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Scientific Report 2006

On the cover: “Click” chemistry refers to the development and use of highly reliable chemical reactions to make molecules that perform a desired function. The most successful click reaction is the copper-catalyzed azide-alkyne cycloaddition (CuAAC) process, an abstract representation of which is shown here. Blue (azide) and red (alkyne) components are efficiently joined by spherical copper ions to give pentagonal 1,4-triazoles. Surrounding the large triazole motif in the foreground are energy diagrams highlighting favorable aspects of the reaction, and its biological applications are represented by icosahedral virus particles. The brick-like mosaic tying the entire image together suggests both the highly modular nature of the CuAAC reaction and its usefullness in the creation of functional small molecules, polymers, and materials. The overall theme celebrates the importance of connections: in chemistry, as in life, while individuals may be unique and pleasing, it is when they “click” together that true art is created. Painting by Yeon-Hee Lim, Ph.D., research associate in the laboratory of M.G. Finn, Ph.D., Department of Chemistry.


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