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Scientific Report 2005
Scripps Florida
Biochemistry
Chairman's Overview
Staff
Steve A. Kay, Ph.D.*
Professor and Chairman
Nagi G. Ayad, Ph.D.
Assistant Professor
Alessandra Cervino, Ph.D.**
Assistant Professor
Michael D. Conkright, Ph.D.
Assistant Professor
Patrick R. Griffin, Ph.D.**
Professor
John B. Hogenesch, Ph.D.***
Professor
Malcolm A. Leissring, Ph.D.
Assistant Professor
Phillip LoGrasso, Ph.D.**
Associate Professor
Kendall W. Nettles, Ph.D.**
Assistant Professor
Howard T. Petrie, Ph.D.
Professor
Mathew T. Pletcher, Ph.D.**
Assistant Professor
Teresa M. Reyes, Ph.D.
Assistant Professor
William R. Roush, Ph.D.****
Professor
Associate Dean,
Kellogg School of Science and Technology, Florida
James Tam, Ph.D.
Professor
Claes Wahlestedt, M.D., Ph.D.**
Professor
Staff Scientists
Michael J. Chalmers, Ph.D.
Qitao Yu, Ph.D.
Jiu Zhao, Ph.D.
Research Associates
Julie E. Baggs, Ph.D.
Kristin Clarke, Ph.D.
Etzer Darout, Ph.D.
Amy C. DeBaillie, Ph.D.
Joshua R. Dunetz, Ph.D.
Masaki Handa, Ph.D.
Dympna Harmey, Ph.D.
Kevin R. Hayes, Ph.D.
Tamara Hopkins, Ph.D.
Jelena Janjic, Ph.D.
Rebecca J. Kocerha, Ph.D.
Brooke H. Miller, Ph.D.
William Mwangi, Ph.D.
Hiroshi Nakase, Ph.D.
Michael H. Ober, Ph.D.
Swati Prasad, Ph.D.
Troy D. Ryba, Ph.D.
Anthony D. Smith, Ph.D.
Achim M. Sorg, Ph.D.
Sahba Tabrizifard, Ph.D.
Mariola Tortosa, Ph.D.
Oliver Umland, Ph.D.
Juliette C. Walker, Ph.D.
Amie L. Williams, Ph.D.
Scientific Associates
Yi An Lu, Ph.D.
Qi Tao Yu, Ph.D.
* Joint appointments in the Department of Cell Biology and
the Institute for Childhood and Neglected Diseases
** Joint appointment in the Translational Research Institute
*** Joint appointments in the Translational Research Institute
and Molecular and Integrative Neurosciences Department
**** Joint appointments in the Translational Research Institute
and the Department of Chemistry
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A
combination of structural approaches, including x-ray crystallography, in the laboratory
of K.W. Nettles, Ph.D., and amide hydrogen-deuterium exchange mass spectrometry,
in the laboratory of P.R. Griffin, Ph.D., were used to dissect how diverse ligands
control the allosteric function of the nuclear receptor ligand-binding domain. The
ligand-binding domain of the estrogen receptor is shown bound to an estrogen derivative,
trifluoromethylphenylvinyl-estradiol.
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