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The Wittenberg Laboratory

Selected Publications

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Travesa, A., Kalashnikova, T.I., de Bruin, R.A.M., Cass, S.R., Chahwan, C., Lee, D.E., Lowndes, N., and Wittenberg, C.  (2013).  Repression of G1-S transcription is mediated via interaction of the GTB motif of Nrm1 and Whi5 with Swi6. Mol. Cell. Biol.  in press.

Travesa, A., Kuo, D., de Bruin, R.A.M., Kalashnikova, T.I., Guaderrama, M., Thai, K., Aslanian, A., Smolka, M.B., Yates, J.R., Ideker, T., and Wittenberg, C.  (2012).  DNA replication stress differentially regulates G1/S genes via Rad53-dependent inactivation of Nrm1.  EMBO J 31, 1811-1822.

Spielewoy, N., Guaderrama, M., Wohlschlegel, J.A., Ashe, M., Yates, J.R., and Wittenberg, C.  (2010).  Npr2, yeast homolog of the human tumor suppressor NPRL2, is a target of Grr1 required for adaptation to growth under suboptimal nutrient conditions. Eukaryotic Cell 9, 592-601.

de Bruin, R., Kalashnikova, T.I., Aslanian, A., Wohlschlegel, J.A., Chahwan, C., Yates, J., 3rd, Russell, P., and Wittenberg, C.  (2008).  DNA replication checkpoint promotes G1-S-specific transcription via Cds1-dependent phosphorylation of the MBF-bound repressor, Nrm1.  Proc. Natl. Acad. Sci. USA 105, 11230-11235.

de Bruin, R., Kalashnikova, T.I., Chahwan, C., McDonald, W.H., Wohlschlegel, J.A., Yates, J., 3rd, Russell, P., and Wittenberg, C.  (2006).  Constraining G1-specific transcription to late G1-phase:  The MBF-associated corepressor Nrm1 acts via negative feedback. Molecular Cell 23, 483-496.

Wittenberg, C., and Reed, S.I. (2005).  Cell cycle-dependent transcription in yeast: promoters, transcription factors, and transcriptomes. Oncogene 24, 2746-2755.

Spielewoy, N., Flick, K., Kalashnikova, T.I., Walker, J.R., and C. Wittenberg (2004).  Regulation and recognition of SCFGrr1 targets in the glucose and amino acid signaling pathways. Mol. Cell. Biol. 24:8994-9005.

de Bruin, R., McDonald, W.H., Kalashnikova, T.I., Yates, J., 3rd, and C. Wittenberg (2004).  Cln3 Activates G1-specific Transcription by Promoting Dissociation of the SBF-Bound Repressor, Whi5. Cell 117:887-898.

Berset, C., Griac, P., Tempel, R., La Rue, J., Wittenberg, C., and Lanker, S. (2002).  Transferable domain in the G(1) cyclin Cln2 sufficient to switch degradation of Sic1 from the E3 ubiquitin ligase SCF (Cdc4) to SCF (Grr1). Mol Cell Biol 22, 4463-4476.

Hsiung, Y.G., Chang, H.C., Pellequer, J.L., La Valle, R., Lanker, S., and Wittenberg, C. (2001).  F-box protein Grr1 interacts with Phosphorylated targets via the cationic surface of its leucine-rich repeat.  Mol Cell Biol 21, 2506-2520.

Lanker, S., Valdivieso, M.H., and Wittenberg, C. (1996).  Rapid Degradation of the G1 Cyclin Cln2 Induced by CDK-Dependent Phosphorylation.  Science 271, 1597-1601.