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The Nettles Laboratory

Publications

Thiophene-core estrogen receptor ligands having superagonist activity.
Min J, Wang P, Srinivasan S, Nwachukwu JC, Guo P, Huang M, Carlson KE, Katzenellenbogen JA, Nettles KW, Zhou HB.
J Med Chem. 2013 Apr 25;56(8):3346-66. doi: 10.1021/jm400157e. Epub 2013 Apr 15. [PubMed Link]

Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α.
Srinivasan S, Nwachukwu JC, Parent AA, Cavett V, Nowak J, Hughes TS, Kojetin DJ, Katzenellenbogen JA, Nettles KW.
Nat Chem Biol. 2013 May;9(5):326-32. doi: 10.1038/nchembio.1214. Epub 2013 Mar 24. [PubMed Link]

Structural mechanisms of allostery and autoinhibition in JNK family kinases.
Laughlin JD, Nwachukwu JC, Figuera-Losada M, Cherry L, Nettles KW, LoGrasso PV.
Structure. 2012 Dec 5;20(12):2174-84. doi: 10.1016/j.str.2012.09.021. Epub 2012 Nov 8. [PubMed Link]

Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides.
Zhu M, Zhang C, Nwachukwu JC, Srinivasan S, Cavett V, Zheng Y, Carlson KE, Dong C, Katzenellenbogen JA, Nettles KW, Zhou HB.
Org Biomol Chem. 2012 Nov 21;10(43):8692-700. doi: 10.1039/c2ob26531a. [PubMed Link]

Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7-oxabicyclo[2.2.1]hept-5-ene scaffold core ligands.
Zheng Y, Zhu M, Srinivasan S, Nwachukwu JC, Cavett V, Min J, Carlson KE, Wang P, Dong C, Katzenellenbogen JA, Nettles KW, Zhou HB.
ChemMedChem. 2012 Jun;7(6):1094-100. doi: 10.1002/cmdc.201200048. Epub 2012 Apr 19. [PubMed Link]

Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2.2.1]hept-2-ene-7-oxide.
Wang P, Min J, Nwachukwu JC, Cavett V, Carlson KE, Guo P, Zhu M, Zheng Y, Dong C, Katzenellenbogen JA, Nettles KW, Zhou HB.
J Med Chem. 2012 Mar 8;55(5):2324-41. doi: 10.1021/jm201556r. Epub 2012 Feb 21. [PubMed Link]

The nuclear receptor signalling scaffold: insights from full-length structures.
Nwachukwu JC, Nettles KW.
EMBO J. 2012 Jan 18;31(2):251-3. doi: 10.1038/emboj.2011.475. Epub 2012 Jan 18. No abstract available. [PubMed Link]

Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1 × 1 nucleotide UU internal loop conformations.
Kumar A, Park H, Fang P, Parkesh R, Guo M, Nettles KW, Disney MD.
Biochemistry. 2011 Nov 15;50(45):9928-35. doi: 10.1021/bi2013068. Epub 2011 Oct 20. [PubMed Link]

A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome.
Kumar A, Fang P, Park H, Guo M, Nettles KW, Disney MD.
Chembiochem. 2011 Sep 19;12(14):2140-2. doi: 10.1002/cbic.201100337. Epub 2011 Jul 15. No abstract available. [PubMed Link]

Coupling of receptor conformation and ligand orientation determine graded activity.Bruning JB,
Parent AA, Gil G, Zhao M, Nowak J, Pace MC, Smith CL, Afonine PV, Adams PD, Katzenellenbogen JA, Nettles KW.
Nat Chem Biol. 2010 Nov;6(11):837-43. doi: 10.1038/nchembio.451. Epub 2010 Oct 10. [PubMed Link]

Insights into PPARgamma from structures with endogenous and covalently bound ligands.
Nettles KW.
Nat Struct Mol Biol. 2008 Sep;15(9):893-5. doi: 10.1038/nsmb0908-893. No abstract available. [PubMed Link]

NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses.
Nettles KW, Bruning JB, Gil G, Nowak J, Sharma SK, Hahm JB, Kulp K, Hochberg RB, Zhou H, Katzenellenbogen JA, Katzenellenbogen BS, Kim Y, Joachmiak A, Greene GL.
Nat Chem Biol. 2008 Apr;4(4):241-7. doi: 10.1038/nchembio.76. Epub 2008 Mar 16. Erratum in: Nat Chem Biol. 2008 Jun;4(6):379. [PubMed Link]

Partial agonists activate PPARgamma using a helix 12 independent mechanism.
Bruning JB, Chalmers MJ, Prasad S, Busby SA, Kamenecka TM, He Y, Nettles KW, Griffin PR.
Structure. 2007 Oct;15(10):1258-71. [PubMed Link]

CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor.
Nettles KW, Gil G, Nowak J, Métivier R, Sharma VB, Greene GL.
Mol Endocrinol. 2008 Feb;22(2):263-72. Epub 2007 Oct 11. [PubMed Link]

Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands.
Zhou HB, Nettles KW, Bruning JB, Kim Y, Joachimiak A, Sharma S, Carlson KE, Stossi F, Katzenellenbogen BS, Greene GL, Katzenellenbogen JA.
Chem Biol. 2007 Jun;14(6):659-69. [PubMed Link]

Structural plasticity in the oestrogen receptor ligand-binding domain.
Nettles KW, Bruning JB, Gil G, O'Neill EE, Nowak J, Guo Y, Kim Y, DeSombre ER, Dilis R, Hanson RN, Joachimiak A, Greene GL.
EMBO Rep. 2007 Jun;8(6):563-8. Epub 2007 Apr 27. Erratum in: EMBO Rep. 2007 Jun;8(6):610. Guo, Yuee [added]; Hughs, Alun [removed]. [PubMed Link]

Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains.
Zhou HB, Sheng S, Compton DR, Kim Y, Joachimiak A, Sharma S, Carlson KE, Katzenellenbogen BS, Nettles KW, Greene GL, Katzenellenbogen JA.
J Med Chem. 2007 Jan 25;50(2):399-403. [PubMed Link]

Ligand control of coregulator recruitment to nuclear receptors.
Nettles KW, Greene GL.
Annu Rev Physiol. 2005;67:309-33. Review. [PubMed Link]

Allosteric control of ligand selectivity between estrogen receptors alpha and beta: implications for other nuclear receptors.
Nettles KW, Sun J, Radek JT, Sheng S, Rodriguez AL, Katzenellenbogen JA, Katzenellenbogen BS, Greene GL.
Mol Cell. 2004 Feb 13;13(3):317-27. [PubMed Link]

Nuclear receptor ligands and cofactor recruitment: is there a coactivator "on deck"?
Nettles KW, Greene GL.
Mol Cell. 2003 Apr;11(4):850-1. Review. [PubMed Link]

Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.
Shiau AK, Barstad D, Radek JT, Meyers MJ, Nettles KW, Katzenellenbogen BS, Katzenellenbogen JA, Agard DA, Greene GL.
Nat Struct Biol. 2002 May;9(5):359-64. [PubMed Link]

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