High-Throughput Molecular Screening Center

Jupiter, Florida Campus

High-Throughput Screening (HTS) is a drug-discovery process widely used in both academia and the pharmaceutical industry. It leverages automation to quickly assay the biological or biochemical activity of a large number of drug-like compounds for the discovery of novel small molecule ligands against: receptors, enzymes, ion-channels and other pharmacological targets, or to pharmacologically profile a cellular or biochemical pathway of interest. Typically, HTS assays are performed in "automation-friendly" microtiter plates at 384 or 1536 well format against large chemical decks with thousands to a few million small molecule entities.

The Scripps Research HTS facility on the Florida campus has a state-of-the-art HTS operation to support both intramural and extramural HTS needs. This facility has both HTS and compound management robotic automation combined with world class expertise in adapting cell-based and biochemical bench-top assays for HTS (target-based and phenotype screening). The Scripps Drug Discovery Library contains over 665,000 small drug-like compounds, including a number of diversity and target-based sub-libraries. Access to the HTS is easy and obtainable via collaborations as funded through grants and special funding proposals or through fee-for-service initiatives.

To request use of the Scripps Research's Florida-based HTS technology, please contact us or visit our SRMSC website. Additional information about grant mechanisms that support High Throughput Screening can also be found at this website.