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News and Publications

Staff Awards and Activities

Barbas, C.F.--Investigator Award, The Cancer Research Institute.

Beachy, R.N.--Member, National Academy of Sciences.

Benard, V.--Postdoctoral Fellowship, Association Pour la Recherché Sur le Cancer, France.

Bloom, F.E.--Golgi Medal, University of Brescia, Italy; Gold Medal Award, Society for Biological Psychiatry; Laquer Lecture, Netherlands Brain Research Institute; Member, National Academy of Sciences, Institute of Medicine, American Academy of Arts and Sciences, American Philosophical Society, Royal Swedish Academy; Editor-in-Chief, Science Magazine.

Boger, D.L.--Katritzsky Award, International Society of Heterocyclic Chemistry; Councilor, American Chemical Society, Division of Medicinal Chemistry; Editor, Bioorganic and Medicinal Chemistry Letters; Executive Editorial Board, Tetrahedron Publications.

Bokoch, G.M.--Editorial Board, Journal of Immunology.

Brooks, C.L. III--Member, Molecular and Cellular Biophysics Panel, National Science Foundation; work for protein folding selected by Computerworld for permanent display in Smithsonian Institute Archives; Editorial Board, Proteins: Structure, Function, and Genetics.

Buchmeier, M.J.--Fellow, American Association for the Advancement of Science; Councilor-Elect, American Society for Microbiology; Editorial Boards, Virology, Journal of Neurovirology.

Campbell, I.L.--Editorial Boards, American Journal of Physiology, Endocrinology and Metabolism, Molecular Psychiatry; Issue Editor, Methods: A Companion to Methods in Enzymology.

Case, D.A.--Associate Editor, Biopolymers; Editorial Boards, Journal of Biological and Inorganic Chemistry, Theoretical Chemistry Accounts.

Chan, E.K.L.--Member, General Medicine A1 Study Section, National Institutes of Health; Editorial Board, Molecular Biology Reports.

Chazin, W.J.--Faculty Research Award, American Cancer Society.

Cheresh, D.A.--Donald and Darlene Shiley Lectureship, La Jolla, CA; Robert Flynn Professorship Award and Lecture, Tufts University School of Medicine, Boston, MA; Dean's Symposium Lecture, Medical College of Georgia, Augusta, GA; Broadhurst Lecture, Schepens Institute, Harvard Medical School, Boston, MA; 15th Hans Lindner Memorial Lecture, Weizmann Institute of Science, Rehovot, Israel.

Chisari, F.V.--Merit Award, National Cancer Institute; Ernst Jung Prize for Medicine, Jung Stiftung für Wissenschaft und Forschung; Distinguished Scientific Achievement Award, American Liver Foundation; Fellow, American Association for the Advancement of Science; Karl Meyer Memorial Lecturer, University of California, San Francisco; Editorial Boards, Journal of Clinical Investigation, Virology, Microbial Pathogenesis, Viral Immunology, Transgenic Research, Journal of Experimental Pathology.

Chuang, T.H.--Investigator Award, Arthritis Foundation.

Cooper, N.R.--Editorial Board, Journal of Immunological Methods.

Curtiss, L.K.--Member, National Institutes of Health Reviewers Reserve; Editorial Boards, Arteriosclerosis, Thrombosis and Vascular Biology; Advisory Board and Editorial Board, Journal of Lipid Research.

Dyson, H.J.--Member, Molecular and Cellular Biophysics Study Section, National Institutes of Health; Editorial Board, Folding and Design.

Edgington, T.S.--Fellow, American Association for the Advancement of Science; Editorial Boards, Nouvelle Revue Française d'Hématologie, Fibrinolysis, Pathology Research and Practice, FASEB Journal, Thrombosis and Haemostasis, Biochemistry.

Elder, J.H.--Advisor, Study Section on AIDS and Related Diseases, National Institute of Allergy and Infectious Diseases; Editorial Boards, Journal of Cellular Biochemistry, Journal of Virology, Virology.

Evans, C.F.--J.D. and Iva Leiper Scholar.

Feeney, A.J.--Section Editor, Journal of Immunology.

Gardner, H.--Mark Flapan Memorial Grant Award, Scleroderma Federation/United Scleroderma Foundation.

Ghadiri, M.R.--Weissberger-Williams Lecturer, Kodak Research Laboratories, Rochester, NY; Johnson Symposium, Stanford University, Palo Alto, CA.

Giacchino, J.--Research Scientist Development Award, National Institutes of Health; Travel Award, College on Problems of Drug Dependence, Inc.

Gilula, N.B.--Visiting Professor, University College, London, England; Editor-in-Chief, Journal of Cell Biology; Editorial Boards, Current Opinion in Cell Biology, Current Biology.

Ginsberg, M.H.--Third Daiichi Lecture, University of California, San Francisco; Associate Editor, Journal of Clinical Investigation; Editorial Boards, Journal of Biological Chemistry, Trends in Cardiovascular Medicine, Blood.

Gold, L.--Joseph Cochin Young Investigator Award, College on Problems of Drug Dependence, Inc.

Gonzalez-Dunia, D.--Young Investigators Award, National Alliance for Research on Schizophrenia and Depression.

Gottesfeld, J.M.--Lecturer, Nobel Symposium, Stockholm; Editorial Boards, Gene Expression, Journal of Biological Chemistry, Archives of Biochemistry and Biophysics.

Gottlieb, R.A.--Junior Faculty Scholar Award, American Society for Hematology; Pew Scholar.

Havran, W.L.--Associate Editor, Journal of Immunology.

Henriksen, S.J.--Secretary/Treasurer, The Sleep Research Society; Chairperson, Joint Operations Committee, Association of Professional Sleep Societies; Editorial Board, Peptide Research.

Heyworth, P.G.--Associate Editor, Journal of Immunology.

Hilvert, D.--Editor, Current Opinion in Chemical Biology; Editorial Boards, Chemical Reviews, Protein Science, Chemistry and Biology.

Hoch, J.E.--Merit Award, National Institute of General Medical Services.

Johnson, E.F.--Merit Award, National Institute of Child Health and Human Development; Reviewing Editor, Science; Volume Editor, Methods in Enzymology, Vol. 272; Editorial Boards, Journal of Biological Chemistry, Molecular Pharmacology, Archives of Biochemistry and Biophysics.

Johnson, J.E.--Board of Scientific Counselors, National Cancer Institute and National Institute of Arthritis and Musculoskeletal and Skin Disorders; Member, International Committee on Taxonomy of Viruses; Associate Editor, Biophysical Journal.

Joyce, G.F.--Herbert W. Dickerman Award, State of New York, Department of Health; Hans Sigrist Award, Universität Bern, Switzerland; Associate Editor, Chemistry and Biology, Evolutionary Computation; Section Editor, Combinatorial Chemistry, Current Opinion in Chemical Biology.

King, C.C.--Postdoctoral Fellowship, Arthritis Foundation.

Koob, G.F.--Member, National Advisory Council, National Institute on Drug Abuse; Merit Award, National Institute on Alcohol Abuse and Alcoholism; U.S. Editor-in-Chief, Pharmacology, Biochemistry and Behavior.

Lane, T.E.--Advanced Postdoctoral Fellow, National Multiple Sclerosis Society.

Lerner, R.A.--The Twelfth Biennial Carl S. Marvel Symposium, University of Arizona; John and Dolores Stille Science Symposium, Colorado State University; Roma Eisenstark Memorial Lecture in Cancer Research, University of Missouri-Columbia; Arrhenius Lecture in Chemistry, Stockholm University; Senior Contributing Editor, Proceedings of the National Academy of Sciences of the United States of America; Editorial Boards, Bioorganic and Medicinal Chemistry, Bioorganic and Medicinal Chemistry Letters, Chemistry and Biology, Drug Targeting and Delivery, In Vivo, Journal of Virology, Molecular Biology and Medicine, Molecular Biology, Peptide Research, Vaccine.

Lotz, M.--Editorial Boards, Arthritis and Rheumatism, Biotherapy, Osteoarthritis and Cartilage, Revue de Rhumatisme.

Mackman, N.--Member, Pathology A Study Section, National Institutes of Health.

Manchester, M.--Fellowship Award, World Health Organization.

Maruyama, I.--Editorial Board, Biotechnology et alia.

McLachlan, A.--Editorial Board, Journal of Virology.

Nemerow, G.R.--Editorial Boards, Trends In Microbiology, Immunopharmacology.

Nicolaou, K.C.--Andrews Lecturer, University of New South Wales Chemical Society, Sydney, Australia; Honorary Ph.D. (honoris causa), Universidad de Alcala, Madrid, Spain; Honorary Member, Pharmaceutical Society of Japan; Co-Editor-in-Chief, Chemistry and Biology; Editorial Boards, Synthesis, Carbohydrate Letters, Chemistry: A European Journal, Perspectives in Drug Discovery and Design, Indian Journal of Chemistry, Tetrahedron Publications.

Novella, I.--Research Award, Theodore and Vada Stanley Foundation.

Oldstone, M.B.A.--Member, Institute of Medicine, National Academy of Sciences; Counselor, American Association of Clinical Immunology; Member, Scandinavian Society of Immunology; Board of Scientific Counselors, National Institute of Allergy and Infectious Diseases; Member, Committee for the Eradication of Poliomyelitis and Measles Virus, World Health Organization; Philip J. Bassford Memorial Lecture, University of North Carolina, Chapel Hill; Bernard Fields Lecturer, FASEB Conference on Microbial Pathogenesis; Editor, Virology; Editorial Boards, Journal of Experimental Medicine, Current Topics in Microbiology and Immunology.

Olson, A.J.--Member, Steering Committee, San Diego Supercomputer Center, Pittsburgh Supercomputer Center; Executive Committee, Molecular Graphics and Modelling Society of the Americas; National Partnership for Advanced Computational Infrastructure; Editorial Boards, Computers and Chemistry, Journal of Molecular Graphics.

Polich, J.--Member, Board of Directors, Society for Psychophysiological Research, Board of Governors, International Organization of Psychophysiology; Editorial Boards, Electroencephalography and Clinical Neurophysiology, International Journal of Psychophysiology.

Quaranta, V.--Ad hoc Member, Cell Biology 1 Study Section, National Institutes of Health; Associate Editor, Cancer Research.

Reed, S.--Advisor, CBY-2 Study Section, National Institutes of Health; Associate Editor, Journal of Molecular Biology; Editorial Boards, Molecular and Cellular Biology, Molecular Biology of the Cell.

Reisfeld, R.A.--Outstanding Investigator Award, National Cancer Institute; First Immunomedics Science Award; Member, Medical Advisory Board, Pediatric Brain Tumor Foundation; Coeditor, Journal of Clinical Laboratory Analysis; Editorial Boards, Bioconjugate Chemistry, Cancer Immunology and Immunotherapy, Clinical and Experimental Immunology, Clinical Cancer Research, Hybridoma, International Journal of Oncology.

Ruf, W.--Established Investigator Award, American Heart Association.

Salomon, D.R.--Editorial Boards, Transplantation, International Journal of Heart and Lung Transplantation.

Sanders, L.C.--Postdoctoral Fellowship, Department of Defense, Breast Cancer Research Program.

Satterthwait, A.C.--Member, Organizing Committee, Chinese Peptide Symposium 1998; Innovative Approaches to AIDS Vaccine Research Study Section, National Institutes of Health.

Schmid, S.L.--Established Investigator, American Heart Association; Editorial Boards, Journal of Cell Biology, Trends in Cell Biology, FASEB Journal.

Sharpless, K.B.--Honorary Doctorate, Université Catholique de Louvain, Belgium; Roger Adams Award in Organic Chemistry, American Chemical Society; ACL Distinguished Lecture, The Chinese University of Hong Kong; 1st Barton Lecture, Texas A&M University; Buchi Lecture, Massachusetts Institute of Technology; McElvain Speaker, University of Wisconsin; Editorial Boards, Acta Chemica Scandinavica, Catalysis Technology, Enantiomer, Chirality, Tetrahedron Publications.

Shattil, S.J.--Councillor, American Society of Hematology; Associate Editor, Blood; Editorial Board, Trends in Cardiovascular Medicine.

Siggins, G.R.--Chairman, Initial Review Group, National Institute on Drug Abuse.

Skolnick, J.--Editorial Board, Biophysical Journal.

Sprent, J.--Councillor, American Association of Immunologists and International Union of Immunological Societies; Scientific Advisory Board, Howard Hughes Medical Institute; Editorial Boards, Journal of Experimental Medicine, Immunity.

Sutcliffe, J.G.--Editorial Boards, DNA and Cell Biology, Molecular Neurobiology Reviews, Journal of Neuroscience Research, Journal of Molecular Neuroscience, Advances in Neuroscience, Journal of Neurochemistry.

Tan, E.M.--Honorary Member, Mexican National Academy of Medicine; Editorial Boards, Journal of Experimental Medicine, Journal of Clinical Investigation, Journal of Molecular Medicine, Clinical Immunology and Immunopathology, Clinical and Experimental Immunology, Journal of Clinical Immunology.

Vogt, P.K.--Editorial Boards, Virology, Current Topics in Microbiology, Cancer Research, Cell Growth and Differentiation, Archives of Biochemistry and Biophysics.

von Herrath, M.G.--Junior Faculty Award, Juvenile Diabetes Association.

Weigle, W.O.--Editorial Board, Cellular Immunology; Associate Editor, Aging: Immunology and Infectious Disease.

Whitton, J.L.--Chair, Special Study Section on Vaccine Development, National Institutes of Health; Member, Virology Study Section, National Institutes of Health; Editorial Boards, Journal of Virology, Virology, FEMS Medical Microbiology and Immunology, Journal of General Virology.

Wilson, C.B.--Editorial Boards, Clinical Nephrology, The American Journal of Nephrology.

Wilson, I.A.--Chairman, BioSync Committee, Structural Biology Synchrotron Users Organization; Associate Editor, Journal of Molecular Biology, Immunity.

Wright, P.E.--Member, Medical Advisory Board, Howard Hughes Medical Institute; Editor-in-Chief, Journal of Molecular Biology; Editorial Boards, Biochemistry, Current Opinion in Structural Biology, Macromolecular Structures, Journal of Biomolecular NMR, Encyclopedia of Molecular Biology.

Yeager, M.--Health Hero Award, Combined Health Agencies of San Diego.

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Graduate Studies Program

Norton B. Gilula, Ph.D.

The Scripps Research Institute's Graduate Studies Program has continued to grow in scope and stature as it fulfills its objective to provide a unique education and training opportunity for a small group of talented students. The program was established in 1989, drawing on the Institute's unique strength in the integration of such disciplines as cell and molecular biology, structure, and chemistry. Three years later, a doctoral degree program in chemistry was initiated in an effort to use the talent of the recently assembled chemistry department.

All aspects of the program stress its multidisciplinary nature. Course work has been designed to focus on the interplay of diverse fields of study. Our faculty members encourage the students to take advantage of the opportunity to participate in numerous ongoing research activities throughout the Institute that provide a tangible representation of the integration of biology with chemistry and structure.

This year, TSRI celebrated the conferral of doctoral degrees on 20 students. At commencement ceremonies held in May, Han-Ting Chang, Christopher Fairman Claiborne, Jonathan L. Gross, Rodney K. Guy, Nancy-Ellen Haynes, J. Heather Hogg, Douglas S. Johnson, Chun-Cheng Lin, Susan Marie McComb, and Eddy Wai Tsun Yue received a degree in Chemistry, and Benjamin F. Cravatt, Tianhua Hu, Jing-Feng Huang, Jonathan S. Rosenblum, Ying Tang, Joyce Tsang, Lin Wu, Yanhai Yin, Christopher B. Yohn, and Zaohui Sunny Zhou received a degree in Macromolecular and Cellular Structure and Chemistry. In addition, Donald W. Seldin, M.D., The University of Texas System Professor of Internal Medicine, was conferred an honorary doctor of science degree. Professor Marvin L. Goldberger, Dean, Division of Natural Science, University of California, San Diego, gave the commencement address.

As has been the case each year, an increasing number of students have obtained financial support from a broad range of highly competitive and prestigious sources. Students have received fellowships from government agencies, private foundations, and corporations, including the National Science Foundation, Howard Hughes Medical Institute, National Science and Engineering Research Council, Economic Development Board, American Cancer Society, American Heart Association, Medical Research Council of Canada, Parsons Foundation, Computational Science Graduate Fellowship Program, Boehringer Ingelheim Fonds, University of Singapore, La Jolla Interfaces in Science, Heiwa Nakajima Foundation, Roche Foundation, and the American Chemical Society.

A number of specially planned activities for the students provide them with the opportunity to interact with TSRI faculty as well as eminent scientists from throughout the United States.

The Distinguished Lecturer Series hosts several prominent researchers at the forefront of the biological and chemical sciences at the Institute each year. In addition to attending a formal presentation, students meet with the scientists on an informal basis in a small group setting. Speakers who participated in the series this year included Dr. Ralph F. Hirschmann, University of Pennsylvania; Dr. Martin Raff, University College, London; Dr. Thomas D. Pollard, The Salk Institute for Biological Studies; Dr. Eric R. Kandel, Columbia University; Dr. Carla J. Shatz, University of California, Berkeley; and Dr. William Lipscomb, Harvard University.

Open Forum Luncheons, held on a monthly basis, provide an informal setting for a general discussion of the students' scientific interests and progress, as well as a discussion of topics relevant to their experiences in the Graduate Program. This activity is part of the program's emphasis on individualized attention to the needs of the students and the desire to create a meaningful dialogue between students, administrators, and faculty.

The fall student-faculty retreat was held at the San Diego Princess Resort on Mission Bay. The program primarily focused on students' presentations of their research activities and poster sessions. This annual event was established to provide an interactive educational experience for faculty and students in a relaxed environment.

TSRI's Graduate Studies Program is accredited by the Western Association of Schools and Colleges.

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General Clinical Research Center

E. Beutler, F.V. Chisari, E.M. Tan, B.L. Zuraw, J.A. Koziol, S. Mirkis, E.E. Jensen, K.H. Cox, E.A. Bieger

Established in 1974 with a generous gift from Mrs. William H. Black and Mr. and Mrs. William F. Black, and later supplemented by a donation from the Stein Endowment Fund, the General Clinical Research Center (GCRC) is in its 23rd year of continuous operation. Financed by a $14 million grant from the National Center for Research Resources, National Institutes of Health, to provide facilities for investigator-initiated, peer-reviewed research with human subjects, the GCRC is the only one of 76 such centers in the United States that is not affiliated with a university or medical school. The Center aims to augment investigative collaborations among the clinicians and researchers at Scripps to facilitate the transfer of basic knowledge generated in research laboratories to the clinical arena, elucidate pathogenetic mechanisms of disease, and evaluate new modes of patient management.

The GCRC provides inpatient and outpatient environments in which investigators conduct studies in human subjects; the protocols followed are approved for safety by the Human Subjects Committee and for scientific merit by the GCRC Scientific Advisory Committee. The GCRC grant pays many of the costs of this research. GCRC facilities include a highly trained research nursing staff in a discrete nursing unit in the Green Hospital. A fully staffed core laboratory provides technical support for specialized research assays; preparation and storage of specimens; samples of normal blood for the laboratories of TSRI; and a DNA/RNA tissue bank, established in cooperation with the Department of Surgery.

In addition, the GCRC operates a computer center with a Unix workstation environment for the management of clinical data, genetic sequencing, and other statistical needs. Additional staff include a biostatistician for consultation on study design and statistical analysis and professional and administrative personnel to help with study design, preparation of protocols, and budgetary matters.

Last year, the GCRC provided these services for more than 7500 outpatient visits, processed about 11,500 specimens, and supported 27 computer-based research protocols from TSRI and the Scripps Clinic Medical Group. Fifty-two patient-related research protocols were carried out in the GCRC. The titles and principal investigators of most of them are listed at the end of this report. Many of these projects are described under the names of the individual investigators elsewhere in this volume. Ninety-two investigators made use of the GCRC's facilities, and 146 peer-reviewed papers and abstracts resulting from GCRC-assisted research were published last year.

Ernest Beutler, MD Normal Blood-Drawing for TSRI Labs
Ernest Beutler, MD Studies and Enzyme Replacement Therapy in Gaucher Disease
Francis Chisari, MD Immunobiology and Pathogenesis of Hepatitis B Virus
John Curnutte, MD, PhD Chronic Granulomatous Disease Treated with IFN-
Denis Darko, MD Fatigue and Sleep Abnormalities in HIV Infection: Identification of Therapies
Denis Darko, MD Mechanism of HIV-Related Fatigue and Disability
Denis Darko, MD Quantitated Sleep and Somnogenic Peptides in Depression
Arthur Dawson, MD Alcohol and Respiration During Sleep
Arthur Dawson, MD Hypoxemia and Pulmonary Hypertension in Gaucher Disease
Gregory del Zoppo, MD Leukocyte Activation in Cerebral Ischemia Due to Stroke
Cindy Ehlers, PhD EEG Markers of Alcoholism Risk
Cindy Ehlers, PhD Fetal Alcohol Syndrome Studies
Cindy Ehlers, PhD Response to Ethanol in Asian and Native Americans
Robert Fox, MD, PhD CdA in Pathogenetic Autoantibodies
Robert Fox, MD, PhD Intractable Arthritis Treated with Azaribine Plus Pyridoxine
Robert Fox, MD, PhD Measurement of EBV DNA in Patients with Sjögren's Syndrome
Mark Ginsberg, MD Construction of a cDNA Expression Library from Normal Bone Marrow
Lawrence Kline, DO DPAP for Obstructive Sleep Apnea
John McHutchison, MD Intron A and Alferon-N for Hepatitis C
Robert McMillan, MD Studies in Idiopathic Thrombocytopenic Purpura (ITP)
Merrill Mitler, PhD Narcolepsy: Human Genetics and HLA Correlates
Paul Pockros, MD Studies of Interferon in Hepatitis B and Hepatitis C
Vance Rodgers, MD 2-CdA for Crohn's Disease and Ulcerative Colitis
Deborah Schiff, MD Recombinant IFN- in Normal Subjects
Jack Sipe, MD Cladribine (2-CdA) Treatment of Multiple Sclerosis
Donald Stevenson, MD Aspirin Desensitization in Asthma
Donald Stevenson, MD MSG Sensitivity in Asthma
Patrick Whelan, MD, PhD Etiology and Consequences of Acute Lymphopenia After CABG
Mark Yeager, MD, PhD Relationship Between Membrane Density of 2ß1 Integrin and CAD
Bruce Zuraw, MD Angioedema and Hageman Factor
Bruce Zuraw, MD Studies in Interstitial Cystitis

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Scripps Reference Laboratory

David J. Bylund, M.D.

The Scripps Reference Laboratory (SRL), located at 11107 Roselle Street in San Diego, California, is a division of TSRI. Its core mission is transfer of new assays from TSRI laboratories into SRL for introduction to the medical community. This transfer of technology targets new, medically useful assays based on innovative research discoveries made by TSRI scientists. These new assays are introduced for medical use only after SRL staff perform extensive validation work. Data and clinical samples from new assays performed for U.S. clients are made available to TSRI investigators in support of the investigators' applied research.

SRL made significant scientific progress during 1996--1997. Working with our U.S. partner, SmithKline Beecham Clinical Laboratories, Inc., we successfully introduced several new assays for medical use. This past year saw the introduction of allele-specific oligonucleotide hybridization assays to detect the two most common point mutations associated with hereditary hemochromatosis. This work was based on assays from Ernest Beutler's laboratory.

We are excited about the introduction of John Curnutte's flow cytometric assay for diagnosis of chronic granulomatous disease. This state-of-the-art functional assay uses dihydrorhodamine 123 to measure the ability of a person's stimulated granulocytes to produce reactive oxygen intermediates. We are currently working with Dr. Curnutte to validate molecular DNA-sequencing assays that indicate the most common genetic alterations in patients with chronic granulomatous disease.

Jerry Ware is assisting David Carney, SRL's staff scientist, with validation of an assay to help diagnose the hemophilia A carrier state. This assay is based on the principle of detecting restriction fragment length polymorphisms in families with a known hemophilia A proband.

Eng Tan and his collaborators recently reported their discovery of the presence of autoantibodies to nuclear envelope antigens in about 50% of persons with chronic fatigue syndrome. This discovery provides new laboratory evidence for an autoimmune component in this syndrome. Although the assay currently available to measure these autoantibodies is technically challenging, we are working with Dr. Tan to evaluate the usefulness of applying this technology to a medical laboratory while further research is under way.

In addition to validating new assays, we also devote resources to improving assays. In the past year, we worked with Ray Schleef to implement significant technological improvements in assays that measure the concentration and activity of plasminogen activator inhibitor 1 and in tests that measure tissue plasminogen activator.

SRL has assembled a set of specialized medical assays in the areas of diagnostic immunopathology, coagulation and thrombosis, and molecular pathology that set the stage for our long-term growth. Despite the major impact of managed care on SRL operations, we remain cautiously optimistic. We continue to face the challenge of working in an industry characterized by constant, rapid change and highly competitive economics. Current government and other third-party health care regulations encourage a rather parsimonious approach to use of medical laboratory tests and strongly encourage us to proactively address medical utility, cost containment, and managed care issues.

SRL remains committed to its role as a close partner with SmithKline Beecham Clinical Laboratories, Inc., in the United States and as a reference laboratory for Special Reference Laboratories, our important affiliate based in Tokyo, Japan.

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Society of Fellows

Society of Fellows officers:
Front row (left to right): Jayashree Srinivasan, Joanne W. Yun, Doree Sitkoff, Colleen McKiernan.
Standing (left to right): Krishna Kumar, Mark Foster, Ann Stiko, Micah Gearhart.

Established 35 years ago at TSRI, the Society of Fellows strives to promote interactions between the postdoctoral fellows and between the fellows and the TSRI community. To facilitate these interactions, the Society sponsored a distinguished lecturer series, a research symposium, and several social activities this year.

In keeping with the tradition of inviting top scientists from diverse areas of research, this year we hosted an outstanding roster of speakers for our seminar series. In the fall, Professor William F. DeGrado, University of Pennsylvania, presented his recent results in "De Novo Protein Design"; the distinguished Professor Carl Djerassi, Stanford University, shared his views on the culture of science in "Noble Science and Nobel Lust"; and Dr. James Wells of Genentech Inc. described his research in "Minimizing Proteins" and provided us with insight into how science and research are carried out in the industrial sector.

In the spring, Dr. Kevin Lafferty, director of the John Curtin School of Medical Research in Australia, presented his latest data in "Autoimmune Diabetes." Later, Dr. Oliver Ryder, head of the genetics division, Center for Reproduction of Endangered Species, Zoological Society of San Diego, emphasized the importance of maintaining genetic diversity among exotic species in a presentation titled "Genome Projects for Endangered Species: Gorillas and Giant Pandas." Our next seminar was "Emerging Viruses: What Emerged and What Can Be Expected to Emerge," given by Clarence J. Peters, chief of the Special Pathogens Branch, Centers for Disease Control and Prevention. Prof. Jacqueline Barton, California Institute of Technology, enlightened us in "DNA-Mediated Electron Transfer: Chemistry at a Distance."

In a forum to conclude the year, Dr. Jeffrey Kirsch, executive director of San Diego's Reuben Fleet Space Theater and Science Center, presented his views in "The Public Understanding of Biology and Medicine in the Age of Cheap Information." The seminar series remains the highlight of our activities, and we look forward to continuing this successful program.

Another major event sponsored by the Society was the Ninth Annual Research Symposium and Vendor Exposition. At the exposition, 56 vendors from several chemical, biotechnical, and instrumentation companies exhibited their new products to TSRI scientists. At the symposium this year, society members were invited to present their research results to the Scripps community through poster presentations. A total of 22 posters were presented and judged. The Society granted awards to six participants. The awards, which help defray travel expenses to conferences, were presented to Drs. David Eliezer, Fan Dong, Qiang Liu, and Signe Holmbeck of the Department of Molecular Biology; Wei Cao of the Department of Neuropharmacology; and Mark Slifka of the Department of Immunology.

In addition to these major events, the Society sponsored several social activities throughout the year, including a wine-tasting trip to Temecula, a whale-watching cruise, a day trip to the ski slopes at Big Bear, and our monthly gatherings. These events were enjoyed by one and all.

The executive committee expresses its appreciation to the office of the President and Dr. William Beers for their enthusiastic support of the Society's activities. The increase this past year in the number of members on the executive committee clearly indicates the desire among the fellows to promote interactions within the research community at TSRI.

Executive Committee 1996--1997
Mark Foster President
Doree Sitkoff Program Chair
Matthias von Herrath Treasurer
Dirk Homann Social Chair
Krishna Kumar Vice-President, Chemistry
Colleen McKiernan Vice-President, Cell Biology
Joanne Yun Vice-President, Chemical Biology
Randy Ketchem Vice-President, Molecular Biology
Ann Stiko Vice-President, Vascular Biology
Isabel Novella Vice-President, Neuropharmacology
Lina Mullen Vice-President, Molecular and Experimental Medicine
Bendahmane Mohammed Vice-President, Plant Biology
Susan Spray Vice-President, Animal Resources
Michael Hickey Technical Staff Representative
Nicole Herold Graduate Student Representative (outgoing)
Micah Gearhart Graduate Student Representative (incoming)
Olivia Jin Officer, Chemistry
Jayashree Srinivasan Officer, Molecular Biology
Henry Zhang Officer, Molecular Biology

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Major Donors To The Scripps Research Institute


The following are those individuals and organizations who, over the years, have given $1 million or more in support of investigations at the Research Institute. We specially honor them and recognize their dedication to the advancement of medical science.

American Cancer Society American Heart Association
Arthritis Foundation Dr. and Mrs. Arnold O. Beckman
Arnold and Mabel Beckman Foundation Council for Tobacco Research
Mr. and Mrs. Richard A. Cramer Pauline S. and Ray T. Edwards
Walter Fitch III Dr. and Mrs. Cecil H. Green
Mr. and Mrs. Ernest W. Hahn Ernest W. and Jean Hahn Charitable Trust
Lita Annenberg Hazen Juvenile Diabetes Foundation
W.M. Keck Foundation Mr. and Mrs. W. Keith Kellogg II
Gladys Q. Knapp Mr. and Mrs. Dirk C. Kok, Jr.
Leukemia Society of America Mr. and Mrs. John D. Lusk
Lucille P. Markey Charitable Trust G. Harold and Leila Y. Mathers Foundation
McNeil Pharmaceutical Meloy Laboratories
Mr. and Mrs. James T. Minor National Multiple Sclerosis Society
Ortho Diagnostic Systems, Inc. Donald and Lois Roon
Leo and Anna Roon The E.W. Scripps Family
Mr. and Mrs. Donald P. Shiley Aline W. and L.S. Skaggs
The Skaggs Institute for Research Mrs. Betty L. Springer
Sam and Rose Stein Charitable Trusts Buddy Taub Foundation
Timken-Sturgis Foundation Weingart Foundation
Mr. and Mrs. N. Paul Whittier

OCTOBER 1, 1996 TO SEPTEMBER 30, 1997

The following list acknowledges the generosity of the many friends of The Scripps Research Institute, Scripps Clinic, and Scripps Foundation who have contributed $1,000 or more during the past year or whose endowment funds have added substantial strength to our scientific programs and achievements.

$100,000 OR MORE
American Cancer Society American Heart Association
Anonymous (1) Arthritis Foundation
Donald and Delia Baxter Foundation Ely R. Callaway, Jr.
CAP CURE Council for Tobacco Research
Joseph H. Hazen Foundation Juvenile Diabetes Foundation
Mr. and Mrs. W. Keith Kellogg II Leukemia Society of America
G. Harold and Leila Y. Mathers Foundation National Multiple Sclerosis Society
Estate of Melvin S. Reeves The Rockefeller Foundation
The Skaggs Institute for Research Estate of Robert and Courtney Snowden
Buddy Taub Foundation
American Diabetes Association Anonymous (1)
Mrs. Margaret S. Buzzelli Cancer Research Institute, Inc.
Mrs. Lela W. Cotter Cystic Fibrosis Foundation
Walter Fitch III Basia Gingold, M.D.
Estate of Dorothy M. McGuire Estate of Harper C. Olmstead
Palley-Needelman Asset Management, Inc. The Ralph M. Parsons Foundation
Ellen Browning Scripps Foundation
American Foundation for AIDS Research Bayer Foundation
Damon Runyon--Walter Winchell Cancer Fund Joseph Drown Foundation
The Emmes Corporation Howard Hughes Medical Institute
Max Kade Foundation, Inc. Mr. David J. Lloyd
Mr. James O. McCaldin McKnight Foundation
Muscular Dystrophy Association, Inc. Estate of Michael Y. Sagor
Schering Corporation Estate of Iris M. Schleibaum
Dr. Seuss Foundation Estate of Taylor Smith
Wynn Foundation
American Liver Foundation Mr. and Mrs. Herbert Berk
Estate of Oscar Bigler Mr. and Mrs. Matt S. Browning
Concern Foundation for Cancer Research Crohn's & Colitis Foundation
Ms. Joan R. Fisher H. Fort Flowers Foundation
Mr. and Mrs. Eugene M. Foster Samuel H. and Katherine W. French Fund
Estate of Melvin E. German Heller Foundation of San Diego
Jeanette B. Hennings Mr. and Mrs. Kenneth E. Hill
Mr. Heinz F. Hutter The J.D. and Iva Leiper Trust
Estate of Maria C. Lipari Mrs. Nackey S. Loeb
Ms. Jeanne Ham Peto Mrs. Jack T. Sakioka
Mr. and Mrs. Mace Siegel Mrs. John T. Snite
Alice and Arthur Weiner Mr. and Mrs. Leonard F. Wood
Mrs. Richard C. Adams Mrs. Barbara K. Alexander
Anonymous (2) Mr. and Mrs. C. Neil Ash
Mr. and Mrs. Jack F. Cassan Mr. Barney G. Corbin
CURE 2000 Leukemia Research Fund John G. Davies, Esq.
Mr. and Mrs. Okey B. Johnson, Jr. Kirkeby Foundation
Mr. Hector V. Leon Mr. and Mrs. Sheldon Magazine
Mr. and Mrs. Manuel Mancebo, Jr. Mr. and Mrs. Oscar G. Mayer
Muchnic Foundation Florence Riford La Jolla Fund
Mr. and Mrs. Yoshiya Sanbonmatsu Sjögren's Syndrome Foundation, Inc.
Mr. and Mrs. David S. Tappan, Jr. Mr. and Mrs. Robert G. Wallace
Mrs. Herbert Wehe, Jr.
Ms. Betsy B. Adams Ms. Denese M. Alexander
The Gene and Elaine Allen Foundation
Mrs. Roberta R. Allen Anonymous (15)
Mr. and Mrs. Charles J. Aschauer, Jr. Mrs. Elaine Baertschi
Mr. and Mrs. Robert E. Balfrey Mr. and Mrs. Thomas W. Balls
Ms. Donna J. Cowley Barba Mr. and Mrs. Nicholas P. Barron
Mr. Oliver L. Bassett Mrs. Daniel J. Bessmer
Mr. and Mrs. William N. Blatt Ms. Jane Botello
Mr. and Mrs. H.G. Bouris Mr. Paul J. Bowron
Robert and Catherine Break Mr. Leslie S. Buck
Mr. Gene Burkard Mr. and Mrs. Manuel L. Carrasco
Mr. and Mrs. Michael L. Catalano Mr. and Mrs. Eli Catran
Mrs. Rose Chassy Mr. and Mrs. Benjamin Coates
Mr. and Mrs. Shelby Collinsworth Clarence and Ellen Conzelman
Mrs. Ellen Tobin Cooley Mrs. Charles E. Cooney
Mr. and Mrs. King Cooper, Jr. Mr. David C. Copley
Mr. and Mrs. Moody Covey Malcolm Cravens Foundation
Mr. and Mrs. Robert W. Culver Mrs. Florance Cuno
Mrs. Mabel Irene Danenberg Mr. and Mrs. William E. Danjczek
Mr. and Mrs. Robert A. Davidow Mr. and Mrs. Frank W. Davis
Delawie Wilkes Rodrigues Barker & Bretton Mrs. Burgess Dempster
Dermatology Foundation Mr. and Mrs. Robert William Deruntz
Mr. and Mrs. Martin C. Dickinson Mr. Karl F. Dietzel
Mr. Robert L. Donley Mr. and Mrs. Arthur E. Duhamell
Mr. and Mrs. Laverne Duker Mrs. Charles K. Duncan
C.A. Dunn and Sharon Dunn Charles C. and Sue K. Edwards Foundation
Mr. and Mrs. Daniel E. Even Mr. and Mrs. David C. Fairchild
Mr. and Mrs. James W. Farschon Mr. and Mrs. Charles R. Faust
Mrs. William Russell Fawcett Mr. and Mrs. Frank Feger, Jr.
Mr. and Mrs. William Ferdi Mr. and Mrs. Stanley Fishfader
Mrs. Ward Fitzpatrick Mr. and Mrs. Carl E. Frahm
Mr. Robert E. Francis Mr. and Mrs. Edwin S. Friendly, Jr.
Mrs. Lourdes A. Garcia Dr. William L. Garman
Mr. Allan R. Gilbert Mr. and Mrs. Roger T. Gilmartin
Dr. and Mrs. Louis Gluck Mr. and Mrs. Karl Godoy
Mr. Howard Leslie Gosch Mr. and Mrs. David Grand
Mr. and Mrs. Howard E. Greene, Jr. Mr. and Mrs. Jack Greening
Mrs. Kenneth R. Grigsby Mr. and Mrs. Arthur V. Grimes
Ms. Eliana Hadinoto-Budi Senor Carlos Hank
Mrs. Virginia M. Hardway Mr. and Mrs. William J. Hefner
Mr. and Mrs. Joseph Heiferman Mrs. Maria A. Herrera
Mr. and Mrs. Warren N. Hessler, Jr. Mr. and Mrs. Richard D. Hibbard
Mr. and Mrs. Arthur H. Hill Dr. and Mrs. John P. Howe
Mr. and Mrs. Roger Howe Mr. and Mrs. James E. Hoyle
Mr. and Mrs. Robert E. Huisken Mr. and Mrs. Lawrence E. Irell
Amelia R. Irvine Mr. and Mrs. John Nichol Irwin II
ITLA Capital Corporation Mr. and Mrs. Oliver B. James, Jr.
Mr. Charles L. Jensen Mrs. Richard W. Judd
Mr. and Mrs. Hubert L. Kaltenbach Mr. and Mrs. William Karatz
Mr. and Mrs. William G. Karnes Mr. and Mrs. Rexford P. Kastner
Terry Kees and Harold L. Kees Mr. and Mrs. Warren H. Klure
Mr. David Howard Knapp Drs. Robert G. and Mary Knight
Mr. and Mrs. W.E. Koerwitz Betty Lou Krause
Mrs. Sandra Krause Mr. and Mrs. Harry J. Kropf
Ms. Florence M. Kyle Mr. Richard P. Laabs
Mrs. Michael D. LaBate Mr. and Mrs. W.R. Lake, Jr.
Mrs. Cecelia Lance Mr. Robert Landers
Helen S. Levitt Mr. and Mrs. Jackson T. Lewis
Mr. Robert M. Loh Mr. And Mrs. William Low
Mr. Leonard B. Lundin Mrs. Josephine R. MacConnell
Mr. and Mrs. Stewart MacDougall Stephen B. Macfarlane
Mr. and Mrs. Gerald J. Manna Mr. and Mrs. William J. Mason
Mr. Richard C. Massen Malcolm L. and Joan E. Matheson
Edith L. McCullough, Ph.D. Mrs. Margaret C. McKenzie
Mr. Michael R. McMillan Mr. and Mrs. Patrick W. McNamara
Mr. Philip Michalove Mr. and Mrs. Owen L. Miller
David L. Mitchell and Judith L. Bradley Harle Garth Montgomery
Mr. and Mrs. Ted Mooschekian Eugenia Riordan Mule
Dr. and Mrs. Joseph E. Mullin Mr. and Mrs. Nejat Munisoglu
Mr. and Mrs. Robert T. Nahas Mr. and Mrs. Douglas K. Nelson
Mr. and Mrs. Floyd Nelson, Jr. Mr. and Mrs. Winston B. Newell, Jr.
Mr. Edmund M. de V. Olivier Mr. and Mrs. Samuel Oran
Mr. William F. Pabst, Jr. Mr. and Mrs. Raymond J. Paige
Mr. and Mrs. Russell P. Paluso Mr. and Mrs. Joseph P. Paoluccio
Mr. and Mrs. Emil J. Parente Mr. and Mrs. William G. Paul, Jr.
Ms. Leonor M. Picard Mr. and Mrs. Charles M. Piester
Mildred Pilot Mr. and Mrs. William J. Polis
Mr. and Mrs. Leonard H. Polster Edna F. Pulver
Mr. George C. Punton Mrs. M. Jeanette Pusateri
Mr. and Mrs. Louis Queyrel Mr. Jerry Rapport
Mr. Fred M. Richards Mrs. George E. Richardson
Mr. and Mrs. L.D. Richins Mr. and Mrs. Mayford L. Roark
Mr. Richard H. Roberts Mr. and Mrs. Stephen Rooth
Helen E. Sachs Mr. and Mrs. John C. Sachs
Ms. Evangeline H. Sacks John A. and Marjorie B. Sage
Mr. and Mrs. George W. Salladay Mr. Bruce T. Sanbonmatsu
Mr. and Mrs. J.B. Saunders III Mrs. Helen E. Saville
Mr. and Mrs. E. Robert Sawyer David B. and Iris H. Carmel
Mr. and Mrs. Sherwood Schwartz Mr. and Mrs. William D. Serven
Mr. Shelly Jay Shafron Mr. and Mrs. Russell O. Shirk
William H. and Barbara A. Short Mr. Guy Showley
Mr. and Mrs. John H. Siegel Mrs. A. Loring Siegener
Mr. and Mrs. Richard F. Silva Mary C. Soares
Mr. Jean R. Solari Mr. Michel H. Solari
Mr. William G. Sommerville Mr. and Mrs. Robert T. Sopko
Mr. and Mrs. Gary L. Stancliff Mr. and Mrs. Raymond O. Stenzel
Mr. and Mrs. Paul I. Stevens Estate of John Straza
Mr. Charles E. Suhr Hon. Alice D. Sullivan (Ret.)
Mrs. Amos Swayne Mr. James W. Swedler
Mr. and Mrs. Jack H. Thompson Mr. William R. Tincher, Sr.
Mr. and Mrs. Charles R. Treat Estate of Daria C. Treweek
Ray and Shirley Tritten Mr. David J. Utick
Mrs. Gladys M. Van Dorn Ms. Sona Vasudevan
Mrs. Gemma Jean Venard Dr. and Mrs. Warren G. Wagers
Mr. and Mrs. Curtis L. Ward Mr. and Mrs. Lewis L. Warner
Dr. and Mrs. Ansel Watrous Mr. and Mrs. Palmer P. Webb
Gwenneth and Robert C. Weiss Mr. and Mrs. Ray A. Wilson
Mr. and Mrs. Robert B. Wilson Mr. and Mrs. Richard S. Witherow
Mr. and Mrs. Ulysses S. Worden Mr. and Mrs. Walter Zumstein
Mr. Gordon C. Zwirtz
Anonymous (2) Carole L. Banka, Ph.D.
Roger N. Beachy, Ph.D. Linda K. Curtiss, Ph.D.
Gregory J. del Zoppo, M.D. Dr. and Mrs. Thomas S. Edgington
M. Reza Ghadiri, Ph.D. Dr. and Mrs. Tony E. Hugli
Jeffery W. Kelly, Ph.D. Mr. and Mrs. Arnold LaGuardia
Arthur J. Olson, Ph.D. Julius Rebek, Jr., Ph.D.
Dr. and Mrs. Ralph A. Reisfeld Dr. and Mrs. Daniel R. Salomon
Dr. and Mrs. Eng M. Tan Peter K. Vogt, Ph.D.
Mr. Carlos Alberto Von Muhlen Dr. and Mrs. William O. Weigle
Mr. and Mrs. David M. Weston Dr. and Mrs. Curtis B. Wilson
Ian A. Wilson, Ph.D. Peter E. Wright, Ph.D.
Mr. Yiyang Xia Dr. and Mrs. Richard D. Ye

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