•   grumbaug@scripps.edu



Nonmuscle myosin IIB as a therapeutic target for the prevention of relapse to methamphetamine use. 

Young EJ, Blouin AM, Briggs SB, Sillivan SE, Lin L, Cameron MD, Rumbaugh G, Miller CA. 

Mol Psychiatry. 2016 May;21(5):615-23. doi: 10.1038/mp.2015.103. Epub 2015 Aug 4.

Prioritizing the development of mouse models for childhood brain disorders. 

Ogden KK, Ozkan ED, Rumbaugh G. 

Neuropharmacology. 2016 Jan;100:2-16. doi: 10.1016/j.neuropharm.2015.07.029. Epub 2015 Jul 29. Review


Input-specific regulation of hippocampal circuit maturation by non-muscle myosin IIB. 

Ozkan ED, Aceti M, Creson TK, Rojas CS, Hubbs CR, McGuire MN, Kakad PP, Miller CA,Rumbaugh G. 

J Neurochem. 2015 Aug;134(3):429-44. doi: 10.1111/jnc.13146. Epub 2015 May 29.

Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue. 

Rumbaugh G, Sillivan SE, Ozkan ED, Rojas CS, Hubbs CR, Aceti M, Kilgore M, Kudugunti S, Puthanveettil SV, Sweatt JD, Rusche J, Miller CA. 

Neuropsychopharmacology. 2015 Sep;40(10):2307-16. doi: 10.1038/npp.2015.93. Epub 2015 Apr 3.

Neuronal death induced by misfolded prion protein is due to NAD+ depletion and can be relieved in vitro and in vivo by NAD+ replenishment. 

Zhou M, Ottenberg G, Sferrazza GF, Hubbs C, Fallahi M, Rumbaugh G, Brantley AF, Lasmézas CI. 

Brain. 2015 Apr;138(Pt 4):992-1008

Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly. 

Aceti M, Creson TK, Vaissiere T, Rojas C, Huang WC, Wang YX, Petralia RS, Page DT, Miller CA,Rumbaugh G. 

Biol Psychiatry. 2015 May 1;77(9):805-15.


Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons.

Ozkan ED, Creson TK, Kramár EA, Rojas C, Seese RR, Babyan AH, Shi Y, Lucero R, Xu X, Noebels JL, Miller CA, Lynch G, Rumbaugh G. 

Neuron. 2014 Jun 18;82(6):1317-33.

Methamphetamine-associated memory is regulated by a writer and an eraser of permissive histone methylation.

Aguilar-Valles A, Vaissière T, Griggs EM, Mikaelsson MA, Takács IF, Young EJ, Rumbaugh G, Miller CA. 

Biol Psychiatry. 2014 Jul 1;76(1):57-65.

Selective, retrieval-independent disruption of methamphetamine-associated memory by actin depolymerization.

Young EJ, Aceti M, Griggs EM, Fuchs RA, Zigmond Z, Rumbaugh G, Miller CA. 

Biol Psychiatry. 2014 Jan 15;75(2):96-104.


SYNGAP1 links the maturation rate of excitatory synapses to the duration of critical-period synaptic plasticity.

Clement JP, Ozkan ED, Aceti M, Miller CA, Rumbaugh G. S

J Neurosci. 2013 Jun 19;33(25):10447-52.

MicroRNA-182 Regulates Amygdala-Dependent Memory Formation. 

Griggs EM, Young EJ, Rumbaugh G, Miller CA. 

J Neurosci. 23;33(4):1734-40.


Pathogenic SYNGAP1 mutations impair cognitive development by disrupting the maturation of dendritic spine synapses. 

Clement JP, Aceti M, Creson TK, Ozkan ED, Shi Y, Reish NJ, Almonte AG, Miller BH, Wiltgen BJ, Miller CA, Xu X, Rumbaugh G. 

Cell. Nov 9;151(4):709-23.

Differences between synaptic plasticity thresholds result in new timing rules for maximizing long-term potentiation. 

Lynch G, Kramár EA, Babayan AH, Rumbaugh G, Gall CM. 

Neuropharm. In Press

Synaptic Evidence for the Efficacy of Spaced Learning. 

Kramár EA, Babayan AH, Gavin CF, Cox CD, Jafari M, Gall CM, Rumbaugh G, Lynch G. 

Proc Natl Acad Sci. 109(13): 5121-6.

Myosin II motor activity in the lateral amygdala is required for fear memory consolidation.

Gavin CF, Rubio MD, Young E, Miller C, Rumbaugh G. 

Learn Mem. Dec 14; 19(1): 9-14. Print 2012 Jan


Regulation of Synapse Structure and Function by Distinct Myosin II Motors. 

Rubio MD, Johnson R, Miller CA, Huganir RL, Rumbaugh G. 

J Neurosci. 31(4): 1448-60.


Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation. 

Rex CS, Gavin CF, Rubio MD, Kramar EA, Chen LY, Jia Y, Huganir RL, Muzyczka N, Gall CM, Miller CA, Lynch G, Rumbaugh G. 

Neuron. 67(4): 603-617. (Cover article)

Cortical DNA methylation maintains remote memory. 

Miller CA, Gavin CF, White JA, Parrish RR, Honasoge A, Yancey CR, Rivera IM, Rubio MD, Rumbaugh G, Sweatt JD. 

Nat Neurosci.  13(6): 664-6. (F1000 selection)

Class 1 histone deacetylase inhibitors reverse contextual memory deficits in a mouse model of Alzheimer’s disease. 

Kilgore M, Miller CA, Haggarty SJ, Sweatt JD, Rumbaugh G. 

Neuropsychopharmacology. 35: 870-880. (Cover article, F1000 selection)


Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia.

Funk AJ, Rumbaugh G, Harotunian V, McCullumsmith RE, Meador-Woodruff JH. 

Neuroreport. Jul 15; 20(11): 1019-22.

Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of schizophrenia. 

Guo X, Hamilton PJ, Reish NJ, Sweatt JD, Miller CA, Rumbaugh G. 

Neuropsychopharmacology. 34(7): 1-12.


Surface Mobility of Postsynaptic AMPARs Tunes Synaptic Transmission. 

Heine M, Groc L, Frischknecht R, Béïque JC, Lounis B, Rumbaugh G, Huganir RL, Cognet L, Choquet D. 

Science. 320 (1): 201 – 205.


Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans.

Wu Y, Arai AC, Rumbaugh G, Srivastava AK, Turner G, Hayashi T, Suzuki E, Jiang Y, Zhang L, Rodriguez J, Boyle J, Tarpey P, Raymond FL, Nevelsteen J, Froyen G, Stratton M, Futreal A, Gecz J, Stevenson R, Schwartz CE, Valle D, Huganir RL, Wang T.

Proc Nat’l Acad Sci U S A. Nov 13; 104(46): 18163-8.


Arc regulates homeostatic synaptic scaling of AMPA receptors in cultured neurons. 

Shepherd JS, Rumbaugh G, Chowdhury A, Huganir RL, Worley P. 

Neuron. 52(3): 475-484.*Equal contribution (Cover article, Featured article, F1000 selection)

SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons. 

Rumbaugh G, Adams JP, Kim JH, Huganir RL. 

PNAS 21; 103(12): 4344-51 (Featured article)


Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein.

Rumbaugh G, Tao YX, Wang GD, Petralia RS, Zhao C, Kauer FW, Tao F, Zhuo M, Wenthold RJ, Raja SN, Huganir RL, Bredt DS, Johns RA. 

J Neurosci 23(17): 6703-12.*Equal contribution

Synapse-associated protein-97 isoform-specific regulation of surface AMPA receptors and synaptic function in cultured neurons. 

Rumbaugh G, Sia GM, Garner CC, Huganir RL. 

J Neurosci 23(11): 4567-76.

Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. 

Lee HK, Takamiya K, Han JS, Man H, Kim CH, Rumbaugh G, Yu S, Ding L, He C, Petralia RS, Wenthold RJ, Gallagher M, Huganir RL. 

Cell112(5): 631-43.


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