Rumbaugh Lab

The Contribution of Synaptic Plasticity to Memory, Cognition and Disease

Our lab has identified several genes that are critical regulators of synaptic function. These genes also increase the risk for developing neurodevelopmental disorders of cognition and sociability, such as intellectual disability and autism spectrum disorders. These genes encode proteins that regulate synaptic properties during critical periods of neurodevelopment. Current studies in the lab are aimed at understanding how disruptions in synaptic properties during these developmentally sensitive periods lead to alterations in cognition, memory and sociability. Based on these studies, we hope to develop novel therapeutic strategies to improve brain function in patients with autism spectrum disorders and intellectual disability.