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Scientific Report 2006
Scripps Florida
Cancer Biology
Chairman's Overview
Staff
John L. Cleveland, Ph.D.
Professor and Chairman
Nagi G. Ayad, Ph.D.
Assistant Professor
Michael D. Conkright, Ph.D.
Assistant Professor
Kendall W. Nettles, Ph.D. *
Assistant Professor
Research Associates
Antoino Amelio, Ph.D
John Bruning, Ph.D.
Frank C. Dorsey, Ph.D.
Jeffrey E. Habel, Ph.D.
Dympna Harmey, Ph.D.
Jelena Janjic, Ph.D.
Becky Mercer, Ph.D.
Anthony D. Smith, Ph.D.
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Activation of the estrogen receptor-a (ER-α).
Ribbon diagram shows ER-α
(yellow) bound to a peptide of the Grip1 coactivator (red) and to the ER-α
agonist tetrahydrocrysene (blue). ER-α has
well-known roles in the progression and treatment of breast and uterine cancer,
whereas ER-β contributes
to resistance to prostate and colon cancer. This structure defines features that
are required for tetrahydrocrysene to act as an ER-α
agonist, but as an antagonist of ER-β,
and it reveals the mechanism of ligand-selective signaling. Work and image done
in the laboratory of Kendall W. Nettles, Ph.D.
Scripps Florida Reports
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