Welcome to the Romesberg Lab

Scripps Research, California

Who we are What we do
  • arylomycin A-C16
  • ubp
  • anti-HNE aptamer
  • anti-HNE aptamer

Romesberg lab research

We use chemistry, biochemistry, molecular biology, microbiology, and spectroscopy to understand how evolution tailors protein function, to improve on evolution through the expansion of the genetic alphabet, and to develop novel antibiotics and aptamers.

Antibiotics

Can we unmask broad-spectrum activity from old natural products?

Alphabet

What happens when bacteria store information using a six-letter alphabet?

SELEX

How can we evolve stable polymers to bind any target?

Biophysics

What is the relationship between protein dynamics and function?


Recent Publications

compound in vial

SI Walsh, et al., AAC

SSO

VT Dien, et al., JACS

SSO

Zhang & Romesberg, Biochemistry

penem

CH Yeh, et al., ACSMCL