Scripps Research Joint Appointments

Associate Professor, Department of Metabolism & Aging
Faculty, Graduate Program

Research Focus

The main emphasis of the research in the laboratory is on the fundamental principles that regulate signaling via G protein coupled receptors (GPCR). GPCRs mediate a vast variety of critical biological processes ranging from proliferation and motility to cellular reception and excitability. GPCR signaling pathways are of particular importance for the nervous system function where they control many fundamental processes including excitability, differentiation, sensory perception, and synaptic transmission. Importantly, but not surprisingly, even a subtle imbalance in GPCR signaling often leads to the most profound nervous system disorders ranging from blindness and cognitive problems to grave neurological diseases.

Specifically, our laboratory is interested in understanding the intricate regulatory dynamics of G protein pathways in the following two neuronal systems.

• Basal ganglia where G proteins mediate reward behavior and movement coordination underlying not only addictive effects of abused drugs such as opioids and cocaine but also dysfunctions observed in movement disorders such as Parkinson's disease, Huntington’s disease, Tourette syndrome, and tardive dyskinesia.
• Retina where G protein signaling systems of primary sensory neurons, photoreceptors, and downstream ON-bipolar cells act in tandem to generate responses to light and synaptically encode them to enable our vision. Dysfunctions in these processes are known to be the leading causes of a range of ocular pathologies including macular degeneration and congenital night blindness.

Much of our current efforts are focused on a family of key regulators of GPCR signaling pathways, the Regulator of G protein Signaling (RGS) proteins. RGS proteins constitute a large family of proteins that promote G protein inactivation by facilitating their GTP hydrolysis thus ensuring timely inactivation of the GPCR responses.  Many members of the RGS family have been clinically linked to human disease conditions that have been recapitulated in the genetic mouse models.  Serving as a central control point in GPCR signaling cascades, RGS proteins hold great promises as targets for the drug development. This brings the major emphasis of our research on elucidating molecular and cellular mechanisms of RGS proteins function in cellular signaling in addition to the efforts to uncover novel regulatory principles.

Research directions in the laboratory include discovery and characterization of novel G protein regulators, delineation of protein-protein interactions, feedback mechanisms, and logistics of signaling pathway organization. In our research, we use a range of multidisciplinary approaches involving identification of components of signaling complexes by proteomics, measurement of protein functional activity by in vitro enzyme kinetics, analysis of synthesis, trafficking and degradation of signaling proteins in cell culture and behavioral characterization of genetic mouse models with altered components of G protein signaling machinery.

Education

B.Sc., Biochemistry, Samara State University, Russia, 1996
M.Sc., Molecular Biology, Pushchino State University, Russia, 1998
Ph.D., Molecular Biology, Institute of Protein Research, Russian Academy of Sciences, 2000

Professional Experience

Awards & Professional Activities

• 1998        European Academy Prize in Biology


• 1999        Russian Biochemical Society Award


• 2008        McKnight Land-Grant Professorship


• 2009        Independent Scientist Award, National Institute on Drug Abuse


• 2014        Cogan Award, Association for Research in Vision and Ophthalmology


• 2015        Cutting Edge Basic Research Award (CEBRA), National Institute on Drug Abuse


• 2015        Joseph M. Bryan Distinguished Lectureship in Ophthalmology, Duke University


• 2016        Wallace O. Fenn Lectureship in Pharmacology, University of Rochester


• 2018        John J. Abel Award, ASPET

Selected References

Song, C., Anderson, G.R., Sutton, L.P., Dao, M., Martemyanov, K.A. (2018) Selective role of RGS9-2 in regulating retrograde synaptic signaling of indirect pathway medium spiny neurons in dorsal striatum. J. Neurosci. pii: 0493-18. doi: 10.1523/JNEUROSCI.0493-18.2018. [Epub ahead of print]  PMID: 30006367

Masuho, I., Chavali, S., Muntean, B.S., Skamangas, N.K., Simonyan, K., Patil, D. N., Kramer, G.M., Ozelius, L., Babu, M.M., Martemyanov, K.A. (2018) Molecular deconvolution platform to establish disease mechanisms by surveying GPCR signaling. Cell Reports 24, 557-568.  PMID:  30021154

Dunn, H.A., Patil, D.N., Cao, Y., Orlandi, C., Martemyanov, K.A. (2018) Synaptic adhesion protein ELFN1 is a selective allosteric modulator of group III metabotropic glutamate receptors in trans. Proc Natl Accad Sci USA. 115, 5022-5027.  PMCID:PMC594899

Gulati, S., Masuho, I., Orban, T., Cai, Y., Pardon, E., Martemyanov, K.A., Kiser, P.D., Stewart, P.L., Ford, C.P., Steyaert, J., and Palczewski, K. (2018) Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 9, 1996  PMCID:PMC47362

Martemyanov, K.A., Garcia-Marcos, M. (2018) Making useful gadgets with miniaturized G proteins. J Biol Chem. 293, 7474-7475.   PMCID:PMC5949992

Kulkarni, K., Xie, X., Fernandez de Velasco, EM.., Anderson, A., Martemyanov, K.A., Wickman, K., Tolkacheva, E.G. (2018) The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart. PLos One 13, e0193798.  PMCID:PMC5905881

Muntean, B.S., Patil, D.N., Madoux, F., Fossetta, J., Scampavia, L., Spicer, T.P., Martemyanov, K.A. (2018) A high-throughput time-resolved fluorescence energy transfer assay to screen for modulators of RGS7/Gβ5/R7BP complex. Assay and Drug Development Technologies. 3,150-161. PMCID:PMC5906730

Marcott, P.F., Gong, S., Donthamsetti, P., Grinnell, S.G., Nelson, M.N., Newman, A.H., Birnbaumer, L., Martemyanov, K.A., Javitch, J.A., Ford, C.P. (2018) Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens. Neuron 98, 575-587  PMCID:PMC6048973

Spicer, T.P., Hubbs, C., Vaissiere, T., Collia, D., Rojas, C., Kilinc, M., Vick, K., Madoux, F., Baillargeon, P., Shumate, J., Martemyanov, K.A., Page, D.T., Puthanveettil, S., Hodder, P., Davis, R., Miller, C.A., Scampavia, L., Rumbaugh, G. (2018) Improved scalability of neuron-based phenotypic screening assays for therapeutic discovery in neuropsychiatric disorders. Molecular Neuropsychiatry 3,141-150.  PMCID:PMC5836166

Sarria, I., Cao, Y., Wang, Y., Ingram, N.T., Orland,i C., Kamasawa, N., Kolesnikov, A.V., Pahlberg, J., Kefalov, V.J., Sampath, A.P., Martemyanov, K.A. (2018) LRIT1 modulates adaptive changes in synaptic communication of cone photoreceptors. Cell Reports 22, 3562-3573.  PMCID:PMC5902029

Sutton, L.P., Orlandi, C., Song, C., Oh, W.C., Muntean, B.S., Xie, K., Filippini, A., Xie, X., Satterfield, R., Yaeger, J.D.W., Renner, K.J., Young, S.M., Xu, B., Kwon, H., Martemyanov, K.A. (2018) Orphan receptor GPR158 controls stress-induced depression. eLife e33273.  PMCID:PMC5823542

Anderson, A., Kulkarni, K., Marron Fernandez de Velasco, E., Carlblom, N., Xia, Z., Nakano, A., Martemyanov, K.A.,Tolkacheva, E.G., Wickman, K. (2018) Expression and relevance of the G protein-gated K+ channel in the mouse ventricle. Scientific Reports 8, 1192.  PMCID:PMC5775354

Qutob, N., Masuho, I., Alon, M., Emmanuel, R., Cohen, I., Di Pizio, A., Madore, J., Elkahloun, A., Ziv, T., Levy, R., Gartner, J.J., Hill, V.K., Lin, J.C., Hevroni, Y., Greenberg, P., Brodezki, A., Rosenberg, S.A., Koslo, M., Hayward, N.K., Admon, A., Niv MY, Scolyer RA, Martemyanov, K.A., Samuels Y. (2018) RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells. Scientific Reports 8, 653.  PMCID:PMC5766496

Hauser, A.S., Chavali, S., Masuho, I., Jahn, L.J., Martemyanov, K.A., Gloriam, D.E., Babu, M.M. (2018) Pharmacogenomics of GPCR drug targets. Cell 172, 41-54.  PMCID:PMC5766829

Muntean, B.S., Zucca, S., MacMullen, C.M., Dao, M.T., Johnston, C., Iwamoto, H., Blakely, R.D., Davis, R.L., Martemyanov, K.A. (2018) Interrogating the spatiotemporal landscape of neuromodulatory GPCR signaling by real-time imaging of cAMP in intact neurons and circuits. Cell Reports 22, 255-268.  PMCID:PMC5761078

Himmelreich, S., Masuho, I., Berry, J.A., MacMullen, C., Skamangas, N.K., Martemyanov, K.A., Davis, R.L. (2017) Dopamine receptor DAMB signals via Gq to mediate forgetting in Drosophila. Cell Reports 21, 2074-2081  PMID: 29166600

Martemyanov, K.A., Sampath, A.P. (2017) The transduction cascade in retinal ON-Bipolar cells: signal processing and disease. Ann Rev Vis Sci. 3, 25-51.  PMCID:PMC5778350

Carmon, K.S., Gong, X., Yi, J., Wu, L., Thomas, A., Moore, C.M., Masuho, I., Timson, D.J., Martemyanov, K.A., Liu, Q.J. (2017) LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway. J Biol Chem. 292, 14989-15001.  PMCID:PMC5592675

Neuillé, M., Cao, Y., Caplette, R., Guerrero-Given, D., Thomas, C., Kamasawa, N., Sahel, J.A., Hamel, C.P., Audo, I., Picaud, S., Martemyanov, K.A., Zeitz, C. (2017) LRIT3 Differentially affects connectivity and synaptic transmission of cones to ON- and OFF-Bipolar cells. Invest Opthalmol Vis Sci. 58, 1768-1778.  PMCID:PMC5374884

Wang, Y., Fehlhaber, K.E., Sarria, I., Cao, Y., Ingram, N.T., Guerrero-Given, D., Throesch, B., Baldwin, K., Kamasawa, N., Ohtsuka, T., Sampath, A.P., Martemyanov, K.A. (2017) The auxiliary calcium channel subunit α2δ4 is required for axonal elaboration, synaptic transmission, and wiring of rod photoreceptors. Neuron 93, 1359-1374.  PMCID:PMC5364038

Lohmann, K., Masuho, I., Patil, D.N., Baumann, H., Hebert, E., Steinrücke, S., Trujillano, D., Skamangas, N.K., Dobricic, V., Hüning, I., Gillessen-Kaesbach, G., Westenberger, A., Savic-Pavicevic, D., Münchau, A., Oprea, G., Klein, C., Rolfs, A., Martemyanov, K.A. (2017) Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans. Hum Mol Genet. doi: 10.1093/hmg/ddx018.  PMID: 28087732

Aguado, C., Orlandi, C., Fajaro-Serrano, A., Gil-Minguez, M., Martemyanov, K.A., Lujan, R. (2016) Cellular and subcellular localization of the RGS7/Gβ5/R7BP complex in the cerebellar cortex. Front Neuroanat. 10:114.  PMCID:PMC5127942

Xie, K., Colgan, L.A., Dao, M.T., Muntean, B.S., Sutton, L.P., Orlandi, C., Boye, S.L., Boye, S.E., Shih, C.C., Li, Y., Xu, B., Smith, R.G., Yasuda, R., Martemyanov, K.A. (2016) NF1 is a direct protein effector essential for opioid signaling to Ras in the striatum. Curr. Biol. 26, 2992-3003.   PMCID:PMC5121064

Victoria, N.C., Marron, Fernandez de Velasco, E., Ostrovskaya, O., Metzger, S., Xia, Z., Kotecki, L., Benneyworth, M.A., Zink, A.N., Martemyanov, K.A., Wickman, K. (2016) G protein-gated K+ channel ablation in forebrain pyramidal neurons selectively impairs fear learning. Biol. Psychiatry. 80, 796-806.  PMCID:PMC4862939

Shamseldin, H.E., Masuho, I., Alenizi, A., Alyamani, S., Patil, D.N., Ibrahim, N., Martemyanov, K.A., Alkuraya, F.S. (2016) GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition. Genome Biol. 17, 195.  PMCID:PMC5037613

Sutton, L.P., Ostrovskaya, O., Dao, M., Xie, K., Orlandi, C., Smith, R., Wee, S., Martemyanov, K.A. (2016) Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum. Biol. Psychiatry. 80, 235-245.   PMCID:PMC4753143

Chen, Y., Palczewska, G., Masuho, I., Gao, S., Jin, H., Dong, Z., Gieser, L., Brooks, M.J., Kiser, P.D., Kern, T.S., Martemyanov, K.A., Swaroop, A., Palczewski, K. (2016) Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Sci. Signal. 9(438):ra74.  PMCID:PMC4972640

Masuho, I., Fang, M., Geng, C., Zhang, J., Jiang, H., Özgul, R.K., Yılmaz, D.Y., Yalnızoğlu, D., Yüksel, D., Yarrow, A., Myers, A., Burn, S.C., Crotwell, P.L., Padilla-Lopez, S., Dursun, A., Martemyanov, K.A., Kruer, M.C. (2016) Homozygous GNAL mutation associated with familial childhood-onset generalized dystonia. Neurol. Genet. 2(3):e78.  PMCID:PMC48666576

Dos Santos, C.O., Masuho, I., da Silva-Júnior, F.P., Barbosa, E.R., Silva, S.M., Borges, V., Ferraz, H.B., Rocha, M.S., Limongi, J.C., Martemyanov, K.A., de Carvalho Aguiar, P. (2016) Screening of GNAL variants in Brazilian patients with isolated dystonia reveals a novel mutation with partial loss of function. J. Neurol. 263, 665-668.   PMCID:PMC4828253

Xu, Y., Orlandi, C., Cao, Y., Yang, S., Choi, C.I., Pagadala, V., Birnbaumer, L., Martemyanov, K.A., Vardi, N (2016) The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go. Sci. Rep. 6:20940.  PMCID:PMC4756708

Tayou, J., Wang, Q., Jang, G.F., Pronin, A.N., Orlandi, C., Martemyanov, K.A., Crabb, J.W., Slepa,k V.Z. (2016) Regulator of G-protein Signaling 7 (RGS7) can exist in a homo-oligomeric form that is regulated by Gαo and R7-binding protein. J. Biol. Chem. 291, 9133-47.   PMCID:PMC4861480

Sarria, I., Orlandi, C., McCall, M.A., Gregg, R.G., Martemyanov, K.A. (2016) Intermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar Neurons. J. Neurosci. 36, 2915-2925.  PMCID:PMC4783495

Muntean, B.S., Martemyanov, K.A. (2016) Association with the Plasma Membrane Is Sufficient for Potentiating Catalytic Activity of Regulators of G Protein Signaling (RGS) Proteins of the R7 Subfamily. J. Biol. Chem. 291, 7195-7204.  PMCID:PMC4807299

Salaga, M., Storr, M., Martemyanov, K.A., Fichna, J. (2016) RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives. Biosessays 38, 344-354.  PMCID:PMC4916644

Masuho, I., Ostrovskaya, O., Kramer, G.M., Jones, C.D., Xie, K., Martemyanov, K.A. (2015 ) Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors. Sci Signal. 8(405):ra123.  PMCID:PMC4886239

Xie, K., Masuho, I., Shih, C.C., Cao, Y., Sasaki, K., Lai, C.W., Han, P.L., Ueda, H., Dessauer, C.W., Ehrlich, M.E., Xu, B., Willardson, B.M., Martemyanov, K.A. (2015) Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling. Elife e10451.  PMCID:PMC4728126

Cao, Y., Sarria, I., Fehlhaber, K.E., Kamasawa, N., Orlandi, C., James, K.N., Hazen, J.L., Gardner, M.R., Farzan, M., Lee, A., Baker, S., Baldwin, K., Sampath, A.P., Martemyanov, K.A. (2015 )Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision. Neuron 87, 1248-1260.  PMCID:PMC4583715

Masuho, .I, Martemyanov, K.A., Lambert, N.A. (2015) Monitoring G Protein Activation in Cells with BRET.  Methods Mol.Biol.  1335, 107-113.  PMCID:PMC4879496

Neuillé, M., Morgans, C.W., Cao, Y., Orhan, E., Michiels, C., Sahel, J.A., Audo, I., Duvoisin, R.M., Martemyanov, K.A., Zeitz, C. (2015) LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation.  Eur. J. Neurosci 42, 1966-1975.  PMCID:PMC4733627

Sarria, I., Pahlberg, J., Cao, Y., Kolesnikov, A.V., Kefalov, V.J., Sampath, A.P., Martemyanov, K.A. (2015) Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior.  Elife  e06358.  PMCID:PMC4412108

Orlandi, C., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Martemyanov, K.A. (2015) Orphan Receptor GPR158 is an Allosteric Modulator of Regulator of G Protein Signaling 7 (RGS7) Catalytic Activity with Essential Role in Dictating its Expression and Localization in the Brain.  J. Biol. Chemi. 290, 13622-13639.  PMCID:PMC4447942

Kumar, K.R.,  Martemyanov, K.A., Lohmann, K. (2014) GNAL mutations and dystonia--reply. JAMA Neurol. 71(8):1053-4.  PMID: 25111209

Martemyanov, K.A. (2014) G protein signaling in the retina and beyond: the cogan lecture.. Invest. Opthalmol. Vis. Sci.55, 8201-07.  PMCID:PMC4541486

Ray, T.A., Heath, K.M., Hasan, N., Noel, J.M., Samuels, I.S., Martemyanov, K.A., Peachey, N.S., McCall, M.A., Gregg, R.G. (2014) GPR179 Is Required for High Sensitivity of the mGluR6 Signaling Cascade in Depolarizing Bipolar Cells. J. Neurosci. 34, 6334-43.  PMCID:PMC4004817

Ostrovskaya, O., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Wickman, K., Martemyanov, K.A. (2014) RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling. Elife 3:e02053.  PMCID:PMC3988575

Kumar, K.R., Lohmann, K., Masuho, I., Miyamoto, R., Ferbert, A., Lohnau, T., Kasten, M., Hagenah, J., Brüggemann, N., Graf, J., Münchau, A., Kostic, V.S., Sue, C.M., Domingo, A.R., Rosales, R.L., Lee, L.V., Freimann, K., Westenberger, A., Mukai, Y., Kawarai, T., Kaj,i R., Klein, C., Martemyanov, K.A., Schmidt, A. (2014) Mutations in GNAL: A Novel Cause of Craniocervical Dystonia. JAMA Neurol. 71(4):490-4.  PMCID:PMC4237020

Wydeven, N., Posokhova, E., Xia, Z., Martemyanov, K.A., Wickman, K. (2014) RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate.  J. Biol. Chemi.289(4):2440-9.  PMCID:PMC3900986

Posokhova, E., NG, D., Opel, A., Masuho, I., Tinker, A., Biesecker, L.G., Wickman, K., Martemyanov, K.A. (2013) Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability. PLoS One 8, e76973 .  PMCID:PMD3812209

Orlandi, C., Cao, Y., Martemyanov, K.A. (2013) Orphan Receptor GPR179 Forms Macromolecular Complexes With Components of Metabotropic Signaling Cascade in Retina ON-Bipolar Neurons. Invest. Opthalmol. Vis. Sci. 54, 7153-61.  PMCID:PMC3813323

Masuho, I., Xie, K., Martemyanov, K.A. (2013) Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells. J. Biol. Chem. 288, 25129-42.  PMCID:PMC3857177

Fajardo-Serrano, A., Wydeven, N., Young, D., Watanabe, M., Shigemoto, R., Martemyanov, K.A., Wickman K., Lujan, R. (2103) Association of Rgs7/Gβ5 complexes with girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons. Hippocampus doi: 10.1002/hipo.22161.  PMCID:PMC4060866

Fuchs, T., Saunders-Pullman, R., Masuho, I., San Luciano, M., Raymond, D., Factor, S., Lang, A.E., Liang, T-W, Trosch, R.M., White, S., Ainehsazan, E., Herve, D., Sharma, N., Ehrlich, M.E., Martemyanov, K.A., Bressma, S.B., Ozelius, L.J. (2013) Mutations in GNAL cause primary torsion dystonia. Nat. Genetics 45, 88-92.  PMCID:PMC3530620

Xie, K., Masuho, I., Brand, C., Dessauer, C.W., Martemyanov, K.A. (2012) The Complex of G Protein Regulator RGS9-2 and Gβ5 Controls Sensitization and Signaling Kinetics of Type 5 Adenylyl Cyclase in the Striatum. Sci. Signal. 5(239):ra63.  PMCID:PMC3580943

Orlandi, C., Posokhova, E., Masuho, I., Ray, T.A., Hasan, N., Gregg, R.G., Martemyanov, K.A. (2012) GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes. J. Cell. Biol. 197:711-719.  PMCID:PMC3373406

Cao, Y., Pahlberg, J., Sarria, I., Kamasaw,a N., Sampath, A.P., Martemyanov K.A. (2012) Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons. Proc Natl Acad Sci. USA 109:7905-7910.   PMCID:PMC3356620

Xie, K., Ge, S., Collins, V.E., Haynes, C.L, Renner, K.J., Meisel, R.L., Lujan, R., Martemyanov, K.A. (2012) Gβ5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems. Psychoparmacology 219:823-834.  PMDID:PMC3260372

Terzi D., Cao Y., Agrimaki I., Martemyanov K.A., Zachariou V. (2012) R7BP Modulates Opiate Analgesia and Tolerance but not Withdrawal. Neuropsychopharmacology 37:1005-1012.  PMCID:PMC3280654

Xie K. and Martemyanov K.A. (2011) Control of striatal signaling by g protein regulators. Front. Neuroanat. 5:49.  PMCID:PMC3151604

Cao Y., Posokhova E., and Martemyanov K.A. (2011) TRPM1 Forms Complexes with Nyctalopin In Vivo and Accumulates in Postsynaptic Compartment of ON-Bipolar Neurons in mGluR6-Dependent Manner. J. Neurosci.31:11521-11526.  PMCID:PMC3164511

Gopalakrishna K.N., Doddapuneni K., Boyd K.K., Masuho I, Martemyanov K.A., and Artemyev N.O. (2011) Interaction of Transducin with Uncoordinated 119 Protein (UNC119): Implications for the model of transducin trafficking in rod photoreceptors. J. Biol. Chem. 286: 28954-289546262.  PMCID:PMC3190703

Masuho I., Wakasugi-Masuho H., Posokhova E.N., Patton J.R., and Martemyanov K.A. (2011) Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors. J. Biol. Chem. 286:21806-21813.  PMCID:PMC3122235

Posokhova E., Song H., Belcastro M., Higgins L., Bigley L.R., Michaud N.A., Martemyanov K.A., Sokolov M. (2011) Disruption of the chaperonin containing TCP-1 function in rods affects multiple protein networks and arrests outer segment morphogenesis. Mol Cell Proteom. 10, M110.000570  PMCID:PMC3013443

Porter M.Y., Xie K., Pozharski E., Koelle M.R., and Martemyanov K.A. (2010) A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins. J. Biol. Chem. 285: 41100-41112.  PMCID:PMC3003408

Posokhova E., Wydeven N., Allen K.L., Wickman K., Martemyanov K.A. (2010) RGS6/Gb5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate. Circ. Res. 107, 1350-1354  PMCID:PMC3014848

Cao Y., Kolesnikov A.V., Masuho I., Kefalov V.J., Martemyanov K.A. (2010) Membrane anchoring subunits specify selective regulation of RGS9/Gb5 GAP complex in photoreceptor neurons. J. Neurosci. 30, 13784-13793.  PMCID:PMC2975674

Xie K., Allen K.L., Kourrich S., Colón-Saez J., Thomas, M.J., Wickman K., Martemyanov K.A. (2010) Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling. Nature Neuroscience 13, 661-663  PMCID:PMC2876203

Panicker L.M., Zhang J.H., Posokhova E., Gastinger M.J., Martemyanov K.A., and Simonds W.F. (2010) Nuclear localization of the G protein beta5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein. J. Neurochem. 113: 1101-1112.  PMCID:PMC2890294

Posokhova E., Uversky V., Martemyanov K.A. (2010) Proteomic identification of Hsc70 as a mediator of RGS9-2 degradation by in vivo interactome analysis. J. Proteome Res. 9, 1510-1521.  PMCID:PMC2890236

Roloff A.M., Anderson G.R., Martemyanov K.A., Thayer S.A. (2010) Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticity. J. Neurosci. 30, 3072-3081.  PMCID:PMC2843151

Anderson G.R., Cao Y., Davidson S., Truong H.V., Pravetoni M., Thomas M., Wickman K., Giesler G.J.Jr., Martemyanov K.A. (2010) R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine. Neuropsychopharmacology 35, 1040-1050.  PMCID:PMC2887292

Masuho I., Celver J., Kovoor A., and Martemyanov K.A. (2010) Membrane Anchor R9AP Potentiates GTPase-accelerating Protein Activity of RGS11/Gbeta5 Complex and Accelerates Inactivation of the mGluR6-Go Signaling. J. Biol. Chem. 285(7): 4781-4787.  PMCID:PMC2836083

Anderson, G.R., Posokhova E., Martemyanov K.A. (2009) The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling. Cell Biochem. Biophys. 54, 33-46.  PMCID:PMC2827338

Martemyanov K.A. and Arshavsky V.Y. (2009) Biology and functions of the RGS9 isoforms. In Progress in Molecular Biology and Translational Science (Fisher, R. Ed.), Elsevier volume 86007: 201-273.  PMID: 20374717

Cao Y., Masuho I., Okawa H., Xie K, Asami J., Kammermeier P., Furukawa T., Inoue Y., Sampath A.P., Martemyanov K.A. (2009) Retina specific GTPase accelerator RGS11/Gb5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons. J. Neurosci. 29, 9301-9313.  PMCID:PMC2731308

Anderson G.R., Lujan R., and Martemyanov K.A. (2009) Changes in striatal signaling induce remodeling of RGS complexes containing Gbeta5 and R7BP subunits. Mol. Cell Biol. 11:3033-3044.   PMCID:PMC2682020

Martemyanov K.A., Krispel C.M., Lishko P.V., Burns M.E., and Arshavsky V.Y. (2008) Functional comparison of RGS9 splice isoforms in a living cell. Proc. Natl. Acad. Sci. USA 105:20988-20993.  PMCID:PMC2634932

Hooks S., Martemyanov K., and Zachariou, V. (2008) A role of RGS proteins in drug addiction. Biochem. Pharmacol. 75, 76-84.  PMID: 17880927

Kim H.J., Martemyanov K.A., and Thayer S.A. (2008) Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death. J. Neurosci. 28:12604-12613  PMCID:PMC2678679

Cao Y., Song H., Okawa H., Sampath A.P., Sokolov M., and Martemyanov K.A. (2008) Targeting of RGS7/G5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP. J. Neurosci. 28: 10443:10449.  PMCID:PMC2587022

Anderson G.R., Lujan R., Semenov A., Pravetoni M., Posokhova E.N., Song J.H., Uversky V., Chen C-K., Wickman K., and Martemyanov K.A. (2007) Expression and Localization of RGS9-2/Gbeta5/R7BP Complex In Vivo Is Set by Dynamic Control of Its Constitutive Degradation by Cellular Cysteine Proteases. J. Neurosci. 27:14117-14127.  PMID: 18094251

Song J.H., Song H., Wensel T.G., Sokolov M., and Martemyanov K.A. (2007) Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina. Mol. Cell. Neurosci. 35:311-319.  PMID:17442586

Anderson G.R., Semenov A., Song J.H., Martemyanov K.A. (2007) The membrane anchor R7BP controls the proteolytic stability of the striatal specific RGS protein, RGS9-2. J. Biol. Chem. 282(7):4772-4781.  PMID: 17158100

Song J.H., Waataja J.J., Martemyanov K.A. (2006) Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP. J. Biol. Chem. 281(22):15361-15369.  PMID:16574655

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Department of Neuroscience