Scientific Report 2007

Scripps Florida

Translational Research Institute

Department Overview

Staff

Patrick R. Griffin, Ph.D.*
Director

Thomas D. Bannister, Ph.D.
Associate Scientific Director, Medicinal Chemistry

Jennifer Caldwell-Busby, Ph.D.*
Associate Scientific Director, Proteomics

Michael Cameron, Ph.D.*
Associate Scientific Director, Drug Metabolism and Pharmacokinetics

Derek R. Duckett, Ph.D.
Associate Scientific Director, Discovery Biology

Yangbo Feng, Ph.D.
Associate Scientific Director, Medicinal Chemistry

Peter Hodder, Ph.D.
Scientific Director, Lead Identification

Ted Kamenecka, Ph.D.
Associate Scientific Director, Medicinal Chemistry

Congxin Liang, Ph.D.
Scientific Director, Medicinal Chemistry

Philip LoGrasso, Ph.D.*
Senior Director, Discovery Biology

Patricia McDonald, Ph.D.
Associate Scientific Director, Discovery Biology

Mathew T. Pletcher, Ph.D.**
Assistant Professor, Genomics Core

William Roush, Ph.D.***
Executive Director, Medicinal Chemistry
Associate Dean, Kellogg School of Science and Technology

Layton Smith, Ph.D.
Associate Scientific Director, Discovery Biology

Senior Scientists

Yenting Chen, Ph.D.

Marcel Koenig, Ph.D.

Jiuxiang Ni, Ph.D.

Alok Pachori, Ph.D.

Louis Scampavia, Ph.D.

Thomas Schroeter, Ph.D.

Youseung Shin, Ph.D.

Tomas Vojkovsky, Ph.D.

Staff Scientists

Juliana Conkright, Ph.D.

Dympna Harmey, Ph.D.

Sahba Tabrizifard, Ph.D.

Research Associates

Xingang Fang, Ph.D.

Jeffrey Habel, Ph.D.

Yuanjun He, Ph.D.

Par Holmberg, Ph.D.

Rong Jiang, Ph.D.

Franck Madoux, Ph.D.

Sanjay Saldanha, Ph.D.

E. Hamp Sessions, Ph.D.

Anthony Smith, Ph.D.

Michael Smolinski, Ph.D.

Xinyi Song, Ph.D.

Prem Subramaniam, Ph.D.

Bo Wang, Ph.D.

Lei Yao, Ph.D.

Yan Yin, Ph.D.

Scientific Associates

Dmitriy Minond, Ph.D.

Timothy Spicer

HTS Robotics Engineers

Pierre Baillargeon

Peter Chase

Lina Deluca

Informatics Staff

Kashif Hoda

Chris Mader

Bruce Pascal

Mark Southern

Joel Zysman

* Joint appointment in the Department of Molecular Therapeutics
** Joint appointments in the Departments of Biochemistry and Molecular Therapeutics
*** Joint appointment in the Department of Chemistry

Src overexpression in NIH-3T3 fibroblasts. Overexpression results in actin relocalization toward structures known as "podosomes," which are thought to be involved in cell motility. In order to examine actin localization and apoptosis activity after treatment with src inhibitors, the cells were stained with Alexa Fluor 488 phalloidin, Bcl-2, and Alexa Fluor 647 F(ab′)₂ goat antirabbit fragment of IgG. The nuclei were stained with Hoechst dye 33342. The cells were plated in a 96-well plate and visualized with the IN Cell 1000. The image was analyzed for granularity by using Developer Toolbox. Further processing was done with Adobe Photoshop. Work done by Evelyn Griffin, research assistant, in the laboratory of Thomas Schroeter, Ph.D., senior scientist.

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