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P450 image


Dave Stout's Lab

We use X-ray crystallography to study the structure and function of the membrane bound mitochondrial enzyme, transhydrogenase, understand the mechanism of the vitamin D metabolizing cytochrome P450, CYP24A1, and enable drug design against HIV protease. Collaborative projects focus on the mechanism of O2 reduction by cytochrome ba3 oxidase, and the basis of substrate specificity in cytochrome P450's.

Scientific research is a community activity that involves interaction, cooperation, training and mentoring. To embrace the stimulating environment for learning and discovery at Scripps, our laboratory engages in a number of collaborative research projects. These provide a context for graduate students and postdoctoral fellows to share ideas, results, and methods. Almost always, communication of overlapping interests and challenges leads to new insights, and increases the excitement of doing research.

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