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Scientific Report 2005

Scripps Florida


Chairman's Overview


Steve A. Kay, Ph.D.*
Professor and Chairman

Nagi G. Ayad, Ph.D.
Assistant Professor

Alessandra Cervino, Ph.D.**
Assistant Professor

Michael D. Conkright, Ph.D.
Assistant Professor

Patrick R. Griffin, Ph.D.**

John B. Hogenesch, Ph.D.***

Malcolm A. Leissring, Ph.D.
Assistant Professor

Phillip LoGrasso, Ph.D.**
Associate Professor

Kendall W. Nettles, Ph.D.**
Assistant Professor

Howard T. Petrie, Ph.D.

Mathew T. Pletcher, Ph.D.
Assistant Professor

Teresa M. Reyes, Ph.D.
Assistant Professor

William R. Roush, Ph.D.
Associate Dean,
Kellogg School of Science and Technology, Florida

James Tam, Ph.D.

Claes Wahlestedt, M.D., Ph.D.

Staff Scientists

Michael J. Chalmers, Ph.D.

Qitao Yu, Ph.D.

Jiu Zhao, Ph.D.

Research Associates

Julie E. Baggs, Ph.D.

Kristin Clarke, Ph.D.

Etzer Darout, Ph.D.

Amy C. DeBaillie, Ph.D.

Joshua R. Dunetz, Ph.D.

Masaki Handa, Ph.D.

Dympna Harmey, Ph.D.

Kevin R. Hayes, Ph.D.

Tamara Hopkins, Ph.D.

Jelena Janjic, Ph.D.

Rebecca J. Kocerha, Ph.D.

Brooke H. Miller, Ph.D.

William Mwangi, Ph.D.

Hiroshi Nakase, Ph.D.

Michael H. Ober, Ph.D.

Swati Prasad, Ph.D.

Troy D. Ryba, Ph.D.

Anthony D. Smith, Ph.D.

Achim M. Sorg, Ph.D.

Sahba Tabrizifard, Ph.D.

Mariola Tortosa, Ph.D.

Oliver Umland, Ph.D.

Juliette C. Walker, Ph.D.

Amie L. Williams, Ph.D.

Scientific Associates

Yi An Lu, Ph.D.

Qi Tao Yu, Ph.D.

* Joint appointments in the Department of Cell Biology and the Institute for Childhood and Neglected Diseases
** Joint appointment in the Translational Research Institute
*** Joint appointments in the Translational Research Institute
and Molecular and Integrative Neurosciences Department

**** Joint appointments in the Translational Research Institute and the Department of Chemistry


A combination of structural approaches, including x-ray crystallography, in the laboratory of K.W. Nettles, Ph.D., and amide hydrogen-deuterium exchange mass spectrometry, in the laboratory of P.R. Griffin, Ph.D., were used to dissect how diverse ligands control the allosteric function of the nuclear receptor ligand-binding domain. The ligand-binding domain of the estrogen receptor is shown bound to an estrogen derivative, trifluoromethylphenylvinyl-estradiol.