News and Publications
The Skaggs Institute For Chemical Biology
Scientific Report 1998-1999
On the front cover: Hot-spot binding surface of the erythropoietin cytokine
receptor. The shaded molecular surface and highlighted residues represent the
target-binding site for the development of small molecules that could stimulate
the production of red blood cells in patients with kidney damage or with anemia
due to azidothymidine therapy for infection with HIV type 1. Work performed in
the laboratory of Ian A. Wilson, D.Phil.
Inside Back Cover: Energy-minimized structure of a scaggs molecule, a semi-capsule
allowing giant guest seizure, synthesized in the laboratory of J. Rebek, Ph.D.,
director of the Skaggs Institute for Chemical Biology. The molecule is composed
of 2 identical self-folding cavitands fused to an extended aromatic wall. The
internal cavity is 10 x 23 Å. The seams of intramolecular hydrogen bonds allow
control of guest seizing and release. Molecular modeling performed by Dmitry
Rudkevich, Ph.D., using MacroModel 5.5.