Drug Metabolism and Pharmacokinetics (DMPK) Core

Jupiter, Florida Campus

Whether you use chemical tools to probe fundamental biological mechanisms or are looking to move an initial lead into clinical trials, the DMPK core can help. Optimizing potency and selectivity are only the beginning of the process. The in vivo utility, or “drugability,” of a compound requires the molecule to reach target tissues at sufficient concentration to elicit the desired biological effect. The impact of solubility, permeability, non-specific binding, metabolic stability, drug transporters, species-specific differences, vehicle choice, and dosing route all influence experiment success. Why start a month-long efficacy study with dozens of mice before knowing the planned doses yield sufficient drug concentrations? Why spend a year improving target potency only to find the choices made to improve potency incorporated significant metabolic liabilities into the molecule? 

Experiments can be modified to fit the specific needs of your project. Direct grant support and fee-for-service models are available. Grant assistance with the description of DMPK assays and how to incorporate the assays into your compound progression plan is available.