•   Mailing Address
    The Scripps Research Institute
    130 Scripps Way #3C1
    Jupiter, Florida 33458

  •   Phone and Fax Numbers
    Lab      (561) 228-2104
    Admin  (561) 228-3509
    Fax      (561) 228-2107


View Dr. Subramaniam's publications in PubMed by clicking here.


Shahani N, Huang WC, Varnum M, Page DT, Subramaniam S*. Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice. Neurobiology of aging. 2017;50:134-43. doi: 10.1016/j.neurobiolaging.2016.11.006. *Corresponding author.


Shahani N, Swarnkar S, Giovinazzo V, Morgenweck J, Bohn L, Scharager-Tapia C, Pascal B, Martinez-Acedo P, Khare K and Subramaniam S.* RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum. Science signaling. 2016;9(454):ra111. doi: 10.1126/scisignal.aaf6670. *Corresponding author


Swarnkar S, Chen Y, Pryor WM, Shahani N, Page D, Subramaniam S* (2015). Ectopic Expression of the Striatal-enriched GTPase Rhes Elicits Cerebellar Degeneration and an Ataxia Phenotype in Huntington's Disease. Neurobiology of Disease. 82:66-77. *Correspondence.

Tyagi, R#, Shahani N#,Gorgen L, Ferretti M, Pryor W, Chen, PY, Swarnkar, S, Worley PF, Karbstein K, Snyder SH* and Subramaniam S* (2015). Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade. Cell Reports. 10(5):684-693. *Correspondence

Shahani N, Seshadri S, Jaaro-Peled H, Ishizuka K, Hirota-Tsuyada Y, Wang Q, Koga M, Sedlak TW, Korth, C, Brandon NJ, Kamiya A, Subramaniam S, Tomoda T, Sawa A (2015). DISC1 regulates trafficking and processing of APP and Aβ generation. Molecular Psychiatry. 20(7):874-879.


Pryor WM, Biagioli M, Shahani N, Swarnkar S, Huang WC, Page DT, MacDonald ME, Subramaniam S*. (2014) Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease.  Science  Signaling. 7(349):ra103. *Corresponding author. (F100selection)

Shahani N, Pryor W, Swarnkar S, Kholodilov N, Thinakaran G, Burke RE, Subramaniam S* (2014) Rheb GTPase Regulates β-Secretase Levels and Amyloid β Generation J Biol Chem289(9):5799.  *Corresponding author

Mealer RG, Murray AJ, Shahani N, Subramaniam S*, Snyder SH. (2014) Rhes, a Striatal-Selective Protein Implicated in Huntington Disease, Binds Beclin-1 and Activates Autophagy. J Biol Chem. 289(6):3547. *Co- correspondence

Narayanan KL, Subramaniam S, Bengston CP, Irmady K, Unsicker K, von Bohlen Und Halbach O. (2014) Role of Transient Receptor Potential Channel 1 (TRPC1) in Glutamate-Induced  Cell  Death  in  the  Hippocampal  Cell  Line HT22 . J Mol Neurosci. 52(3):425


Mealer RG, Subramaniam S and Snyder SH. (2013). Rhes deletion is neuroprotective in 3-nitropropionic acid (3NP) toxin mouse model of Huntington’s disease. J Neurosci. 33(9):4206


Srinivasa  Subramaniam*,  Francesco  Napolitano*,  Robert  G.  Mealer,  Seyun  Kim,  Francesco  Errico,  Roxanne Barrow, Neelam Shahani, Richa Tyagi, Solomon H. Snyder and Alessandro Usiello. (2012). Rhes, a striatal-enriched small G-protein, mediates mTOR signaling and L-DOPA-induced dyskinesia. Nature Neuroscience. 15(2):191. *First authors (F1000 selection)


Subramaniam S and Snyder SH. (2010). Huntington’s disease is a disorder of corpus striatum: Focus on Rhes (Ras homologue enriched in the striatum). Neuropharmacology, 60(7-8):1187

Subramaniam S*, Mealer R*, Sixt KM, Barrow R, Usiello A & Snyder SH. (2010). RHES, a physiological regulator of sumoylation, mediates cross-sumoylation among basic sumo enzymes E1 and  Ubc9. J Bio. Chem. 285, 20428.*Contributed  equally

Subramaniam S* & Unsicker K. (2010). ERK in cell death: ERK1/2 in neuronal death (review). FEBS J, 277, 22. *Corresponding  author


Subramaniam S, Sixt KM, Barrow R and Snyder SH. (2009). Rhes, a Striatal Specific Protein, Mediates Mutant- Huntingtin Cytotoxicity. Science 324, 1327. (F1000 selection)

Alavian KN, Sgado P, Alberi L, Subramaniam S & Simon HH. (2009). Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Dev 4, 11


Subramaniam S*, Strelau J & Unsicker K. (2008). GDNF prevents TGF-beta-induced damage of the plasma membrane in cerebellar granule neurons by suppressing activation of  p38-MAPK  via  the  phosphatidylinositol  3- kinase pathway. Cell Tissue Res 331, 373. *Corresponding author

Narayanan KL, Irmady K, Subramaniam S, Unsicker K & von Bohlen und Halbach O. (2008). Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death. Neurosci Lett 446, 117

Subramaniam  S*  &  Unsicker  K.  (2006).  Extracellular  signal-regulated  kinase  as  an  inducer  of  non-apoptotic neuronal death. Neuroscience 138, 1055-1065 (review). *Corresponding author

Shahani N, Subramaniam S, Wolf T, Tackenberg C & Brandt R. (2006). Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. J Neurosci26, 6103

Shahani  N,  Subramaniam  S  &  Brandt  R.  (2006).  Purification  of  MINUS:  A  negative  regulator  of  microtubule nucleation in a variety of organisms. Int. J Biol. Macromol. 39, 15

Subramaniam S*, Shahani N, Strelau J, Laliberte C, Brandt R, Kaplan D & Unsicker K. (2005). Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3- kinase/protein kinase A/c-Raf pathway. J Neurosci 25, 2838. *Corresponding author

Subramaniam  S*,  Zirrgiebel  U,  von  Bohlen  Und  Halbach  O,  Strelau  J,  Laliberte  C,  Kaplan  DR  &  Unsicker  K. (2004).  ERK  activation  promotes  neuronal  degeneration  predominantly  through  plasma  membrane  damage  and independently of caspase-3. J Cell Biol 165, 357. *Corresponding author

Subramaniam  S*,  Strelau  J*  &  Unsicker  K.  (2003).  Growth  differentiation  factor-15  prevents  low  potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways. J Biol Chem 78, 8904. *Contributed equally

Scholzke  MN,  Potrovita  I,  Subramaniam  S,  Prinz  S  &  Schwaninger  M.  (2003). Glutamate  activates  NF-kappaB through calpain in neurons. Eur J Neurosci 18, 3305

Schuster N, Bender H, Philippi A, Subramaniam S, Strelau J, Wang Z & Krieglstein K. (2002). TGF-beta induces cell death in the oligodendroglial cell line OLI-neu. Glia 40, 95