Publications

(Last update: December 4, 2018)


  1. The following 12 publications are earlier work in the area of peptide and protein chemistry: J. Chin. Biochem. Soc., 2, 64–69, (1973); 4, 24, (1975); 5, 1–6, (1976); 9, 25, (1980); J. Chin. Chem. Soc., 23, 155, (1976); 24, 129–133, (1977); 25, 209–214, (1978); 26, 75–78, (1979); 25, 215, (1978); 26, 11, (1979); Toxicon, 14, 420, (1976); Proc. Natl. Acad. Council R.O.C., 2, 346–351, (1978).

  1. C.-H. Wong, S.W. Chen, C. L. Ho, K. T. Wang, "Synthesis of cobra neurotoxin", Proc. Natl. Sci. Council R.O.C., 2, 149–153, (1978).

  2. C.-H. Wong, Y. H. Chen, M.C. Hung, K. T. Wang, C. L. Ho, T. B. Lo, "Regeneration of a reduced cobra cardiotoxin", Biochim. Biophys. Acta, 533, 105–111, (1978).

  3. C.-H. Wong, C. L. Ho, K. T. Wang, "Purification of synthetic cardiotoxin by affinity chromatography", J. Chromatogr., 154, 25–32, (1978).

  4. C.-H. Wong, K. T. Wang, "Electrochemistry in organic synthesis: large-scale preparation of cysteine from cystine", J. Chin. Chem. Soc., 25, 149–152, (1978).

  5. C.-H. Wong, S.-T. Chen, C.-L. Ho, K.-T. Wang, "Synthesis of a fully active snake venom cardiotoxin by fragment condensation on a solid polymer", Biochim. Biophys. Acta, 536, 376–389, (1978).

  6. C.-H. Wong, M. F. Ho, K. T. Wang, "Preparation of optically pure N-tert-butyloxycarbonyl-O-benzyl-L-serine and its antipode", J. Org. Chem., 43, 3604, (1978).

  7. C.-H. Wong, K. T. Wang, "Mutual resolution of (+-)-ephedrine and Z-DL-amino acid induced by seeding chiral salt", Tetrahedron Lett., 40, 3813–3816, (1978).

  8. C.-H. Wong, S.T. Chen, K. T. Wang, "Enzymic synthesis of opioid peptides", Biochim. Biophys. Acta, 576, 247–249, (1979).

  9. C.-H. Wong, S.D. McCurry, G. M. Whitesides, "Practical enzymatic synthesis of ribulose-1,5-bisphosphate and ribose-5-phosphate", J. Am. Chem. Soc., 102, 7938–7939, (1980).

  10. C.-H. Wong, G. M. Whitesides, "Enzyme-catalyzed organic synthesis: NAD(P)H cofactor regeneration using glucose-6-phosphate and the glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides", J. Am. Chem. Soc., 103, 4890–4899, (1981).

  11. C.-H. Wong, L. Daniels, W. H. Orme-Johnson, G. M. Whitesides, "Enzyme-catalyzed organic synthesis: NAD(P)H cofactor regeneration using dihydrogen and the hydrogenase from Methanobacterium thermoautotrophicum", J. Am. Chem. Soc., 103, 6227–6228, (1981).

  12. C.-H. Wong, J. Gordon, C. L. Cooney, G. M. Whitesides, "Regeneration of NAD(P)H using glucose-6-sulfate and glucose-6-phosphate dehydrogenase", J. Org. Chem., 46, 4676–4679, (1981).

  13. R. DiCosimo, C.-H. Wong, L. Daniels, G. M. Whitesides, "Enzyme-catalyzed organic synthesis: electrochemical regeneration of NAD(P)H from (NAD(P) using methyl viologen and flavoenzymes", J. Org. Chem., 46, 4622–4623, (1981).

  14. C.-H. Wong, A. Pollak, S. McCurry, J. Sue, J. R. Knowles, G. M. Whitesides, "Ribulose-1,5-bisphosphate: routes from glucose-6-phosphate (via 6-phosphogluconate and ribose-5-phosphate) and from adenosine monophosphate (via ribose-5-phosphate and ribulose-5-phosphate)", Method. Enzymol., 89, 108–121, (1982).

  15. C.-H. Wong, G. M. Whitesides, "Enzyme-catalyzed transhydrogenation between nicotinamide cofactors and its application in organic synthesis", J. Am. Chem. Soc., 104, 3542–3544, (1982).

  16. C.-H. Wong, G. M. Whitesides, "Enzyme-catalyzed organic synthesis: NAD(P)H cofactor regeneration using ethanol/alcohol dehydrogenase/aldehyde dehydrogenase and methanol/alcohol dehydrogenase/aldehyde dehydrogenase/formate dehydrogenase", J. Org. Chem., 47, 2816–2818, (1982).

  17. C.-H. Wong, S. L. Haynie, G. M. Whitesides, "Enzyme-catalyzed synthesis of N-acetyllactosamine with in situ regeneration of uridine 5'-diphosphate glucose and uridine 5'-diphosphate galactose", J. Org. Chem., 47, 5416–5418, (1982).

  18. C.-H. Wong, S. L. Haynie, G. M. Whitesides, "Preparation of a mixture of nucleoside triphosphates from yeast RNA: use in enzymatic synthesis requiring nucleoside triphosphate regeneration, and conversion to nucleoside diphosphate sugars", J. Am. Chem. Soc., 105, 115–117, (1983).

  19. C.-H. Wong, G. M. Whitesides, "Enzyme-catalyzed organic synthesis: regeneration of deuterated nicotinamide cofactors for use in large-scale enzymatic synthesis of deuterated substances", J. Am. Chem. Soc., 105, 5012–5014, (1983).

  20. C.-H. Wong, G. M. Whitesides, "Synthesis of sugars by aldolase-catalyzed condensation reactions", J. Org. Chem., 48, 3199–3205, (1983).

  21. C.-H. Wong, F. P. Mazenod, G. M. Whitesides, "Chemical and enzymatic synthesis of 6-deoxyhexoses; conversion to 2,5-dimethyl-4-hydroxy-2,3-dihydrofuran-3-one (furaneol) and analogs", J. Org. Chem., 48, 3493–3497, (1983).

  22. G. M. Whitesides, C.-H. Wong, "Enzymes as catalysts in organic synthesis", Aldrichimica, 16, 27–34, (1983).

  23. J. R. Matos, M. B. Smith, C.-H. Wong, "Enantioselectivity of alcohol dehydrogenase-catalyzed oxidation of 1,2-diols and aminoalcohols", Bioorg. Chem., 13, 121–130, (1985).

  24. C.-H. Wong, D. G. Drueckhammer, H. M. Sweers, "Enzymatic versus fermentative synthesis: thermostable glucose dehydrogenase catalyzed regeneration of NAD(P)H for use in enzymatic synthesis", J. Am. Chem. Soc., 107, 4028–4031, (1985).

  25. R. L. Root, J. R. Durrwachter, C.-H. Wong, "Enzymatic synthesis of unusual sugars: galactose oxidase-catalyzed stereospecific oxidation of polyols", J. Am. Chem. Soc., 107, 2997–2999, (1985).

  26. C.-H. Wong, J. R. Matos, "Enantioselective oxidation of 1,2-diols to L-a-hydroxy acids using co-immobilized alcohol dehydrogenase/aldehyde dehydrogenase as catalysts", J. Org. Chem., 50, 1992–1994, (1985).

  27. C.-H. Wong, D. G. Drueckhammer, "Enzymatic synthesis of chiral hydroxy compounds using immobilized glucose dehydrogenase from Bacillus cereus for NAD(P)H regeneration", Bio/Technology, 3, 649–651, (1985).

  28. G. M. Whitesides, C.-H. Wong, "Enzymes as catalysts in synthetic organic chemistry", Angew. Chem. Int. Ed. Engl., 24, 617–638, (1985).

  29. C.-H. Wong "Enzymes in organic synthesis: aldol condensation", Industrial Chemical News, 6(12), 24–25, (1985).

  30. D. G. Drueckhammer, C.-H. Wong, "FMN Reductase-catalyzed regeneration of NAD(P) for use in enzymatic synthesis", J. Org. Chem., 50, 5387–5389, (1985).

  31. D. G. Drueckhammer, C.-H. Wong, "Chemoenzymatic syntheses of fluoro sugar phosphates and analogues", J. Org. Chem., 50, 5912–5913, (1985).

  32. J. R. Durrwachter, H. M. Sweers, K. Nozaki, C.-H. Wong, "Enzymatic aldol reaction/isomerization as a route to unusual sugars", Tetrahedron Lett., 27, 1261–1264, (1986).

  33. J. B. West, C.-H. Wong, "Enzyme-catalyzed synthesis of peptides containing D-amino acids", J. Chem. Soc. Chem. Commun., 417–418, (1986).

  34. J. R. Matos, C.-H. Wong, "Biphasic one-pot synthesis of two useful and separable compounds using cofactor-requiring enzymatic reactions: glutamate dehydrogenase-catalyzed synthesis of L-2-aminoadipate coupled with alcohol dehydrogenase-catalyzed synthesis of a chiral lactone", J. Org. Chem., 51, 2388, (1986).

  35. J. B. West, C.-H. Wong, "Enzyme-catalyzed irreversible formation of peptides containing D-amino acids", J. Org. Chem., 51, 2728–2735, (1986).

  36. C.-H. Wong, J. B. West "Enzymatic synthesis of peptides containing D-amino acids", Fed. Proc., 45, 1789, (1986).

  37. H. M. Sweers, C.-H. Wong, "Enzyme-catalyzed regioselective deacylation of protected sugars in carbohydrate synthesis", J. Am. Chem. Soc., 108, 6421–6422, (1986).

  38. S.-T. Chen, K.-T. Wang and C.-H. Wong, "Chirally selective hydrolysis of D,L-amino acid esters catalyzed by alkaline protease", J.C.S. Chem. Comm., 1514–1516, (1986)

  39. C.-H. Wong, "Enzyme-catalyzed synthesis of unusual carbohydrates and peptides", Proceeding of 5th International Symposium on Life Science: Prospects for Enzyme Technology (H. Yamada, ed.), Kyoto, Japan. 1986, pp 86–89.

  40. J. R. Durrwachter, D. G. Drueckhammer, K. Nozaki, H.M. Sweers, C.-H. Wong, "Enzymatic aldol condensation/isomerization as a route to unusual sugar derivatives", J. Am. Chem. Soc., 108, 7812–7818, (1986).

  41. D. C. Crans, R. J. Kazlauskas, B. L. Hirschbein, C.-H. Wong, O. Abril, G. M. Whitesides, "Enzymatic regeneration of ATP: acetyl phosphate, phosphoenolpyruvate, methoxycarbonyl phosphate, dihydroxyacetone phosphate, 5-phospho-D-ribosyl-1-pyrophosphate, uridine-5'-diphosphoglucose", Method Enzymol., 136, 263–280, (1987).

  42. J. R. Matos, F. M. Raushel, C.-H. Wong, "S-Adenosylmethionine: studies on chemical and enzymatic synthesis", Biotech. Appl. Biochem., 9, 39–52, (1987).

  43. J. R. Matos, C.-H. Wong, "S-Adenosylmethionine: stability and stabilization", Bioorg. Chem., 15, 71–80, (1987).

  44. C. F. Barbas, C.-H. Wong, "Papain catalyzed peptide synthesis: control of amidase activity and the introduction of unusual amino acids", J.C.S. Chem. Comm., 533–534, (1987).

  45. J. B. West, C.-H. Wong, "Use of non-proteases in peptide synthesis", Tetrahedron Lett., 28, 1629–1632, (1987).

  46. D. G. Drueckhammer, S. K. Sadozai, S. M. Roberts, C.-H. Wong, "Biphasic one-pot synthesis of two useful and separable compounds using cofactor-requiring enzymes as catalysts", Enzyme Microb. Tech., 9, 564–569, (1987).

  47. J. R. Matos, J. B. West, C.-H. Wong, "Lipase catalyzed synthesis of peptides: preparation of a penicillin G precursor and other peptides", Biotech. Lett., 9, 233–236, (1987).

  48. J. J. Lalonde, D. E. Bergbreiter, C.-H. Wong, "Enzymatic kinetic resolution of a-nitro a-methyl carboxylic acids", J. Org. Chem., 53, 2323–2327, (1988).

  49. D. G. Drueckhammer, C. F. Barbas, III, K. Nozaki, C. Y. Wood, M. Cinfolini, "Chemoenzymatic synthesis of chiral furan derivatives: useful building blocks for optically active structures", J. Org. Chem., 53, 1607–1611, (1988).

  50. C. F. Barbas, J. R. Matos, J. B. West, C.-H. Wong, "A search for peptide ligase: cosolvent mediated conversion of proteases to esterases for peptide synthesis", J. Am. Chem. Soc., 110, 5162–5166, (1988).

  51. J. B. West, J. Scholten, W. J. Stolowich, J. L. Hogg, A. I. Scott, C.-H. Wong, "Modification of proteases to esterases for peptide synthesis: methylchymotrypsin", J. Am. Chem. Soc., 110, 3709–3710, (1988).

  52. Y.-F. Wang, J. J. Lalonde, M. Momogan, D. E. Bergbreiter, C.-H. Wong, "Lipase catalyzed irreversible transesterification using enol esters as acylating reagents: preparative enantio- and regioselective synthesis of alcohols, glycerol derivatives, sugars and organometallics", J. Am. Chem. Soc., 110, 7200–7205, (1988).

  53. C. F. Barbas, C.-H. Wong, "One-pot tripeptide synthesis catalyzed by papain", Tetrahedron Lett., 29, 2907–2910, (1988).

  54. M. J. Kim, W. J. Hennen, H. M. Sweers, C.-H. Wong "Enzymes in carbohydrate synthesis: N-acetylneuraminic acid aldolase catalyzed reactions and preparation of N-acetyl-2-deoxy- D-neuraminic acid derivatives", J. Am. Chem. Soc., 110, 6481–6486, (1988).

  55. Y. F. Wang, C.-H. Wong "Lipase-catalyzed irreversible transesterification for preparative synthesis of chiral glycerol derivatives", J. Org. Chem., 53, 3127–3129, (1988).

  56. J. R. Durrwachter, C.-H. Wong "Fructose-1,6-diphosphate aldolase catalyzed stereoselective synthesis of C-alkyl and N-containing sugars: thermodynamically controlled C–C bond formations", J. Org. Chem., 53, 4175–4181, (1988).

  57. W. J. Hennen, H. M. Sweers, Y. F. Wang, C.-H. Wong "Enzymes in carbohydrate synthesis: lipase-catalyzed selective acylation and deacylation of furanose and pyranose derivatives", J. Org. Chem., 53, 4939–4945, (1988).

  58. R. L. Pederson, M. J. Kim, C.-H. Wong "A combined chemical and enzymatic procedure for the synthesis of 1-deoxynojirimycin and 1-deoxymannojirimycin", Tetrahedron Lett., 29, 4645–4648, (1988).

  59. C.-H. Wong, J. R. Matos, J. B. West, and C. F. Barbas "Practical enzymatic approaches to unusual peptides", J. Indust. Microbiol. Supp., 3, 171–177, (1988).

  60. D. G. Drueckhammer, J. R. Durrwachter, R. L. Pederson, D. C. Crans, C.-H. Wong, "Reversible and in situ formation of organic arsenates and vanadates as organic phosphate mimics in enzymatic reactions: investigation of aldol reactions and synthetic applications", J. Org. Chem., 54, 70–77, (1989).

  61. Y.-F Wang, C.-H. Wong "Lipase catalyzed irreversible transesterification using enol esters: resolution of cyanohydrins and syntheses of ethyl (R)-2-hydroxy-4-phenylbutyrate and (S)-propanolol", Tetrahedron Lett., 30, 1917–1920, (1989).

  62. R. L. Pederson, C.-H. Wong, "Enzymatic aldol reactions as a route to heterocycles: synthesis of 1,4-dideoxy-1,4-imino-D-arabinitol, fagomine, 1-deoxynojirimycin and 1-deoxymannojirimycin", Heterocycles, 28, 477–480, (1989).

  63. C. H. von der Osten, A. J. Sinskey, C.F. Barbas, R. L. Pederson, Y.-F. Wang, C.-H. Wong "Use of recombinant bacterial fructose-1,6-diphosphate aldolase in aldol reactions: preparative synthesis of 1-deoxynojirimycin, 1-deoxymannojirimycin, 1,4-dideoxy-1,4-imino-D-arabinitol and fagomine", J. Am. Chem. Soc., 111, 3924–3927, (1989).

  64. C.-H. Wong "Enzymatic catalysts in organic synthesis", Science, 244, 1145–1152, (1989).

  65. C. H. Von der Osten, C. F. Barbas, C.-H. Wong, A. J. Sinskey, "Molecular cloning, nucleotide sequence and fine structural analysis of the Corynebacterium glutamicum fda gene: structural comparison of C. glutamicum fructose-1,6-diphosphate aldolase to class I and class II aldolases", Mol. Microbiol., 3, 1625–1637, (1989).

  66. W. J. Hennen, C.-H. Wong, "A new method for the enzymatic synthesis of nucleosides using purine nucleoside phosphorylase", J. Org. Chem., 54, 4692–4699, (1989).

  67. S.-T. Chen, C.-H. Wong, "Studies on angiotensin-converting enzyme inhibitors: protease catalyzed resolution of aryl 3-mercapto-2-methylpropionic ester", J. Chin. Chem. Soc., 36, 451–458, (1989).

  68. Y.-F. Wang, C.-H. Wong, "Enantioselective synthesis of platelet-activating factor and a phospholipase A2 inhibitor from chiral synthons prepared enzymatically", J. Chin. Chem. Soc., 36, 463–468, (1989).

  69. C. F. Barbas, Y.-F. Wang, C.-H. Wong, "Deoxyribose-5-phosphate aldolase as a synthetic catalyst", J. Am. Chem. Soc., 112, 2013–2014, (1990).

  70. J. B. West, W. J. Hennen, J. A. Bibbs, J. L. Lalonde, Z. Zhong, E. F. Meyer, C.-H. Wong, "Enzymes as synthetic catalysts: mechanistic and active site considerations of natural and modified chymotrypsin", J. Am. Chem. Soc., 112, 5313–5320, (1990).

  71. C.-H. Wong, "Enzymes in organic synthesis", Chemtracts-Organic Chemistry, 3, 91–111, (1990).

  72. K. K.-C. Liu, K. Nozaki, C.-H. Wong, "Problems of acyl migration in lipase-catalyzed enantioselective transformation of meso-1,3-diol systems", Biocatalysis, 3, 169–177, (1990).

  73. C.-H. Wong, S.-T. Chen, W. J. Hennen, J.A. Bibbs, Y.-F. Wang, J. L.-C. Liu, M.W. Pantoliano, M. Whitlow, P.N. Bryan, "Enzymes in organic synthesis: use of subtilisin and a highly stable mutant derived from multiple site-specific mutations", J. Am. Chem. Soc., 112, 945–953, (1990).

  74. R. L. Pederson, K. K.-C. Liu, J. F. Rutan, L. Chen, C.-H. Wong, "Enzymes in organic synthesis: Synthesis of highly enantiomerically pure 1,2-epoxy aldehyde, epoxyalcohols, thiirane, aziridine and glyceraldehyde 3-phosphate", J. Org. Chem., 55, 4897–4901, (1990).

  75. Y.-F. Wang, C.-H. Wong, John S. Ngo, K. A. Babiak, J. H. Dygos, "Lipase-catalyzed transesterifications using enol esters: resolution of prostaglandin synthons 4-hydroxy-2-alkyl-2-cyclopentenones and inversion of the 4S enantiomer to the 4R Enantiomer", J. Org. Chem., 55, 3377–3381, (1990).

  76. G.-J. Shen, Y.-F. Wang, C. Bradshaw, C.-H. Wong, "A new NAD-dependent alcohol dehydrogenase with opposite facial selectivity useful for asymmetric reduction and cofactor regeneration", J. Chem. Soc., Chem. Commun., 677–679, (1990).

  77. S.-H. Hsu, S.-S. Wu, Y.-F. Wang, C.-H. Wong, "Lipase-catalyzed irreversible transesterification using enol esters: XAD-8 immobilized lipoprotein lipase-catalyzed resolution of secondary alcohols", Tetrahedron Lett., 31, 6403–6406, (1990).

  78. C.-H. Wong, "Design and development of enzymatic organic synthesis", Chem. Aspects Enzyme Biotech., Scott, A. I., Baldwin, T., Raushel, F. (eds.), Plenum, 1990, pp 165–178.

  79. S.-H. Hsu, S.-S. Wu, Y.-F. Wang, C.-H. Wong, "Lipase catalyzed irreversible transesterification using enol esters: XAD-8 immobilized lipoprotein lipase-catalyzed resolution of secondary alcohols", Tetrahedron Lett., 31, 6403–6406, (1990).

  80. Z. Zhong, J. L.-C. Liu, L. M. Dinterman, M. A. J. Finkelman, W. Thomas Mueller, M. L. Rollence, M. Whitlow, C.-H. Wong, "Engineering subtilisin for reaction in dimethylformamide", J. Am. Chem. Soc., 113, 683–684, (1991).

  81. Z. Zhong, J. A. Bibbs, W. Yuan, C.-H. Wong "Active-site directed modification of subtilisin", J. Am. Chem. Soc., 113, 2259–2263, (1991).

  82. D. G. Drueckhammer, W. J. Hennen, R. L. Pederson, C. F. Barbas III, C. M. Gautheron, T. Krach, C.-H. Wong, "Enzyme catalysis in synthetic carbohydrate chemistry", Synthesis, 7, 499–525, (1991).

  83. C.-H. Wong, K.-T. Wang, "New development in enzymatic peptide synthesis", Experientia, 47, 1123–1129, (1991).

  84. C. F. Barbas, C.-H. Wong, "Overexpression and substrate specificity studies of phosphodeoxyribomutase and thymidine phosphorylase", Bioorg. Chem., 19, 261–269, (1991).

  85. C. Bradshaw, C.-H. Wong, W. Hummel, M.-R. Kula, "Enzyme-catalyzed asymmetric synthesis of (S)-2-hydroxy-4-phenylbutyric acid and (R)-2-amino-4-phenylbutyric acid", Bioorg. Chem., 19, 29–39, (1991).

  86. C.-H. Wong, G.-J. Shen, R. L. Pederson, Y.-F. Wang, W. J. Hennen, "Concepts and applications of enzymatic catalysis in organic synthesis", Method. Enzymol., 202, 591–602, (1991).

  87. H. Fu, G.-J. Shen, C.-H. Wong, "Asymmetric epoxidation of allyl alcohol derivatives by w-hydroxylase from Pseudomonas oleovorans", Recueil (Journal of the Royal Netherlands Chemical Society), 110, 167–170, (1991).

  88. R. L. Pederson, J. Esker, C.-H. Wong, "An improved synthesis of dihydroxyacetone phosphate", Tetrahedron, 47, 2643–2648, (1991).

  89. T. Kajimoto, L. Chen, K. K.-C. Liu, C.-H. Wong "Palladium-mediated stereocontrolled reductive amination of azasugars prepared from enzymatic aldol condensation: a general approach to the synthesis of azasugars", J. Am. Chem. Soc., 113, 6678–6680, (1991).

  90. T. Kajimoto, K. K.-C. Liu, R. L. Pederson, Z. Zhong, Y. Ichikawa, J. A. Porco, C.-H. Wong, "Enzyme-catalyzed aldol condensation for asymmetric synthesis of azasugars: synthesis, evaluation, and modeling of glycosidase inhibitors", J. Am. Chem. Soc., 113, 6187–6196, (1991).

  91. H. Fu, M. Newcomb, C.-H. Wong, "Pseudomonas oleovorans monooxygenase-catalyzed asymmetric epoxidation of allyl alcohol derivatives and hydroxylation of a hypersensitive radical probe with the radical ring opening rate exceeding rebound rate", J. Am. Chem. Soc., 113, 5878–5880, (1991).

  92. Y. Ichikawa, G.-J. Shen, C.-H. Wong, "Enzyme-catalyzed synthesis of sialyl oligosaccharide with in situ regeneration of CMP-sialic acid", J. Am. Chem. Soc., 113, 4698–4700, (1991).

  93. C.-H. Wong, C. Gautheron, T. Krach, Y. Ichikawa, G. C. Look, F. Gaeta, D. Thomson, K. C. Nicolaou, "Synthesis of novel disaccharides using glycosyltransferases: b-1,4-galactosyltransferase", Tetrahedron Lett., 32, 4867–4870, (1991).

  94. C. Gautheron, Y. Ichikawa, C.-H. Wong, "A complete change of stereoselectivity in sialic acid aldolase reactions: a novel synthetic route to the KDO type of nine carbon L-sugars", J. Am. Chem. Soc., 113, 7816–7818, (1991).

  95. C. Bradshaw, G.-J. Shen, C.-H. Wong, "A new alcohol dehydrogenase with unique stereospecificity from Pseudomonas sp.", Bioorg. Chem., 19, 398–417, (1991).

  96. K. C. Nicolaou, C. W. Hummel, N. J. Bockovich, C.-H. Wong, "Stereocontrolled synthesis of sialyl Lex, the oligosaccharide binding ligand to ELAM-1", J. Chem. Soc., Chem. Commun., 870–871, (1991).

  97. C. Gautheron, C.-H. Wong, "Glycosyltransferase-catalyzed stereoselective glycosylation of monosaccharide-based glycosidase inhibitors: a new approach to the synthesis of sequence-specific glycosidase inhibitors", J. Chem. Soc., Chem. Commun., 1130–1131, (1991).

  98. C.-H. Wong, Y. Ichikawa, T. Krach, C. Gautheron, D. Dumas, G. Look, "Probing the acceptor specificity of b-1,4-galactosyltransferase for the development of enzymatic synthesis of novel oligosaccharides", J. Am. Chem. Soc., 113, 8137–8145, (1991).

  99. K. K.-C. Liu, T. Kajimoto, L. Chen, Y. Ichikawa, C.-H. Wong, "Use of dihydroxyacetone phosphate dependent aldolases in the synthesis of deoxyazasugars", J. Org. Chem., 56, 6280–6289, (1991).

  100. Y. Ichikawa, J. L.-C. Liu, G.-J. Shen, C.-H. Wong, "A highly efficient multienzyme system for the one-step synthesis of a sialyl trisaccharide: in situ generation of sialic acid and N-acetyllactosamine coupled with regeneration of UDP-glucose, UDP-galactose and CMP-sialic acid", J. Am. Chem. Soc., 113, 6300–6302, (1991).

  101. D. P. Dumas, Y. Ichikawa, C.-H. Wong, J. B. Lowe, R. P. Nair, "Enzymatic synthesis of sialyl Lex and derivatives based on a recombinant fucosyltransferase", Bioorg. Med. Chem. Lett., 1, 425–428, (1991).

  102. W. Yuan, Z. Zhong, C.-H. Wong, J. Z. Haeggstrom, A. Witterholm, B. Samuelsson, "Probing the inhibition of leukotriene A4 hydrolase based on its aminopeptidase activity", Bioorg. Med. Chem. Lett., 10, 551–556, (1991).

  103. K. K.-C. Liu, R. L. Pederson, C.-H. Wong, "Fructose-1,6-diphosphate aldolase catalyzed stereoselective C–C bond formation", J. Chem. Soc. Perkin, 1, 2669, (1991).

  104. H. Fu, G .C. Look, W. Zhang, E. N. Jacobsen, C.-H. Wong, "Mechanistic study of a synthetically useful mono-oxygenase model using the hypersensitive probe trans-2-phenyl-1-vinylcyclopropane", J. Org. Chem., 56, 6497–6500, (1991).

  105. Z. Zhong, C.-H. Wong, "Development of new enzymatic catalysts for peptide synthesis in aqueous and organic solvents", Biomed. Biochim. Acta, 50, S9–S14, (1991).

  106. G.-J. Shen, C.-H. Wong, "Construction of a diverse Fab expression library from autoimmunized mice based on an improved preparation of cloning arms from bacteriophage vectors: a new library with potential for screening of biocatalysts", Biocatalysis, 6, 101–114, (1992).

  107. G.-J. Shen, J. L.-C. Liu, C.-H. Wong, "Cloning and overexpression of CMP-N-acetylneuraminic acid synthetase from E. coli using a lambda phage system", Biocatalysis, 6, 31–42, (1992).

  108. L. Chen, D. P. Dumas, C.-H. Wong, "Deoxyribose 5-phosphate aldolase as a catalyst in asymmetric aldol condensation", J. Am. Chem. Soc., 114, 741–748, (1992).

  109. C. W. Bradshaw, H. Fu, G.-J. Shen, C.-H. Wong, "A pseudomonas sp. alcohol dehydrogenase with broad substrate specificity and unusual stereospecificity for organic synthesis", J. Org. Chem., 57, 1526–1532, (1992).

  110. D. P. Dumas, T. Kajimoto, K. K.-C. Liu, C.-H. Wong, D. B. Berkowitz, S. J. Danishefsky, "Azasugar and glycal inhibitors of a-L-fucosidase", Bioorg. Med. Chem Lett., 2, 33–36, (1992).

  111. C. W. Bradshaw, W. Hummel, C.-H. Wong, "Lactobacillus kefir alcohol dehydrogenase: A useful catalyst for synthesis", J. Org. Chem., 57, 1532–1536, (1992).

  112. J. L.-C. Liu, G.-J. Shen, Y. Ichikawa, J. R. Rutan, C. Zapata, W.F. Vann, C.-H. Wong, "Overproduction of CMP-sialic acid synthetase for organic synthesis", J. Am. Chem. Soc., 114, 3901–3910, (1992).

  113. Y. Ichikawa, M. M. Sim, C.-H. Wong, "Efficient chemical synthesis of GDP-Fucose", J. Org. Chem., 57, 2943–2946, (1992).

  114. C. W. Bradshaw, J. J. Lalonde, C.-H. Wong, "Enzymatic synthesis of (R)- and (S)-1-deuterohexanol", Appl. Biochem. Biotech., 33, 15–24, (1992).

  115. C.-H. Wong, K. K.-C. Liu, T. Kajimoto, L. Chen, Z. Zhong, D. P. Dumas, J. L.-C. Liu, Y. Ichikawa, G.-J. Shen, "Enzymes for carbohydrate and peptide syntheses", Pure Appl. Chem., 64, 1197–1202, (1992).

  116. Y. Ichikawa, G. C. Look, C.-H. Wong, "Enzymatic oligosaccharide synthesis," Anal. Biochem., 202, 215–238, (1992).

  117. Y.-C. Lin, C. W. Hummel, D.-H. Huang, Y. Ichikawa, K. C. Nicolaou, C.-H. Wong, "Conformational studies of sialyl LeX in aqueous solution", J. Am. Chem. Soc., 114, 5452–5454, (1992).

  118. E. Fernholz, D. Schloeder, K. K.-C. Liu, C. W. Bradshaw, H. Huang, K. Janda, R. A. Lerner, C.-H. Wong, "Specificity of antibody catalyzed transesterifications using enol esters: a comparison with lipase reactions", J. Org. Chem., 57, 4756–4761, (1992).

  119. K. K.-C. Liu, C.-H. Wong, "Enzymatic halohydration of glycals", J. Org. Chem., 57, 3748–3750, (1992).

  120. C.-H. Wong, R. Wang, Y. Ichikawa, "Regeneration of sugar nucleotides for enzymatic oligosaccharide synthesis: use of galactose 1-phosphate uridyltransferase in the regeneration of UDP-galactose, UDP-2-deoxygalactose and UDP-galactosamine", J. Org. Chem., 57, 4343–4344, (1992).

  121. G. C. Look, C.-H. Wong, "A facile enzymatic synthesis of Gal b1,3glucal: a key intermediate for the synthesis of Lea and sialyl Lea", Tetrahedron Lett., 33, 4253–4256, (1992).

  122. W. Yuan, J. Z. Haeggstrom, A. Wetterholm, B. Samuelsson, C.-H. Wong, "Novel tight-binding inhibitors of leukotriene A4 hydrolase", J. Am. Chem. Soc., 114, 6552–6553, (1992).

  123. C.-H. Wong, D. P. Dumas, Y. Ichikawa, K. Koseki, S. J. Danishefsky, B. W. Weston, J. B. Lowe, "Specificity, inhibition, and synthetic utility of a recombinant human a-1,3-fucosyltransferase", J. Am. Chem. Soc. 114, 7321–7322, (1992).

  124. Y. Ichikawa, Y.-C. Lin, D. P. Dumas, G.-J. Shen, E. Garcia-Junceda, M. A. Williams, R. Bayer, C. Ketcham, L. Walker, J. C. Paulson, C.-H. Wong, "Chemical-enzymatic synthesis and conformational study of sialyl lewis x and derivatives", J. Am. Chem. Soc., 114, 9283–9297, (1992).

  125. K. K.-C. Liu, C.-H. Wong, "A new strategy for the enzymatic synthesis of nucleoside analogs using fructose-1,6-diphosphate aldolase", J. Org. Chem., 57, 4789–4791, (1992).

  126. S. J. Danishefsky, J. Geruay, J. M. Peterson, F. E. McDonald, K. Koseki, T. Oriyama, D. A. Griffith, C.-H. Wong, D. P. Dumas, "Remarkable regioselectivity in the chemical glycosylation of glycal acceptors: a concise solution to the synthesis of sialyl-Lewis x glycal, a fucosyltransferase inhibitor", J. Am. Chem. Soc., 114, 8329–8331, (1992).

  127. R. L. Pederson, C.-H. Wong, "Lipoprotein lipase catalyzed kinetic resolution of 2-acetoxy-3-azidopropanal diethyl acetal", in Preparative Biotransformations, S. M. Roberts, K. Wiggins, G. Casy, eds. 1992, 1:6.14.

  128. H. Kondo, Y. Ichikawa, C.-H. Wong, "b-Sialyl phosphite and phosphoramidite: Synthesis and application to the chemo-enzymatic synthesis of CMP-sialic acid and sialyl Lewis X", J. Am. Chem. Soc., 114, 8748–8750, (1992).

  129. H. Fu, H. Kondo, Y. Ichikawa, G. C. Look, C.-H. Wong, "Chloroperoxidase catalyzed asymmetric synthesis: Enantioselective reactions of chiral hydroperoxides with sulfides, and bromohydration of glycals", J. Org. Chem., 57, 7265–7270, (1992).

  130. W. J. Hennen, H. M. Sweers, Y.-F. Wang, C.-H. Wong, "Enzymatic regioselective hydrolysis of a peracetylated furanose derivative", in Preparative Biotransformations, S. M. Roberts, K. Wiggins, G. Casy, eds. 1992, 1:7.1.

  131. C.-H. Lin, T. Sugai, R. L. Halcomb, Y. Ichikawa, C.-H. Wong, "Unusual stereoselectivity in sialic acid aldolase catalyzed aldol condensations: Synthesis of both enantiomers of high-carbon monosaccharides", J. Am. Chem. Soc., 114, 10138–10145, (1992).

  132. C.-H. Wong, "Engineering enzymes for chemoenzymatic synthesis Part I: Practical routes to aza-sugars and complex carbohydrates", TIBTECH, 10, 337–341, (1992).

  133. C.-H. Wong, "Engineering enzymes for chemoenzymatic synthesis Part II: Modifying proteases for peptide synthesis", TIBTECH, 10, 378, (1992).

  134. K. K.-C. Liu, R. L. Pederson, C.-H. Wong, "Rabbit muscle aldolase catalyzed preparation of 6-deoxy-6-chloro-D-fructose and 6-deoxy-6-chloro-L-sorbose from 3-chloro-2-hydroxypropanal and DHAP", in Preparative Biotransformations, S. M. Roberts, K. Wiggins, G. Casy, eds. 1992, 4:1.1.

  135. C.-H. Wong, K. K.-C. Liu, T. Kajimoto, L. Chen, Z. Zhong, Y. Ichikawa, G.-J. Shen, "Developing better enzymes for organic synthesis", Enzyme Engineering XI, Ann. N.Y. Acad. Sci. 672, 343–351, (1992).

  136. W. Yuan, B. Munoz, J. Haeggstrom, A. Wetterholm, B. Samuelsson, C.-H. Wong, "Synthesis of selective tight-binding inhibitors of leukotriene A4 hydrolase", J. Med. Chem., 36, 211–220, (1993).

  137. M. Schuster, B. Munoz, W. Yuan, C.-H. Wong, "Papain catalyzed synthesis of peptide isosteres", Tetrahedron Lett., 34, 1247–1250, (1993).

  138. Y.-F. Wang, D. Dumas, C.-H. Wong, "Chemo-enzymatic synthesis of five-membered aza sugars as inhibitors of fucosidase and fucosyltransferase: An issue of stereochemistry discrimination at transition state", Tetrahedron Lett., 34, 403–406, (1993).

  139. T. Sugai, G.-J. Shen, Y. Ichikawa, C.-H. Wong, "Synthesis of 3-deoxy-D-manno-2-octulosonic acid (KDO) and its analogs based on KDO aldolase-catalyzed reactions", J. Am. Chem. Soc., 115, 413–421, (1993).

  140. P. Wang, G.-J. Shen, Y.-F. Wang, C.-H. Wong, "Enzymes in oligosaccharide synthesis: Active-domain overproduction, specificity study, and synthetic use of an a-1,2-mannosyltransferase with regeneration of GDP-mannose", J. Org. Chem., 58, 3985–3990, (1993).

  141. M. M. Sim, H. Kondo, C.-H. Wong, "Synthesis of dibenzyl glycosyl phosphites using dibenzyl N,N-diethylphosphoramidite as phosphitylating reagent: An effective route to glycosyl phosphates, sugar nucleotides, and glycosides", J. Am. Chem. Soc., 115, 2260–2267, (1993).

  142. G. C. Look, C. H. Fotsch, C.-H. Wong, "Enzyme-catalyzed organic synthesis: Practical routes to aza-sugars and their analogs for use as glycoprocessing inhibitors", Acc. Chem. Res., 26, 182–190, (1993).

  143. C.-H. Wong, Y. Ichikawa, T. Kajimoto, K. K.-C. Liu, G.-J. Shen, C.-H. Lin, Y.-F. Wang, D. P. Dumas, Y.-C. Lin, R. Wang, G. C. Look, "Practical synthesis of carbohydrates based on aldolases and glycosyltransferases", Pure Appl. Chem., 65, 803–808, (1993).

  144. G. Siuzdak, Y. Ichikawa, T. J. Caulfield, B. Munoz, C.-H. Wong, K. C. Nicolaou, "Evidence of Ca++ dependent carbohydrate association through ion spray mass spectrometry", J. Am. Chem. Soc., 115, 2877–2881, (1993).

  145. G. F. Herrmann, Y. Ichikawa, C. Wandrey, F. C. A. Gaeta, J.C. Paulson, C.-H. Wong, "A new multi-enzyme system for a one-pot synthesis of sialyl-oligosaccharides: combined use of a-galactosidase and ?(2,6)-sialyltransferase coupled with regeneration in situ of CMP-sialic acid", Tetrahedron Lett., 19, 3091–3094, (1993).

  146. C.-H. Wong, M. Schuster, P. Wang, P. Sears, "Enzymatic synthesis of N- and O-linked glycopeptides", J. Am. Chem. Soc., 115, 5893–5901, (1993).

  147. G. C. Look, Y. Ichikawa, G.-J. Shen, P.-W. Cheng, C.-H. Wong, "A combined chemical and enzymatic strategy for the construction of carbohydrate-containing antigen core units", J. Org. Chem., 58, 4326–4330, (1993).

  148. C.-H. Wong, "Development of enzymes for chemo-enzymatic synthesis", Chimia, 47, 127–132, (1993).

  149. Y. Takaoka, T. Kajimoto, C.-H. Wong, "Inhibition of N-acetylglucosaminyltransfer enzymes: Chemical-enzymatic synthesis of new five-membered acetamido azasugars", J. Org. Chem., 58, 4809–4812, (1993).

  150. S. A. DeFrees, F. C. A. Gaeta, Y.-C. Lin, Y. Ichikawa, C.-H. Wong, "Ligand recognition by E-selectin: Analysis of conformation and activity of synthetic monomeric and bivalent sialyl Lewis x analogs", J. Am. Chem. Soc., 115, 7549–7550, (1993).

  151. T. Sugai, H. Ritzen, C.-H. Wong, "Towards the chemoenzymatic synthesis of lipid A", Tetrahedron Asymmetry, 4, 1051–1058, (1993).

  152. T. Kajimoto, T. Sugai, C.-H. Wong, "Aldolase catalyzed reaction for carbohydrate synthesis", Trends Glycosci. Glycotechnol., 5, 193–207, (1993).

  153. R. L. Halcomb, C.-H. Wong, "Synthesis of oligosaccharides, glycopeptides, and glycolipids", Curr. Opin. Struct. Biol., 3, 694–700, (1993).

  154. P. Wang, M. Schuster, Y.-F. Wang, C.-H. Wong, "Synthesis of phospholipid-inhibitor conjugates by enzymatic transphosphatidylation with phospholipase D", J. Am. Chem. Soc., 115, 10487–10491, (1993).

  155. I. Henderson, K. B. Sharpless, C.-H. Wong, "Synthesis of carbohydrates via tandem use of the osmium-catalyzed asymmetric dihydroxylation and enzyme-catalyzed aldol addition reactions", J. Am. Chem. Soc., 116, 558–561, (1994).

  156. I. Henderson, K. Laslo, C.-H. Wong, "Chemoenzymatic synthesis of homoazasugars", Tetrahedron Lett., 35, 359–362, (1994).

  157. H. J. M. Gijsen, C.-H. Wong, "Unprecedented asymmetric aldol reactions with three aldehyde substrates catalyzed by 2-deoxyribose-5-phosphate aldolase", J. Am. Chem. Soc., 116, 8422–8423, (1994).

  158. L. Provencher, D. Steensma, C.-H. Wong, "Five-membered ring azasugars as potent inhibitors of L-a-rhamnosidase from Penicillium decumbens", Bioorg. Med. Chem., 2, 1179–1188, (1994).

  159. J.-M. Fang, C.-H. Wong, "Enzymes in organic synthesis: Alteration of reversible reactions to irreversible processes", Synlett, 6, 393–402, (1994).

  160. C. H. Fotsch, C.-H. Wong, "Synthesis of a guanidino-sugar as a glycosyl cation mimic", Tetrahedron Lett., 35, 3481–3484, (1994).

  161. Y.-F. Wang, Y. Takaoka, C.-H. Wong, "Remarkable stereoselectivity in the inhibition of a-galactosidase from coffee bean by a new polyhydroxypyrrolidine inhibitor", Angew. Chem. Int. Ed. Engl., 33, 1242–1244, (1994).

  162. W.-C. Chou, L. Chen, J.-M. Fang, C.-H. Wong, "A new route to deoxythiosugars based on aldolases", J. Am. Chem. Soc., 116, 6191–6194, (1994).

  163. G. F. Herrmann, P. Wang, G.-J. Shen, C.-H. Wong, "Recombinant whole cells as catalysts for the enzymatic synthesis of oligosaccharides and glycopeptides", Angew. Chem. Int. Ed. Engl., 33, 1241–1242, (1994).

  164. B. Munoz, C.-Z. Giam, C.-H. Wong, "a-Ketoamide Phe-Pro isostere as a new core structure for the inhibition of HIV protease", Bioorg. Med. Chem., 2, 1085–1090, (1994).

  165. G. F. Herrmann, P. Wang, G.-J. Shen, E. Garcia-Junceda, S. Chen, S. H. Khan, K. L. Matta, C.-H. Wong, "Large scale production of recombinant a-1,2-mannosyltransferase from E. coli for the study of acceptor specificity and use of the recombinant whole cells in synthesis", J. Org. Chem., 59, 6356–6362, (1994).

  166. Y. Ichikawa, R. L. Halcomb, C.-H. Wong, "Sticky solutions", Chemistry in Britain, 30, 117–121, (1994).

  167. H. Kondo, S. Aoki, Y. Ichikawa, R. L. Halcomb, H. Ritzen, C.-H. Wong, "Glycosylphosphites as glycosylation reagents: Scope and mechanism", J. Org. Chem., 59, 864–877, (1994).

  168. P. Sears, P. Wang, K. Witte, M. Schuster, C.-H. Wong, "Engineering subtilisin for peptide coupling: studies on the effects of counterions and site-specific modifications on the stability and specificity of the enzyme in aqueous and organic solvents", J. Am. Chem. Soc., 116, 6521–6530, (1994).

  169. I. Henderson, E. Garcia-Junceda, G.-J. Shen, C.-H. Wong, "Cloning, overexpression and isolation of the Type II FDP aldolase from E. coli for specificity study and synthetic application", Bioorg. Med. Chem., 2, 837–843, (1994).

  170. M. Schuster, P. Wang, J. C. Paulson, C.-H. Wong, "Solid-phase chemical-enzymatic synthesis of glycopeptides and oligosaccharides", J. Am. Chem. Soc., 116, 1135–1136, (1994).

  171. Y. Ichikawa, R. Wang, C.-H. Wong, "Regeneration of sugar nucleotides in glycosyltransferase-catalyzed oligosaccharide synthesis", Method. Enzymol., 247, 107–127, (1994).

  172. H. Kondo, M. M. Sim, R. Halcomb, Y. Ichikawa, S. Aoki, C.-H. Wong, "Dibenzyl glycosyl phosphites: preparation and use in glycosylation", Method. Enzymol., 247, 193–211, (1994).

  173. J. L. Marquardt, E.D. Brown, W. S. Lane, T. M. Haley, Y. Ichikawa, C.-H. Wong, C. T. Walsh, "Kinetics, stoichiometry and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolypyruvyl transferase by the antibiotic fosfomycin", Biochemistry, 33, 10646–10651, (1994).

  174. S. Hiranuma, T. Kajimoto, C.-H. Wong, "A facile synthesis of 1-thiopentofuranosides", Tetrahedron Lett., 35, 5257–5260, (1994).

  175. H. Yuasa, T. Kajimoto, C.-H. Wong, "Synthesis of iminothiasugar as a potential transition-state analog inhibitor of glycosyltransfer reactions", Tetrahedron Lett., 35, 8243–8246, (1994).

  176. R. L. Halcomb, H. Huang, C.-H. Wong, "Solution- and solid-phase synthesis of inhibitors of H. pylori attachment and E-selectin-mediated leukocyte adhesion", J. Am. Chem. Soc., 116, 11315–11322, (1994).

  177. S.-H. Jung, J.-H. Jeong, P. Miller, C.-H. Wong, "An efficient multigram scale preparation of dihydroxyacetone phosphate", J. Org. Chem., 59, 7182–7184, (1994).

  178. R. L. Halcomb, W. Fitz, C.-H. Wong, "Enzymatic synthesis of 7-deoxy-N-acetylneuraminic acid and 7-0-methyl-N-acetylneuraminic acid", Tetrahedron: Asymmetry, 5, 2437–2442, (1994).

  179. W. Fitz, C.-H. Wong, "Combined use of subtilisin and N-acetylneuraminic acid aldolase for the synthesis of a fluorescent sialic acid", J. Org. Chem., 59, 8279–8280, (1994).

  180. G. Siuzdak, Z.-L. Zheng, J. R. Ramphal, Y. Ichikawa, K. C. Nicolaou, F. C. A. Gaeta, K.S. Chatman, C.-H. Wong, "Examination of the sialyl Lewis X - calcium complex by electrospray mass spectrometry", Bioorg. Med. Chem Lett., 4, 2863–2866, (1994).

  181. T. Sugai, C.-H. Lin, G.-J. Shen, C.-H. Wong, "CMP-KDO synthetase: overproduction and application to the synthesis of CMP-KDO and analogs", Bioorg. Med. Chem, 3, 313–320, (1995).

  182. S. A. DeFrees, W. Kosch, W. Way, J. C. Paulson, S. Sabesan, R. Halcomb, D.-H. Huang, Y. Ichikawa, C.-H. Wong, "Ligand recognition by E-selectin: synthesis, inhibitory activity, and conformational analysis of bivalent sialyl Lewis x analogs", J. Am. Chem. Soc., 117, 66–79, (1995).

  183. C.-H. Wong, E. Garcia-Junceda, L. Chen, O. Blanco, D. H. Steensma, "Recombinant 2-deoxyribose-5-phosphate aldolase in organic synthesis: use of sequential two-substrate and three-substrate aldol Reactions", J. Am. Chem. Soc., 117, 3333–3339, (1995).

  184. C.-M. Fang, C.-H. Wong, "Enzymes in organic synthesis: oxidoreductions", J. Chem. Soc., Perkin Trans I., 967–978, (1995).

  185. C.-H. Wong, R. Halcomb, Y. Ichikawa, T. Kajimoto, "Enzymes in organic synthesis: application to the problems of carbohydrate recognition (Part I)", Angew. Chem. Int. Ed. Engl., 34, 412–432, (1995).

  186. C.-H. Wong, R. Halcomb, Y. Ichikawa, T. Kajimoto, "Enzymes in organic synthesis: application to the problems of carbohydrate recognition (Part II)", Angew. Chem. Int. Ed. Engl., 34, 521–546, (1995).

  187. P. Wang, W. Fitz, C.-H. Wong, "Making complex carbohydrates via enzymatic routes", Chemtech, 22–32, (1995).

  188. C.-H. Wong, "Enzymatic and chemo-enzymatic synthesis of carbohydrates", Pure Appl. Chem., 67, 1609–1616, (1995).

  189. C.-H. Wong, R. Alajarin, F. Moris-Varas, O. Blanco, E. Garcia-Junceda, "Enzymatic synthesis of L-fucose and analogs", J. Org. Chem., 60, 7360–7363, (1995).

  190. H. Huang, C.-H. Wong, "Synthesis of biologically active sialyl Lewis X mimetics", J. Org. Chem., 60, 3100–3106, (1995).

  191. V. P. Vassilev, T. Uchiyama, T. Kajimoto, C.-H. Wong, "An efficient chemo-enzymatic synthesis of a-amino-b-hydroxy g-butyrolactone", Tetrahedron Lett., 36, 5063, (1995).

  192. C.-H. Lin, G.-J. Shen, C.-H. Wong, "Enzymatic synthesis and regeneration of 3'-phosphoadenosine-5'-phosphosulfate (PAPS) for use in regiospecific enzymatic sulfation", J. Am. Chem. Soc., 117, 8031–8032, (1995).

  193. C.-H. Wong, L. Provencher, J. Porco, S.-H. Jung, Y.-F. Wang, L. Chen, R. Wang, D. Steensma, "Synthesis and evaluation of homoazasugars as glycosidase inhibitors", J. Org. Chem., 60, 1492–1502, (1995).

  194. E. A. Stura, S. Gosh, E. Garcia-Junceda, L. Chen, C.-H. Wong, I. A. Wilson, "Crystallization and preliminary crystallographic data for class I deoxyribose-5-phosphate aldolase from E. coli: An application of reverse screening", Proteins: Struct., Funct., Genet., 22, 67–72, (1995).

  195. T. Ikeda, T. Kajimoto, T. Nohara, J.-E. Kinjo, C.-H. Wong, "Preparation of a neoglycolipid carrying the oligosaccharide component of saponin from Albizzia julibrissin", Tetrahedron Lett., 36, 1509–1510, (1995).

  196. A. Wetterholm, J. Z. Haeggstrom, B. Samuelsson, W. Yuan, B. Munoz, C.-H. Wong, "Potent and selective inhibitors of leukotriene A4 hydrolase: effects on purified enzyme and human polymorphonuclear leukocytes", J. Pharmacol. Exp. Ther., 275, 31–37, (1995).

  197. R. Ollmann, J. H. Hogg, B. Munoz, C.-H. Wong, J. Z. Haeggstrom, B. Samuelsson, "Investigation of the inhibition of leukotriene A4 hydrolase", Bioorg. Med. Chem., 3, 969–995, (1995).

  198. J. H. Hogg, I. R. Ollmann, C.-H. Wong, J. Z. Haeggstrom, B. Samuelsson, "Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase", Bioorg. Med. Chem., 3, 1405–1415, (1995).

  199. W. Fitz, J.-R. Schwark, C.-H. Wong, "Aldotetroses and C(3)-modified aldohexoses as substrates for N-acetylneuraminic acid aldolase: comments on the lack of stereospecificity displayed by the enzyme", J. Org. Chem., 60, 3663–3670, (1995).

  200. W.-C. Chou, C. Fotsch, C.-H. Wong, "Synthesis of nitrocyclitols based on enzymatic aldol reaction and intramolecular nitroaldol reaction", J. Org. Chem., 60, 2916–2917, (1995).

  201. H. J. M. Gijsen, C.-H. Wong, "Sequential one-pot aldol reactions catalyzed by 2-deoxyribose-5-phosphate aldolase and fructose-1,6-diphosphate aldolase", J. Am. Chem. Soc., 117, 2947–2948, (1995).

  202. E. Garcia-Junceda, G.-J. Shen, T. Sugai, C.-H. Wong, "A new strategy for the cloning, overexpression and one step purification of three DHAP-dependent aldolases: rhamnulose-1-phosphate aldolase, fuculose-1-phosphate aldolase and tagatose-1,6-diphosphate aldolase", Bioorg. Med. Chem., 3, 945–953, (1995).

  203. T. Uchiyama, V.P. Vassilev, T. Kajimoto, W. Wong, H. Huang, C.-C. Lin, C.-H. Wong, "Design and synthesis of sialyl Lewis X mimetics", J. Am. Chem. Soc., 117, 5395–5396, (1995).

  204. V. P. Vassilev, T. Uchiyama, T. Kajimoto, C.-H. Wong, "L-Threonine aldolase in organic synthesis: preparation of novel b-hydroxy-a-amino acids based on threonine aldolase", Tetrahedron Lett., 36, 4081–4084, (1995).

  205. C. De Luca, M. Lansing, I. Martin, F. Crescenzi, G.-J. Shen, M. O’Regan, C.-H. Wong, "Enzymatic synthesis of hyaluronic acid with regeneration of sugar nucleotides", J. Am. Chem. Soc., 117, 5869–5870, (1995).

  206. M. Hendrix, C.-H. Wong, "Enzymes in organic synthesis: Application to the study of carbohydrate recognition", Proceedings of the Chiral ‘95 USA Symposium, Spring Innovation Ltd., 1995, pp 27–34.

  207. H. J. M. Gijsen, C.-H. Wong, "Sequential three- and four-substrate aldol reactions catalyzed by aldolases", J. Am. Chem. Soc., 117, 7585–7591, (1995).

  208. R. Alajarin, E. Garcia-Junceda, C.-H. Wong, "A short enzymatic synthesis of L-glucose from dihydroxyacetone phosphate and L-glyceraldehyde", J. Org. Chem., 60, 4294–4295, (1995).

  209. C.-H. Wong, "Intervention of carbohydrate-mediated biological recognitions", RIKEN Rev., 8, 3–4, (1995).

  210. T. Kajimoto, C.-H. Wong, "Transition-state analog inhibitors for N-acetylglucosaminyltransfer enzymes", RIKEN Rev., 8, 13–14, (1995).

  211. S. Hiranuma, V. P. Vassilev, T. Kajimoto, C.-H. Wong, "Design of oligosaccharide mimetics with higher stability and simpler structures than parent oligosaccharides", RIKEN Rev., 8, 19–20, (1995).

  212. T. Ikeda, T. Kajimoto, C.-H. Wong, "Oligosaccharides components in traditional Chinese medicines and the liposomes carrying oligosaccharides", RIKEN Rev., 8, 21–22, (1995).

  213. V. P. Vassilev, T. Kajimoto, C.-H. Wong, "Application of L-allo-threonine aldolase in the synthesis of glycoconjugate precursors", RIKEN Rev., 8, 25–26, (1995).

  214. E. Garcia-Junceda, G.-J. Shen, R. Alajarin, C.-H. Wong, "Cloning and overexpression of rhamnose isomerase and fucose isomerase", Bioorg. Med. Chem., 3, 1349–1355, (1995).

  215. D. H. Slee, K. L. Laslo, J. H. Elder, I. R. Ollmann, A. Gustchina, J. Kervinen, A. Zdanov, A. Wlodawer, C.-H. Wong, "Selectivity in the inhibition of HIV and FIV protease: Inhibitory and mechanistic studies of pyrrolidine-containing a-keto amide and hydroxyethylamine core structures", J. Am. Chem. Soc., 117, 11867–11878, (1995).

  216. H. J. M. Gijsen, C.-H. Wong, "Synthesis of a cyclitol via a tandem enzymatic aldol-intramolecular Horner-Wadsworth-Emmons reaction", Tetrahedron Lett., 36, 7057–7060, (1995).

  217. C.-H. Lin, M. Shimazaki, C.-H. Wong, M. Koketsu, L. R. Juneja, M. Kim, "Enzymatic synthesis of a sialyl Lewis X dimer from egg yolk as an inhibitor of E-selectin", Bioorg. Med. Chem., 3, 1625–1630, (1995).

  218. J.-H. Jeong, B. W. Murray, S. Takayama, C.-H. Wong, "Cyclic guanidino-sugars with low pKa as transition-state analog inhibitors of galactosidases: neutral instead of charged species are the active forms", J. Am. Chem. Soc., 118, 4227–4234, (1996).

  219. H. M. Gijsen, L. Qiao, W. Fitz, C.-H. Wong, "Recent advances in the chemo-enzymatic synthesis of carbohydrates and carbohydrate mimetics", Chem. Rev., 96, 443–473, (1996).

  220. W. Fitz, C.-H. Wong, "Synthesis of a thiomethylmercuric sialic acid to be used in the X-ray structure determination of an influenza virus esterase", Bioorg. Med. Chem., 4, 1349–1353, (1996).

  221. B. Orsat, P. Alper, W. Moree, C. P. Mak, C.-H. Wong, "Homocarbonates as substrates for the enantioselective enzymatic protection of amines", J. Am. Chem. Soc., 118, 712–713, (1996).

  222. P. Sears, C.-H. Wong, "Engineering enzymes for bioorganic synthesis: peptide bond formation", Biotech. Prog., 12, 423–433, (1996).

  223. S.-H. Wu, M. Shimazaki, C.-C. Lin, L. Qiao, W.J. Moree, C.-H. Wong, "Synthesis of fucopeptides as sialyl Lewis X mimetics", Angew. Chem. Int. Ed. Engl., 35, 88–89, (1996).

  224. C.-C. Lin, M. Shimazaki, M-P. Heck, S. Aoki, R. Wang, T. Kimura, H. Ritzen, S. Takayama, S.-H. Wu, G. Weitz-Schmidt, C.-H. Wong, "Synthesis of sialyl Lewis X mimetics and related structures using the glycosyl phosphite methodology and evaluation of E-selectin inhibition", J. Am. Chem. Soc., 118, 6826–6840, (1996).

  225. S. Takayama, M. Shimazaki, C.-H. Wong, "Efficient synthesis of lactosamine derivatives using b-D-galactosidase from B. circulans", Bioorg. Med. Chem Lett., 6, 1123–1126, (1996).

  226. J. E. Patterson, I. R. Ollmann, B. F. Cravatt, D. L. Boger, C.-H. Wong, R. A. Lerner, "Inhibition of oleamide hydrolase catalyzed hydrolysis of the endogenous sleep-inducing lipid cis-9-octadecenamide", J. Am. Chem. Soc., 118, 5938–5945, (1996).

  227. C.-H. Wong, "Chemoenzymatic synthesis: application to the study of carbohydrate recognition", Acta Chem. Scan., 50, 211–218, (1996) (Nobel Symposium on Catalytic Asymmetric Synthesis).

  228. M. Hendrix, C.-H. Wong, "A chemoenzymatic approach to carbohydrate-mediated cell adhesion", Pure Appl. Chem., 68, 2081–2087, (1996).

  229. L. Qiao, B. W. Murray, M. Shimazaki, J. Schultz, C.-H. Wong, "Synergistic inhibition of human a-1,3-fucosyltransferase V", J. Am. Chem. Soc., 118, 7653–7662, (1996).

  230. W. K. C. Park, M. Auer, C.-H. Wong, "Rapid combinatorial synthesis of aminoglycoside mimetics using a multiple component condensation strategy: Use of a polyethylene glycol-linked amine and a neamine-derived aldehyde as key components", J. Am. Chem. Soc., 118, 10150–10155, (1996).

  231. K. Hiruma, I. R. Ollmann, T. Kajimoto, G. Weitz-Schmidt, C.-H. Wong, "Rational design and synthesis of a 1,1-linked disaccharide that is five times as active as sialyl Lewis X in binding to E-selectin", J. Am. Chem. Soc., 118, 9265–9270, (1996).

  232. C. De Luca, M. Lansing, F. Crescenzi, I. Martini, G.-J. Shen, M. O’Regan, C.-H. Wong, "Overexpression, one-step purification and characterization of UDP-glucose dehydrogenase and UDP-N-acetylglucosamine pyrophosphorylase", Bioorg. Med. Chem., 4, 131–142, (1996).

  233. R. D. Kidd, H. P. Yennawar, P. Sears, C.-H. Wong, G. K. Farber, "A weak calcium binding site in subtilisin BPN’ has a dramatic effect on protein stability", J. Am. Chem. Soc., 118, 1645–1650, (1996).

  234. R. Wang, C.-H. Wong, "Synthesis of sialyl Lewis X mimetics: use of O-a-fucosyl-(1R,2R)-2-aminocyclohexanol as core structure", Tetrahedron Lett., 37, 5427–5430, (1996).

  235. F. Moris-Varas, X. H. Qian and C.-H. Wong, "Enzymatic and chemical synthesis of seven-membered iminocyclitols as inhibitors of glycosidases", J. Am. Chem. Soc., 118, 7647–7652, (1996).

  236. C.-C. Lin, T. Kimura, S.-H. Wu, G. Weitz-Schmidt, C.-H. Wong, "Liposome-like fucopeptides as sialyl Lewis X mimetics", Bioorg. Med. Chem Lett., 6, 2755–2760, (1996).

  237. X. Qian, F. Moris-Varas, C.-H. Wong, "Synthesis of C2-symmetrical polyhydroxyazepanes as inhibitors of glycosidases", Bioorg. Med. Chem Lett., 6, 1117–1122, (1996).

  238. M. W. Cappi, W. J. Moree, L. Qiao, T. G. Marron, G. Weitz-Schmidt, C.-H. Wong, "The synthesis of novel 6-amino-6-deoxy-L-galactose glycopeptides as potent sialyl Lewis X mimetics", Angew. Chem. Int. Ed. Engl., 35, 2346–2347, (1996).

  239. S.-C. Hung, C.-H. Wong, "Samarium diiodide-mediated coupling of glycosyl phosphates with carbon radical or carbon anion acceptors for the synthesis of C-glycosides", Angew. Chem. Int. Ed. Engl., 35, 2671–2674, (1996).

  240. P. B. Alper, S.-C. Hung C.-H. Wong, "Metal catalyzed diazo transfer for the synthesis of azides from amines", Tetrahedron Lett., 37, 6029–6032, (1996).

  241. T. Uchiyama, T. J. Woltering, W. Wong, T. Kajimoto, M. Takebayashi, G. Weitz-Schmidt, C.-H. Wong, "Design and synthesis of C-linked fucopeptides as inhibitors of E-selectin", Bioorg. Med. Chem., 4, 1149–1165, (1996).

  242. B. W. Murray, S. Takayama, C.-H. Wong, "Mechanism and specificity of human a-1,3-fucosyltransferase V" Biochemistry, 35, 11183–11195, (1996).

  243. K. Shibata, K. Shingu, V. P. Vassilev, K. Nishide, T. Fujita, M. Node, T. Kajimoto, C.-H. Wong, "Kinetic and thermodynamic control of L-threonine aldolase catalyzed reaction and its application to the synthesis of Mycestericin D", Tetrahedron Lett., 37, 2791–2794, (1996).

  244. S.-C. Hung, C.-H. Wong, "Synthesis of glycosyl chlorides with acid-labile protecting group", Tetrahedron Lett., 37, 4903–4906, (1996).

  245. T. Kimura, S. Takayama, H. Huang, C.-H. Wong, "A practical method for the synthesis of N-acetyl-D-lactosamine derivatives by the tandem use of galactose oxidase and b-galactosidase", Angew. Chem. Int. Ed. Engl., 35, 2348–2349, (1996).

  246. S. Takayama, W. J. Moree, C.-H. Wong, "Enzymatic resolution of amines and amino alcohols using pent-4-enoyl derivatives", Tetrahedron Lett., 37, 6287–6290, (1996).

  247. T. J. Woltering, G. Weitz-Schmidt, C.-H. Wong, "C-Fucopeptides as selectin antagonists: Attachment of lipid moieties enhances the activity", Tetrahedron Lett., 37, 9033–9036, (1996).

  248. T. G. Marron, T. J. Woltering, G. Weitz-Schmidt, C.-H. Wong, "C-Mannose derivatives as potent mimics of sialyl Lewis X", Tetrahedron Lett., 37, 9037–9040, (1996).

  249. S. Takayama, P. O. Livingston, C.-H. Wong, "Synthesis of the melanoma-associated ganglioside 9-0-acetyl GD3 through regioselective enzymatic acetylation of GD3 using subtilisin", Tetrahedron Lett., 37, 9271–9274, (1996).

  250. P. Sears, C.-H. Wong, "Intervention of carbohydrate recognition by proteins and nucleic acids", Proc. Natl. Acad. Sci. U.S.A., 93, 12086–12093, (1996).

  251. X. Qian, F. Moris-Varas, M. C. Fitzgerald, C.-H. Wong, "C2-Symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and HIV/FIV proteases", Bioorg. Med. Chem., 4, 2055–2069, (1996).

  252. M. Hendrix, C.-H. Wong, "A chemo-enzymatic approach to the study of carbohydrate recognition in biological systems", Enantiomer, 1, 305–310, (1996).

  253. J. Wu, S. Takayama, C.-H. Wong, G. Siuzdak, "Quantitative electrospray mass spectrometry for the rapid assay of enzyme inhibitors", Chem. Biol., 4, 653–657, (1997).

  254. T. Hayashi, B. W. Murray, R. Wang, C.-H. Wong, "A chemo-enzymatic synthesis of UDP-(2-deoxy-2-fluoro)galactose and evaluation of its interaction with galactosyltransferase", Bioorg. Med. Chem., 5, 497–500, (1997).

  255. R. Wang, D. H. Steensma, Y. Takaoka, C.-H. Wong, "A search of pyrophosphate mimetics for the development of substrates and inhibitors of glycosyltransferases", Bioorg. Med. Chem., 5, 641–644, (1997).

  256. M. Hendrix, P. B. Alper, E. S. Priestley, C.-H. Wong, "Hydroxyamines as a new motif for the molecular recognition of phosphodiesters: implications for aminoglycoside RNA interactions", Angew. Chem. Int. Ed. Engl., 36, 95–96, (1997).

  257. B. W. Murray, V. Wittmann, M. D. Burkart, S. -C. Hung, C.-H. Wong, "Mechanism of human a-1,3-fucosyltransferase V: Glycosidic cleavage occurs prior to nucleophilic attack", Biochemistry, 36, 823-831, (1997).

  258. C.-H. Lin, B. W. Murray, I. R. Ollmann, C.-H. Wong, "Why is CMP-KDO highly unstable?", Biochemistry, 36, 780–785, (1997).

  259. W. Fitz, C.-H. Wong, "Oligosaccharide synthesis by enzymatic glycosidation", in Preparative Carbohydrate Chemistry, S. Hanessian ed., M. Dekker Publication Inc., New York 1997, pp 485–504.

  260. S. Takayama, C.-H. Wong, "Chemo-enzymatic approach to carbohydrate recognition", Curr. Org. Chem., 1, 109–126, (1997).

  261. V. Wittmann, C.-H. Wong, "1H-Tetrazole as catalyst in phosphoromorpholidate coupling reactions: efficient synthesis of GDP-fucose, GDP-mannose and UDP-galactose", J. Org. Chem., 62, 2144–2147, (1997).

  262. M. Hendrix, E. S. Priestley, G. Joyce, C.-H. Wong, "Direct observation of aminoglycoside–RNA interactions by surface plasmon resonance", J. Am. Chem. Soc., 119, 3641–3646, (1997).

  263. W. J. Moree, P. Sears, K. Kawashiro, K. Witte, C.-H. Wong, "Exploitation of subtilisin BPN’ as catalysts for the synthesis of peptides containing noncoded amino acids, peptide mimetics and peptide conjugates", J. Am. Chem. Soc., 119, 3942–3947, (1997).

  264. K. D. Janda, L.-C. Lo, C.-H. Lo, M.-M. Sim, R. Wang, C.-H. Wong, R.A. Lerner, "Chemical selection for catalysis in combinatorial antibody libraries", Science, 275, 945–948, (1997).

  265. C.-H. Wong, F. Moris-Varas, S.-C. Hung, T. G. Marron, C.-C. Lin, K. W. Gong, G. Weitz-Schmidt, "Small molecules as structural and functional mimics of the tetrasaccharide sialyl Lewis X in selectin inhibition: A remarkable enhancement of inhibition by additional negative charge and/or hydrophobic group", J. Am. Chem. Soc., 119, 8152–8158, (1997).

  266. S.-C. Hung, C.-C. Lin, C.-H. Wong, "One-pot synthesis of 1-allyl and 1-allenyl-6-O-benzyl-a-D-glycosides from methyl tetra-O-benzyl-a-D-glycosides", Tetrahedron Lett., 38, 5419–5422, (1997).

  267. M. W. Cappi, W. J. Moree, L. Qiao, T. G. Marron, G. Weitz-Schmidt, C.-H. Wong, "Synthesis of novel 6-amino-6-deoxy-L-galactose derivatives as potent sialyl Lewis x mimetics", Bioorg. Med. Chem., 5, 283–296, (1997).

  268. G. J. McGarvey, C.-H. Wong, "Chemical, enzymatic and structural studies in molecular glycobiology", Liebigs Annal., 6, 1059–1074, (1997).

  269. S. Takayama, G. J. McGarvey, C.-H. Wong, "Microbial aldolases and transketolases: New biocatalytic approaches to simple and complex sugars", Annu. Rev. Microbiol., 51, 285–310, (1997).

  270. C.-C. Lin, C.-H. Lin, C.-H. Wong, "Sialic acid aldolase-catalyzed condensation of pyruvate and N-substituted mannosamine: A useful method for the synthesis of N-substituted sialic acids", Tetrahedron Lett., 38, 2649–2652, (1997).

  271. K. Witte, P. Sears, R. Martin, C.-H. Wong, "Enzymatic glycoprotein synthesis: Preparation of ribonuclease glycoforms via enzymatic glycopeptide condensation and glycosylation", J. Am. Chem. Soc., 119, 2114–2118, (1997).

  272. M. J. Kim, I. T. Lim, H.-J. Kim, C.-H. Wong, "Enzymatic single aldol reactions of remote dialdehydes", Tetrahedron Asymmetry, 8, 1507–1509, (1997).

  273. C.-H. Wong, "A chemo-enzymatic approach to the study of carbohydrate-based biological recognitions," Pure Appl. Chem., 69, 419–422, (1997).

  274. T. Kimura, V. P. Vassilev, G.-J. Shen, C.-H. Wong, "Enzymatic synthesis of b-hydroxy-a-amino acids based on D- and L-threonine aldolases", J. Am. Chem. Soc., 119, 11734–11742, (1997).

  275. O. Seitz, C.-H. Wong, "Chemoenzymatic solution- and solid-phase synthesis of an O-glycopeptides of the mucin domain of MAdCAM-1. a general route to O-LacNAc, O-sialyl-LacNAc, and O-sialyl-Lewis-X peptides", J. Am. Chem. Soc., 119, 8766–8776, (1997).

  276. S. Takayama, G. J. McGarvey, C.-H. Wong, "Enzymes in organic synthesis: Recent development in aldol reactions and glycosylations", Chem. Soc. Rev., 26, 407–415, (1997).

  277. S. Takayama, R. Martin, J. Wu, K. Laslo, G. Siuzdak, C.-H. Wong, "Chemoenzymatic preparation of novel cyclic imine sugars and rapid biological activity evaluation using electrospray mass spectrometry and kinetic analysis", J. Am. Chem. Soc., 119, 8146–8151, (1997).

  278. M. D. Burkart, S.-C. Hung, Z. Zhang, C.-H. Wong, "A new method for the synthesis of fluoro-carbohydrates and glycosides using SelectfluorTM", J. Am. Chem. Soc., 119, 11743–11746, (1997).

  279. M. Koketsu, T. Nitoda, H. Sugino, L. R. Juneja, M. Kim, T. Yamamoto, N. Abe, T. Kajimoto, C.-H. Wong, "Synthesis of a novel sialic acid derivative (sialylphospholipid) as an antirotaviral agent", J. Med. Chem., 40, 3332–3335, (1997).

  280. T. Ikeda, T. Kajimoto, H. Kondo, C.-H. Wong, "Design and synthesis of an a-mannosyl terpenoid as a selective inhibitor of p-selectin", Bioorg. Med. Chem. Lett., 7, 2485–2490, (1997).

  281. M. Kanebo, O. Kanie, T. Kajimoto, C.-H. Wong, "Toward a transition state analog inhibitor of N-acetylglucosaminyl transferase V", Bioorg. Med. Chem. Lett., 7, 2809–2812, (1997).

  282. J. B. Jones, C.-H. Wong, "Biocatalysis and biotransformation exploiting nature’s magic", Curr. Opin. Chem. Biol., 2, 67–69, (1998).

  283. E. Simanek, G. J. McGarvey, C.-H. Wong, "Selectin-carbohydrate interaction: From natural ligands to designed mimics", Chem. Rev., 98, 838–862, (1998).

  284. P. Sears, C.-H. Wong, "Enzyme action in glycoprotein synthesis", Cell. Mol. Life Sci., 54, 223-252, (1998).

  285. P. B. Alper, M. Hendrix, C.-H. Wong, "Probing the specificity of aminoglycoside–RNA interactions with designed synthetic analogs", J. Am .Chem. Soc., 120, 1965–1978, (1998).

  286. T. F. J. Lampe, G. Weitz-Schmidt, C.-H. Wong, "Parallel synthesis of sialyl Lewis x mimetics on solid phase, a library approach toward fucopeptides", Angew. Chem. Int Ed. Engl., 37, 1707–1711, (1998).

  287. K. Hiruma, O, Kanie, C.-H. Wong, "Synthesis of analogs of 1,1-linked galactosyl mannoside as mimetics of sialyl Lewis x tetrasaccharide", Tetrahedron, 54, 15781–15792, (1998).

  288. T. Lee, G. S. Laco, B. E. Torbett, H. S. Fox, D. L. Lerner, J. H. Elder, C.-H. Wong, "Analysis of the S3 and S3' subsite specificity of FIV protease: Development of a broad-based protease inhibitor efficacious against FIV, SIV and HIV in vitro and ex vivo", Proc. Natl. Acad. Sci. U.S.A., 95, 939–944, (1998).

  289. C. Y. Tsai, W. K. C. Park, G. Weitz-Schmidt, B. Ernst, C.-H. Wong, "Synthesis of sialyl Lewis x mimetics using the Ugi four-component reaction", Bioorg. Med. Chem Lett., 8, 2333–2338, (1998).

  290. E. E. Simanek, D.-H. Huang, L. Pasternack, T. D. Machajewski, O. Seitz, D. S. Millar, H. J. Dyson and C.-H. Wong, "Glycosylation of Threonine of the Repeating Unit of RNA Polymerase II with ß-Linked N-Acetylglucosame Leads to a Turnlike Structure", J. Am. Chem. Soc., 120 (45), 11567–11575, (1998).

  291. P. Sears, C.-H. Wong, "Mechanism-based inhibition of carbohydrate-mediated biological recognitions", Chem. Comm., 11, 1161–1170, (1998).

  292. R. Martin, K. L. Witte, C.-H Wong, "The synthesis and enzymatic incorporation of sialic acid derivatives for use as tools to study the structure, activity and inhibition of glycoproteins and other glycoconjugates", Bioorg. Med. Chem., 6, 1283–1292, (1998).

  293. Y. Kanie, A. Kirsch, O. Kanie, C.-H. Wong, "Enzymatic assay of galactosyltransferase by capillary electrophoresis", Anal. Biochem., 263, 240–245, (1998).

  294. H. Kamitakahara, T. Suzuki, N. Nishigori, Y. Suzuki, O. Kanie, C.-H. Wong, "Lyso GM3 ganglioside-poly-L-glutamic acid conjugate as picomolar inhibitor of influenza hemagglutinin", Angew. Chem. Int. Ed. Engl., 37, 1524–1528, (1998).

  295. V. Wittmann, S. Takayama, K. W. Kong, G. Weitz-Schmidt, C.-H. Wong, "Ligand recognition by E- and P-selectin: chemoenzymatic synthesis and inhibitory activity of bivalent sialyl Lewis x derivatives and sialyl Lewis x carboxylic acids", J. Org. Chem., 63, 5137–5143, (1998).

  296. J. H. Hogg, I. R. Ollmann, A. Wetterhold, M.B. Andberg, J. Haeggstrom, B. Samuelsson, C.-H. Wong, "Probing the activities and mechanisms of leukotriene A4 hydrolase with synthetic inhibitors", Chem. Eur. J., 4, 1698–1713, (1998).

  297. K. Witte, O. Seitz, C.-H. Wong, "Solution and solid-phase synthesis of N-protected peptide esters of the benzyl type as substrates for subtilisin-catalyzed glycopeptide coupling", J. Am. Chem. Soc., 120, 1979–1989, (1998).

  298. V. P. Vassilev, E. E. Simanek, M. R. Wood, C.-H. Wong, "Enzymatic synthesis of a chiral gelator with remarkably low molecular weight", Chem. Comm., 1865–1866, (1998).

  299. C.-H. Wong, M. Hendrix, D. D. Manning, C. Rosenbohm, W. A. Greenberg, "A library approach to the discovery of small molecules that recognize RNA: use of a 1,3-hydroxyamine motif as core", J. Am. Chem. Soc., 120, 8319–8327, (1998).

  300. C.-H. Wong, M. Hendrix, E. S. Priestley, W. A. Greenberg, "Specificity of aminoglycoside antibiotics for the ribosomal decoding region A-site RNA", Chem. Biol., 5, 397–406, (1998).

  301. C.-H. Wong, X.-S. Ye, Z. Zhang, "Assembly of oligosaccharide libraries using a designed building block and an efficient orthogonal protection-deprotection strategy", J. Am. Chem. Soc., 120, 7137–7138, (1998).

  302. R. Wischnat, R. Martin, C.-H. Wong, "Synthesis of a new class of N-linked Lewis x and LacnAc analogs as potential inhibitors of human fucosyltransferases: A general method for the incorporation of an iminocyclitol as transition-state mimic of the donor sugar to the acceptor", J. Org. Chem., 63, 8361–8365, (1998).

  303. T. Miura, T. Kajimoto, M. Jimbo, K. Yamagishi, J.-C. Inokuchi, C.-H. Wong, "Synthesis and evaluation of morpholino- and pyrrolidinosphingolipids as inhibitors of glycosylceramide synthase", Bioorg. Med. Chem., 6, 1481–1489, (1998).

  304. T. Kanemitsu, O. Kanie, C.-H. Wong, "Quantitative monitoring of solid-phase synthesis using gated decoupling 13C-NMR with 13C-enriched protecting group and internal standard in the synthesis of sialyl Lewis x tetrasaccharide", Angew. Chem. Int. Ed. Engl., 37, 3415–3418, (1998).

  305. K. Witte, J. Skolnick, C.-H. Wong, "A synthetic retrotransition (backwards reading) sequence of the right handed three-helix bundle domain B (10-53) of protein A shows similarity in conformation as predicted by computation", J. Am. Chem. Soc., 120, 13042–13045, (1998).

  306. R. Wischnat, R. Martin, S. Takayama, C.-H. Wong, "Chemoenzymatic synthesis of iminocyclitol derivatives: A useful library strategy for the development of selective fucosyltransfer enzymes inhibitors", Bioorg. Med. Chem. Lett., 8, 3353–3358, (1998).

  307. P. B. Rosenthal, X. Zhang, F. Formanowski, W. Fitz, C.-H. Wong, H. Meier-Ewert, J. Skehel, D.C. Wiley, "Three dimensional structure of the haemagglutinin-esterase-function glycoprotein of influenza C virus", Nature, 396, 92–96, (1998).

  308. S. J. Chung, S. Takayama, C.-H. Wong, "Acceptor substrate-based selective inhibition of galactosyltransferases", Bioorg. Med. Chem. Lett., 8, 3359–3364, (1998).

  309. C.-T. Guo, C.-H. Wong, T. Kajimoto, T. Miura, Y. Ida, L. R. Juneja, M.-J. Kim, H. Masuda, T. Suzuki, Y, Suzuki, "Synthetic sialylphosphatidylethanolamine binds to human influenza A viruses and inhibits the viral infection", Glycoconjugates, 15, 1099–1108, (1998).

  310. X. Zhang, P. B. Rosenthal, W. Fitz, C.-H. Wong, H. Meier-Ewert, J. J. Skehel, D. C. Wiley, "X-ray crystallographic determination of the structure of the influenza C virus haemagglutinin-esterase-function glycoprotein", ACTA Cryst., D55, 945–961, (1999).

  311. P. Sears, K. Witte, C.-H. Wong, "The effect of counterion, water concentration, and stirring on the stability of subtilisin BPN’ in organic solvents", J. Mol. Catalysis, 6, 297–304, (1999).

  312. H. Yuasa, H. Hashimoto, Y. Abe, T. Kajimoto, C.-H. Wong, "Studies on the unusual stability of cis-2,5-diethoxy-1,4-dioxane-2,5-dimethanol", Tetrahedron 55, 2193–2204, (1999).

  313. C.-C. Lin, F. Moris-Varas, G. Weitz-Schmidt, C.-H. Wong, "Synthesis of sialyl Lewis x mimetics as selectin inhibitors by enzymatic aldol condensation reactions", Bioorg. Med. Chem., 7, 425–434, (1999).

  314. G.-J. Shen, A. K. Datta, C.-C. Lin, K. Koeller, R.-F. Huang, C.-H. Wong, "Expression of (2,8/2,9-polysialyltransferase from E.coli K92: Characterization of the enzyme and its reaction products", J. Biol. Chem., 274, 35139–35146, (1999).

  315. C.-H. Wong, "Mimics of complex carbohydrates recognized by receptors", Acc. Chem. Res., 32, 376–385, (1999).

  316. S. Takayama, S. J. Chung, Y. Igarashi, Y. Ichikawa, A. Sepp, R. I. Lechler, J. Wu, T. Hayashi, G. Siuzdak, C.-H. Wong, "Selective inhibition of b-1,4- and a-1,3-galactosyltransferases: donor sugar-nucleotide based approach", Bioorg. Med. Chem., 7, 401–409, (1999).

  317. S. Takayama, S. T. Lee, S.-C. Hung, C.-H. Wong, "Designing acylating reagents for enzymatic resolution of amines", Chem. Comm., 127–128, (1999).

  318. Z. Zhang, I. R. Ollmann, X.-S. Ye, R. Wischnat, T. Baasov, C.-H. Wong, "Programmable one-pot oligosaccharide synthesis", J. Am. Chem. Soc., 121, 734–753, (1999).

  319. M. Takebayashi, S. Hiranuma, Y. Kanie, T. Kajimoto, O. Kanie, C.-H. Wong, "A versatile synthetic strategy for the preparation and discovery of new iminocyclitols as inhibitors of glycosidases", J. Org. Chem., 64, 5280–5291, (1999).

  320. C. M. Huwe, T. J. Woltering, J. Jiricek, G. Weitz-Schmidt, C.-H. Wong, "Design, synthesis and biological evaluation of aryl-substituted sialyl Lewis X mimetics prepared via cross-metathesis of C-fucopeptides", Bioorg. Med. Chem., 7, 773–788, (1999).

  321. T. Lee, V.-D. Le, Y.-C. Lin, A. L. Wong, G. M Morris, A. J. Olson, J. H. Elder, C.-H. Wong, "Development of a new type of protease inhibitors efficacious against FIV and HIV variants", J. Am. Chem. Soc., 121, 1145–1155, (1999).

  322. G. Weitz-Schmidt, K. W. Gong, C,-H. Wong, "Selectin/glycoconjugate binding assays for the identification and optimization of selectin antagonists", Anal. Biochem., 273, 81–88, (1999).

  323. W.-G. Wu, L. Pasternak, D.-H. Huang, K. M. Koeller, C.-C. Lin, O. Seitz, C.-H. Wong, "Structural study on O-glycopeptides: glycosylation-induced conformational changes of O-GlcNAc, O-LacNAc, O-Sialyl-LacNAc and O-sialyl Lewis x peptides of the mucin domain of MadCAM-1", J. Am. Chem. Soc., 121, 2409–2417, (1999).

  324. S. Mao, C. Gao, L. Lo, P. Wirsching, C.-H. Wong, K. D. Janda, "Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewis x and Lewis x", Proc. Natl. Acad. Sci. U.S.A., 96, 6953–6958, (1999).

  325. S. Vincent, M.D. Burkart, Z. Zhang, C.-Y. Tsai, C.-H. Wong, "Electrophilic fluorination-nucleophilic addition reaction mediated by Selectfluor: mechanistic studies and new applications", J. Org. Chem., 64, 5264–5279, (1999).

  326. W. A. Greenberg, E. S. Priestley, P.S. Sears, P. B. Alper, C. Rosenbohm, S.-C. Hung, C.-H. Wong, "Design and synthesis of new aminoglycoside antibiotics using neamine as a core structure: correlation of antibiotic activity with in vitro inhibition of translation", J. Am. Chem. Soc., 121, 6527–6541, (1999).

  327. R. D. Kidd, P. Sears, D.-H. Huang, K. Witte, C.-H. Wong, G. K. Farber, "Breaking the low barrier hydrogen bond in a serine protease", Protein Sci., 8, 410–417, (1999).

  328. S. Hiranuma, O. Kanie, C.-H. Wong, "Formation of the 1,2,6-orthoester of mannose and its utilization in the glycosylation reaction", Tetrahedron Lett., 40, 6423–6426, (1999).

  329. P. Sears, C.-H. Wong, "Carbohydrate mimetics: A new strategy for tackling the problem of carbohydrate-mediated biological recognition", Angew. Chem. Int. Ed. Engl., 38, 2300-2324, (1999).

  330. M. D. Burkart, M. Izumi, C.-H. Wong, "Enzymatic regeneration of 3'-phosphoadenosine-5'-phosphosulfate (PAPS) using aryl sulfotransferase: Synthesis of sulfated carbohydrates and spectrophotometric assay of sulfotransferases", Angew. Chem. Int. Ed. Engl., 38, 2747–2750, (1999).

  331. T. D. Machajewski, C.-H. Wong, "Chemoenzymatic synthesis of key epothilone fragments", Synthesis, S1, 1469–1472, (1999).

  332. M. D. Burkart, S. P. Vincent, C.-H. Wong, "An efficient synthesis of CMP-3-fluoro-neuraminic acid", Chem. Comm., 1525–1526, (1999).

  333. M. D. Burkart, C.-H. Wong, "A continuous assay for the spectrophotometric analysis of sulfotransferases using aryl sulfotransferase IV", Anal. Biochem., 274, 131–137, (1999).

  334. D. Depre, A. Duffels, L. G. Green, R. Lenz, S. V. Ley, C.-H. Wong "Synthesis of glycans from the glycodelins: two undeca-, two deca-, three nona-, an octa- and a heptasaccharide", Chem. Eur. J., 5, 3326–3340, (1999).

  335. M. Li, G. M. Morris, T. Lee, G. S. Laco, C.-H. Wong, A. J. Olson, J. H. Elder, A. Wlodawer, A. Gustchina, "Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease", Proteins: Struct. Funct. Genet., 38, 29–40, (1999).

  336. V. Wittmann, A. K. Datta, K. M. Koeller, C.-H. Wong, "Chemoenzymatic synthesis and fluorescent visualization of cell-surface selectin-bound sialyl Lewis X derivatives", Chem. Eur. J., 6, 162–171, (2000).

  337. V.-D. Le, C.-H. Wong, "Synthesis of 2-substituted polyhydroxyhexahydropyrimidines (N-hydroxy cyclic guanidino-sugars): transition-state mimics of enzymatic glycosidic cleavage", J. Org. Chem., 65, 2399–2409, (2000).

  338. S. J. Sucheck, W. A. Greenberg, T. J. Tolbert, C.-H. Wong, "Design of small molecules that recognize RNA: development of aminoglycosides as potential antitumor agents targeting oncogenic RNA sequences", Angew. Chem. Int. Ed. Engl., 39, 1080–1084, (2000). Angew. Chem., 112, 1122–1126, (2000).

  339. K. M. Koeller, C.-H. Wong, "Chemoenzymatic synthesis of sialyl-trimeric-Lewis X", Chem. Eur. J., 6, 1243–1251, (2000).

  340. K. M. Koeller, M. E. B. Smith, C.-H. Wong, "Tyrosine sulfation on a PSGL-1 glycopeptide influences the reactivity of glycosyltransferases responsible for synthesis of the attached O-glycan", J. Am. Chem. Soc., 122, 742–743, (2000).

  341. T. D. Machajewski, C.-H. Wong, "The catalytic asymmetric aldol reaction", Angew. Chem. Int. Ed. Engl., 39, 1352–1374, (2000). Angew. Chem., 112, 1406–1430, (2000).

  342. K. M. Koeller, M. E. B. Smith, R.-F. Huang, C.-H. Wong, "Chemoenzymatic synthesis of a PSGL-1 N-terminal glycopeptide containing tyrosine sulfate and a-O-linked sialyl Lewis X", J. Am. Chem. Soc., 122, 4241–4242, (2000).

  343. X.-L. Sun, Y. Kanie, C.-T. Guo, O. Kanie, Y. Suzuki, C.-H. Wong, "Syntheses of C-3 modified sialylglycosides as selective inhibitors of influenza hemagglutinin and neuraminidase", Eur. J. Org. Chem., 14:2643–2653, (2000).

  344. X.-S. Ye, C.-H. Wong, "Anomeric reactivity-based one-pot oligosaccharide synthesis: A rapid route to oligosaccharide libraries", J. Org. Chem., 65, 2410–2431, (2000).

  345. T. J. Tolbert, C.-H. Wong, "Intein-mediated synthesis of proteins containing carbohydrates and other molecular probes", J. Am. Chem. Soc., 122, 5421–5428, (2000).

  346. S. Fong, T. D. Machajewski, C. C. Mak, C.-H. Wong, "Directed evolution of D-2-keto-3-deoxy-6-phosphogluconate s to new aldolases capable of making D- and L-sugars", Chem. Biol., 7, 873–883, (2000).

  347. M. D. Burkart, M. Izumi, E. Chapman, C.-H. Lin, C.-H. Wong, "Regeneration of PAPS for the enzymatic synthesis of sulfated oligosaccharides", J. Org. Chem., 65, 5565–5574, (2000).

  348. C. Saotome, Y. Kanie, O. Kanie, C.-H. Wong, "Synthesis and enzymatic evaluation of five-membered iminocyclitols and a pseudodisaccharide", Bioorg. Med. Chem., 8, 2249–2261, (2000).

  349. M. Takayanagi and C.-H. Wong, "A strategy for the solution-phase parallel synthesis of N-(pyrrolidinylmethyl)hydroxamic acids", J. Org. Chem., 65, 3811–3815, (2000).

  350. S. P. Vincent, A. Schleyer, C.-H. Wong, "Asymmetric strecker synthesis of C-glycosides", J. Org. Chem., 651, 4440–4443, (2000).

  351. K. M. Koeller, C.-H. Wong, "Synthesis of complex carbohydrates and glycoconjugates: enzyme-based and programmable one-pot strategies", Chem. Rev., 100, 4465–4493, (2000).

  352. K. M. Koeller, M. E. B. Smith C.-H. Wong, "Chemoenzymatic synthesis of PSGL-1 glycopeptides: Sulfation on tyrosine affects glycosyltransferase-catalyzed synthesis of the O-glycan", Bioorg. Med. Chem., 8, 1017–1025, (2000).

  353. S. J. Sucheck, A. L. Wong, K. M. Koeller, D. D. Boehr, K.-A. Draker, P. Sears, G. D. Wright, C.-H. Wong, "Design of bifunctional antibiotics that target bacterial rRNA and inhibit resistance-causing enzymes", J. Am. Chem. Soc., 122, 5230–5231, (2000).

  354. K. Shibata, K. Hiruma, O. Kanie, C.-H. Wong, "Synthesis of 1,1-linked galactosyl mannosides carrying a thiazine ring as mimetics of sialyl Lewis x antigen: Investigation of the effect of carboxyl group orientation on P-selectin inhibition", J. Org. Chem., 65, 2393–2398, (2000).

  355. A. Romero, C.-H. Wong, "Chemo-enzymatic total synthesis of 3-epiaustraline, australine and 7-epialexine", J. Org. Chem., 65, 8264–8268, (2000).

  356. O. Kanie, G. Grotenberg, C.-H. Wong, "Removal of benzyl protecting group from solid supported compounds by hydrogenolysis using palladium nanoparticles", Angew. Chem. Int. Ed., 39, 4545–4546, (2000). Angew. Chem., 112, 4719–4721, (2000).

  357. K. M. Koeller, C.-H. Wong, "Emerging themes in medicinal glycoscience", Nature Biotech., 18, 835–844, (2000).

  358. M. D. Burkart, S. P. Vincent, A. Düffels, B. W. Murray, S. V. Ley, C.-H. Wong, "Chemo-enzymatic synthesis of fluorinated sugar nucleotide; useful mechanistic probes for glycosyltransferases", Bioorg. Med. Chem., 8, 1937–1946, (2000).

  359. S. J. Sucheck, C.-H. Wong, "RNA as a target for small molecules", Curr. Opin. Chem. Biol., 4, 678–686, (2000).

  360. K. M. Koeller, C.-H. Wong, "Complex carbohydrate synthesis tools for glycobiologists: enzyme-based approach and programmable one-pot strategies", Glycobiology, 10, 1157–1169, (2000).

  361. T. Flessner, C.-H. Wong, "Efficient synthesis of triazoles from D-arabinose and L-fucose", Tetrahedron Lett., 41, 7805–7808, (2000).

  362. T. L. Sheppard, C.-H. Wong, G. F. Joyce, "Nucleoglycoconjugates: design and synthesis of a new class of DNA–carbohydrate conjugates", Angew. Chem. Int. Ed., 39, 3660–3663, (2000); Angew. Chem., 112, 3806–3809, (2000).

  363. C.-Y. Tsai, X. Huang, C.-H. Wong, "Design and synthesis of cyclic sialyl Lewis x mimetics: A remarkable enhancement of inhibition by pre-organizing all essential functional groups", Tetrahedron Lett., 41, 9299–9503, (2000).

  364. A. Düffels, L. G. Green, R. Lenz, S. V. Ley, S. P. Vincent, C.-H. Wong, "Chemoenzymatic synthesis of L-galactosylated dimeric sialyl Lewis X structures employing a-1,3-fucosyltransferase V", Bioorg. Med. Chem., 8, 2519–2525, (2000).

  365. Y.-C. Lin, Z. Beck, T. Lee, V.-D. Le, B. M. Morris, A. J. Olson, C.-H. Wong, J. H. Elder, "Alteration of substrate and inhibitor specificity of feline immunodeficiency virus protease", J. Virol., 74, 4710–4718, (2000).

  366. X.-S. Ye, X. Huang, C.-H. Wong, "A new glycosyl donor for efficient sialylation with unusual stereoselectivity: conversion of the carboxyl group to a protected hydroxymethyl increases the reactivity and yield dramatically with no elimination", Chem. Comm., 11, 974–975, (2001).

  367. F. Burkhart, Z. Zhang, S. Wacowich-Sgarbi, C.-H. Wong, "Synthesis of Globo H using the programmable reactivity-based one-pot strategy", Angew. Chem. Int. Ed., 40, 1274–1276, (2001).

  368. M. G. Silvestri, C.-H. Wong, "Opening of thiiranes: Preparation of orthogonal protected 2-thioglyceraldehyde", J. Org. Chem., 66, 910–914, (2001).

  369. C. C. Mak, V.-D. Le, Y.-C. Lin, J. H. Elder, C.-H. Wong, "Design, synthesis and biological evaluation of HIV/FIV protease inhibitors incorporating conformational-constrained macrocycle with a small P3’ residue", Bioorg. Med. Chem. Lett., 11, 219–222, (2001).

  370. T. K. Ritter, C.-H. Wong, "Synthesis of N-acetyl glucosamine thiazoline/lipid II hybrids", Tetrahedron Lett., 42, 615–618, (2001).

  371. V.-D. Le, C. C. Mak, Y.-C. Lin, J. H. Elder, C.-H. Wong, "Structure–activity studies of FIV and HIV proteases inhibitors containing allophenylnorstatine", Bioorg. Med. Chem., 9, 1185–1195, (2001).

  372. I. A. Kozlov, S. Mao, Y. Xu, X. Huang, L. Lee, P. S. Sears, C. Gao, A. R. Coyle, K.D. Janda, C.-H. Wong, "Synthesis of solid-supported mirror-image sugars: a novel method for selecting receptors for cellular-surface carbohydrates", ChemBioChem, 2, 741–746, (2001).

  373. K. M. Koeller, C.-H. Wong, "Enzymes for chemical synthesis", Nature, 409, 232–240, (2001).

  374. P. Sears, C.-H. Wong, "Toward automated synthesis of oligosaccharides and glycoproteins", Science, 291, 2344–2350, (2001).

  375. J. Liu, A. R. Shikhaman, M. K. Lotz, C.-H. Wong, "Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis", Chem. Biol., 8, 701–711, (2001).

  376. T. K. Ritter, C.-H. Wong, "Carbohydrate-based antibiotics: a new approach to tackling the problem of resistance", Angew. Chem. Int. Ed., 40, 3508–3533. Angew. Chem., 113, 3616–3641, (2001).

  377. X. Huang, K. L. Witte, D. E. Bergbreiter, C.-H. Wong, "Homogeneous enzymatic synthesis using a thermoresponsive water-soluble polymer support", Adv. Synth. Catal., 343, 675–681, (2001).

  378. C.-S. Yu, K. Niikura, C.-C. Lin, C.-H. Wong, "The thioglycoside and glycosyl phosphite of 5 azido sialic acid: excellent donors for a-glycosylation of primary hydroxyls", Angew. Chem. Int. Ed., 40, 2900–2903, (2001); Angew. Chem., 113, 2984–2987, (2001).

  379. C. Saotome, C.-H. Wong, O. Kanie, "Combinatorial library of five-membered iminocyclitol and the inhibitory activities against glyco-enzymes", Chem. Biol., 8, 1061–1070, (2001).

  380. H. Liu, R. Sadamoto, P. S. Sears, C.-H. Wong, "An efficient chemo-enzymatic strategy for the synthesis of wild-type and vancomycin-resistant bacterial cell-wall precursors: UDP-N-acetylmuramyl-peptides", J. Am. Chem. Soc., 123, 9916–9917, (2001).

  381. M. Izumi, G.-J. Shen, S. Wacowich-Sgarbi, T. Nakatani, O. Plettenburg, C.-H. Wong, "Microbial glycosyltransferases for carbohydrate synthesis: a-2,3-sialyltrasferase from Neisseria gonorrheae", J. Am. Chem. Soc., 123, 10909–10918, (2001).

  382. A. Heine, G. DeSantis, J. G. Luz, M. Mitchell, C.-H. Wong, I. A. Wilson, "Observation of covalent intermediates in an enzyme mechanism at atomic resolution", Science, 294, 369–374, (2001).

  383. M. Mitchell, L. Qaio, C.-H. Wong, "Chemical-enzymatic synthesis of iminocyclitol phosphonic acids", Adv. Synth. Catal., 343, 596–599, (2001).

  384. B. Buhler, Y.-C. Lin, G. Morris, A. Olson, C.-H. Wong, D. D. Richman, J. H. Elder, B. E. Torbett, "Viral evolution in response to the broad-based retroviral protease inhibitor TL-3", J. Virol., 75, 9502–9508, (2001).

  385. E. Chapman, C.-H. Wong, "A pH sensitive colorimetric assay for the high-throughput screening of enzyme inhibitors and substrates: a case study using kinases", Bioorg. Med. Chem., 10, 551–555, (2002).

  386. Y.-Y. Wang, K.-H. Khoo, S.-T. Chen, C.-C. Lin, C.-H. Wong, C.-H. Lin, "Studies on the immunomodulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: Functional and proteomic analysis of a fucose-containing glycoprotein responsible for the activities", Bioorg. Med. Chem., 10, 1057–1062, (2002).

  387. C.-T. Guo, X.-L. Sun, O. Kanie, K. F. Shortridge, T. Suzuki, D. Miyamoto, K. I.-P. J. Hidari, C.-H. Wong, Y. Suzuki, "An O-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses", Glycobiology, 12, 183–190, (2002).

  388. T. Kanemitsu, C.-H. Wong, O. Kanie, "Solid-phase synthesis of oligosaccharides and on-resin quantitative monitoring using gated decoupling 13C-NMR", J. Am. Chem. Soc., 124, 3591–3599, (2002).

  389. Z. Zhang, K. Niikura, X. Huang, C.-H. Wong, "A new strategy for the one-pot synthesis of sialylated oligosaccharides", (Ray Lemieux special issue) Can. J. Chem., 80, 1051–1054, (2002).

  390. J. Liu, G. DeSantis, C.-H. Wong, "Structure-based rationalization of aldolase-catalyzed asymmetric synthesis", (in honor of J. B. Jones) Can. J. Chem., 80, 643–645, (2002).

  391. J. Liu, C.-H. Wong, "Aldolase-catalyzed asymmetric synthesis of novel pyranose synthons as a new entry to heterocycles and epothilones", Angew. Chem. Int. Ed., 41, 1404–1407, (2002).

  392. T. J. Tolbert, C.-H. Wong, "New methods for proteomic research: preparation of proteins with N-terminal cysteines for labeling and conjugation", Angew. Chem. Int. Ed., 41, 2171–2174, (2002); Angew. Chem., 114, 2275, (2002).

  393. M. C. Bryan, O. Plettenburg, P. Sears, D. Rabuka, S. Wacowich-Sgarbi, C.-H. Wong, "Saccharide display on microtiter plates", Chem. Biol., 9, 713–720, (2002).

  394. O. Plettenburg, C.-H. Wong, "Rapid preparation of glycolipid libraries by cross metathesis", Adv. Synth. Catal., 344, 622–626, (2002).

  395. O. Plettenburg, V. Narkevitch, C.-H. Wong, "Synthesis of a-galactosyl ceramide, a potent immunostimulatory agent", J. Org Chem., 67, 4559–4564, (2002).

  396. M. L. Mitchell, F. Tian, L. V. Lee, C.-H. Wong "Synthesis and evaluation of transition-state analogue inhibitors of a-1,3-fucosyltransferases", Angew. Chem. Int. Ed., 41 (16), 3041–3044, (2002). Angew. Chem., 114, 3167–3170, (2002).

  397. J. Liu, C.-Y. Huang, C.-H. Wong, "An efficient method for the preparation of 2-hydroxy- and 2 aminoglycals from glycosyl sulfoxides", Tetrahedron Lett., 43, 3447–3448, (2002).

  398. J. Liu, C.-H. Wong, "An efficient method for the cleavage of p-methoxybenzylidene (PMP), tetrahydropyranyl (THP) and 1,3-dithiane protecting groups by Selectfluor", Tetrahedron Lett., 43, 3915–3917, (2002).

  399. J. Liu, C.-H. Wong, "Selectfluor-mediated allylstannation of aldehydes and imines", Tetrahedron Lett., 43, 3915–3917, (2002).

  400. R. Sadamoto, K. Niikura, P.S. Sears, H. Liu, C.-H. Wong, A. Suksomcheep, F. Tomita, K. Monde, S.-I. Nishimura, "Cell-wall engineering of living bacteria", J. Am. Chem. Soc., 124, 9018–9019, (2002).

  401. A. Brik, Y.-C. Lin, J. Elder, C.-H. Wong, "A quick diversity-oriented amide-forming reaction to optimize P-subsite residues of HIV protease inhibitors", Chem. Biol., 9, 891–896, (2002).

  402. M. L. Mitchell, L. V. Lee, C.-H. Wong, "Synthesis and evaluation of six-membered GDP-iminocyclitol", Tetrahedron Lett., 43, 5691–5793, (2002).

  403. Z. Zhang, C.-H. Wong, "Regioselective benzoylation of sugars mediated by excessive Bu2SnO: observation of temperature promoted migration", Tetrahedron, 58, 6513–6519, (2002).

  404. F. Fazio, M. C. Bryan, O. Blixt, J. C. Paulson, C.-H. Wong, "Synthesis of sugar arrays in microtiter plates", J. Am. Chem. Soc., 124, 14397–14402, (2002).

  405. E. Chapman, S. Ding, P. G. Schultz, C.-H. Wong, "A potent, and highly selective sulfotransferase inhibitor", J. Am. Chem. Soc., 124, 14524–14525, (2002).

  406. P. T. Nyffeler, C.-H. Liang, K. M. Koeller, C.-H. Wong, "The chemistry of amine-azide interconversion: Catalytic diazotransfer and regioselective azide reduction", J. Am. Chem. Soc., 124, 10773–10778, (2002).

  407. K.-K. T. Mong, C.-H. Wong, "The reactivity based one-pot synthesis of Lewis y carbohydrate hapten: A colon-rectal cancer antigen determinant", Angew. Chem. Int. Ed., 41, 4087–4090, (2002); Angew. Chem., 114, 4264–4267, (2002).

  408. M. M. G. M. Thunnissen, B. Andersson, B. Samuelsson, C.-H. Wong, J. Z Haeggstrom, "Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors", FASEB J., 16 (12), 1648-1650, (2002).

  409. A. R. Sawkar, W.-C. Cheng, E. Beutler, C.-H. Wong, W. E. Balch, J. W. Kelly, "Chemical chaperones increase the cellular activity of N370S a-glucosidase; a therapeutic strategy for Gaucher disease", Proc. Natl. Acad. Sci. U.S.A., 99, 15428–15433, (2002).

  410. E. Chapman, M. C. Bryan, C.-H. Wong, "Mechanistic studies of b-arylsulfotransferase IV," Proc. Natl. Acad. Sci. U.S.A., 100, 910–915, (2003).

  411. C.-H. Wong, M. C. Bryan, P. T. Nyffeler, H. Liu, E. Chapman, "Synthesis of carbohydrate-based antibiotics", Pure Appl. Chem., 75, 179–186, (2003).

  412. G. DeSantis, J. Liu, D. P. Clark, A. Heine, I. A. Wilson, C.-H. Wong, "Structure-based mutagenesis approaches toward expanding the substrate specificity and enantioselectivity of D-2-deoxy-ribose-5-phosphate aldolase", Bioorg. Med. Chem., 11, 43–52, (2003).

  413. T. K-K. Mong, C.-Y. Huang, C.-H. Wong, "A new reactivity-based one-pot synthesis of N-acetyllactosamine oligomers", J. Org. Chem., 68, 2135–2142, (2003).

  414. M. Wada, C.-C. Hsu, D. Franke, M. Mitchell, A. Heine, I. Wilson, C.-H. Wong, "Directed evolution of N-acetylneuraminic acid aldolase to catalyze enantiomeric aldol reactions", Bioorg. Med. Chem., 11, 2091–2098, (2003).

  415. M. G. Silvestri, G. DeSantis, C.-H. Wong, "Asymmetric aldol reactions using aldolases", Top. Stereochem., 23, 267–342, (2003).

  416. A. Brik, C.-H. Wong, "HIV-1 protease: Mechanism and drug discovery", Org. Biomol. Chem., 1, 1–14, (2003).

  417. H. Liu, T. K. Ritter, R. Sadamoto, P.S. Sears, M. Wu, C.-H. Wong, "Acceptor specificity and inhibition of the bacterial cell-wall glycosyltransferase Mur G", ChemBioChem, 4, 603–609, (2003).

  418. H. Liu, L. Wang, A. Brock, C.-H. Wong, P. G. Schultz, "A method for the generation of glycoprotein mimetics", J. Am. Chem. Soc., 125, 1702–1703, (2003).

  419. T. K.-K. Mong, H. K. Lee, S. G. Duron, C.-H. Wong, "Reactivity-based one-pot synthesis of fucose GM1 oligosaccharide: A sialylated antigenic epitope of small-cell lung cancer", Proc. Natl. Acad. Sci. U.S.A., 100, 797–802, (2003).

  420. C. C. Mak, A. Brik, D. L. Lerner, J. H. Elder, G. M. Morris, A. J. Olson, C.-H. Wong, "Design and synthesis of broad-based mono- and bicyclic inhibitors of HIV and FIV proteases", Bioorg. Med. Chem., 11, 2025–2040, (2003).

  421. L. V. Lee, M. L. Mitchell, S.-J. Huang, V. V. Fokin, K. B. Sharpless, C.-H. Wong, "A potent and highly selective inhibitor of human a-1,3-fucosyltransferase via click chemistry", J. Am. Chem. Soc., 125, 9588–9599, (2003).

  422. C.-Y. Wu, C.-F. Chang, J. S.-Y. Chen, C.-H. Wong, C.-H. Lin, "Rapid diversity-oriented synthesis in microtiter plates for in situ screening: discovery of potent and selective a-fucosidase inhibitors", Angew. Chem. Int. Ed., 42, 4661–4664, (2003).

  423. A. Brik, J. Muldoon, Y.-C. Lin, J. H. Elder, D. Goodsell, A. J. Olson, V. V. Fokin, K. B. Sharpless, C.-H. Wong, "Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors", ChemBioChem, 4, 1246–1248, (2003).

  424. T. K. Ritter, K.-K. T. Mong, H. Liu, T. Nakatani, C.-H. Wong, "A programmable one-pot oligosaccharide synthesis for diversifying the sugar domains of natural products: A case study of vancomycin", Angew. Chem. Int. Ed., 42, 4657-4660, (2003).

  425. C.-H. Wong, M. C. Bryan, "Sugar arrays in microtiter plates", Methods Enzymol., 362, 218-225, (2003).

  426. K.-K. T. Mong, L. V. Lee, J. R. Brown, J. D. Esko, C.-H. Wong, "Synthesis of N-acetyl-lactosamine derivatives with variation in the aglycon moiety for the study of inhibition of sialyl Lewis X expression", ChemBioChem., 4, 835-840, (2003).

  427. D. Franke, T. Machajewski, C.-C. Hsu, C.-H. Wong, "One-pot synthesis of L-fructose using coupled multienzyme systems based on rhamnulose-1-phosphate aldolase". J. Org. Chem., 68, 6828-6831, (2003).

  428. F. Fazio, C.-H. Wong, "RuCl3-promoted amide formation from azides and thioacids", Tetrahedron Lett., 44, 9083-9085, (2003)

  429. T. Feizi, F. Fazio, W. Chai, C.-H. Wong, "Carbohydrate microassays – a new set of technologies at the frontier of glycomics", Curr. Opin. Struct. Biol., 13, 637-645, (2003).

  430. C.-H. Wong, F.-S. Liang, "Surface plasmon resonance study of RNA-aminoglycoside interactions", in Methods in Enzymol, 362, 340-353, (2003).

  431. A. Heine, J. G. Luz, C. -H. Wong and I. A. Wilson, "Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution", J. Mol. Biol., 343, 1019-1034, (2004).

  432. F. Agnelli, S. J. Sucheck, K. A. Marby, D. Rabuka, S.-L. Yao, P. S. Sears, F.-S. Liang, C.-H Wong: "Dimeric aminoglycosides as antibiotics", Angew Chem. Int. Ed., 43, 1562-1566, (2004).

  433. J. Liu, C.-C Hsu, C.–H. Wong, "Sequential aldol condensation catalyzed by DERA mutant Ser238Asp and a formal total synthesis of Atorvastatin", Tetrahedron Lett., 45, 2439-2441, (2004).

  434. C.-W. Cheng, K.-C. Lin, F.-M. Pan, S. Sinchaikul, C.-H. Wong, W.-C. Su, C.-H. Hsu, S.-T. Chen, "Facile synthesis of metal-chelating peptides on chip for protein array", Bioorg. Med. Chem. Lett., 14, 1987-1990, (2004).

  435. H.-K. Lee, C. N. Scanlan, C.-Y. Huang, A. Y. Chang, D. A. Calarese, R. A. Dwek, P. M. Rudd, I. A. Wilson, D. R. Burton, C.-H. Wong "Reactivity based one-pot synthesis of oligomannoses: defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody", Angew. Chem. Int. Ed., 43, 1000-1003, (2004).

  436. C.-H. Chou, C.-S. Wu, C.-H. Chen, L.-D. Lu, S.S. Kulkarni, C.-H. Wong, S.-C. Hung, "Regioselective glycosylation of neamine core: A facile entry to kanamycin B related analogues", Org. Lett., 6, 585-588, (2004).

  437. H. N. Yu, J.-I. Furukawa, T. Ikeda, C.-H. Wong, "Novel efficient routes to heparin monosaccharides and disaccharides achieved via regio- and stereoselective glycosidation", Org. Lett., 6, 723-726, (2004).

  438. S. G. Duron, T. Polat, C.-H. Wong, "N-(Phenylthio)-e-caprolactam: A new promoter for the activation of thioglycosides", Org. Lett., 6, 839-841, (2004).

  439. T.-J. Cheng, A. Brik, C.-H. Wong, C.-C. Kan, "Model system for high-throughput screening of novel human immunodeficiency virus protease inhibitors in Escherichia coli", Antimicrob. Agent Chemother., 48, 2437-2447, (2004).

  440. M. C. Bryan, C.-H. Wong, "Aminoglycoside array for the high-throughput analysis of small molecule–RNA interactions", Tetrahedron Lett., 45, 3639-3642, (2004).

  441. F. Fazio, M. C. Bryan, H.-K. Lee, A. Chang, C.-H. Wong, "Assembly of sugars on polystyrene plates: a new facile microarray fabrication technique", Tetrahedron Lett., 45, 2689-2692, (2004).

  442. L. V. Lee, K. E. Bower, F.-S. Liang, J. Shi, D. Wu, S. J. Sucheck, P. K. Vogt, C.-H. Wong, "Inhibition of the proteolytic activity of anthrax lethal factor by aminoglycosides", J. Am. Chem. Soc., 126, 4774-4775, (2004).

  443. M. C. Bryan, L. V. Lee, C.-H. Wong, "High-throughput identification of fucosyltransferase inhibitors using carbohydrate microarrays," Bioorg. Med. Chem. Lett., 14:3185-3188 (2004).

  444. E. Chapman, M.D. Best, S. R. Hanson, C.-H. Wong, "Sulfotransferases: structure, mechanism, biological activity, inhibition and synthetic utility," Angew. Chem. Int. Ed., 43:3526-3548 (2004).

  445. S. R. Hanson, M.D. Best, C.-H. Wong, "Sulfatases: mechanism, biological activity, inhibition and synthetic utility," Angew. Chem. Int. Ed., 43:5736-5763 (2004).

  446. M. D. Best, A. Brik, E. Chapman, L. V. Lee, W.-C. Cheng, C.-H. Wong, "Rapid discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in microplates followed by in situ screening", ChemBioChem, 5, 811-819, (2004).

  447. D. Klostermeier, P. Sears, C.-H. Wong, D. P. Millar, J. R. Williamson, "A three-fluorophore FRET assay for high-throughput screening of small-molecule inhibitors of ribosome assembly", Nucleic Acid. Res., 32, 2707-2715, (2004).

  448. T. J. Tolbert, C.-H. Wong, "Carbohydrate chains: enzymatic and chemical synthesis", in Encyclopedia of Biological Chemistry, Elsevier: New York, NY, Volume 1, pp 307–313, (2004).

  449. D. Franke, C.-C. Hsu, C.-H. Wong, "Directed evolution of aldolases", Methods Enzymol., 388, 224-238, (2004).

  450. M. C. Bryan, F. Fazio, H.-K. Lee, C.-Y. Huang, A. Chang, M. D. Best, D. A. Calarese, O. Blixt, J. C. Paulson, D. Burton, I. A. Wilson, C.-H. Wong, "Covalent display of oligosaccharide arrays in microtiter plates", J. Am. Chem. Soc., 126, 8640-8641, (2004).

  451. C.-F. Chang, C.-W. Ho, C.-Y. Wu, T. A. Chao, C.-H. Wong, C.-H. Lin, "Discovery of picomolar slow tight-binding inhibitors of a-fucosidase", Chem. Biol., 11, 1301-1306, (2004).

  452. J. Liu, M. M. D. Numa, H. Liu, S.-J. Huang, P. Sears, A. R. Shikhman, C.-H. Wong, "Novel synthesis and high-throughput screening of N-acetyl-b-hexosaminidase inhibitor libraries targeting osteoarthritis", J. Org. Chem., 69, 6273-6283, (2004).

  453. F.-S. Liang, S.-K. Wang, T. Nakatani, C.-H. Wong, "Targeting RNAs by Tobramycin Analogs", Angew. Chem., 43, 6496-6500, (2004).

  454. H.-S. Chen, Y.-F. Tsai, S. Lin, C.-C. Lin, K.-H. Khoo, C.-H. Lin, C.-H. Wong, "Studies on the Immuno-Modulating and Antitumor Activities of Ganoderma lucidum (Reishi) Polysaccharides", Bioorg. Med. Chem., 12, 5595-5601, (2004).

  455. C. M. Chien, J.-L. Cheng, W.-T. Chang, M.-H. Tien, W.-Y. Wu, Y.-H. Chang, H.-Y. Chang, J.-F. Hsieh, C.-H. Wong, S.-T. Chen, "Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cord blood", Bioorg. Med. Chem., 12, 5603-5609, (2004).

  456. H.-Y. Hsu, K.-F. Hua, C.-C. Lin, C.-H. Lin, C.-H. Wong, "Extract of Reishi polysaccharides induces cytokine expression via toll-like receptor 4-modulated protein kinase signaling pathways", J. Immunol., 173, 5989-5999, (2004).

  457. C.-Y. Wu, J.-T. Jan, H.-H. Ma, C.-J. Kuo, H.-F. Juan, Y.-S. E. Cheng, H.-H. Hsu, H.-C. Huang, D. Wu, A. Brik, F.-S. Liang, R.-S. Liu, J.-M. Fang, S.-T. Chen, P.-H. Liang, C.-H. Wong, "Small molecules targeting severe acute respiratory syndrome (SARS) human coronavirus", Proc. Natl. Acad. Sci. U.S.A., 101, 10012-10017, (2004).

  458. M.-P. Heck, S. P. Vincent, B. W. Murray, F. Bellamy, C.-H. Wong, C. Mioskowski, "Cyclic amidine sugars as transition-state analogue inhibitors of glycosidases: potent competitive inhibitors of mannosidases", J. Am. Chem. Soc., 126, 1971-1979, (2004).

  459. P. T. Nyffeler, L. Eltepu, N. A. Boyle, C.-H. Wong, A. Eschenmoser, R. A. Lerner, P. Wentworth, Jr., "Dihydrogen trioxide (HOOOH) is generated during the thermochemical reaction between hydrogen peroxide and ozone", Angew. Chem. Int. Ed., 43, 4656-4659, (2004).

  460. H. Lin, D.A. Thayer, C.-H. Wong, C. T. Walsh, "Macrolactamization of glycosylated peptide thioesters by the thioesterase domain of tyrocidine synthetase", Chem. Biol., 11, 1635-1642, (2004).

  461. O. Blixt, S. Head, T. Mondala, C. Scanlan, M.E. Huflejt, R. Alvarez, M.C. Bryan, F. Fazio, D. Calarese, J. Stevens, N. Razi, I. van Die, D. Burton, I. A. Wilson, R. Cummings, N. Bovin, C.-H. Wong, J.C. Paulson, "Printed covalent glycan array for ligand profiling of diverse glycan binding proteins", Proc. Natl. Acad. Sci. U.S.A., 101, 17033-17038, (2004).

  462. J. H. Chen, Y.-W. Chang, C.-W. Yao, T.-S. Chiueh, S.-C. Huang, K.-Y. Chien, A. Chen, F.-Y. Chang, C.-H. Wong, Y.-J. Chen, "Plasma proteome of severe acute respiratory syndrome (SARS) analyzed by two-dimensional gel eletrophoresis and mass spectrometry", Proc. Natl. Acad. Sci. U.S.A., 101, 17039-17044, (2004).

  463. S. R. Hanson, M. D. Best, M. C. Bryan, C.-H. Wong, "Chemo-enzymatic synthesis of oligosaccharides and glycoproteins", Trends Biochem. Sci., 29, 656-663, (2004).

  464. V. P. Mocharla, B. Colasson, L. V. Lee, S. Romper, K. B. Sharpless, C.-H. Wong, H. C. Kolb, "In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrate II", Angew. Chem. Int. Ed., 44, 116-120, (2004).

  465. P. Nyffeler, C.-H. Wong, "Selectflour: mechanistic insight and application", Angew. Chem. Int. Ed., 44, 192-212, (2004).

  466. T. J. Tolbert, D. Franke, C.-H. Wong, "A new strategy for glycoprotein synthesis: ligation of synthetic glycopeptides with truncated proteins expressed in E. coli as TEV protease cleavable fusion protein", Bioorg. Med. Chem., 13, 909-915, (2005).

  467. D. Wu, G.-W. Xing, M. Poles, Y. Kinjo, B. Sullivan, O. Plettenburg, M. Kronenberg, M. Tsuji, D. D. Ho, C.-H. Wong, "Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells," Proc. Natl. Acad. Sci. U.S.A., 102, 1351-1356, (2005).

  468. M. Fridman, V. Belakhov, L. V. Lee, F.-S. Liang, C.-H. Wong, T. Baasov, "Dual effect of synthetic aminoglycosides: antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor", Angew. Chem. Int. Ed., 44, 447-452, (2005).

  469. Y. Kinjo, D. Wu, G. Kim, G.-W. Xing, M. Poles, D. D. Ho, M. Tsuji, K. Kawahara, C.-H. Wong, M. Kronenberg, "Recognition of bacterial glycosphingolipids by natural killer T cells", Nature, 434, 520-525, (2005).

  470. G.-T. Fan, Y.-s. Pan. K.-C. Lu, Y.-P. Cheng, W.-C. Lin, S. Lin, S.-H. Lin, C.-H. Wong, J.-M. Fang, C.-C. Lin, "Synthesis of a-galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes", Tetrahedron, 61, 1855-1862 (2005).

  471. A. Brik, C.-Y. Wu, M.D. Best, C.-H. Wong, "Tetrabutylammonium fluoride-assisted rapid N9-alkylation on purine ring: application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ", Bioorg. Med. Chem., 13, 4622-4626, (2005).

  472. G.-W. Xing, D. Wu, M.A. Poles, A. Horowitz, M. Tsuji, D. D. Ho, C.-H. Wong, "Synthesis and human NKT cell stimulating properties of 3-O-sulfo-a/b-galactosylceramides", Bioorg. Med. Chem., 13, 2907-2916, (2005).

  473. A. Brik, J. Alexandratos, Y.-C. Lin, J. H. Elder, A. J. Olson, A. Wlodawer, D. S. Goodsell, C.-H. Wong, "1,2,3-Triazole as a peptide surrogate in the rapid synthesis of HIV protease inhibitors", ChemBioChem, 6, 1167-1169, (2005).

  474. H. N. Yu, D.A. Thayer, M.C. Galan, C.-H. Wong, "A general strategy to S-linked glycopeptides", Angew. Chem. Int. Ed., 44, 4596-4599, (2005).

  475. M. M. D. Numa, L. V. Lee, C.-C. Hsu, K. E. Bower, C.-H. Wong, "Identification of novel anthrax lethal factor inhibitors generated by combinatorial Pictet–Spengler reaction followed by screening in situ", ChemBioChem, 6, 1002-1006, (2005).

  476. C.-H. Wong, "Protein glycosylation: new challenges and opportunities", J. Org. Chem., 70, 4219-4225, (2005).

  477. J.-J. Shie, J.-M. Fang, C.-J. Kuo, T.-H. Kuo, P.-H. Liang, H.-J. Huang, W.-B. Yang, C.-H. Lin, J.-L. Chen, Y. T. Wu, C.-H. Wong, "Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease", J. Med. Chem., 48, 4469-4473, (2005).

  478. J.-J. Shie, J.-M. Fang, T.-H. Kuo, C.-J. Kuo, P.-H. Liang, H.-J. Huang, Y.-T. Wu, J.-T. Jan, Y.-S.E. Cheng, C.-H. Wong, "Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic a,b-unsaturated esters", Bioorg. Med. Chem., 13, 5240-5252, (2005).

  479. C.-Y. Wu, A. Brik, S.-K. Wang, Y.-H. Chen, C.-H. Wong, "Tetrabutylammonium fluoride-mediated rapid alkylation reaction in microtiter plates for discovery of enzyme inhibitors in situ", ChemBioChem, 6 (12), 2176–2180 (2005).

  480. C.-C. Hsu, Y. Zhang, M. Wada, D. Franke, C.-H. Wong, "Directed evolution of d-sialic acid aldolase l-3-deoxy-manno-2-octulosonic acid (l-KDO) aldolases", Proc. Natl. Acad. Sci. U.S.A., 102, 9122–9126, (2005).

  481. S. H. Wei, H. Rosen, M. P. Matheu, M. G. Sanna, S.-K. Wang, E. Jo, C.-H. Wong, I. Parker, M. D. Cahalan, "Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses", Nat. Immunol., 6 (12), 1228–1235, (2005).

  482. D. A. Calarese, H.-K. Lee, C.-Y. Huang, M. D. Best, R. D. Astronomo, R. L. Stanfield, H. Katinger, D. R. Burton, C.-H. Wong, I. A. Wilson "Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12", Proc. Natl. Acad. Sci. U.S.A., 102 (38), 13372–13377, (2005).

  483. D. M. Zajonc, I. Maricic, D. Wu, R. Halder, K. Roy, C.-H. Wong, V. Kumar, I. A. Wilson, "Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity", J. Exp. Med., 202 (11), 1517–1526, (2005).

  484. A. R. Sawkar, S. L. Adamski-Werner, W.-C. Cheng, C.-H. Wong, E. Beutler, K.-P. Zimmer, J. W. Kelly, "Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles", Chem. Biol., 12 (11), 1235–1244, (2005).

  485. S. Sinchaikul, F.-M. Pan, C.-W. Cheng, C.-H. Wong, J.-M. Fang, M.-J. Tseng, S.-T. Chen, "Protein microarray using alpha-amino acids as metal tags on chips", Bioorg. Med. Chem. Lett., 15 (5), 1413-1416, (2005).

  486. M. Brigl, P. van den Elzen, X. Chen, J. H. Meyers, D. Wu, C.-H. Wong, P. A. Illarianov, G. S. Besra, M. B. Brenner and J. E. Gumperz, "Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors", J. Immunol., 176 (6), 3625-3634, (2006).

  487. P.-H. Liang, W.-C. Cheng, Y.-L. Lee, H.-P. Yu, Y.-T. Wu, Y.-L. Lin, C.-H. Wong, "Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis", ChemBioChem, 7 (1), 165-173, (2006).

  488. L. Liu, C. S. Bennett, C.-H. Wong, "Advances in glycoprotein synthesis," Chem. Commun., 1, 21–33, (2006).

  489. F.-S. Liang, A. Brik, Y.-C. Lin, J. H. Elder, C.-H. Wong, "Epoxide opening in water and in situ screening for rapid inhibitors in microtiter plate", Bioorg. Med. Chem., 14 (4), 1058–1062, (2006).

  490. C.-Y. Huang, D. A. Thayer, A. Y. Chang, M. D. Best, J. Hoffman, S. Head, C.-H. Wong, "Carbohydrate microarray for profiling the antibodies interacting with Globo H tumor antigen", Proc. Natl. Acad. Sci. U.S.A., 103 (1), 15–20, (2006).

  491. L. Liu, Z. Hong, C.-H. Wong, "Convergent glycopeptide synthesis by traceless Staudinger ligation and enzymatic coupling", ChemBioChem, 7 (3), 429-432, (2006).

  492. M.-H. Chuang, M.-S. Wu, W.-L. Lo, J.-T. Lin, C.-H. Wong, S.-H. Chiou, "The antioxidant protein alkylhydroperoxide reductase of Helicobacter pylori switches from a peroxide reductase to a molecular chaperone function", Proc. Natl. Acad. Sci. U.S.A., 103 (8), 2552-2557, (2006).

  493. D. Wu, D. M. Zajonc, M. Fujio, B.A. Sullivan, Y. Kinjo, M. Kronenberg, I. A. Wilson, C.-H. Wong, "Design of NKT-cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d", Proc. Natl. Acad. Sci. U.S.A., 103 (11), 3972-3977, (2006).

  494. C.-Y. Wu, K.-Y. King, C.-J. Kuo, J.-M. Fang, Y.-T. Wu, M.-Y. Ho, C.-L. Liao, J.-J. Shie, P-H. Liang, C.-H. Wong, "Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3CL protease", Chem. & Biol., 13, 261-268, (2006).

  495. A. Brik, C.-Y. Wu, C.-H. Wong, "Microtiter plate based chemistry and in situ screening: a useful approach for enzymatic inhibitor discovery", Org. Biomol. Chem., 4, 1446–1457, (2006).

  496. J.-C. Lee, C.-Y. Wu, J. V. Apon, G. Siuzdak, C.-H. Wong, "Reactivity-based one-pot synthesis of tumor-associated antigen N3 minor octasaccharide for the development of a photocleavable DIOS-MS sugar array", Angew. Chem. Int. Ed., 45 (17), 2753-2757, (2006).

  497. A. Brik, Y.-Y. Yang, S. Ficht, C.-H. Wong, "Sugar-assisted glycopeptide ligation", J. Am. Chem. Soc., 128, 5626-5627, (2006).

  498. H.-Y. Hsu, K.-F. Hua, Y.-C. Su, L.-C. Chu, H.-W. Chiu, C.-H. Wong, S. U-S. Yang, L. K. Chao, "Alkali-soluble polysaccharides of Rhizoclonium riparium alga induces IL-1 gene expression via protein kinase signaling pathways", J. Agricultural & Food Chem., 54, 3558-3565, (2006).

  499. H. Qiu, A. Gabrielsen, H. E. Agardh, M. Wan, A. Wetterholm, C.-H. Wong, U. Hedin, J. Swedenborg, G. K. Hansson, B. Samuelsson, G. Paulsson-Berne, J. Z. Haeggstrom, "Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlate with symptoms of plaque instability", Proc. Natl. Acad. Sci. U.S.A., 103 (21), 8161-8166, (2006).

  500. L. J. Whalen, C.-H. Wong, "Enzymes in organic synthesis: aldolase-mediated synthesis of iminocyclitols and novel heterocycles", Aldrichimica Acta, 39 (3), 63-71, (2006).

  501. Y.-C. Lin, A. Brik, A. P., K. Tam, A. Parseval, B. E. Torbett, C.-H. Wong, J. H. Elder, "Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system", J. Virology, 80 (16), 7832-7834, (2006).

  502. M. Fujio, D. Wu, R.Garcia-Navarro, D. D. Ho, M. Tsuji, C.-H. Wong, "Structure-based discovery of glycolipids for CD1d-mediated NKT cell activation: tuning the adjuvant versus immunosuppression activity", J. Am. Chem. Soc., 128, 9022-9023, (2006).

  503. F.-S. Liang, W. A. Greenberg, J. A. Hammond, J. Hoffmann, S. R. Head, C.-H. Wong, "Evaluation of RNA binding specificity of aminoglycosides with DNA microarrays", Proc. Nat. Acad. Sci. U.S.A., 103 (33), 12311-12316, (2006).

  504. M. G. Sanna, S.-K. Wang, P. J. Gonzalez-Cabrera, A. Don, D. Marsolais, M. P. Matheu, S. H. Wei, I. Parker, E. Jo, W.-C. Cheng, M. D. Cahalan, C.-H. Wong, H. Rosen, "Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo", Nature Chem. Biol., 2 (8), 434-441, (2006).

  505. M. Sawa, T.-L. Hsu, T. Itoh, M. Sugiyama, S. R. Hanson, P. K. Vogt, and C.-H. Wong, "Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo", Proc. Nat. Acad. Sci. U.S.A., 103 (33), 12371-12376, (2006).

  506. K.-T. Huang, B.-C. Wu, C.-C. Lin, S.-C. Luo, C. Chen, C.-H. Wong, C.-C. Lin, "Multi-enzyme one-pot strategy for the synthesis of sialyl Lewis X-containing PSGL-1 glycopeptide," Carbohydrate Res., 341 (12), 2151-2155, (2006).

  507. Y. Kinjo, E. Tupin, D. Wu, M. Fujio, R. Garcia-Navarro, M. R. E. I. Benhnia, D. M. Zajonc, G. Ben-Menachem, G. D. Ainge, G. F. Painter, A. Khurana, K. Hoebe, S. M. Behar, B. Beutler, I. A. Wilson, M. Tsuji, T.J. Sellati, C.-H. Wong, M. Kronenberg, "NKT cells recognize diacylglycerol antigens from pathogenic bacteria", Nature Immunol., 7 (9), 978-986, (2006).

  508. H. Liu, C.-H. Wong, "Characterization of a transglycosylase domain of Streptococcus pneumonia PBP1b", Bioorg. Med. Chem., 14, 7187-7195, (2006).

  509. D. Thayer, C.-H. Wong, "Vancomycin analogs with improved biological activity: a combined one-pot enzymatic glycosylation and chemical diversification strategy", Chem. An Asian J., 1, 445-452, (2006).

  510. L. Liu, Z.-Y. Hong, C.-H. Wong, "Three-step synthesis of sialic acids and derivatives", Angew. Chem. Int. Ed., 45 (44), 7417-21, (2006).

  511. K.-I. Lin, Y.-Y. Kao, H.-K. Kuo, W.-B. Yang, A. Chou, H.-H. Lin, A. L.-T. Yu, C.-H. Wong, "Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor Blimp-1", J. Biol. Chem., 281 (34), 24111-24123, (2006).

  512. Y.-S. E. Cheng, K.-H. Lo, H.-H. Hsu, Y.-M. Shao, W.-B. Yang, C.-H. Lin, C.-H. Wong, "Screening for HIV protease inhibitors by protection against activity-mediated cytotoxicity in Escherichia coli", J. Virological Methods, 137 (1), 82-87, (2006).

  513. A. Brik, S. Ficht, C.-H. Wong, "Strategies for the preparation of homogenous glycoproteins", Curr. Opin. Chem. Biol., 10 (6), 638-44, (2006).

  514. A. Brik, S. Ficht, Y.-Y. Yang, C. Bennett, C.-H. Wong, "Sugar-assisted ligation (SAL) of N-linked glycopeptides with broad sequence tolerance at the ligation junction", J. Am. Chem. Soc., 128 (46), 15026-33, (2006).

  515. S. Hanson, L. Whalen, C.-H. Wong, "Synthesis and evaluation of general mechanism-based inhibitors of sulfatases based on (difluoro)methyl phenol sulfate and phenol cyclic sulfamate motifs", Bioorg. Med. Chem., 14 (24), 8386-8395, (2006).

  516. M. Sugiyama, L. J. Whalen, Z.-Y. Hong, W. A. Greenberg, C.-H. Wong, "borate as a phosphate ester mimic in aldolase-catalyzed reactions: practical syntheses of L-fructose and L-iminocyclitols", Adv. Syn. Catal., 348, 2555-2559, (2006).

  517. J.-C. Lee, W. A. Greenberg, C.-H. Wong, "Programmable reactivity-based one-pot oligosaccharide synthesis", Nature Protocols, 1 (6), 3143-3152, (2006).

  518. S.-C. Cheng, W.-B. Yang, S.-W. Chin, C.-C. Lin, C.-H. Lin, Y.-J. Chen, P.-C. Lin, M.-F. Wu, C.-H. Wong, S.-L. Hsieh, "Profiling of polysaccharide-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins", Glycobiology, 11, 1131-1132, (2006).

  519. Z. Yu, A. R. Sawkar, L. J. Whalen, C.-H. Wong, J. W. Kelly, "Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention", J. Med. Chem., 50, 94-100, (2007).

  520. T.-L. Hsu, S. R. Hanson, K. Kishikawa, S.-K. Wang, M. Sawa, C.-H. Wong, "Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells", Proc. Nat. Acad. Sci. U.S.A., 104 (8), 2614-2619, (2007).

  521. M.-L. Michel, A. C. Keller, C. Paget, M. Fujio, F. Trottein, P. B. Savage, C.-H. Wong, E. Schneider, M. Dy, & M. C. Leite-de-Moraes, "Identification of an IL-17–producing NK1.1neg iNKT cell population involved in airway neutrophilia", J. Exper. Med., 204 (5), 995-1001, (2007).

  522. S. R. Hanson, T.-L Hsu, E. Weerapana, K. Kishikawa, G. M. Simon, B. F. Cravatt, C.-H. Wong, "Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes", J. Am. Chem. Soc., 129 (23), 7266-7267, (2007).

  523. N.-Y. Hsu, W.-B. Yang, C.-H. Wong, Y.-C. Lee, R.-T. Lee, Y.-S. Wang, C.-H. Chen, "Matrix-assisted laser desorption/ionization mass spectrometry of polysaccharides with 20,40,60-trihydroxyacetophenone as matrix", Rapid Commun. Mass Spectrom., 21, 2137-2146, (2007).

  524. Y.-Y. Yang, S. Ficht, A. Brik, C.-H. Wong, "Sugar-assisted ligation in glycoprotein synthesis", J. Am. Chem. Soc., 129 (24), 7690-701, (2007).

  525. Y.-J. Chang, J.-R. Huang, Y.-C. Tsai, J.-T. Hung, D. Wu, M. Fujio, C.-H. Wong, A. L. Yu, "Potent immune-modulating and anti-cancer effects of NKT cell stimulatory glycolipids", Proc. Nat. Acad. Sci. U.S.A., 104 (25), 10299-10304, (2007).

  526. A. Brik, C.-H. Wong, "Sugar-assisted ligation for the synthesis of glycopeptides", Chemistry-A Euro. J., 13 (20), 5670-5675, (2007).

  527. S. M. Dean, W. A. Greenberg, C.-H. Wong "Recent advances in aldolase-catalyzed asymmetric synthesis", Adv. Syn. Catal., 349, 1308-1320, (2007).

  528. M. Sugiyama, Z-Y. Hong, W. A. Greenberg, C.-H. Wong, "In vivo selection for the directed evolution of L-rhamnulose aldolase from L-rhamnulose-1-phosphate aldolase (RhaD)", Bioorg. Med. Chem., 15 (17), 5905-5911, (2007).

  529. S. Ficht, R.J. Payne, A. Brik, C.-H. Wong, "Second generation sugar-assisted ligation: an effective new method for the synthesis of cysteine-containing glycopeptides", Angew. Chem. Int. Ed., 46 (31), 5975-5979, (2007).

  530. C. S. Bennett, C.-H. Wong, "Chemoenzymatic approaches to glycoprotein synthesis", Chem. Soc. Rev., 36 (8), 1227-1238, (2007).

  531. E. Kaltgrad, S. Sen Gupta, S. Punna, C.-Y. Huang, A. Chang, C.-H. Wong, M. G. Finn, O. Blixt, "Anti-carbohydrate antibodies elicited by polyvalent display on a viral scaffold", ChemBioChem, 8 (12), 1455-1462, (2007).

  532. M.-T. Wei, K.-F. Hua, J. Hsu, A. Karmenyan, K.-Y. Tseng, C.-H. Wong, H.-Y. Hsu, A. Chiou, "The interaction of lipopolysaccharide with membrane receptors on macrophages pretreated with extract of Reishi polysaccharides measured by optical tweezers", Optical Soc. Amer., 15 (17), 11020-11032, (2007).

  533. P.-H. Liang, S.-K. Wang, C.-H. Wong, "Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants", J. Am. Chem. Soc., 129 (36), 11177-11184, (2007).

  534. Y.-M. Shao, W.-B. Yang, H.-P. Peng, M.-F. Hsu, K.-C. Tsai, T.-H. Kuo, A.-S. Yang, A.H.-J. Wang, P.-H. Liang, C.-H. Lin, C.-H. Wong, "Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors", ChemBioChem, 8 (14), 1654-1657, (2007).

  535. K.-F. Hua, H.-Y Hsu, L.-K. Chao, S.-T. Chen, W.-B. Yang, J. Hsu, C.-H. Wong, "Ganoderma lucidum polysaccharides enhance CD14 endocytosis of LPS and promote TLR4 signal transduction of cytokine expression", J. Cell. Physiol., 212, 537-550, (2007).

  536. J.-J. Shie, J.-M. Fang, S.-Y. Wang, K.-C. Tsai, Y.-S. E. Cheng, A.-S. Yang, S.-C. Hsiao, C.-Y. Su, C.-H. Wong, "Synthesis of Tamiflu and its phosphonate congeners possessing potent anti-influenza activity", J. Am. Chem. Soc., 129 (39), 11892-11893, (2007).

  537. C. Casey, C.-H. Wong, "Partly cloudy with a chance of showers", Chem. Biol., 2 (9), 573-576, (2007).

  538. T. Polat, C.-H. Wong, "Anomeric reactivity-based one-pot synthesis of heparin-like oligosaccharides", J. Am. Chem. Soc., 129 (42), 12795-12800, (2007).

  539. R. J. Payne, S. Ficht, S. Tang, A. Brik, Y.-Y. Yang, D.A. Case, C.-H. Wong, "Extended sugar-assisted ligations: development, scope and applications", J. Am. Chem. Soc., 129 (44), 13527-13536, (2007).

  540. M. Sugiyama, Z. Hong, P.-H. Liang, L. J. Whalen, W. A. Greenberg, C.-H. Wong, "D-Fructose-6-phosphate aldolase catalyzed one-pot synthesis of iminocyclitols", J. Am. Chem. Soc., 129 (47), 14811-14817, (2007).

  541. K.-C. Cheng, H.-C. Huang, J.-H. Chen, J.-W. Hsu, H.-C. Cheng, C.-H. Ou, W.-B. Yang, S.-T. Chen, C.-H. Wong, H.-F. Juan, "Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction", BMC Genomics, 8 (1), 411, (2007).

  542. S. R. Hanson, W. A. Greenberg, C.-H. Wong, "Probing glycans with the copper(I)-catalyzed [3+2] azide-alkyne cycloaddition", QSAR Comb. Sci., 26, 1243-1252, (2007).

  543. T.-J. R. Cheng, M.-T. Sung, H.-Y. Liao, Y.-F. Chang, C.-W. Chen, C.-Y. Huang, L.-Y. Chou, Y.-D. Wu, Y.-H. Chen, Y.-S. E. Cheng, C.-H. Wong, C. Ma, W.-C. Cheng, "Domain requirement of moenomycin binding to bi-functional transglycosylases and its application for high-throughput drug discovery", Proc. Nat. Acad. Sci. U.S.A., 105 (2), 431-436, (2008).

  544. D. Wu, M. Fujio, C.-H. Wong, "Glycolipids as immunostimulating agents", Bioorg. Med. Chem., 16, 1073–1083, (2008).

  545. T. R. Northen, J.-C. Lee, L. Hoang, J. Raymond, D.-R. Hwang, S. M. Yannone, C.-H. Wong, G. Siuzdak, "A nanostructure-initiator mass spectrometry based enzyme activity assay", Proc. Nat. Acad. Sci. U.S.A., 105 (10), 3678-3683, (2008).

  546. S.-K. Wang, P.-H. Liang, R. Astronomo, T.-L. Hsu, S.-L. Hsieh, D. Burton, C.-H. Wong, "Targeting the carbohydrates on HIV-1: interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN", Proc. Nat. Acad. Sci., U.S.A., 105 (10), 3690-3695, (2008).

  547. P.-H. Liang, C.-Y. Wu, W. A. Greenberg, C.-H. Wong, "Glycan arrays: perspectives in biological and medical applications", Current Opin. Chem. Biol., 12 (1), 86-92, (2008).

  548. S. Ficht, R. Payne, R. Guy, C.-H. Wong, "Solid-phase synthesis of peptide- and glycopeptide thioesters via side chain anchoring strategies", Chemistry- A Euro. J., 14 (12), 3620-3629, (2008).

  549. Y.-M. Shao, W.-B. Yang, T.-H. Kuo, K.-C. Tsai, C.-H. Lin, A.-S. Yang, P.-H. Liang, C.-H. Wong, "Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease", Bioorg. Med. Chem., 16, 4652-4660, (2008).

  550. R. Payne, S. Ficht, W. A. Greenberg, C.-H. Wong, "Cysteine-free peptide and glycopeptide ligation by direct aminolysis", Angew. Chem. Int. Ed., 47, 4411-4415, (2008).

  551. S.-T. Chen, Y.-L. Lin, M.-T. Huang, M.-F. Wu, S.-C. Cheng, H.-Y. Lei, C.-K. Lee, T.-W. Chiou, C.-H. Wong, S.-L. Hsieh, "CLEC5A is critical for dengue virus-induced lethal disease", Nature, 453, 672-676, (2008).

  552. N.-Y. Hsu, S. Y. Tseng, C.-Y. Wu, C.-T. Ren, Y.-C. Lee, C.-H. Wong, C.-H. Chen, "Desorption ionization of biomolecules on metals", Analyt. Chem., 80, 5203-5210, (2008).

  553. R. D. Astronomo, H. K. Lee, C. N. Scanlan, R. Pantophlet, C. Y. Huang, I. A. Wilson, O. Blixt, R. A. Dwek, C.-H. Wong, D. R. Burton,"A glycoconjugate antigen based on the recognition motif of a broadly-neutralising human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120", J. Virology, 82, 6359-6368, (2008).

  554. Y. S.-Y. Hsieh, C. Chien, S. K.-S. Liao, S.-F. Liao, W.-T. Hung, W.-B. Yang, C.-C. Lin, T.-J. R. Cheng, C.-C. Chang, J.-M. Fang, C.-H. Wong, "Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense", Bioorg. Med. Chem., 16, 6054-68, (2008).

  555. Y. Kinjo, B. Pei, S. Bufali, R. Raju, S. K. Richardson, M. Imamura, M. Fujio, D. Wu, A. Khurana, K. Kawahara, C.-H. Wong, A. R. Howell, P. H. Seeberger, M. Kronenberg, "Natural Sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells", Chem. Biol., 15 (7), 654-664, (2008).

  556. C.-C. Wang, Y.-L. Huang, C.-T. Ren, C.-W. Lin, J.-T. Hung, J.-C. Yu, A. Yu, C.-Y. Wu, C.-H. Wong, "Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer", Proc. Nat. Acad. Sci., U.S.A., 105, 11661-11666, (2008).

  557. W.-W. Chang, C. H. Lee, P. Lee, J. Lin, C.-W. Hsu, J.-T. Hung, J.-J. Lin, J.-C. Yu, L. E. Shao, J. Yu, C.-H. Wong, A. L. Yu, "Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 & 2 in Globo H synthesis", Proc. Nat. Acad. Sci., U.S.A., 105, 11667-11672, (2008).

  558. C.-Y. Su, S.-Y. Wang, J.-J. Shie, K.-S. Jeng, N. J. Temperton, J.-M. Fang, C.-H. Wong, Y.-S.E. Cheng, "In vitro evaluation of neuraminidase inhibitors using the neuraminidase-dependent release assay of hemagglutinin-pseudotyped viruses", Antiviral Res., 79 (3), 199-205, (2008).

  559. J.-J. Shie, J.-M. Fang, C.-H. Wong, "A concise and flexible synthesis of the potent anti-influenza agents – Tamiflu and Tamiphosphor", Angew. Chem. Int. Ed., 47 (31), 5788-5791, (2008).

  560. P.-H. Liang, M. Imamura, X. Li, D. Wu, M. Fujio, R. Guy, B.-C. Wu, M. Tsuji, C.-H. Wong, "Quantitative microarray analysis of intact glycolipid-CD1d interaction and correlation with cell-based cytokine production", J. Am. Chem. Soc., 130 (37), 12348-12354, (2008).

  561. C. Bennett, S. Dean, R. Payne, S. Ficht, A. Brik, C.-H. Wong, "Sugar-assisted glycopeptide ligation with complex oligosaccharides: scope and limitations", J. Am. Chem. Soc., 130 (36), 11945-11952, (2008).

  562. S. Y. Tseng, C. C. Wang, C.-W. Lin, C.-L. Chen, W.-Y. Yu, C.-H. Chen, C.-Y. Wu, C.-H. Wong, "Glycan arrays on aluminum coated glass slides", Chemistry – An Asian J., 3 (8), 1395-1405, (2008).

  563. C.-S. Shi, G.-Y. Shi, S.-M. Hsiao, Y.-C. Kao, K.-L. Kuo, C.-Y. Ma, C.-H. Kuo, B.-I. Chang, C.-F. Chang, C.-H. Lin, C.-H. Wong, H.-L. Wu, "Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response", Blood, 112 (9), 3661-3670, (2008).

  564. M. W. Chen, T.-J. R. Cheng, Y. Huang, J.-T. Jan, S.-H. Ma, A. L. Yu, C.-H. Wong, D. D. Ho, "A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 Influenza viruses", Proc. Nat. Acad. Sci., U.S.A., 105 (36), 13538-43, (2008).

  565. M.-L. Chen, A. K. Adak, N.-C. Yeh, W.-B. Yang, Y.-J. Chuang, C.-H. Wong, K.-C. Hwang, J.-R. R. Hwu, S.-L. Hsieh, C.-C. Lin, "Fabrication of an oriented Fc-fused lectin microarray through boronate formation", Angew. Chem. Int. Ed., 47 (45), 8627-8630, (2008).

  566. M. J. Giffin, H. Heaslet, A. Brik, Y.-C. Lin, G. Cauvi, C.-H. Wong, D. E. McRee, J. H. Elder, C. D. Stout, B. E. Torbett, "A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant", J. Med. Chem., 51 (20), 6263-6270, (2008).

  567. E. Tupin, M. R.-E.-I. Benhnia, Y. Kinjo, R. Patsey, C. Lena, M. Haller, M. J. Caimano, M. Imamura, C.-H. Wong, S. Crotty, J. D. Radolf, T. J. Sellati, M. Kronenberg, "NKT cells prevent chronic joint inflammation following infection with Borrelia burgdorferi", Proc. Nat. Acad. Sci. U.S.A., 105 (50), 19863-19868, (2008).

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  574. W.-H. Wen, M. Lin, C.-Y. Su, S.-Y. Wang, Y.-S. E. Cheng, J.-M. Fang and C.-H. Wong, "Synergistic effect of zanamivir–porphyrin conjugates on inhibition of neuraminidase and inactivation of influenza virus", J. Med. Chem., 52 (15), 4903-4910, (2009).

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  577. J. C. Lewis, S. Bastian, C. S. Bennett, Y. Fu, Y. Mitsuda, M. M. Chen, W. A. Greenberg, C.-H. Wong, and F. H. Arnold, "Chemoenzymatic Elaboration of Monosaccharides Using Engineered Cytochrome P450BM3 Demethylases", Proc. Nat. Acad. Sci. U.S.A., 106 (39), 16550-16555, (2009).

  578. C.-C. Wang, J.-R. Chen, Y.-C. Tseng, C.-H. Hsu, Y.-F. Hung, S.-W. Chen, C.-M. Chen, K.-H. Khoo, T.-J. Cheng, Y.-S. E. Cheng, J.-T. Jan, C.-Y. Wu, C. Ma, and C.-H. Wong, "Glycans on influenza hemagglutinin affect receptor binding and immune response", Proc. Nat. Acad. Sci. U.S.A., 106 (43), 18137-18142, (2009).

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  580. M.-H. Chuang, S.-H. Chiou, C.-H. Huang, W.-B. Yang and C.-H. Wong, "The lifespan-promoting effect of acetic acid and Reishi polysaccharide", Bioorg. Med. Chem., 17 (22), 7831-7840, (2009).

  581. T.-L. Hsu, S.-C. Cheng, W.-B. Yang, S.-W. Chin, B.-H. Chen, M.-T. Huang, S.-L. Hsieh, C.-H. Wong, "Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins", J. Biol. Chem., 284 (50), 34479-34489, (2009).

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  584. C.-Y. Liu, C.-W. Guo, Y.-F. Chang, J.-T. Wang, H.-W. Shih, Y.-F. Hsu, C.-W. Chen, S.-K. Chen, Y.-C. Wang, T.-J. Cheng, C. Ma, C.-H. Wong, J.-M. Fang, W.-C. Cheng, "Synthesis and evaluation of a new fluorescent transglycosylase substrate: lipid II-based molecule possessing a dansyl-C20 polyprenyl moiety", Org Lett., 12 (7), 1608-1611, (2010).

  585. C.-C. Chang, A. F. Ku, Y.-Y. Tseng, W.-B. Yang, J.-M. Fang, and C.-H. Wong, "6,8-Di-C-glycosyl flavonoids from Dendrobium huoshanense", J. Nat. Prod., 73 (2), 229-232, (2010).

  586. R. D. Astronomo, E. Kaltgrad, A. K. Udit, S.-K. Wang, R. Pantophlet, C.-Y. Huang, J. C. Paulson, C.-H. Wong, M. G. Finn and D. R. Burton, "Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds", Chemistry & Biology, 17 (4), 357-370, (2010).

  587. H.-W. Shih, K.-T. Chen, S.-K. Chen, C.-Y. Huang, T.-J. Cheng, C. Ma, C.-H. Wong, W.-C. Cheng, "Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors", Organic & Biomolecular Chemistry, 8 (11), 2586-2593, (2010).

  588. W.-H. Wen, S.-Y. Wang, K.-C. Ysai, Y.-S. E. Cheng, A.-S. Yang, J.-M. Fang, C.-H. Wong, "Analogues of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses", Bioorg. Med. Chem., 18 (11), 4074-4084, (2010).

  589. S. Otsuki, S. Hanson, S. Miyaki, S. Grogan, M. Kinoshita, H. Asahara, C.-H. Wong, M. Lotz, "Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways", Proc. Nat. Acad. Sci. U.S.A., 107 (22), 10202-10207, (2010).

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  592. K.-H. Lin, J.-J. Liang, W.-I. Huang, S.-Y. Lin-Chu, C.-Y. Su, Y.-L. Lee, J.-T. Jan, Y.-L. Lin, Y.-S. E. Cheng, and C.-H. Wong, "In vivo protection of bacterial and viral infections in murine models using a synthetic new alpha-GalCer analog", Antimicrobial Agents and Chemotherapy, 54 (10), 4129-4136, (2010).

  593. S.-H. Chang, J.-L. Han, Susan Y. Tseng, H.-Y. Lee, C.-W. Lin, Y.-C. Lin, W.-Y. Jeng, A. H.-J. Wang, C.-Y. Wu, C.-H. Wong, "Glycan array on aluminum oxide coated glass slides through phosphonate chemistry", J. Am. Chem. Soc., 132 (38), 13371-13380, (2010).

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  595. H.-Y. Liao, C.-H. Hsu, S.-C. Wang, C.-H. Liang, H.-Y. Yen, C.-Y. Su, J.-T. Jan, C.-T. Ren, T.-J. Cheng, C.-Y. Wu, C.-H. Wong, "Differential receptor binding affinities of influenza hemagglutinins on glycan arrays", J. Am. Chem. Soc., 132 (42), 14849-14856, (2010).

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  597. M. Schelwies, D. Brinson, Y.-H. Hong, M. K. Lotz, C.-H. Wong, and S. R. Hanson, "GlcN-6-sulfamate heparan analogs as inhibitors of endosulfatases", ChemBioChem, 11 (17), 2393-2397, (2010).

  598. J. C. Lewis, S. M. Mantovani, Y. Fu, C. D. Snow, R. S. Komor, C.-H. Wong, F. H. Arnold, "Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates", ChembioChem, 11 (18), 2502-2505, (2010).

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  600. T.-J. R. Cheng, Y.-T. Wu, S.-T. Yang, A. Loh, S.-K. Chen, Y.-H. Chen, W.-I. Huang, C.-H. Yuan, H.-W. Shih, Y.-S. E. Cheng, W.-C. Cheng, C.-H. Wong, "High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase", Bioorg. Med. Chem., 18 (24), 8512-8529, (2010).

  601. C.-H. Liang, S.-K. Wang, C.-W. Lin, C.-C. Wang, C.-H. Wong, C.-Y. Wu, "Effects of neighboring glycans on antibody-carbohydrate interaction", Angew. Chem. Int. Ed., 50 (7), 1608-1612, (2011).

  602. E. K. Culyba, J. L. Price, S. R. Hanson, A. Dhar, C.-H. Wong, M. Gruebele, E. T. Powers and J. W. Kelly, "Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns", Science, 331 (6017), 571-575, (2011).

  603. M. W. Chen, H.-Y. Liao, T.-J. R. Cheng, C.-T. Ren, C.-Y. Wu, Y. Huang, D. D. Ho, C.-H. Wong, "Broadly neutralizing DNA vaccine with site specific mutation alters the antigenicity and sugar binding activities of influenza hemagglutinin", Proc. Nat. Acad. Sci. U.S.A., 108 (9), 3510-3515, (2011).

  604. R. T. Lee, T.-L. Hsu, S. K. Huang, S.-L. Hsieh, C.-H. Wong, and Y. C. Lee, "Survey of immune-related, mannose/fucose-binding C-Type lectin receptors reveals widely divergent sugar-binding specificities", Glycobiology, 21 (4), 512-520, (2011).

  605. C.-Y. Chou, T.-P. Ko, K.-J. Wu, K.-F. Huang, C.-H. Lin, C.-H. Wong, A. H.-J. Wang, "Modulation of substrate specificities of D-sialic acid aldolase through single mutations of Val251", J. Biol. Chem., 286 (16), 14057-14064, (2011).

  606. B.-L. Tsai, J.-L. Han, C.-T. Ren, C.-Y. Wu and C.-H. Wong, "Programmable one-pot synthesis of tumor-associated carbohydrate antigens Lewis X dimer and KH-1 epitopes", Tetrahedron Letters, 52 (17), 2132-2135, (2011).

  607. C.-F. Chang, J.-F. Pan, C.-N. Lin, C.-H. Wong, C.-H. Lin, "Rapid characterization of sugar-binding specificity by in-solution proximity binding with photosensitizers", Glycobiology, 21 (7), 895-902, (2011).

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  610. Y.-C. Liu, H.-Y. Yen, C.-Y. Chen, C.-H. Chen, P.-F. Cheng, Y.-H. Juan, C.-H. Chen, K.-H. Khoo, C.-J. Yu, P.-C. Yang, T.-L. Hsu, C.-H. Wong, "Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells", Proc. Nat. Acad. Sci. U.S.A., 108 (28), 11332-11337, (2011).

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  613. H.-L. Yen, C.-H. Liang, C.-Y. Wu, H. L. Forrest, A. Ferguson, K.-T. Choy, J. Jones, D. D.-Y. Wong, P. P.-H. Cheung, C.-H. Hsu, O. T. Li, K. M. Yuen, R. W. Y. Chan, L. L. M. Poon, M. C. W. Chan, J. Nicholls, S. Krauss, C.-H. Wong, Y. Guan, R. G. Webster, R. J. Webby & J. S. M. Peiris, "Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets", Proc. Nat. Acad. Sci. U.S.A., 108 (34), 14264-14269, (2011).

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  622. R. Pejchal, K. J. Doores, L. M. Walker, R. Khayat, P.-S. Huang, S.-K. Wang, R. L. Stanfield, J.P. Julien, A. Ramos, M. Crispin, R. Depetris, U. Katpally, A. Marozsan, A. Cupo, S. Maloveste, Y. Liu, R. McBride, Y. Ito, R.W. Sanders, C. Ogohara, J. C. Paulson, T. Feizi, C. N. Scanlan, C.-H. Wong, J. P. Moore, W. C. Olson, A. B. Ward, P. Poignard, W. R. Schief, D. R. Burton, I. A. Wilson, "A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield", Science, 334 (6059), 1097-1103, (2011).

  623. T.-N. Wu, K.-H. Lin, Y.-J. Chang, J.-R. Huang, J.-Y. Cheng, A. L. Yu, and C.-H. Wong, "Avidity of CD1d-ligand-receptor ternary complex contributes to Th1 polarization and anticancer efficacy", Proc. Nat. Acad. Sci. U.S.A., 108 (42), 17275-17280, (2011).

  624. J.-J. Shie, J.-M. Fang, P.-T. Lai, W.-H. Wen, S.-Y. Wang, Y.-S. Cheng, K.-C. Tsai, A.-S. Yang, C.-H. Wong, "A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity", J. Am. Chem. Soc., 133 (44), 17959-17965, (2011).

  625. D. Punyadarsaniya, C.-H. Liang, C. Winter, H. Petersen, S. Rautenschlein, I. Hennig-Pauka, C. Schwegmann-Wessels, C.-Y. Wu, C.-H. Wong, G. Herrler, "Infection of differentiated porcine airway epithelial cells by influenza virus: differential susceptibility to infection by porcine and avian viruses", PLOS One, 6 (12), e28429, (2011).

  626. S.-H. Chen, D.-R. Hwang, G.-H. Chen, N.-S. Hsu, Y.-T. Wu, T.-L. Li, C.-H. Wong, "Engineering transaldolase in Pichia stipitis to improve bioethanol production", ACS Chem. Biol., 7 (3), 481-486, (2012).

  627. J. Lenger, M. Schröder, E. C. Ennemann, B. Müller, C.-H. Wong, T. Noll, T. Dierks, S. R. Hanson, N. Sewald, "Evaluation of sulfatase-directed quinone methide traps for proteomics", Bioorg. Med. Chem., 20 (2), 622-627, (2012).

  628. Y. Hsu, X.-A. Lu, M. Zulueta, C.-M. Tsai, K.-I. Lin, S.-C. Hung, C.-H. Wong, "Acyl and silyl group effects in reactivity-based one-pot glycosylation: synthesis of embryonic stem cell surface carbohydrates Lc4 and IV2Fuc-Lc4", J. Am. Chem. Soc., 134 (10), 4549-4552, (2012).

  629. C.-Y. Huang, H.-W. Shih, L-Y. Lin, Y.-W. Tien, T.-J. R. Cheng, W.-C. Cheng, C.-H. Wong and C. Ma, "Crystal structure of Staphylococcus aureus membrane-bound transglycosylase in complex with a lipid II analog and elucidation of the mechanism of peptidoglycan synthesis", Proc. Nat. Acad. Sci. U.S.A., 109 (17), 6496-6501, (2012).

  630. S.-C. Hung, M. Zulueta, S.-Y. Lin, Y.-T. Lin, C.-J. Huang, C.-C. Wang, C.-C. Ku, Z.-H. Shi, C.-L. Chyan, D. Irene, L.-H. Lim, T.-I. Tsai, Y.-P. Hu, S. Arco, C.-H. Wong, "a-Glycosylation by D-glucosamine-derived donors: synthesis of heparosan and heparin analogs that interact with mycobacterial heparin-binding hemagglutinin", J. Am. Chem. Soc., 134: 8988-8995, (2012).

  631. M.-H. Hsieh, J.-T. Hung, Y.-W. Liw, Y.-J. Lu, C.-H. Wong, A. L. Yu, and P.-H. Liang, "Synthesis and evaluation of acyl-chain- and galactose-6’’-modified analogues of a-GalCer for NKT cell activation", ChemBioChem, 13 (11), 1689-1697, (2012).

  632. J. L. Price, E. K. Culyba, W. Chen, A. N. Murray, S. R. Hanson, C.-H. Wong, E. T. Powers, J. W. Kelly, "N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability", Biopolymers, 98 (3), 195-211, (2012).

  633. H.-W. Shih, Y.-F. Chang, W.-J. Li, F.-C. Meng, C.-Y. Huang, C. Ma, T.-J. R. Cheng, C.-H. Wong, W.-C. Cheng, "Effect of the peptide moiety of lipid II on bacterial transglycosylase", Angew. Chem. Int. Ed., 51 (40), 10123-10126, (2012).

  634. K.-C. Liu, J.-M. Fang, J.-T. Jan, T.-J. R. Cheng, S.-Y. Wang, Y.-S. E. Cheng, K.-C. Tsai, A.-S. Yang, and C.-H. Wong, "Enhanced anti-influenza agents conjugated with anti-inflammatory activity", J. Med. Chem., 55 (19), 8493-8501, (2012).

  635. T.-J. R. Cheng, S. Weinheimer, E. B. Tarbet, J.-T. Jan, Y.-S. E. Cheng, J.-J. Shie, C.-L. Chen, C.-A. Chen, W.-C. Hsieh, P.-W. Huang, W.-H. Lin, S.-Y. Wang, J.-M. Fang, O. Y.-P. Hu, and C.-H. Wong, "Development of oseltamivir phosphonate congeners as anti-influenza agents", J. Med. Chem., 55 (20), 8657-8670, (2012).

  636. T.-J. R. Cheng, S.-Y. Wang, W.-H. Wen, C.-Y. Su, M. Lin, W.-I. Huang, M.-T. Liu, H.-S. Wu, N-S. Wang, C.-K. Cheng, C.-L. Chen, C.-T. Ren, C.-Y. Wu, J.-M. Fang, Y.-S. E. Cheng and C.-H. Wong, "Chemical probes for drug resistance assessment by binding competition (RABC) oseltamivir susceptibility evaluation", Angew. Chem. Int. Ed., 52, 366-370, (2013).

  637. E. Al-Shareffi, J.-L. Chaubard, C. Leonhard-Melief, C.-H. Wong, and R. S. Haltiwanger, "6-alkynyl fucose is a bioorthogonal analogue for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein O-fucosyltransferases 1 and 2", Glycobiology, 23 (2), 188-198, (2013).

  638. K.-T. Chen, Y.-C. Kuan, W.-C. Fu, P.-H. Liang, T.-J. R. Cheng, C.-H. Wong, and W.-C. Cheng, "Rapid preparation of mycobacterium N-glycolyl lipid I and lipid II derivatives: a biocatalytic approach", Chemistry -A European Journal, 19 (3), 834-838, (2013).

  639. K. J. Doores, M. Huber, K. M. Le, S.-K. Wang, C. Doyle-Cooper, A. Cooper, R. Pantophlet, C.-H. Wong, D. Nemazee, D. R. Burton, "2G12-expressing B cell lines inform HIV carbohydrate vaccine design strategies", Journal of Virology, 87 (4), 2234-2241, (2013).

  640. C.-Y. Chen, Y.-H. Jan, Y.-H. Juan, C.-J. Yang, M.-S. Huang, C.-J. Yu, P.-C. Yang, M. Hsiao, T.-L. Hsu, C.-H. Wong, "Fucosyltransferase 8 as a functional regulator of non-small cell lung cancer", Proc. Nat. Acad. Sci. U.S.A., 110 (2), 630-635, (2013).

  641. Y.-L. Huang, J.-T. Hung, S. K.-C. Cheung, H.-Y. Lee, K.-C. Chu, S.-T. Li, Y.-C. Lin, C.-T. Ren, T.-J. R. Cheng, T.-L. Hsu, A. L. Yu, C.-Y. Wu, C.-H. Wong "Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer", Proc. Natl. Acad. Sci. U.S.A., 110, 2517-2522, (2013).

  642. C.-S. Tsai, H.-Y. Yen, M.-I. Lin, T.-I. Tsai, S.-Y. Wang, W.-I. Huang, T.-L. Hsu, Y.-S. E. Cheng, J.-M. Fang, C.-H. Wong, "A cell permeable probe for identification and imaging of sialidases", Proc. Nat. Acad. Sci. U.S.A., 110, 2466-2471, (2013).

  643. T.-C. Hung, C.-W. Lin, T.-L. Hsu, C.-Y. Wu, C.-H. Wong, "Investigation of SSEA-4 binding protein in breast cancer cells", J. Am. Chem. Soc., 135 (16), 5934-5937, (2013).

  644. C.-C. Tsai, C.-R. Lin, H.-Y. Tsai, C.-J. Chen, W.-T. Li, H.-M. Yu, Y.-Y. Ke, W.-Y. Hsieh, C.-Y. Chang, C.-Y. Wu, S.-T. Chen, C.-H. Wong, "The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via toll-like receptor-2 signaling", J. Biol. Chem., 288 (24), 17689-17697, (2013).

  645. C.-Y. Yang, J.-B. Chen, T.-F. Tsai, Y.-C. Tsai, C.-Y. Tsai, P.-H. Liang, T.-L. Hsu, C.-Y. Wu, M. G. Netea, C.-H. Wong, S.-L. Hsieh, "CLEC4F is an inducible C-type lectin in F4/80-positive cells and is involved in alpha-galactosylceramide presentation in liver", PLOS ONE, 8 (6), e65070, (2013).

  646. S.-C. Lin, J.-T. Jan, B. Dionne, M. Butler, M.-H. Huang, C.-Y. Wu, C.-H. Wong, S.-C. Wu, "Different immunity elicited by recombinant H5N1 hemagglutinin proteins containing pauci-mannose, high-mannose, or complex type N-glycans", PLOS ONE, 8 (6), e66719, (2013).

  647. H.-W. Huang, C.-H. Chen, C.-H. Lin, C.-H. Wong, K.-I. Lin, "B cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention", Proc. Nat. Acad. Sci. U.S.A., 110 (27), 10928-10933, (2013).

  648. K. Ohara, C.-C. Lin, P.-J. Yang, W.-T. Hung, W.-B. Yang, T.-J. Cheng, J.-M. Fang, C.-H. Wong, "Synthesis and bioactivity of ?-(1?4)-linked oligomannoses and partially acetylated derivatives", J. Org. Chem., 78 (13), 6390-6411, (2013).

  649. W. Chen, S. Enck, J. Price, D. Powers, E. Powers, C.-H. Wong, H. J. Dyson, J. Kelly, "Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins", J. Am. Chem. Soc., 135 (26), 9877-9884, (2013).

  650. C.-H. Wang, S.-T. Li, T.-L. Lin, Y.-Y. Cheng, T.-H. Sun, J.-T. Wang, T.-J. Cheng, K.-K. Mong, C.-H. Wong, C.-Y. Wu, "Synthesis of Neisseria meningitidis serogroup W135 capsular oligosaccharides for immunogenicity comparison and vaccine development", Angew. Chem. Int. Ed., 52 (35), 9157-9161, (2013).

  651. H.-Y. Chuang, C.-T. Ren, C.-A. Chao, C.-Y. Wu, S. Shivatare; T.-J. R. Cheng, C.-Y. Wu, C.-H. Wong, "Synthesis and vaccine evaluation of the tumor associated carbohydrate antigen RM2 from prostate cancer", J. Am. Chem. Soc., 135 (30), 11140-11150, (2013).

  652. S.-F. Liao, C.-H. Liang, M.-Y. Ho, T.-L. Hsu, T.-I. Tsai, Y. S.-Y. Hsieh, S.-T. Li, Y.-Y. Cheng, S.-M. Tsao, T.-Y. Lin, Z.-Y. Lin, W.-B. Yang, C.-T. Ren, K.-I. Lin, K.-K. Khoo, C.-H. Lin, H.-Y. Hsu, C.-Y. Wu, C.-H. Wong, "Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies against tumor-associated Globo H-series epitopes", Proc. Nat. Acad. Sci. U.S.A., 110 (34), 13809-13814, (2013).

  653. S. Shivatare, S.-H. Chang, T.-I. Tsai, C.-T. Ren, H.-Y. Chuang, L. Hsu, C.-W. Lin, S.-T. Li, C.-Y. Wu, C.-H. Wong, "Efficient convergent synthesis of bi-, tri-, and tetraantennary complex type N-glycans and their HIV-1 antigenicity", J. Am. Chem. Soc., 135 (41), 15382-15391, (2013).

  654. T.-I. Tsai, H.-Y. Lee, S.-H. Chang, C.-H. Wang, Y.-C. Tu, Y.-C. Lin, D.-R. Hwang, C.-Y. Wu, C.-H. Wong, "Effective sugar nucleotide regeneration for the large-scale enzymatic synthesis of Globo H and SSEA4", J. Am. Chem. Soc., 135 (39), 14831-14839, (2013).

  655. N. Padte, M. B. Carrera, C. A. McManus, B. Grasperge, A. Gettie, J. Coelho-dos-Reis, X. Li, N. Levenkova, D. Wu, J. T. Bruder, M. Sedegah, N. Petterson, T. Richie, C.-H. Wong, D. D. Ho, S. Vasan, M. Tsuji, "A glycolipid adjuvant, 7DW8-5, enhances CD8+ T cell responses induced by an adenovirus-vectored malaria vaccine in non-human primates", PLOS ONE, 8 (10), e78407, (2013).

  656. S.-H. Huang, W.-S. Wu, L.-Y., Huang, W.-F., Huang, W.-C., Fu, S.-T. Yang, P.-T. Chen, J.-M. Fang, W.-C. Cheng, T.-J. Cheng, C.-H. Wong, "A new continuous fluorometric assay for bacterial transglycosylase using Förster resonance energy transfer", J. Am. Chem. Soc., 135 (45), 17078-17089, (2013).

  657. R. Bryk, N. Arango, C. Maksymiuk, A. Balakrishnan, Y.-T. Wu, C.-H. Wong, T. Masquelin, P. Hipskind, C. D. Lima, and C. Nathan, "Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase", Biochemistry, 52 (51), 9375-9384, (2013).

  658. T.-L. Hsu, G. Lin, A. Koizumi, K. Brehm, N. Hada, P.-K.Chuang, C.-H. Wong, S.-L. Hsieh, A. Diaz, "The surface carbohydrates of the Echinococcus granulosus larva interact selectively with the rodent Kupffer cell receptor", Molecular & Biochemical Parasitology, 192 (1-2), 55-59, (2013).

  659. J.-M. Fang, Y.-S. Chen, H.-M. Yu, J.-J. Shie, T.-J. R. Cheng, C.-Y. Wu, C.-H. Wong, "Chemical constituents of Plectranthus amboinicus and the synthetic analogs possessing anti-inflammatory activity", Bioorg. Med. Chem., 22 (5), 1766-72, (2014).

  660. C.-S. Chu, P.-W. Lo, Y.-H. Yeh, P.-H. Hsu, S.-H. Peng, Y.-C. Teng, M.-L. Kang, C.-H. Wong and L.-J. Juan, "O-GlcNAcylation regulates EZH2 protein stability and function", Proc. Nat. Acad. Sci. U.S.A., 111 (4), 1355-1360, (2014).

  661. J.-R. Chen, Y.-H. Yu, Y.-C. Tseng, W.-L. Chiang, M.-F. Chiang, Y.-A. Ko, Y.-K. Chiu, S.-H. Ma, C.-Y. Wu, J.-T. Jan, K.-I. Lin, C. Ma and C.-H. Wong, "Vaccination of monoglycosylated hemagglutinin induces cross-strain protection against influenza virus infections", Proc. Nat. Acad. Sci. U.S.A., 111 (7), 2476-2481, (2014).

  662. Y.-W. Lou, P.-Y. Wang, S.-C. Yeh, P.-K. Chuang, S.-T. Li, C.-Y. Wu, K.-H. Khoo, M. Hsiao, T.-L. Hsu, C.-H. Wong, "Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers", Proc. Nat. Acad. Sci. U.S.A., 111 (7), 2482-2487, (2014).

  663. J -R. Huang, Y.-C. Tsai, Y.-J. Chang, J.-C. Wu, J.-T. Hung, K.-H. Lin, C.-H. Wong and Alice L. Yu, "a-GalCer but not phenyl-glycolipids induced NKT cell anergy and IL-33 mediated MDSC accumulation via upregulation of egr2/3", Journal of Immunology, 192 (4), 1972-1981, (2014).

  664. A.-K. Sauer, C.-H. Liang, J. Stech, B. Peeters, P. Quéré, C. Schwegmann-Wessels, C.-Y. Wu, C.-H. Wong, G. Herrler , "Characterization of the sialic acid binding activity of influenza A viruses using soluble variants of the H7 and H9 hemagglutinin subtypes as lectins", PLOS ONE, 9 (2), e89529, (2014).

  665. J. Lin, Y.-J. Chang, W.-B. Yang, A. L. Yu, and C.-H. Wong, "The multifaceted effects of Dendrobium huoshanense on immune functions with the induction of Interleukin-1 receptor antagonist (IL-1ra) in monocytes", PLOS ONE, 9 (4), e94040, (2014).

  666. S.-C. Lin, W.-C. Liu, J.-T. Jan, C.-H. Wong, S.-C. Wu, "Glycan Masking of hemagglutinin for adenovirus vector and recombinant protein immunizations elicits broadly neutralizing antibodies against H5N1 avian influenza viruses", PLOS ONE, 9 (3), e92822, (2014).

  667. J.-J. Shie, Y.-C. Liu, Y.-M. Lee, C. Lim, J.-M. Fang, C.-H. Wong, "An azido-BODIPY probe for glycosylation: initiation of strong fluorescence upon triazole formation", J. Am. Chem. Soc., 136 (28), 9953-9961, (2014).

  668. P.-C. Chen, P.-K. Chuang, C.-H. Chen, J.-R. Chen, S.-W. Lin, C. Ma, T.-L. Hsu, C.-H. Wong, "Role of N-linked glycans in the interactions of the HCV envelope glycoproteins with cellular receptors", ACS Chemical Biology, 9 (7), 1437-1443, (2014).

  669. E. Falkowska, A. Ramos, K. J. Doores, J. H. Lee, C. Blattner, A. Ramirez, R. Derking, M. J. van Gils, C.-H. Liang, R. Mcbride, S. S. Shivatare, C.-Y. Wu, P.-Y. Chan-Hui, Y. Liu, T. Feizi, M. B. Zwick, W. C. Koff, M. S. Seaman, K. Swiderek, J. P. Moore, J. C. Paulson, C.-H. Wong, A. B. Ward, I. A. Wilson, R. W. Sanders, P. Poignard, and D. R. Burton, "Broadly neutralizing HIV antibodies define a novel glycan-dependent epitope on the pre-fusion conformation of gp41 on cleaved Envelope trimmers", Immunity, 40 (5), 657-668, (2014).

  670. Y.-Y. Tseng, J.-M. Liou, T.-L. Hsu, W.-C. Cheng, M.-S. Wu, C.-H. Wong, "Development of bacterial transglycosylase inhibitors as new antibiotics: moenomycin A treatment for drug-resistant Helicobacter pylori", Bioorg. Med. Chem. Lett., 24 (11), 2412-2414, (2014).

  671. C.-L. Chen, T.-C. Lin, S.-Y. Wang, J.-J. Shie, K.-C. Tsai, Y.-S. E. Cheng, J.-T. Jan, C.-J. Lin, J.-M. Fang, and C.-H. Wong, "Tamiphosphor monoesters as effective anti-influenza agents", Eur. J. Med. Chem., 81, 106-118, (2014).

  672. L.-Y. Huang, S.-H. Huang, Y.-C. Chang, W.-C. Cheng, T.-J. R. Cheng, and C.-H. Wong, "Enzymatic synthesis of Lipid II and analogues", Angew. Chem. Int. Ed., 53 (31), 8060-8065, (2014).

  673. C.-Y. Wang, C.-Y. Wu, T.-J. Hung, C.-H. Wong, C.-H. Chen, "Sequence-constructive SELEX: A new strategy for screening DNA aptamer binding to Globo H", Biochem. Biophys. Res. Commun., 452 (3), 484-489, (2014).

  674. C.-H. Hsu, M. Schelwies, S. Enck, L.-Y. Huang, S.-H. Huang, Y.-F. Chang, T.-J. Cheng, W.-C. Cheng, C.-H. Wong, "Iminosugar C-glycoside analogues of alpha-D-GlcNAc-1-phosphate: synthesis and bacterial transglycosylase inhibition", J. Org. Chem., 79 (18), 8629-37, (2014).

  675. J.-T. Hung, Y.-C. Tsai, W.-D. Lin, J.-T. Jan, K.-H. Lin, J.-R. Huang, J.-Y. Cheng, M.-W. Chen, C.-H. Wong, and A. L. Yu, "Potent adjuvant effects of novel NKT stimulatory glycolipids on hemagglutinin based DNA vaccine for H5N1 influenza virus", Antiviral Res., 107, 110-118, (2014).

  676. B.-T. Hong, C.-L. Chen, J.-M. Fang, S.-Y. Wang, W.-I. Huang, Y.-S. E. Cheng, and Chi-Huey Wong, "Oseltamivir hydroxamate and acyl sulfonamide derivatives as influenza neuraminidase inhibitors", Bioorg. Med. Chem., 22 (23), 6647-6654, (2014).

  677. H.-Y. Lee, C.-Y. Chen, T.-I. Tsai, S.-T. Li, K.-H. Lin, Y.-Y. Cheng, C.-T. Ren, T.-J. Cheng, C.-Y. Wu, C.-H. Wong, "Immunogenicity study of Globo H derivatives with modification at the reducing or non-reducing end of the tumor antigen", J. Am. Chem. Soc., 136 (48), 16844-16853, (2014).

  678. S. Danishefsky, Y.-K. Shue, M. Chang, C.-H. Wong, "Development of Globo-H cancer vaccine", Accounts of Chemical Research, 48 (3), 643-652, (2015).

  679. C.-C. Tsai, C.-R. Lin, H.-Y. Tsai, C.-J. Chen, W.-T. Li, H.-M. Yu, Y.-Y. Ke, W.-Y. Hsieh, C.-Y. Chang, Y.-T. Wu, S.-T. Chen, C.-H. Wong, "The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via toll-like receptor-2 signaling", J. Biol. Chem., 290 (19), 11935, (2015).

  680. H.-Y. Yen, Y.-C. Liu, N.-Y. Chen, C.-F. Tsai, Y.-T. Wang, Y.-J. Chen, T.-L. Hsu, P.-C. Yang, C.-H. Wong, "Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition", Proc. Nat. Acad. Sci. U.S.A., 12 (22), 6955-6960, (2015).

  681. C.-H. Wong, "Chemistry in Taiwan and Academia Sinica", Angew. Chem. Int. Ed., 54 (46), 13472-13473, (2015).

  682. Y.-L. Huang, F.-S. Pai, Y.-T. Tsou, H.-C. Mon, T.-L. Hsu, C.-Y. Wu, T.-Y. Chou, W.-B. Yang, C.-H. Chen, C.-H. Wong, S.-L. Hsieh, "Human CLEC18 gene cluster contains C-type lectins with differential glycan-binding specificity", J. Biol. Chem., 290 (35), 21252-21263, (2015).

  683. T.-W. Lin, H.-T. Chang, C.-H. Chen, C.-H. Chen, S.-W. Lin, T.-L. Hsu, C.-H. Wong, "Galectin-3 binding protein and galectin-1 interaction in breast cancer cell aggregation and metastasis", J. Am. Chem. Soc., 137 (30), 9685-9693, (2015).

  684. X. Li, A. Kawamura, C. Andrews, J. Miller, D. Wu; T. Tsao, M. Zhang, D. Oren, N. N. Padte, S. A. Porcelli, C.-H. Wong, S. H. I. Kappe, D. D. Ho, M. Tsuji, "Co-localization of a CD1d-binding glycolipid with a radiation attenuated sporozoite vaccine in LN-resident DCs for a robust adjuvant effect", Journal of Immunology, 195 (6), 2710-2721, (2015).

  685. C.-W. Lin, M.-H. Tsai, S.-T. Li, T.-I. Tsai, K.-C. Chu, Y.-C. Liu, M.-Y. Lai, C.-Y. Wu, Y.-C. Tseng, S. S. Shivatare, C.-H. Wang, P. Chao, S.-Y. Wang, H.-W. Shih, Y.-F. Zeng, T.-H. You, J.-Y. Liao, Y.-C. Tu, Y.-S. Lin, H.-Y. Chuang, C.-L. Chen, C.-S. Tsai, C.-C. Huang, N.-H. Lin, C. Ma, C.-Y. Wu, and C.-H. Wong, "A common glycan structure on immunoglobulin G for enhancement of effector functions", Proc. Nat. Acad. Sci. U.S.A., 112 (34), 10611-10616, (2015).

  686. J.-T. Chen, K.-L. Ku, C.-H. Chen, M. Hsiao, C.-P. Chiang, T.-L. Hsu, M.-H. Chen, and C.-H. Wong, "Glycoprotein B7-H3 as a marker for oral cancer: overexpression and aberrant glycosylation in tumor growth and immune response", Proc. Nat. Acad. Sci. U.S.A., 112 (42), 13057-13062, (2015).

  687. Y.-Y. Ke, C.-H. Tsai, H.-M. Yu, Y.-C. Jao, J.-M. Fang, C.-H. Wong, "Latifolicinin A from a fermented soymilk product and the structure-activity relationship of synthetic analogues as inhibitors of breast cancer cell growth", J Agric Food Chem., 63 (44), 9715-9721, (2015).

  688. S. K. C. Cheung, P.-K. Chuang, H.-W. Huang, W. W. Hwang-Verslues, C. H.-H. Cho, W.-B. Yang, C.-N. Shen, M. Hsiao, T.-L. Hsu, C.-F. Chang, C.-H. Wong, "Stage-specific embryonic antigen-3 (SSEA-3) and ß3GalT5 are cancer specific and significant markers for breast cancer stem cells", Proc. Nat. Acad. Sci. U.S.A., 113 (4), 960-965, (2016).

  689. S. S. Shivatare, S.-H. Chang, T.-I. Tsai, S. Y. Tseng, Y.-S. Lin, Y.-Y. Cheng, C.-T. Ren, S. Pawar, C.-S. Tsai, H.-W. Shi, Y.-F. Zeng, C.-H. Liang, P. D. Kwong, D. R. Burton, C.-Y. Wu and C.-H. Wong, "Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies", Nature Chemistry, 8 (4), 338-46, (2016).

  690. G. B. E. Stewart-Jones, C. Soto, T. Lemmin, G.-Y. Chuang, A. Druz, R. Kong, P. V. Thomas, K. Wagh, T. Zhou, A.-J. Behrens, T. Bylund, C. W. Choi, J. R. Davison, I. S. Georgiev, M. G. Joyce, Y. D. Kwon, M. Pancera, J. Taft, Y. Yang, B. Zhang, S. S. Shivatare, V. S. Shivatare, C.-C. D. Lee, C.-Y. Wu, C. A. Bewley, D. R. Burton, W. C. Koff, M. Connors, M. Crispin, B. T. Korber, C.-H. Wong, J. R. Mascola and P. D. Kwong, "Trimeric HIV-1-Env structures define glycan shields from clades A, B, and G", Cell, 165, 813-826, (2016).

  691. P.-C. Wang, J.-M. Fang, K.-C. Tsai, S.-Y. Wang, W.-I. Huang, Y.-S. Cheng, R. C., C.-H. Wong, "Peramivir phosphonate derivatives as influenza neuraminidase inhibitors", J. Med. Chem., 59 (11), 5297-5310, (2016).

  692. L. Krasnova and C.-H. Wong, "Understanding the chemistry and biology of glycosylation with glycan synthesis", Annual Review of Biochemistry, 85, 599-630, (2016).

  693. L. Krasnova and C.-H. Wong, "Exploring human glycosylation for better therapies", Molecular Aspects of Medicine, S0098-2997 (16), 30013-30019, (2016).

  694. S.-C. Yeh, P.-Y. Wang, Y.-W. Lou, K.-H. Khoo, M. Hsiao, T.-L. Hsu, C.-H. Wong, "Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity", Proc. Nat. Acad. Sci. U.S.A., 113 (20), 5592-5597, (2016).

  695. T.-C. Kuo, L.-W. Li, S.-H. Pan, J.-M. Fang, J.-H. Liu, T.-R. Cheng, C.-J. Wang, P.-F. Hung, H.-Y. Chen, T.-M. Hong, Y.-L .Hsu, C.-H. Wong, P.-C. Yang, "Purine-type compounds induce microtubule fragmentation and lung cancer cell death through interaction with katanin", J. Med. Chem., 59 (18), 8521-34, (2016).

  696. C.-H. Hsu, S. Park, D. E. Mortenson, B. L. Foley, X. Wang, R. J. Woods, D. A. Case, E. T. Powers, C.-H. Wong, H. J. Dyson, J. W. Kelly, "The dependence of carbohydrate-aromatic interaction strengths on the structure of the carbohydrate", J. Am. Chem. Soc., 138 (24), 7636-7648, (2016).

  697. D. Sok, M. Pauthner, B. Briney, J.-H. Lee, K. L. Saye-Francisco, J. Hsueh, A. Ramos, K.-M. Le, M. Jones, J. G. Jardine, R. Bastidas, A. Sarkar, C.-H. Liang, S. S. Shivatare, C.-Y. Wu, W. R. Schief, C.-H. Wong, I. A. Wilson, A. B. Ward, J. Zhu, P. Poignard, D. R. Burton, "A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 binding and its camouflaging glycans", Immunity, 45 (1), 31-45, (2016).

  698. D. T. MacLeod, N. M. Choi, B. Briney, F. Garces, L. S. Ver, E. Landais, B. Murrell, T. Wrin, W. Kilembe, C.-H. Liang, A. Ramos, C.-B. Bian, L. Wickramasinghe, L. Kong, K. Eren, C.-Y. Wu, C.-H. Wong, S. L. Kosakovsky Pond, I. A. Wilson, D. R. Burton, P. Poignard, "Early antibody lineage diversification and independent limb maturation lead to broad HIV-1 neutralization targeting the env high-mannose patch", Immunity, 44 (5), 1215-1226, (2016).

  699. S. Y. Tseng, W.-H. Cho, J. Su, S.-H. Chang, D. Chiang, C.-Y. Wu, C.-N. Hsiao, C.-H. Wong, "Preparation of aluminum oxide-coated glass slides for glycan microarray", ACS Omega, 1 (5), 773–783, (2016).

  700. T.-N. Wu, K.-H. Lin, Y.-T. Wu, J.-R. Huang, J.-T. Hung, J.-C. Wu, C.-Y. Chen, K.-C. Chu, N.-H. Lin, A. L. Yu, C.-H. Wong, "Phenyl glycolipids with different glycosyl groups exhibit marked differences in murine and human iNKT cell activation", ACS Chem. Biol., 11 (12), 3431-3441, (2016).

  701. Y.-L. Lo, G.-G. Liou, C.-H. Lu, M. Hsiao, T.-L. Hsu, C.-H. Wong, "Dengue virus infection is through a cooperative interaction between a mannose receptor and CLEC5A on macrophage as a multivalent hetero-complex", PLOS ONE, 11 (11), e0166474, (2016).

  702. Y. Kizuka, S. Funayama, H. Shogomori, M. Nakano, K. Nakajima, R. Oka, S. Kitazume, Y. Yamaguchi, M. Sano, H. Korekane, T.-L. Hsu, H.-Y. Lee, C.-H. Wong and N. Taniguchi, "High sensitivity and low toxicity fucose probe for glycan imaging and biomarker discovery", Cell Chem. Biol., 23 (7), 782-792, (2016).

  703. C.-Y. Wu, C.-W. Lin, T.-L. Tsai, C.-C. D. Lee, H.-Y. Chuang, J.-B. Chen, M.-H. Tsai, B.-R. Chen, P.-W. Lo, C.-P. Liu, V. S. Shivatare and C.-H. Wong, "Influenza A surface glycosylation and vaccine design", Proc. Nat. Acad. Sci. U.S.A., 114 (2), 280-285, (2017).

  704. T.-I. Tsai, S.-T. Li, C.-P. Liu, K. Chen, S. S. Shivatare, C.-W. Lin, S.-F. Liao, C.-W. Lin, T.-L. Hsu, Y.-T. Wu, M.-H. Tsai, M-Y. Lai, N.-H. Lin, C.-Y. Wu, C.-H. Wong, "An effective bacterial fucosidase for glycoprotein remodeling", ACS Chemical Biology, 12 (1), 63-72, (2017).

  705. J.-J. Shie, Y.-C. Liu, J.-C. Hsiao, J.-M. Fang, C.-H. Wong, "A Cell-Permeable and Triazole-forming fluorescence probe for glycoconjugate imaging in live cells", ChemComm, 53 (9), 1490-1493, (2017).

  706. W. Yang, D. Punyadarsaniya, R. Lambertz, D. Lee, C.-H. Liang, D. Höper, S. Leist, A. Hernandez-Caceres, J. Stech, M. Beer, C.-Y. Wu, C.-H. Wong, K. Schughart, F. Meng, and G. Herrler, "Mutations during the adaptation of H9N2 avian influenza virus to the respiratory epithelium of pigs enhance the sialic acid binding activity and the virulence in mice", Journal of Virology, 91 (8), pii: e02125-16, (2017).

  707. C.-L. Chen, J.-C. Hsu, C.-W. Lin, C.-H. Wang, M.-H. Tsai, C.-Y. Wu, C.-H. Wong, C. Ma, "Crystal structure of a homogeneous IgG-Fc glycoform with the N-glycan designed to maximize the antibody dependent cellular cytotoxicity", ACS Chemical Biology, 12 (5), 1335-1345, (2017).

  708. A. M. Stax, J. Tuengel, E. Girardi, N. Kitano, L. L. Allan, J. I. Alvarez, V. Li, D. Zheng, W. J. Panenka, C.-H. Wong, S. van Calenbergh, D. M. Zajonc, P. van den Elzen, "Autoreactivity to sulfatide by human invariant NKT cells", Journal of Immunology, 199 (1), 97-106, (2017).

  709. T. H. Tseng, T.-W. Lin, C.-Y. Chen, C.-H. Chen, J.-L. Lin, T.-L. Hsu, C.-H. Wong, "Substrate preference and interplay of fucosyltransferase 8 and N-acetylglucosaminyltransferases", J. Am. Chem. Soc., 139 (28), 9431-9434, (2017).

  710. Y.-W. Huang, H.-I. Yang, Y.-T. Wu, T.-L. Hsu, T.-W. Lin, J. Kelly, C.-H. Wong, "Residues comprising the enhanced aromatic sequon influence protein N-glycosylation efficiency", J. Am. Chem. Soc., 139 (37), 12947-12955, (2017).

  711. C.-Y. Ting, Y.-W. Lin, C.-Y. Wu, C.-H. Wong, "Design of disaccharide modules for the programmable one-pot synthesis of building blocks with LacNAc repeats for asymmetric N-glycans", Asian Journal of Organic Chemistry, 6 (12), 1800–1807, (2017).

  712. L.-Y. Huang, S.-C. Wang, T.-J. R. Cheng, C.-H. Wong "Undecaprenyl phosphate phosphatase activity of undecaprenol kinase regulates the lipid pool in Gram-positive bacteria", Biochemistry, 56 (40), 5417-5427, (2017).

  713. Y. Kizuka, M. Nakano, Y. Yamaguchi, K. Nakajima, R. Oka, K. Sato, C.-T. Ren, T.-L. Hsu, C.-H. Wong, N. Taniguchi, "An alkynyl-fucose halts hepatoma cell migration and invasion by inhibiting GDP-fucose-synthesizing enzyme FX, TSTA3", Cell Chem Biol., 24 (12), 1467-1478, (2017).

  714. R. Andrabi, C.-Y. Su, C.-H. Liang, S.-S. Shivatare, B. Briney, J. E. Voss, S. K. Nawazi, C.-Y. Wu, C.-H. Wong, D. R. Burton, "Glycans function as anchors for antibodies and help drive HIV broadly neutralizing antibody development", Immunity, 47 (3), 524-537, (2017).

  715. H.-W. Cheng, R.-J. Chein, T.-J. Cheng, P.-S. Wu, H.-Y. Wu, P.-F. Hung, C.-J. Wang, Y.-L. Hsu, J.-M. Wong, A. Yuan, C.-H. Wong, P.-C. Yang, S.-H. Pan, "2-anilino-4-amino-5-aroylthiazole-type compound AS7128 inhibits lung cancer growth through decreased iASPP and p53 interaction", Cancer Science, 109 (3), 832-842, (2018).

  716. C.-P. Liu, T.-I Tsai, T. Cheng, V. S. Shivatare, C.-Y. Wu, C.-Y. Wu, C.-H. Wong, "Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation", Proc. Nat. Acad. Sci. U.S.A., 115 (4), 720-725, (2018).

  717. S. S. Shivatare, V. S. Shivatare, C.-Y. Wu, C.-H. Wong, "Chemo-Enzymatic Synthesis of N-Glycans for array development and HIV antibodies profiling", Journal of Visualized Experiments, 132, (2018).

  718. W.-S. Wu, W.-C. Cheng, T.-R. Cheng, C.-H. Wong, "Affinity-based screen for inhibitors of bacterial transglycosylase", J. Am. Chem. Soc., 140 (8), 2752-2755, (2018).

  719. C.-F. Huang, K. S. Liang, T.-L. Hsu, T.-T. Lee, Y.-Y. Chen, S.-M. Yang, H.-H. Chen, S.-H. Huang, W.-H. Chang, T.-K. Lee, P. Chen, K.-E. Peng, C.-C. Chen, C.-Z. Shi, Y.-F. Hu, G. Margaritondo, T. Ishikawa, C.-H. Wong and Y. Hwu, "Free-electron-laser coherent diffraction images individual drug-carrying liposome particles in solution", Nanoscale, 10 (6), 2820-2824, (2018).

  720. V. S. Shivatare, S. S. Shivatare, C.-C. Lee, C.-H. Liang, K.-S. Liao, Y.-Y. Cheng, G. Saidachary, C.-Y. Wu, N.-H. Lin, P. D. Kwong, D. Burton, C.-Y. Wu, C.-H. Wong, "Unprecedented role of hybrid N-glycans as ligands for HIV-1 broadly neutralizing antibodies", J. Am. Chem. Soc., 140 (15), 5202-5210, (2018).

  721. T. Zhou, A. Zheng, U. Baxa, G.-Y. Chuang, I. S. Georgiev, R. Kong, S. O’Dell, S. Shahzad-ul-Hussan, C.-H. Shen, Y. Tsybovsky, R. T. Bailer, S. K. Gift, M. K. Louder, K. McKee, R. Rawi, C. H. Stevenson, G. B. E. Stewart-Jones, J. D. Taft, E. Waltari, Y. Yang, B. Zhang, S. S. Shivatare, V. S. Shivatare, C.-C. D. Lee, C.-Y. Wu, NISC Comparative Sequencing Program, J. C. Mullikin, C. A. Bewley, D. R. Burton, V. R. Polonis, L. Shapiro, C.-H. Wong, J. R. Mascola, P. D. Kwong, and X. Wu, "Structural basis of recognition by an antibody targeting the silent face of HIV envelope", Immunity, 48 (3), 500-513, (2018).

  722. X. Wang, L. Krasnova, K. B. Wu, W.-S. Wu, T.-J. Cheng, C.-H. Wong, "Towards new antibiotics targeting bacterial transglycosylase: synthesis of a lipid II analog as stable transition-state mimic inhibitor", Bioorg. Med. Chem. Lett., pii: S0960-894X (18), 30228-2, (2018).

  723. P.-W. Lo, J.-J. Shie, C.-H. Chen, C.-Y. Wu, T.-L. Hsu, C.-H. Wong, "O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2", Proc. Nat. Acad. Sci. U.S.A., 115 (28), 7302-7307, (2018).

  724. S. S. Shivatare, L.-Y. Huang, Y.-F. Zeng, J.-Y. Liao, T.-H. You, S.-Y. Wang, T. Cheng, C.-W. Chiu, P. Chao, L.-T. Chen, T.-I. Tsai, C.-C. Huang, C.-Y. Wu, N.-H. Lin, and C.-H. Wong, "Development of Endo-S2 mutants for the synthesis of homogeneous antibody glycoforms to elucidate effector functions", Chem, Comm., 54 (48), 6161-6164, (2018).

  725. S. Dey and C.-H. Wong, "Programmable one-pot synthesis of heparin pentasaccharides enabling access to regiodefined sulfate derivatives", Chemical Science, 9 (32), 6685-6691, (2018).

  726. S. Dey, S. O. Bajaj, T.-I. Tsai, H.-J. Lo, K. Wu, and C.-H. Wong, "Synthesis of modular building blocks using glycosyl phosphate donors for the construction of asymmetric N-Glycans", Tetrahedron, 74 (41), 6003-6011, (2018).

  727. S.-C. Wang, H.-Y. Liao, J.-Y. Zhang, T.-J. R. Cheng, C.-H. Wong, "Development of a universal influenza vaccine using hemagglutinin stem protein produced from Pichia pastoris", Virology, 526 (2), 125-137, (2019).

  728. C.-W. Cheng, Y. Zhou, W.-H. Pan, S. Dey, C.-Y. Wu, W.-L. Hsu, and C.-H. Wong, "Hierarchical and programmable one-pot synthesis of oligosaccharides", Nature Communications, in press, (2018).

  729. P.-K. Chuang, M. Hsiao, T.-L. Hsu, C.-F. Chang, B.-R. Chen, H.-W. Huang, S.-M. Yang, C. W. Kuo, P. Chen, P.-T. Chiu, I.-J. Chen, J.-S. Lai, C.-D. T. Yu, and C.-H. Wong, "Functional study and signaling pathway of globo-series glycosphingolipids and b1,3-galactosyltransferase V (b3GalT5) in breast cancer", Proc. Nat. Acad. Sci. U.S.A., submitted (2018).

  730. C.-H. Wong and L. Krasnova, "Highlights in chemical glycobiology", Israel Journal of Chemistry, submitted (2018).

  731. L. Krasnova and C.-H. Wong, "Oligosaccharide synthesis and translational innovation", J. Am. Chem. Soc., submitted (2018).

Patents

(Last updated: December 4, 2018)

  1. G. M. Whitesides, P. F. Mazenod, C.-H. Wong, "Preparation of 6-Deoxy-d-Fructose and 6-deoxy-L-Sorbose" US Patent No. 4,440,854 (1984).

  2. G. M. Whitesides, P. F. Mazenod, C.-H. Wong, "Preparation of 6-Deoxy-d-Fructose and 6-deoxy-L-Sorbose" US Patent No. 4,440,854 (1984).

  3. C.-H. Wong, W. J. Hennen, "Process for the enzymatic synthesis of nucleosides" US Patent No. 5075225 (1991).

  4. C.-H. Wong, Y.-F. Wang, W. J. Hennen, "Enantio- and Regioselective Synthesis of Organic Compounds Using Enol Esters as Irreversible Transacylation Reagents" US Patent No, 5106750 (1992).

  5. C.-H. Wong, J. R. Durrwachter, R. L. Pederson, "Fructose-1,6-diphosphate Aldolase Catalyzed Stereoselective Synthesis of Sugars" US Patent No. 5,143,831 (1992).

  6. P.N. Bryan, M. Pantoliano, M. L. Rollence, C.-H. Wong, "Biosynthetic uses of thermostable proteases" US Patent No. 5,116,741 (1992).

  7. C.-H. Wong, "l-Isomeric sugars having formed stereogenic centers of (R)-configuration: Methods and compositions" US Patent No. 5,162,513 (1992).

  8. C.-H. Wong, W. J. Hennen, "2-Deoxy Derivatives of N-Acetyl Neuraminic Acid and Their Preparation" US Patent No. 5,239,091 (1993).

  9. C.-H. Wong, K. K.-C. Liu, "2-Methyl-5-hydroxymethyl and 2,5-dimethyl-3,4-dihydroxypyrrolidines" US Patent No. 5,229,523 (1993).

  10. C.-H. Wong, C. W. Bradshaw, "Lactobacillus kefir alcohol dehydrogenase" US Patent No. 5,225,339 (1993).

  11. C.-H. Wong, G.-J. Shen, Y. Ichikawa, "A method and composition for synthesizing sialylated glycosyl compounds" US Patent No. 5,278,299 (1994).

  12. C.-H. Wong, T. Kajimoto, K. K.-C. Liu, L. Chen, "Process for forming Omega-deoxy-azasugars" US Patent No. 5,276,120 (1994).

  13. C.-H. Wong, K. K.-C. Liu, "Aldolase enzyme process for making 5-azido-5-deoxy-hexulose-1-phosphate" US Patent No. 5,352,591 (1994).

  14. C.-H. Wong, T. Sugai, G.-J. Shen, "KDO aldolase and condensation reactions employed therewith" US Patent No. 5,358,859 (1994).

  15. C.-H. Wong, F. Gaeta, "Combined use of b-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one-pot synthesis of oligosaccharides" US Patent No. 5,374,541 (1994).

  16. C.-H. Wong, M. Schuster, "Process for solid-phase glycopeptide synthesis" US Patent No. 5,369,017 (1994).

  17. C.-H. Wong, G. C. Look, "Enzymatic process for producing a galactosyl b-1,3-glycal disaccharide using b-galactosidase" US Patent No. 5,403,726 (1995).

  18. W. Yuan, C.-H. Wong, B. Samuelsson, "Novel tight-binding inhibitors of leukotriene A4 hydrolase" US Patent No. 5,455,271 (1995).

  19. C. W. Bradshaw, C.-H. Wong, G.-J. Shen, "Pseudomonas sp. ATCC 49794 PED alcohol dehydrogenase" US Patent No. 5,385,833 (1995).

  20. C.-H. Wong, C. W. Bradshaw, "Lactobacillus kefir alcohol dehydrogenase" US Patent No. 5,342,767 (1995).

  21. C.-H. Wong, K. K.-C. Liu, "Fructosyl C-glycoside nucleoside analogs" US Patent No. 5,393,879 (1995).

  22. C.-H. Wong, Y. Ichikawa, "Oligosaccharide enzyme substrates and inhibitors: Methods and composition" US Patent No. 5,461,143 (1995), Australian Patent No. 668505 (1996), Canadian Patent No. 2106301 (1999).

  23. C.-H. Wong, "N-Acetylgalactosaminyl or N-acetylglucosaminyl transfer using N-acetylglucosaminyl-1-phosphate or N-acetylgalactosaminyl-1-phosphate as precursor and glycosyl-nucleotide regeneration" US Patent No. 5, 516, 665 (1996).

  24. C.-H. Wong, Y.-F. Wang, W. J. Hennen, "Enantio- and regio-selective synthesis of organic compounds using enol esters as irreversible transacylation reagents" US Patent No. 5,585,252 (1996).

  25. C.-H. Wong, R. L. Pederson, Y.-F. Wang, "Azido diacetal propane derivatives" US Patent No. 5,565,585 (1996).

  26. C.-H. Wong, W. J. Hennen, "2-Deoxyderivatives of N-acetylneuraminic acid and their preparation" US Patent No. 5,554,771 (1996).

  27. C.-H. Wong, J. R. Durrwachter, R. L. Pederson, "Aldolase catalyzed stereoselective synthesis of arabinohexulose, xyloheptulose, threohexulose and xylohexulose" US Patent No. 5,576,426 (1996).

  28. C.-H. Wong, H. Kondo, "Thio Linked Glycosyl Compounds" US Patent No. 5,514,784 (1996).

  29. C.-H. Wong, H. Kondo, "Carbon Linked Glycosyl Compounds" US Patent No. 5,597,906 (1997).

  30. C.-H. Wong, T. Kajimoto, "Sialyl Lewis X mimetics" US Patent No. 5,599,915 (1997).

  31. C.-H. Wong, "Sialyl Lewis x mimetics incorporating fucopeptides" US Patent No. 5,614,615 (1997).

  32. C.-H. Wong, T. Kajimoto, K. C. Liu, L. Chen, "Omega-deoxy-azasugars" US Patent No. 5,596,005 (1997).

  33. C.-H. Wong, G. C. Look, "A facile enzymatic synthesis of galactosyl-b-1,3-glycals" Australian Patent No. 672029 (1997); Canadian Patent No. 2,139,506 (1998).

  34. C.-H. Wong, Y. Ichikawa, G.-J. Shen, "Oligosaccharide enzyme substrates and inhibitors: methods and compositions" US Patent No. 5,593,887 (1997), US Patent No. 5,759,823 (1998), US Patent No. 6,168,934 (2001), EP0576592 (2000).

  35. C.-H. Wong, "Method for synthesizing 2-ketoaldonic acids" US Patent No. 5,759,825 (1998).

  36. C.-H. Wong, S. Takayama, "Synthesis of 9-0-acetyl N-acetyl-neuraminic acid oligosaccharides" US Patent No. 5,766,887 (1998) C.-H. Wong, T. Hayashi, "Process for preparing nucleoside inhibitors of glycosyltransferases" US Patent No. 5,770,407 (1998).

  37. C.-H. Wong, H. J. M. Gijsen, "Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives" US Patent No. 5,795,749 (1998).

  38. C.-H. Wong, T. G. Marron, T. J. Woltering, G. Weitz-Schmidt, "Sialyl Lewis x mimetics incorporating mannopeptides" US Patent No. 5,837,862 (1998).

  39. C.-H. Wong, F. Moris-Varas, C.-C. Lin, "Inhibitors of E-, P-, and L-selectin binding" US Patent No. 5,830,871 (1998).

  40. C.-H. Wong, H. Kondo, "Glycosylation of peptides using glycosyl phosphite reagents" US Patent No. 5854391 (1998).

  41. C.-H. Wong, T. Kimura, "Transglycosylation reactions employing a-galactosidase" US Patent No. 5,876,981 (1999).

  42. C.-H. Wong, T. Sugai, G.-J. Shen, "Biologically pure culture of aureobacterium barkeri: KDO-37-2" US Patent No. 5, 869,316 (1999).

  43. C.-H. Wong, C.-H. Lin, G.-J. Shen, "One-pot enzymatic sulfation process using 3'-phosphoadenosine-5'-phosphosulfate and recycled phosphorylated adenosine intermediates" US Patent No. 5,919673 (1999).

  44. R. A. Lerner, C.-H. Wong, D. L. Boger, S. J. Henriksen, "Inhibitors of oleamide hydrolase" US Patent No. 5,856,537 (1999), US Patent No. 6,096,784 (2000).

  45. C.-H. Wong, C.-C. Lin, T. Kajimoto "Sialyl Lewis X mimetics incorporating fucopeptides" US Patent No. 5,962,660 (1999).

  46. C.-H. Wong, S. Takayama, B. Orsat, W. Moree, "Enantioselective enzymatic protection of amines" US Patent No. 5981267 (1999).

  47. C.-H. Wong, D. Slee, K. Laslo "HIV protease inhibitors" US Patent No. 6900238 (2005). EP0873519 (1999).

  48. C.-H. Wong, C.-C. Lin, T. Woltering "Sialyl Lewis X mimetics incorporating fucopeptides" US Patent No. 5962660 (1999).

  49. C.-H. Wong, Y. Ichikawa, G.-J. Shen, "Production of fucosylated carbohydrates by enzymatic fucosylation; synthesis of sugar nucleotides; and in situ regeneration of GDP-fucose" US Patent No. 6319695B1 (2001), Russian Patent No. 2125092 (1999).

  50. C.-H. Wong, C.-H. Lin, "Ketoaldonic acids having formed stereogenic centers of R configuration: Methods and Compositions" US Patent No. 6,080,563 (2000).

  51. C.-H. Wong, M. Hendrix, P. Alper, S. Priestley "Nucleic acid binders having a hydroxyamine motif" US Patent No. 6,120,997 (2000).

  52. C.-H. Wong, "Inhibition of human fucosyltransferases with N-Linked Lewis-X and LacNAc analogs" U.S. Patent No. 6,232,450 (2001).

  53. C.-H. Wong, M. D. Burkart "Enzymatic sulfation of biomolecules" US Patent No. 6255088 (2001).

  54. C.-H. Wong "Mannosyl transfer with regeneration of GDP-mannose" US Patent No. 6,485,930 (2002).

  55. C.-H. Wong, F. Moris-Varas "Hydroxyazepanes as inhibitors of glycosidases and HIV protease" US Patent No. 6,462,143 (2002); US Patent No. 6,462,193 (2002).

  56. C.-H. Wong, Z. Zhang, I. Ollmann, T. Bassov, X. S. Yeh "Programmable one-pot oligosaccharide synthesis" US Patent No. 6,538,117 (2003), and 7,019,131 (2006).

  57. C.-H. Wong, "Enzymatic synthesis of l-fucose and l-fucose analogs" US Patent No. 6,713,287 (2004).

  58. T. Lee, J. H. Elder, C.-H. Wong "HIV/FIV protease inhibitors with small P3 residues" PCT Patent Application No. PCT/US1998/025964, US Patent No. 6,803,466 (2004).

  59. C.-H. Wong, S. J. Sucheck "Bifunctional antibiotics" US Patent No. 6921810 (2005).

  60. F. W. Okumu, Y. Ichikawa, S.-B. Huang, M. Lotz, Y.-K. Shue, N. K. Orida, C.-H. Wong "Treatment of degenerative cartilage conditions in a mammal with glycosidase inhibitors" US Patent Application No. 10/586,578, European Patent Application No. EP20050706017, Canadian Patent Application No. CA 2553866 (2005).

  61. C.-H. Wong, D. R. Burton, I. A. Wilson "Arrays with cleavable linkers" PCT Patent Application No. PCT/US2005/022517, Australian Patent Application No. 2005258281, Canadian Patent Application No. 2571431, European Patent Application No. 2005789058, Japanese Patent Application No. 2007518318 (2005), Germany Patent Application, US Patent Application No. 11/645,273, US Patent Application No. 11/645,188 (2006).

  62. C.-H. Wong, J. Liu "Iminocyclitol inhibitors of hexoaminidase and glycosidase" US Patent No. 7135578 (2006).

  63. C.-H. Wong, C.-Y. Wu, J.-T. Jan "Anti-coronavirus compounds" US Patent No. 8,481,571 (2013), Taiwan Patent No. I372048 (2012), Chinese Patent No. CN1949977B (2010), New Zealand Patent No. NZ550945 (2010), Indonesia Patent Application No. W-00200603110, Indian Patent Application No. 1413/MUMNP/2006.

  64. Y.-Y Wang, K.-H. Khoo, S.-T. Chen, C.-C. Lin, C.-H. Wong, C.-H. Lin, H.-S. Chen, Y.-F. Tsai "Immuno-modulating antitumor activities of Ganoderma Lucidum (Reishi) polysaccharides" US Patent No. 7,135,183 (2006), US Patent No. 7,323,176 (2008), US Patent No. 7,560,114 (2009), Taiwan Patent No. I281399 (2007).

  65. Alice L. Yu, C.-H. Wong, J. T. Jan, Y.-S. E. Cheng "Anti-viral effect of an extract of Ganoderma lucidum" US Patent Application No. 11/859,729 (2007).

  66. Brik, Y.-Y. Yang, S. Ficht, R. Payne and C.-H. Wong "Method of preparing glycopeptides" PCT Patent Application No. PCT/US07/07410 (2007), US Patent No. 8,816,050 (2014), European Patent No. 1996609 (2016), Japanese Patent No. 5885378 (2016).

  67. D. T.-B. Shih, W.-Y. Chen, C.-H. Wong "Reishi-mediated enhancement of human tissue progenitor cell adhesion and differentiation" US Patent Application No. 11/859,738 (2007), US Patent Application No. 12/547,388 (2009).

  68. C.-H. Wong, R. Xu, S. R. Hanson, Z. Zhang, Y.-Y. Yang, P. G. Schultz "Site-specific incorporation of mucin-type N-acetylgalactosamine a-O-threonine into protein in E. Coli" US Patent No. 7378263 (2008).

  69. C.-H. Wong, J.-M. Fang, J.-J. Shie, Y.-S. Cheng, J.-T. Jan "Synthesis Of oseltamivir containing phosphonate congeners with anti-influenza activity" US Patent No. 7,888,337 (2011), Chinese Patent No. ZL200880113461.2 (2013), Australian Patent No. 2008292859 (2014), Japanese Patent No. 5509080 (2014), Korean Patent No. 10-1535691 (2015), PCT Patent Application No. PCT/US2008/074914 (2008), Canadian Patent No. 2697837 (2016), European Patent No. EP2190439 (2016).

  70. C.-H. Wong, M.-H. Chuang, W.-B. Yang, S.-H. Chiou "Longevity-Promoting Effects of acetic acid and Reishi polysaccharide" US Patent Application No. 12/425,319 (2009), PCT Patent Application No. PCT/US09/40879 (2009), Japanese Patent Application No. 2011505217 (2009).

  71. C.-H. Wong, C.-Y. Wu, C.-C. Wang, Alice L. Yu "Cancer diagnosis based on levels of antibodies against Globo-H and its fragments" Indian Patent Application No. 201738034602 (2017), Mexican Patent Application No. MX/a/2014/004316 (2014), Hong Kong Patent No. HK1153273 (2014), New Zealand Patent No. 590064 (2012), US Patent No. 8,158,367 (2012), PCT Patent Application No. PCT/US09/47532 (2009), Japanese Patent No. 5216139 (2013), Canadian Patent Application No. CA 2728574 (2009), Australian Patent No. 2009271411(2013), European Patent No. 2307887B1 (2014), Indian Patent Application No. 4966/KOLNP/2011 (2009), Chinese Patent No. CN102066940B (2015), Mexican Patent No. 315453 (2013), Korean Patent No. 10-1324109 (2013).

  72. C.-H. Wong, C.-Y. Wu, A. Yu, J. Yu "Globo H and related anti-cancer vaccines with novel glycolipid adjuvants" Chinese Patent Application No. 201610100376.9 (2016), Japanese Patent No. 6151319 (2017), US Patent No. 9,603,913B2 (2017), Mexican Application No. MX/a/2014/004316 (2009), Australian Patent No. 2014201215 (2016), New Zealand Patent No. 590140 (2012), US Patent No. 8,268,969 (2012), US Patent No. 9,028,836 B2 (2015), Taiwan Patent No. I392502 (2013), Taiwan Patent No. I583393 (2017), PCT Patent Application No. PCT/US2009/004519 (2009), Japan Patent No. 5795655 (2015), Japanese Patent No. 5628158 (2014), Canadian Patent Application No. 2728341 (2009), Australian Patent No. 2009269127 (2014), European Patent No. EP2310047A1 (2016), Chinese Patent No. ZL200980122743.3 (2016), Indian Patent Application No. 5005/KOLNP/2010 (2009), Korean Patent No. 10-1677279 (2016), Mexican Patent No. 319370 (2014), Hong Kong Patent Application No. 11107459.6 (2009).

  73. M. Tsuji, D. D. Ho, C.-H. Wong, D. Wu, M. Fujio, X. Li "Glycolipids and analogues thereof as antigens for NKT cells" US Patent No. 8,586,051 (2013), US Patent No. 8,163,290 (2012), US Patent No. 7,923,013 (2011), US Patent No. 7,534,434 (2009).

  74. C.-H. Wong, A. Yu, Y.-J. Chang, K.-H. Lin, J.-T. Hung "Alpha-galactosyl ceramide analogs and their use as immunotherapies" US Patent No. 7,928,077 (2011), UK Patent No. GB2461656 (2012), PCT Patent Application No. PCT/US09/50328 (2009), European Patent No. EP2320947 (2015), Philippines Patent No. 1-2011-500318 (2016), Indonesia Patent No. IDP000038138 (2015), Chinese Patent No. ZL200980138107.X (2015), Singapore Patent No. 168917 (2012), Korean Patent No. 10-1755526 (2017), Colombia Patent Application No. CO 11-016.372 (2009), Indian Patent Application No. IN 1044/DELNP/2011 (2009), South Africa Patent No. 2011/01128 (2014), Australian Patent No. 2009268381 (2016), New Zealand Patent Application No. NZ 591086 (2009), Russia Patent Application No. RU 2011105145 (2009), Canadian Patent Application No. CA 2,756,053 (2009).

  75. C.-H. Wong, C.-Y. Wu, S. Y. Tseng, "Glycan arrays on PTFE-like aluminum coated glass slides and related methods" US Patent No. 8,680,020 (2014), US Patent Application No. 14/182,290 (2014), European Patent No. EP2318832 (2013), PCT Patent Application No. PCT/US09/50754 (2009), Japanese Patent No. 5986745 (2016), Japanese Patent Application No. 2015023510 (2015), Japanese Patent Application No. 2016-169045 (2016).

  76. K.-F. Hua, H.-Y. Hsu, C.-H. Wong "Methods and compositions associated with administration of an extract of Ganoderma lucidum" US Patent No. 7,687,064 (2010).

  77. T.-R. Tu, C.-F. Li, S.-H. Su, C.-H. Wong, E. Fan "Compositions and methods for treating psoriasis by Ganoderma lucidum (Reishi) polysaccharides" US Patent No. 7,947,283 (2010).

  78. T.-R. Tu, C.-F. Li, S.-H. Su, C.-H. Wong, E. Fan "Compositions and methods for treating allergies, auto-immune diseases, and improving skin condition by Ganoderma lucidum (Reishi) polysaccharides" US Patent No. 7,785,600 (2010).

  79. C.-H. Wong, S.-L. Hsieh, T.-L. Hsu, S.-C. Cheng, S.-T. Chen "Methods and reagents for the analysis and purification of polysaccharides" US Patent No. 7998482 (2011), Taiwan Patent No. I333959 (2010).

  80. C.-H. Wong, C.-Y. Wu "Methods for modifying human antibodies by glycan engineering" US Patent Application No. 12/959,351 (2010).

  81. C.-H. Wong, C.-Y. Wu "Alpha-selective sialyl phosphate donors for preparation of sialosides and sialoside arrays for influenza virus" US Patent No. 8,507,660 (2013), PCT Patent Application No. PCT/US2010/029058 (2010), European Patent No. 2411528 (2015).

  82. C.-H. Wong, C. Ma, C.-C. Wang, J.-R. Chen "Methods and compositions for immunization against virus" Chinese Patent Application No. 201710696137.9 (2017), Korean Patent Application No. 10-2017-7031207 (2017), Israel Patent Application No. 248607 (2017), US Patent No. 8,741,311 (2014), Taiwan Patent No. I510247 (2015), PCT Patent Application No. PCT/US10/28968 (2010), Mexican Patent No. 327466 (2015), Korean Patent No. 10-1793195 (2017), Israel Patent No. 215430 (2017), EP Patent Application No. EP 10756977.4 (2010), Colombia Patent No. 30288 (2016), Chinese Patent No. ZL201080022917.1 (2017), Chile Patent Application No. CL 2354-2011 (2010), Canadian Patent Application No. CA 2,756,206 (2010), Brazil Patent Application No. BR PI10126350 (2010), Australian Patent No. 2010229675 (2016).

  83. S.-M. Liang, Y.-P. Chen, W.-B. Yang, C.-H. Wong "Reishi F3 sub fraction polysaccharides and methods of using same" US Patent No. 8,071,105 (2011).

  84. C.-H. Wong, E. Fan, H.-Y. Hsu, T.-R. Tu, W.-C. Lin, C.-F. Li, S.-T. Weng, W.-T. Wang "Reishi polysaccharide-based compositions and methods for treatment of cancer" Taiwan Patent No. I606835 (2017), PCT Patent Application No. PCT/US2011/033831 (2011).

  85. C.-H. Wong, C. A. Ma, Y.-C. Tseng "Methods for producing virus particles with simplified glycosylation of surface proteins" Australian Patent Application No. AU 2016203431 (2016), Japanese Patent Application No. 2016-200454 (2016), Mexican Patent Application No. MX/a/2017/009717 (2017), Australian Patent Application No. AU 2016204276 (2016), US Patent Application No. 15/164,968 (2016), Chinese Patent Application No. 201711437066.7 (2017), Taiwan Patent No. I537385 (2016), PCT Patent Application No. PCT/US 2011/59449 (2011), US Patent No. 9,403,878 B2 (2016), US Patent Application No. 14/182,296 (2014), Mexican Patent No. 349530 (2017), Korean Patent Application No. KR 10-2013-7014380 (2011), Japanese Patent No. 6166178 (2017), Israel Patent Application No. 226143 (2011), EP Patent Application No. EP 11838917.0 (2011), Colombia Patent Application No. CO 13.111.806 (2011), Chinese Patent Application No. 201180063980.4 (2011), Chile Patent Application No. CL2415-2014 (2011), Canadian Patent Application No. 2854619 (2011), Brazil Patent Application No. BR 1120130111984 (2011), Australian Patent Application No. AU 2011323141 (2011), Russian Patent No. 2607452 (2017).

  86. C.-H. Wong, C.-Y. Wu, C.-H. Liang, A.-S. Yang "Glycan arrays for high throughput screening of viruses" PCT Patent Application No. PCT/US2011/32192 (2011), US Patent Application No. 14/376,837 (2011).

  87. C.-H. Wong, J.-M. Fang, J.-J. Shie, Y.-S. Cheng "Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses" PCT Patent Application No. PCT/US2011/35982 (2011), US Patent Application No. 9,403,855 (2016), Korean Patent No. 10-1745386 (2017), Japanese Patent No. 5947289 (2016), European Patent No. 2568976 (2015), Chinese Patent No. ZL 201180034218.3 (2016), Australian Patent No. 2011250970 (2017), Canadian Patent Application No. 2,835,489 (2011), Chinese Patent Application No. 201510157505.3, European Patent Application No. 20150181446, US Patent Application No. 15/210,565, Korean Patent Application No. 10-2017-7014263.

  88. C.-H. Wong, Y.-T. Wu "Compounds and methods for treating tuberculosis infection" PCT Patent Application No. PCT/US2011/42217 (2011), US Patent No. 9,073,941 (2015).

  89. C.-H. Wong, T.-L. Hsu, S. Hanson, Masaaki Sawa "Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells" US Patent No. 7,960,139 (2011), US Patent Application No. 13/159,339 (2011).

  90. C.-H. Wong, T.-L. Hsu, S. Hanson "Tailored glycoproteomic methods for the sequencing, mapping and identification of cellular glycoproteins" US Patent No. 7,943,330 (2011).

  91. P.-H. Liang, Y.-L. Lin, C.-H. Wong "Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis therapeutics" US Patent No. 7,919,521 (2011), US Patent No. 8,273,788 (2012).

  92. C.-H. Wong, T.-L. Hsu, S. Hanson, M. Sawa "Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo" US Patent No. 7,910,319 (2011), US Patent No. 8,329,413 (2012).

  93. D. Ho, Y. Hung, M.-W. Chen, R. T. J. Cheng, C.-H. Wong, A. Yu "Flu vaccines and methods of use thereof" US Patent No. 7,981,428 (2011), US Patent No. 8,030,029 (2011), Taiwan Patent No. I403518 (2013).

  94. S.-L. Hsieh, C.-H. Wong, T.-L. Hsu, S.-T. Chen "Compositions and methods for identifying response targets and treating flavivirus infection responses" TW Patent No. I403586 (2013), US Patent No. 7943134 (2011), US Patent No. 8460669 (2013), CN Patent No. 1455393 (2014), BR Patent Application No. PI 0822472-2 (2014), EP Patent Application No. 08 873 539.4 (2014), IN Patent Application No. 7325/DELNP/2010 (2014).

  95. C.-H. Wong, M.-D. Tsai, Y.-T. Wu, Y.-S. E. Cheng, Y.-H. Chen, Y.-F. Shen "Influenza virus inhibitors that disrupt nucleoprotein trimerization" US Patent Application No. 13/567,355 (2012).

  96. C.-H. Wong, Y.-S. Cheng, H.-M. Yu, T.-J. Cheng, C.-Y. Wu, J.-M. Fang "Compositions and methods for treating inflammation and inflammation-related disorders by Plectranthus amboinicus extract" US Patent No. 8,105,636 (2012).

  97. C.-H. Wong, Alice L. Yu , W.-B. Yang, E. Fan, H.-Y. Hsu, P. Lee T.-R. Tu, C.-C. Hung "Hirsutella sinensis mycelia compositions and methods for treating sepsis and related inflammatory responses" US Patent No. 8,486,914 (2013).

  98. C.-H. Wong, P.-H. Liang "Quantitative microarray of intact glycolipid CD1d interaction and correlation with cell-based cytokine production" US Patent No. 8,383,554 (2013).

  99. C.-H. Wong, J.-M. Fang, W.-B. Yang, T.-J. R. Cheng, Y. S.-Y. Hsieh, C. Chien, C.-C. Lin, H.-Y. Wen "Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense" US Patent No. 8,354,127 (2013), Taiwan Patent No. I488636 (2015).

  100. Yu, J. Yu, K.-I. Lin, W.-B. Yang, C.-H. Wong "Fungal immunostimulatory compositions" Taiwan Patent No. I386220 (2013), US Patent No. US 8,906,380 B2 (2014).

  101. C.-H. Wong, J.-M. Fang, Y.-S. E. Cheng, C.-S. Tsai "Cell-permeable probes for identification and imaging of sialidases" US Patent Application No. 15/881,581 (2018), PCT Patent Application No. PCT/US2013/55472 (2013), US Patent Application No. 14/422,310(2013), EP Patent Application No. 2013831440 (2013), Japanese Patent Application No. ??2015-527678 (2013).

  102. C.-H. Wong, J.-M. Fang, J.-J. Shie "Benzocyclooctynes and their uses" PCT Patent Application No. PCT/US2013/56018 (2013), US Patent No. 9,547,009 (2017), EP Patent Application No. 20130830785 (2013), Japanese Patent No. 6211084 (2017).

  103. C.-H. Wong, J.-M. Fang, K.-C. Liu, J.-T. Jan, T.-J. R. Cheng, Y.-S. E. Cheng "Enhanced anti-influenza agents conjugated with anti-inflammatory activity" PCT Patent Application No. PCT/US2013/36308 (2013), US Patent Application No. 13/836,356 (2013), Mexican Patent Application No. MX/a/2014/012413 (2013), Korean Patent Application No. KR 10-2014-7031945 (2013), Japanese Patent Application No. ??2015-505931 (2013), Israel Patent Application No. 235117 (2013), EP Patent Application No. EP 20130775664 (2013), Chinese Patent Application No. 201380030579.X (2013), Canadian Patent Application No. 2,870,335 (2013), Australian Patent Application No. AU 2013245756 (2013).

  104. C.-H. Wong, T.-I. Tsai, C.-Y. Wu "Large scale enzymatic synthesis of oligosaccharides" Australian Patent Application No. 2018200094 (2018), Japanese Patent Application No. 2017- 75480, Australian Patent Application No. 2016206315 (2016), US Patent Application No. 15/003,362 (2016), PCT Patent Application No. PCT/US2013/55731(2013), US Patent No. 9,340,812 (2016), Taiwan Patent No. I510627 (2015), Taiwan Patent No. I563092 (2016), Taiwan Patent No. I573876 (2017), Taiwan Patent No. I563091 (2016), Taiwan Patent No. I567200 (2017), Indian Patent Application No. 365/DELNP/2015 (2013), Korean Patent No. 10-1685628 (2016), Japanese Patent No. 6125637 (2017), Hong Kong Patent Application No. 15108043.3 (2013), EP Patent Application No. EP 13 830306.0 (2013), Chinese Patent Application No. 201380044460.8 (2013), Canadian Patent Application No. 2882294 (2013), Australian Patent No. 2013305937 (2016).

  105. C.-H. Wong, T.-J. Cheng, C. Ma, W.-C. Cheng "Antibiotic compositions and related screening methods" US Patent No. 8,916,540 B2 (2014).

  106. C.-H. Wong, P.-H. Liang "Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: determination of surface and solution dissociation constants" US Patent No. 8,906,832 B2 (2014), US Patent Application No. 14/565,323 (2014).

  107. F. H. Arnold, C.-H. Wong, Y. Mitsuda, M. M. Yu Chen, C. Bennett, W. Greenberg, J. C. Lewis, S. Bastian, "Methods and compositions for preparation of selectively protected carbohydrates" US Patent No. 8,802,401 (2014).

  108. C.-H. Wong, C.-Y. Wu, C.-H. Wang, S.-T. Li "Glycan conjugates and use thereof" PCT Patent Application No. PCT/US2014/044740 (2014), US Patent Application No. 14/392,333 (2015), EP Patent Application No. 14818055.7 (2015).

  109. C.-H. Wong, C.-Y. Wu, H.-Y. Chuang, C.-T. Ren "RM2 antigens and use thereof" PCT Patent Application No. PCT/US2014/044465 (2014), US Patent Application No. 14/392,341 (2015), EP Patent No. 3013365 (2016).

  110. C.-H. Wong, C.-Y. Wu, H.-Y. Hsu, S.-F. Liao, C.-H. Liang "Antibody-mediated anti-tumor activity induced by Reishi mushroom polysaccharides" PCT Patent Application No. PCT/US2014/48325 (2014), Taiwan Patent No. I599370 (2017), US Patent Application No. 14/906,663 (2014), Chinese Patent Application No. 201480042265.6 (2014).

  111. C.-H. Wong, A. Yu, K.-H. Lin, T.-N. Wu "Human iNKT cell activation using glycolipids with altered glycosyl groups" PCT Patent Application No. PCT/US14/054617 (2014), US Patent Application No. 14/480,521 (2014), US Patent Application No. 15/689,165 (2017), Japanese Patent Application No. 2016-540472 (2016), Israel Patent Application No. 244326 (2016), Korean Patent Application No. 10-2016-7008727 (2016), EP Patent Application No. 14841728.0, Chinese Patent Application No. 201480049320.4, Canadian Patent Application No. 2923579.

  112. C.-H. Wong, Y.-W. Lou, C.-W. Lin, S.-C. Yeh, T.-L. Hsu, C.-Y. Wu, Han-Chung Wu, "Compositions and methods for treatment and detection of cancers" PCT Patent Application No. PCT/US2016/015856 (2016), US Patent Application No. 15/011,543 (2016), Taiwan Patent Application No. 105103098 (2016), PCT Patent Application No. PCT/US15/11748 (2015), US Patent Application No. 14/599,174 (2015), Taiwan Patent Application No. 104101624 (2015), Australian Patent Application No. 2015506370 (2015), Canadian Patent Application No. 2937123(2015), Chinese Patent Application No. 201580004867.7 (2015), EP Patent Application No. 20150737180(2015), Korean Patent Application No. 10-2016-7021483 (2015), Japanese Patent Application No. 2016-546791(2015), Israel Patent Application No. 246707(2015), PCT Patent Application No. PCT/US15/040,199 (2015), US Patent Application No. 14/798,312 (2015),Taiwan Patent Application No. 104122684 (2015), Australian Patent Application No. 2015377230 (2015), Canadian Patent Application No. 2972067 (2015), Chinese Patent Application No. 201580073451.0 (2015), EP Patent Application No. 15878250.8 (2015), Korean Patent Application No. 10-2017-7022487 (2015), Japanese Patent Application No. 2017-537359 (2015), Israel Patent Application No. 253162 (2015).

  113. C.-H. Wong, J.-M. Fang, J.-J. Shie "Reactive labelling compounds and uses thereof" PCT Patent Application No. PCT/US2015/022977 (2015), US Patent No. 9,759,726 B2 (2017), US Patent Application No. 15/666,242 (2015), Taiwan Patent Application No. 104110104 (2015), Japanese Patent Application No. 2016-558730 (2015), Chinese Patent Application No. 201580016671.X (2015), EP Patent Application No. 15770237.4 (2015).

  114. C.-H. Wong, C.-Y. Wu, Ming-Hung Tsai "Anti-CD20 glycoantibodies and uses thereof" PCT Patent Application No. PCT/US15/32740 (2015), US Patent Application No. 14/723,020 (2015), Taiwan Patent Application No. 104117112 (2015), Japanese Patent Application No. 2016-569717 (2015), Chinese Patent Application No. 201580027984.5 (2015), EP Patent Application No. 2015799789 (2015), Australian Patent Application No. 2015267047 (2015), Canadian Patent Application No. 2950415 (2015), Korean Patent Application No. 10-2016-7036516 (2015), Israel Patent Application No. 249186 (2015).

  115. C.-H. Wong, C.-Y. Wu "Anti-HER2 glycoantibodies and uses thereof" PCT Patent Application No. PCT/US2015/32738 (2015), US Patent Application No. 14/723,181 (2015), Taiwan Patent Application No. 104117114 (2015), Japanese Patent Application No. 2106-569745 (2015), Chinese Patent Application No. 201580027983.0 (2015), EP Patent Application No. 2015800387 (2015), Australian Patent Application No. 2015267045 (2015), Canadian Patent Application No. 2950440 (2015), Korean Patent Application No. 10-2016-7036523 (2015), Israel Patent Application No. 249188 (2015).

  116. C.-H. Wong, C.-Y. Wu "Anti-TNF-alpha glycoantibodies and uses thereof" PCT Patent Application No. PCT/US2015/32737 (2015), US Patent Application No. 14/722,775 (2015), Taiwan Patent Application No. 104117109 (2015), Japanese Patent Application No. 2016-569732 (2015), Chinese Patent Application No. 201580027936.6 (2015), EP Patent Application No. 2015800059 (2015), Australian Patent Application No. 2015267044 (2015), Canadian Patent Application No. 2950433 (2015), Korean Patent Application No. 10-2016-7036499 (2015), Israel Patent Application No. 249184 (2015).

  117. C.-H. Wong, T.-I. Tsai "Fucosidase from bacteroides and methods using the same" PCT Patent Application No. PCT/US2015/032744 (2015), US Patent Application No. 14/722,612 (2015), Taiwan Patent Application No. 104117110 (2015), Japanese Patent Application No. 2016-569720 (2015), Chinese Patent Application No. 201580027982.6 (2015), EP Patent Application No. 2015800191 (2015), Australian Patent Application No. 2015267051 (2015), Canadian Patent Application No. 2950577 (2015), Korean Patent Application No. 10-2016-7036507 (2015), Israel Patent Application No. 249183 (2015).

  118. C.-H. Wong, C.-Y. Wu, H.-Y. Lee "Novel glycan conjugates and use thereof" PCT Patent Application No. PCT/US15/46197 (2015), US Patent Application No. 15/505,763 (2017), Japanese Patent Application No. 2017-510554 (2017), Chinese Patent Application No. 201580045205.4 (2017), EP Patent Application No. 15833684.2 (2017), Australian Patent Application No. 2015305332 (2017), Canadian Patent Application No. 2959030 (2017), Korean Patent Application No. 10-2017-7007433 (2017), Mexican Patent Application No. MX/a/2017/002333 (2017), Indian Patent Application No. 201727005828 (2017), New Zealand Patent Application No. 729243 (2017), Taiwan Patent No. I587871 (2017).

  119. C.-H. Wong, A. Yu, K.-H. Lin, T.-N. Wu "Human iNKT cell activation using glycolipids" PCT Patent Application No. PCT/US2015/049014 (2015), US Patent Application No. 14/847,835 (2015), US Patent Application No. 15/866,378 (2018), Taiwan Patent Application No. 104129739 (2015), Japanese Patent Application No. 2017-513138 (2015), Chinese Patent Application No. 201580048074.5 (2015), EP Patent Application No. 15839183.9 (2015), Canadian Patent Application No. 2960712 (2015), Korean Patent Application No. 10-2017-7009106 (2015) , Israel Patent Application No. 250957 (2015), Taiwan Patent Application No. 104129739 (2015).

  120. C.-H. Wong, C.-Y. Wu, "Novel glycan conjugates and methods of use thereof" PCT Patent Application No. PCT/US2015/46420 (2015), US Patent Application No. 14/832,993 (2015), Taiwan Patent Application No. 104127439 (2015), Japanese Patent Application No. 2017-538643 (2015), Chinese Patent Application No. 201580074177.9 (2015), EP Patent Application No. 15879212.7 (2015), Australian Patent Application No. 2015378564 (2015), Canadian Patent Application No. 2972072 (2015), Korean Patent Application No. 10-2017-7023508 (2015), Israel Patent Application No. 253161 (2015).

  121. C.-H. Wong, C.-Y. Wu, C. Ma, "Compositions and methods relating to universal glycoforms for enhanced antibody efficacy" PCT Patent Application No. PCT/US2015/032745 (2015), US Patent Application No. 14/723,297 (2015), Taiwan Patent Application No. 104117111 (2015) , Japanese Patent Application No. 2016-569735 (2015), Chinese Patent Application No. 201580074177.9 (2015), EP Patent Application No. 2015799981 (2015), Australian Patent Application No. 2015267052 (2015), Canadian Patent Application No. 2950423 (2015), Korean Patent Application No. 10-2016-7036488 (2015), Israel Patent Application No. 249195 (2015), PCT Patent Application No. PCT/US2016/015858 (2016), US Patent Application No. 15/011,544 (2016), Taiwan Patent Application No. 105103073 (2016), Japanese Patent Application No. 2017-538643 (2015), Chinese Patent Application No. 201580074177.9 (2015), EP Patent Application No. 15879212.7 (2015), Australian Patent Application No. 2015378564 (2015), Canadian Patent Application No. 2972072 (2015), Korean Patent Application No. 10-2017-7023508 (2015), Israel Patent Application No. 253161 (2015).

  122. C.-H. Wong, C.-Y. Wu, Sarah K.-C. Cheung, P.-K. Chuang, T.-L. Hsu, "Cancer markers and methods of use thereof" PCT Patent Application No. PCT/US2016/014771 (2016), US Patent Application No. 15/005,930 (2016), Taiwan Patent Application No. 105102276 (2016), Japanese Patent Application No. 2017-538630 (2016), Chinese Patent Application No. 201680006858.6 (2016), Australian Patent Application No. 2016209056 (2016), Canadian Patent Application No. 2972731 (2016), Korean Patent Application No. 10-2017-7023545 (2016), Israel Patent Application No. 253160 (2016).

  123. C.-H. Wong, T.-J. Cheng, R.-J. Chein, P.-C. Yang, S.-H. Pan, "4, 9-Dioxo-4,9-dihydronaphtho[2,3-b]furan-3-carboxamide derivatives and uses thereof for treating proliferative diseases and infectious diseases" PCT Patent Application No. PCT/US17/19964 (2017), Taiwan Patent Application No. 106106701 (2017).

  124. C.-H. Wong, T.-J. Cheng, J.-M. Fang, P.-C. Yang, S.-H. Pan, L.-W. Li, "Purine compounds possessing anticancer activity" PCT Patent Application No. PCT/US2017/016453 (2017), Taiwan Patent Application No. 106103823 (2017).

  125. C.-H. Wong, C.-Y. Wu, Sachin S Shivatare, "Methods for modular synthesis of N-glycans and arrays thereof" PCT Patent Application No. PCT/US2017/021454 (2017), Taiwan Patent Application No. 106107652 (2017), US Patent Application No. 15/453,836 (2017).

  126. C.-H. Wong, C.-Y. Wu, "Recombinant virus, composition comprising the same, and uses thereof" PCT Patent Application No. PCT/US17/60510 (2017), Taiwan Patent Application No. 106138582 (2017).

  127. C.-H. Wong, C.-Y. Wu, N.-H. Lin, C.-C. Huang, L.-Y. Huang, Sachin S. Shivatare, T. Cheng, L.-T Chen, "Endoglycosidase mutants for glycoprotein remodeling and methods of using it" PCT Patent Application No. PCT/US2017/048252 (2017), Taiwan Patent Application No. 106128522 (2017), US Patent Application No. 15/684,897 (2017).

  128. C.-H. Wong, T.-J. Cheng, W.-S. Wu, "Inhibitors of bacterial transglycosylase with broad-spectrum antibacterial activities" US Patent Application No. 62/626,321 (2018).

  129. C.-H. Wong, C. Ma, T.-J. Cheng, W.-C. Cheng "Crystal structure of bifunctional transglycosylase pbp1b from E. coli and inhibitors thereof" US Patent No. 9,890,111 B2 (2018).

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