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Chisari/GCRC General Clinical Research Center

Frank V. Chisari, M.D.

E. Beutler, F.V. Chisari, B.L. Zuraw, D.R. Salomon, J.A. Koziol, D.A. Gilder, S.L. Mirkis, C.V. Grininger, K.H. Cox, E.A. Bieger

Established in 1974 with a generous gift from Mrs. William H. Black and Mr. and Mrs. William F. Black, and later supplemented by a donation from the Stein Endowment Fund, the General Clinical Research Center (GCRC) is in its 28th year of continuous operation. Financed by a grant of about $2 million annually from the National Center for Research Resources, National Institutes of Health, to provide facilities for investigator-initiated, peer-reviewed research with human subjects, the GCRC is the only one of 77 such centers in the United States that is not affiliated with a university or a medical school. The GCRC aims to augment investigative collaborations among the clinicians and researchers at Scripps to facilitate the transfer of basic knowledge generated in research laboratories to the clinical arena, to elucidate pathogenetic mechanisms of disease, and to evaluate new modes of patient management.

The GCRC provides inpatient and outpatient environments in which investigators conduct studies in humans; the protocols are approved for safety by the Human Subjects Committee and for scientific merit by the GCRC Scientific Advisory Committee. The GCRC grant pays many of the costs of this research. GCRC facilities include a highly trained research nursing staff in a discrete nursing unit in the Scripps Green Hospital. A fully staffed core laboratory provides technical support for specialized research assays; preparation and storage of specimens; samples of normal blood for the laboratories of TSRI; and a DNA/RNA tissue bank, established in cooperation with the Department of Surgery.

In addition, the GCRC operates a computer center for the management of clinical data, genetic sequencing, and other statistical needs. Additional staff include a biostatistician for consultation on study design and statistical analysis and professional and administrative personnel to help with study design, preparation of protocols, and budgetary matters.

Last year, the GCRC provided these services for about 4600 outpatient visits, processed about 9730 specimens, and supported several computer-based research protocols from TSRI and Scripps Clinic Medical Group. Forty-nine patient-related research protocols were carried out in the GCRC; the titles and principal investigators of most of them are listed at the end of this report. Many of these projects are described under the names of the individual investigators elsewhere in this volume. A total of 57 investigators made use of the GCRC facilities last year.

Ernest Beutler, MDEpidemiologic Studies of Hemochro-matosis and the Creation of an Anonymized DNA Database
Dennis R. Burton, PhDHuman Antibodies to Infectious Agents
Francis Chisari, MDImmunobiology and Pathogenesis of Hepatitis
Cindy Ehlers, PhDEEG Markers of Alcoholism Risk
Cindy Ehlers, PhDResponse to Ethanol in Asian-, African-, and Native Americans
Mary Jo Heeb, PhDForms of Prostate-Specific Antigen and hK2 in Cancer
Lawrence Kline, DODPAP for Obstructive Sleep Apnea
Thomas Kunicki, PhD Relationship Between Membrane Density of a2b1 Integrin and CAD
Martin Lotz, MDMesenchymal Stem Cells in the Pathogenesis of Arthritis
Nigel Mackman, PhDEstablishment of a New Assay to Measure Tissue Factor Activity in Whole Blood
James R. Mason, MDDose Escalation of Anti-CD33 x Humanized Murine Anti-FcgRI Bispecific Antibody in Relapsed AML
David A. Mathison, MDGenomic and Molecular Determinants of Airway Hyperreactivity in Human Asthma
John McHutchison, MDIntron A and Alferon-N for Hepatitis C
Robert McMillan, MDTreatment of Chronic ITP
Donald E. Mosier, MD, PhDCoreceptor Usage and HIV Disease Kinetics
Michael B.A. Oldstone, MDLong-term Immunity After Childhood Measles Vaccination in the Presence or Absence of Circulating Measles
Michael B.A. Oldstone, MDCharacterization of Myelin-Specific Immune Response as an Indicator of Disease State in Multiple Sclerosis
J. Steven Poceta, MDSleep and Alertness in Parkinson's and Restless Legs: Dopaminergic Mechanisms
Paul Pockros, MDStudies of Interferon in Hepatitis B and Hepatitis C
Pascal Poignard, MDViral Evasion and HIV Entry-Blocking Strategies
Zaverio M. Ruggeri, MDMechanisms of Platelet Thrombus Formation
Daniel R. Salomon, MDNormal Blood-Drawing for TSRI Labs
Jack Sipe, MDCladribine (2-CdA) Treatment of Multiple Sclerosis
Donald Stevenson, MDAnalgesic Desensitization in Aspirin-Sensitive Asthma
Andrea Suhner, PhDMelatonin and Estrogen Therapy in Perimenopausal Sleep Dysfunction
Bruce Zuraw, MDAngioedema and Hageman Factor
Bruce Zuraw, MD Functional Consequences of B1 BK Receptor Expression During Allergic Airway Inflammation



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