functions, including a wine-tasting tour of Temecula, 2 ski trips to the local mountains, a whale-watching adventure, and monthly gatherings that everyone enjoyed.

The executive committee expresses its appreciation to Dr. William Beers and the office of the President for their enthusiastic support of the Society's activities.

EXECUTIVE COMMITTEE 1997-1998
Signe Holmbeck President
Colleen McKiernan Treasurer
Dirk Homann Social Chair
Jayashree Srinivasan Program Chair
Krishna Kumar Vice-President, Chemistry
Olivia Jin Vice-President, Chemical Biology
Lina Mullen Vice-President, Molecular and Experimental Medicine
Richard Santucci Vice-President, Immunology
Patricia Fagan Jones Vice-President, Molecular Biology
Isabel Novella Vice-President, Neuropharmacology
Bendahmane Mohammed Vice-President, Plant Biology
Ann Stiko Vice-President, Vascular Biology
Micah Gearhart Graduate Student Representative
Jane Lloyd Technical Staff Representative
Matthias von Herrath Honorary Officer
Doree Sitkoff Former President, July 1997 to October 1997

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MAJOR DONORS TO THE SCRIPPS RESEARCH INSTITUTE

SPECIAL ACKNOWLEDGMENT

OCTOBER 1, 1997, TO SEPTEMBER 30, 1998

The following list acknowledges the generosity of the many friends of The Scripps Research Institute, Scripps Clinic, and Scripps Foundation who have contributed $1,000 or more during the past year or whose endowment funds have added substantial strength to our scientific programs and achievements.

$100,000 OR MORE
Acute Therapeutics, Inc. American Heart Association
Anonymous (9) Arthritis Foundation
Alma Lee Barker Estate William and Sharon Bauce Family Foundation
Donald E. and Delia B. Baxter Foundation Arnold and Mabel Beckman Foundation
Becton Dickinson Becton Dickinson and Company Corporate
CaP CURE Arthur Vining Davis Foundations
Harold L. Dorris Neuroscience Foundation Juanita L. Francis Estate
Mr. Allan R. Gilbert Arthur L. Glore Estate
Juvenile Diabetes Foundation Mrs. Eugene V. Klein
Leukemia Society of America G. Harold and Leila Y. Mathers Foundation
Mr. John E. McCaw, Jr. Mr. and Mrs. John Jay Moores
National Multiple Sclerosis Society The Rockefeller Foundation
Guy R. Showley The Skaggs Institute for Research
Taylor Smith Estate Trudeau Institute, Inc.

$50,000-$99,999
Anonymous (5) Burroughs Wellcome Fund
Chicago Community Trust Cor Therapeutics, Inc.
The Council for Tobacco Research Crohn's & Colitis Foundation
Cystic Fibrosis Foundation Lois N. Dobbs Estate
Joseph Drown Foundation Howard Hughes Medical Institute
Mr. and Mrs. W. Keith Kellogg II La Jolla Children's Foundation
La Jolla Institute for Allergy Merck & Co., Inc.
NARSAD National Foundation for Cancer Research
The Ralph M. Parsons Foundation Mr. Robert P. Scripps, Sr.
Mr. Samuel H. Scripps The Seaver Institute

$25,000-$49,999
American Chemical Society Anonymous (3)
Arthritis Foundation, San Diego Blum-Kovler Foundation
Boehringer Ingelheim, Ltd. Bristol-Myers Squibb Company
Cancer Research Institute, Inc. Ms. Sandra C. Cattermole
Concern Foundation for Cancer Research Mrs. Lela W. Cotter
Mr. and Mrs. Sidney H. Craig Cyanotech Corporation
Cytel Corporation Mr. John Foley
Mr. Allan G. Fraser Mrs. Elizabeth A. Gustafson
Mr. Robert P. Gustafson Fred Hutchinson Cancer Research Center
Henry and Gladys Hutton Estate ISIS Pharmaceuticals
Mr. Don L'Arrivee Lawrence W. Lytton Estate
McKnight Foundation Ms. Nicola Paradiso
Mr. Jonathan Peachey Mrs. Susan E. Peachey
Mr. Douglas W. Perry Diana Lewis Powell Estate
San Diego State University Foundation Ellen Browning Scripps Foundation
Mr. and Mrs. Fred Snider Mrs. Mary E. Stater

$10,000-$24,999
American Liver Foundation American Society of Hematology
Anonymous (4) ARCS Foundation, Inc.
Mrs. Betty Anne Money Arenz Arthritis National Research Foundation
Jane Coffin Childs Memorial Fund Mr. and Mrs. Albert W. Day
H. Fort Flowers Foundation Samuel H. and Katherine W. French Fund
Evelyn K. Friedland Estate Mr. Ed W. Hennings
Hutter Family Foundation Mr. Robert Landers
Max Kade Foundation, Inc. Mayo Clinic Arizona
Meguiar's, Inc. Pfizer, Inc.
San Diego Convention and Visitors Bureau Mr. and Mrs. Mace Siegel
University of Colorado Health Sciences University of Virginia

$5,000-$9,999
Mrs. Richard C. Adams American Diabetes Association
Applied Phytologics, Inc. Mrs. Alfred L. Brosio
Mr. Brook H. Byers Canadian Diabetes Association
Corbin Foundation for Molecular Biology John G. Davies, Esq.
Mr. and Mrs. James W. Dennis Mr. and Mrs. Robert J. Eichenberg
Mr. and Mrs. David C. Fairchild Mr. Walter Fitch III
The Gooding Family Foundation Heller Foundation of San Diego
Hospital for Joint Diseases, Orthopaedic Mrs. Sandra Krause
Mr. and Mrs. Norman A. Lassey Mr. Hector V. Leon
Mr. and Mrs. Sheldon Magazine McCarthy Family Foundation
Molecular Medicine Foundation Pediatric Aids Foundation
Marguerite F. Pierce SCEEE Services Corporation
Scleroderma Foundation Sjögren's Syndrome Foundation, Inc.
Edward Slisz Estate The Tappan Foundation
Tucker, Sadler & Associates, AIA University of Alabama at Birmingham
Warner Lambert Company Mrs. Herbert W. Wehe, Jr.
Mrs. Nell A. Wills Mr. and Mrs. Leonard F. Wood

$1,000-$4,999
Betsy B. Adams Mrs. Barbara K. Alexander
Gene and Elaine Allen Foundation Anonymous (15)
Mr. G. Vance Askew Mr. Edwin D. Austin II
Mr. and Mrs. Thomas W. Balls Mr. John E. Barbey, Jr.
Mr. and Mrs. Robert L. Beck Oscar Bigler Estate
Dr. and Mrs. Edwin R. Black Mr. Louis L. Borick
Ms. Jane C. Botello Mr. Paul J. Bowron
Mr. and Mrs. Robert K. Break Mr. and Mrs. Martin K. Brogden
Mr. and Mrs. David B. Carmel Mrs. Rose Chassy
Mr. and Mrs. W.B. Chilcote Mr. and Mrs. J. Dallas Clark
Mr. and Mrs. Shelby Collinsworth James C. Conly, Ph.D.
Mrs. Van Blackie Cooke Mr. David C. Copley
Malcolm Cravens Foundation The Diana and Robert Davidow Foundation
Delawie Wilkes Rodrigues Barker & Bretton Deloitte & Touche
Jean Fay Drexler Estate Mrs. Charles K. Duncan
Mr. and Mrs. Ronald C. Erbetta Mr. and Mrs. Frank Feger, Jr.
Mr. and Mrs. Willis L. Fehlman Mrs. Carl E. Frahm
Mr. Robert E. Francis Ms. Catherine Georggin
Mr. and Mrs. Thomas O. Gephart Mr. and Mrs. Roger T. Gilmartin
Glenn Foundation for Medical Research Mrs. Eugenia C. Glow
Mr. and Mrs. Harvey J. Gosch Mr. Joseph Bernard Gould
Greater Media, Inc. Mr. and Mrs. Howard E. Greene, Jr.
Mrs. Kenneth R. Grigsby Mr. and Mrs. Arthur V. Grimes
Mr. and Mrs. Robert C. Gunness Senor Carlos Hank
Mrs. Virginia M. Hardway Mrs. Bruce A. Hecker
Mr. and Mrs. William J. Hefner Mr. and Mrs. Richard D. Hibbard
Mr. and Mrs. Arthur H. Hill Dr. and Mrs. John P. Howe
Mrs. Richard P. Irwin ITLA Capital Corporation
Mr. and Mrs. John J. Jachym Mr. Charles L. Jensen
Fordyce Johnson, M.D. Mr. and Mrs. Stanley E. Johnson
Johnson & Higgins of California Ms. Betty Judd
Mr. and Mrs. Yoneo Kariya Mrs. Newton M. Karp
Mr. and Mrs. Rexford P. Kastner Norman R. Klinman, M.D.
Mrs. Betty Lou Krause Mr. and Mrs. Harry J. Kropf
La Jolla Beach & Tennis Club Mr. and Mrs. William Low
Mr. and Mrs. Marvin L. Magid Marsh & McLennan, Incorporated
Mr. and Mrs. William J. Mason Mr. Richard C. Massen
Mrs. Deane B. Mather Edith L. McCullough, Ph.D.
Mercedes-Benz North America, Inc. Mr. and Mrs. Edward Michelman
Mrs. Roy K. Mitsuuchi Mr. and Mrs. Brian Monaghan
Mr. and Mrs. Neil Morgan Ms. Susan Motoike
Mr. and Mrs. John Mule National Kidney Foundation
Mr. and Mrs. Winston B. Newell, Jr. Nigro Associates
Mr. and Mrs. David Oliver Ms. Nathan G. Osborne, Jr.
Mr. and Mrs. Russell P. Paluso Mr. and Mrs. Robert G. Park
Mr. and Mrs. Robert W. Phipps Mr. and Mrs. Charles M. Piester
Ms. Mildred Pilot Mr. and Mrs. Howard M. Plant
Howard M. Plant Charitable Foundation Mrs. Edna F. Pulver
Mr. Fred M. Richards Mrs. George E. Richardson
Florence Riford La Jolla Fund Mr. and Mrs. Mayford L. Roark
Mrs. Louis Roripaugh Mr. John C. Sachs
SAIC Mr. and Mrs. Yoshiya Sanbonmatsu
Mr. and Mrs. E. Robert Sawyer Mrs. Lesly Starr Shelton
Mr. and Mrs. William H. Short Mr. and Mrs. John H. Siegel
Mr. and Mrs. Richard F. Silva Captain Harriet A. Simmons
Mr. Jean R. Solari Mr. William G. Sommerville
Mrs. Ralph W. Staver Mrs. Frank Sugg
Mr. and Mrs. Joseph E. Sutorius Mr. James W. Swedler
Dr. and Mrs. S. Jerome Tamkin Mr. and Mrs. Ray A. Tritten
Mrs. Alma Rosa Vasic Mrs. Gemma Jean Venard
Dr. and Mrs. Ansel Watrous Mr. and Mrs. Robert C. Weiss
Mr. and Mrs. Robert B. Wilson Mr. Alan J. Winkelman
Wissahickon Spring Water, Inc. Mr. and Mrs. Ulysses S. Worden
Mrs. Penny S. Zorn

FACULTY AND STAFF
Roger N. Beachy, Ph.D. Dr. Richard Boismenu
Dr. and Mrs. Francis V. Chisari Linda K. Curtiss, Ph.D.
Gregory J. del Zoppo, M.D. Dr. and Mrs. Thomas S. Edgington
Dr. M. Reza Ghadiri Donald Hilvert, Ph.D.
Dr. and Mrs. Tony E. Hugli Dr. and Mrs. David J. Loskutoff
Dr. and Mrs. K.C. Nicolaou Dr. and Mrs. Zaverio M. Ruggeri
Dr. and Mrs. Daniel R. Salomon Dr. and Mrs. Eng M. Tan
Dr. Peter Tobias Peter K. Vogt, Ph.D.
Dr. Carlos Alberto von Muhlen Dr. and Mrs. William O. Weigle
Mr. and Mrs. David M. Weston Ian A. Wilson, D.Phil.

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