Torbett Laboratory
The Torbett Laboratory
The Torbett Laboratory has three research areas: Evolution of HIV-1 inhibitor resistance and fitness; Hematopoietic stem and T cell gene delivery strategies to block HIV-1entry and limit infection; and The regulation of normal and abnormal myeloid development and function by the ets transcription factor PU.1 (spi). Please check the Research page for more information on our research program.
Publications
Understanding the rules of the road: proteomic approaches to interrogate the blood brain barrier. Torbett BE, Baird A, Eliceiri BP. Front Neurosci. 2015 Mar 4;9:70. eCollection 2015. Review. PMID: 25788875 PMCID: PMC 4349081
Linking the SUMO protease SENP5 to neutrophil differentiation of AML cells. Federzoni EA, Gloor S, Jin J, Shan-Krauer D, Fey MF, Torbett BE, Tschan MP. Leuk Res Rep. 2015 Apr 23;4(1):32-5. eCollection 2015. PMID: 25984443 PMCID:PMC4431638
Current Topics in Microbiology and Immunology© 2015. The Future of HIV-1 Therapeutics: Resistance Is Futile? Editors: Torbett, Bruce, Goodsell, David S., Richman, Douglas (Eds.)
Advances in targeting nucleocapsid-nucleic acid interactions in HIV-1 therapy. Garg, D., Torbett, B.E. Virus Res. 2014 Jul 12. pii: S0168-1702(14)00270-6. PMID: 25026536 PMCID:PMC4252855
Deep sequencing of protease inhibitor resistant HIV patient isolates reveals patterns of correlated mutations in Gag and protease. Flynn WF, Chang MW, Tan Z, Oliveira G, Yuan J, Okulicz JF, *Torbett BE, *Levy RM. PLoS Comput Biol. 2015 Apr 20;11(4):e1004249. doi: 10.1371/journal.pcbi.1004249. eCollection 2015 Apr. PMID: 25894830 Free PMC Article Related citations Select item 25788875 PMCID: PMC4404092
Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells. Wang CX, Sather BD, Wang X, Adair J, Khan I, Singh S, Lang S, Adams A, Curinga G, Kiem HP, Miao CH, Rawlings DJ, Torbett BE. Blood. 2014 Aug 7;124(6):913-23. Epub 2014 Jun 9. PMID: 24914132 PMCID:PMC4126331
Rapid deep sequencing of patient-derived HIV with ion semiconductor technology. Chang MW, Oliveira G, Yuan J, Okulicz JF, Levy S, Torbett BE. J Virol Methods. 2013 Apr;189(1):232-4. Epub 2013 Feb 4. PMID: 23384677 PMCID:PMC3608812
Role of the mammalian target of rapamycin pathway in lentiviral vector transduction of hematopoietic stem cells. Wang, CX. Torbett, BE. Curr Opin Hematol. 2015 Jul;22(4):302-308. PMID:26049750
Department of
Immunology and Microbiology
The Scripps Research Institute
Director, Molecular Basis of Viral PathogenesisTraining Grant
Co-Director, CFAR Protein Expression and Proteomics Core
10550 North Torrey Pines Road, MEM-131
La Jolla, CA 92037
Phone: (858) 784-9123
FAX: (858) 784-7714