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The Skaggs Institute For Chemical Biology
Scientific Report 1998-1999

On the front cover: Hot-spot binding surface of the erythropoietin cytokine receptor. The shaded molecular surface and highlighted residues represent the target-binding site for the development of small molecules that could stimulate the production of red blood cells in patients with kidney damage or with anemia due to azidothymidine therapy for infection with HIV type 1. Work performed in the laboratory of Ian A. Wilson, D.Phil.

Inside Back Cover: Energy-minimized structure of a scaggs molecule, a semi-capsule allowing giant guest seizure, synthesized in the laboratory of J. Rebek, Ph.D., director of the Skaggs Institute for Chemical Biology. The molecule is composed of 2 identical self-folding cavitands fused to an extended aromatic wall. The internal cavity is 10 x 23 . The seams of intramolecular hydrogen bonds allow control of guest seizing and release. Molecular modeling performed by Dmitry Rudkevich, Ph.D., using MacroModel 5.5.



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