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Human Genetics and Genomics

The focus of this course will be on the human genome and in particular on naturally occurring DNA sequence variations and their impact on molecular physiology, clinical phenotypic expression, the diversity of populations, human evolution, clinic practice and ethical issues. Basic DNA sequencing, genotyping technologies and their research and clinical applications will be discussed, as will genetic (meiotic) mapping strategies for identifying DNA sequence variations that influence phenotypic expression. The classes each week will be paired, with one didactic lecture to be offered on Monday and one student-led discussion-oriented session involving two papers of relevance to the topic covered in the didactic lecture on Wednesday. Of the two papers presented on Wednesday, one will be a ‘classic’ paper and one a contemporary, high-impact paper. Students will be graded on their participation, presentations, a mid-term exam and a final exam.

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SPPS 219/Pharm 235 Pharmacogenomics

Intro to Statistical Genetics and Quantitative Genomics: Application to Pharmocogenomics

BIOM 262: Quantitative Methods in Genetics

Geneaological and Pedigree Analysis

FPM237 Microarray (Genomics) Techonology and Informatics

Microarray Applications in the Health Sciences