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Pathogenesis Affinity Group

The Pathogenesis Affinity Group meets to provide a forum for intellectual enrichment, scientific discussion, and exchange of ideas among scientists studying diverse aspects of animal and plant virology, , viral immunology and viral pathogenesis. Scripps Research scientists and outside guest speakers are invited to present their experimental data. The areas of interest are (1) study of virus-host cell interactions and genetics; (2) defining the molecular basis of viral persistence; (3) analysis of virus-immune cell interactions with resultant immunosuppression or autoimmunity; (4) analysis of mechanism(s) whereby viruses cause acute, chronic-degenerative and demyelinating diseases; (5) mapping of neural tracts and studying virus-CNS cell interactions; (6) development of antiviral therapies and vaccines; and (7) targeting drugs into the central nervous system by use of viruses as carriers.

Additionally, the Pathogenesis Affinity Group hosts an annual day retreat.

Upcoming Events  *

The Dixon Lecture, Thursday, February 23, 2017 from 4:00 – 6:00 pm 

Speaker: Dr. Klaus Rajewsky

Head, Immune Regulation and Cancer Group, Max-Delbrück-Center for Molecular Medicine, Berlin

The Auditorium at TSRI, 10640 John Jay Hopkins Drive, The Scripps Research Institute, La Jolla, CA 

Pathogenesis Affinity Group Lecture, Monday, March 13, 2107 from 4:00 – 5:00 pm

Speaker: Ralph Baric, Ph.D.

Professor at Chapel Hill - University of North Carolina School of Medicine is Head of the Collaborative Cross (CC) Genetic Program.

Host Genetic Regulation of SARS-CoV Pathogenesis in the Collaborative Cross

Collaborative Cross is a forward genetic strategy that employs genetic, biochemical, molecular and immunologic approaches to study viral evolution, immunity and host interactions.  Founder mice and genetic crosses and clusters, along with SNPs are tools on hand that allow mapping of the mouse genome. The majority of Baric's contributions have been in understanding the basic pathogenesis of coronaviruses, especially SARS and MERS.  He has also pioneered observations with noroviruses, flaviviruses (Dengue), and influenza in conjunction with host susceptibility/resistant alleles as well as studies for TLR3, TLR4, TRIFF, Trim55, and Serpine1.

This lecture is funded by Sun Lee and his family.  Sun Lee was a master of and internationally known for his contributions, work and teaching in the field of organ microsurgery.  He was recruited in 1994 by Frank Dixon, the first Director of The Scripps Research Institute (formerly called Scripps Clinic and Research Foundation) and Head of the Department of Experimental Pathology that became the Department of Immunology.  Lee performed whole kidney transplants, thymectomies, and parabiosis surgeries to assist many colleagues during his 15 years at Scripps before leaving for a professorship at UCSD.  Sun Lee passed away in 2015. 

The Committee Lecture Hall - MBB2N, The Skaggs Institute Building (MBB), The Scripps Research Institute, La Jolla, CA

Unless noted otherwise, all seminars are held 12:00 to 1:00 pm. at:

The Scripps Research Institute, La Jolla, CA
The Skaggs Institute Building (MBB)


The PAG mailing list is primarily for subscribers to receive notification of regularly scheduled meetings, schedule changes/cancellations, and scheduling appointments to meet with invited speakers.

Pathogenesis Affinity Group Members

Pathogenesis Series Presentations on the Scripps Talks Calendar

See Salk Institute Calendar

San Diego Biotechnology Calendar