Professor
Department of Neuroscience
Florida Campus
Laboratory Website
kirill@scripps.edu
(561) 228-2770
Associate Professor, Department of Metabolism & Aging
Faculty, Graduate Program
The main emphasis of the research in the laboratory is on the fundamental principles that regulate signaling via G protein coupled receptors (GPCR). GPCRs mediate a vast variety of critical biological processes ranging from proliferation and motility to cellular reception and excitability. GPCR signaling pathways are of particular importance for the nervous system function where they control many fundamental processes including excitability, differentiation, sensory perception, and synaptic transmission. Importantly, but not surprisingly, even a subtle imbalance in GPCR signaling often leads to the most profound nervous system disorders ranging from blindness and cognitive problems to grave neurological diseases.
Specifically, our laboratory is interested in understanding the intricate regulatory dynamics of G protein pathways in the following two neuronal systems.
Much of our current efforts are focused on a family of key regulators of GPCR signaling pathways, the Regulator of G protein Signaling (RGS) proteins. RGS proteins constitute a large family of proteins that promote G protein inactivation by facilitating their GTP hydrolysis thus ensuring timely inactivation of the GPCR responses. Many members of the RGS family have been clinically linked to human disease conditions that have been recapitulated in the genetic mouse models. Serving as a central control point in GPCR signaling cascades, RGS proteins hold great promises as targets for the drug development. This brings the major emphasis of our research on elucidating molecular and cellular mechanisms of RGS proteins function in cellular signaling in addition to the efforts to uncover novel regulatory principles.
Research directions in the laboratory include discovery and characterization of novel G protein regulators, delineation of protein-protein interactions, feedback mechanisms, and logistics of signaling pathway organization. In our research, we use a range of multidisciplinary approaches involving identification of components of signaling complexes by proteomics, measurement of protein functional activity by in vitro enzyme kinetics, analysis of synthesis, trafficking and degradation of signaling proteins in cell culture and behavioral characterization of genetic mouse models with altered components of G protein signaling machinery.
B.Sc., Biochemistry, Samara State University, Russia, 1996
M.Sc., Molecular Biology, Pushchino State University, Russia, 1998
Ph.D., Molecular Biology, Institute of Protein Research, Russian Academy of Sciences, 2000
Song, C., Anderson, G.R., Sutton, L.P., Dao, M., Martemyanov, K.A. (2018) Selective role of RGS9-2 in regulating retrograde synaptic signaling of indirect pathway medium spiny neurons in dorsal striatum. J. Neurosci. pii: 0493-18. doi: 10.1523/JNEUROSCI.0493-18.2018. [Epub ahead of print] PMID: 30006367
Masuho, I., Chavali, S., Muntean, B.S., Skamangas, N.K., Simonyan, K., Patil, D. N., Kramer, G.M., Ozelius, L., Babu, M.M., Martemyanov, K.A. (2018) Molecular deconvolution platform to establish disease mechanisms by surveying GPCR signaling. Cell Reports 24, 557-568. PMID: 30021154
Dunn, H.A., Patil, D.N., Cao, Y., Orlandi, C., Martemyanov, K.A. (2018) Synaptic adhesion protein ELFN1 is a selective allosteric modulator of group III metabotropic glutamate receptors in trans. Proc Natl Accad Sci USA. 115, 5022-5027. PMCID:PMC594899
Gulati, S., Masuho, I., Orban, T., Cai, Y., Pardon, E., Martemyanov, K.A., Kiser, P.D., Stewart, P.L., Ford, C.P., Steyaert, J., and Palczewski, K. (2018) Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 9, 1996 PMCID:PMC47362
Martemyanov, K.A., Garcia-Marcos, M. (2018) Making useful gadgets with miniaturized G proteins. J Biol Chem. 293, 7474-7475. PMCID:PMC5949992
Kulkarni, K., Xie, X., Fernandez de Velasco, EM.., Anderson, A., Martemyanov, K.A., Wickman, K., Tolkacheva, E.G. (2018) The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart. PLos One 13, e0193798. PMCID:PMC5905881
Muntean, B.S., Patil, D.N., Madoux, F., Fossetta, J., Scampavia, L., Spicer, T.P., Martemyanov, K.A. (2018) A high-throughput time-resolved fluorescence energy transfer assay to screen for modulators of RGS7/Gβ5/R7BP complex. Assay and Drug Development Technologies. 3,150-161. PMCID:PMC5906730
Marcott, P.F., Gong, S., Donthamsetti, P., Grinnell, S.G., Nelson, M.N., Newman, A.H., Birnbaumer, L., Martemyanov, K.A., Javitch, J.A., Ford, C.P. (2018) Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens. Neuron 98, 575-587 PMCID:PMC6048973
Spicer, T.P., Hubbs, C., Vaissiere, T., Collia, D., Rojas, C., Kilinc, M., Vick, K., Madoux, F., Baillargeon, P., Shumate, J., Martemyanov, K.A., Page, D.T., Puthanveettil, S., Hodder, P., Davis, R., Miller, C.A., Scampavia, L., Rumbaugh, G. (2018) Improved scalability of neuron-based phenotypic screening assays for therapeutic discovery in neuropsychiatric disorders. Molecular Neuropsychiatry 3,141-150. PMCID:PMC5836166
Sarria, I., Cao, Y., Wang, Y., Ingram, N.T., Orland,i C., Kamasawa, N., Kolesnikov, A.V., Pahlberg, J., Kefalov, V.J., Sampath, A.P., Martemyanov, K.A. (2018) LRIT1 modulates adaptive changes in synaptic communication of cone photoreceptors. Cell Reports 22, 3562-3573. PMCID:PMC5902029
Sutton, L.P., Orlandi, C., Song, C., Oh, W.C., Muntean, B.S., Xie, K., Filippini, A., Xie, X., Satterfield, R., Yaeger, J.D.W., Renner, K.J., Young, S.M., Xu, B., Kwon, H., Martemyanov, K.A. (2018) Orphan receptor GPR158 controls stress-induced depression. eLife e33273. PMCID:PMC5823542
Anderson, A., Kulkarni, K., Marron Fernandez de Velasco, E., Carlblom, N., Xia, Z., Nakano, A., Martemyanov, K.A.,Tolkacheva, E.G., Wickman, K. (2018) Expression and relevance of the G protein-gated K+ channel in the mouse ventricle. Scientific Reports 8, 1192. PMCID:PMC5775354
Qutob, N., Masuho, I., Alon, M., Emmanuel, R., Cohen, I., Di Pizio, A., Madore, J., Elkahloun, A., Ziv, T., Levy, R., Gartner, J.J., Hill, V.K., Lin, J.C., Hevroni, Y., Greenberg, P., Brodezki, A., Rosenberg, S.A., Koslo, M., Hayward, N.K., Admon, A., Niv MY, Scolyer RA, Martemyanov, K.A., Samuels Y. (2018) RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells. Scientific Reports 8, 653. PMCID:PMC5766496
Hauser, A.S., Chavali, S., Masuho, I., Jahn, L.J., Martemyanov, K.A., Gloriam, D.E., Babu, M.M. (2018) Pharmacogenomics of GPCR drug targets. Cell 172, 41-54. PMCID:PMC5766829
Muntean, B.S., Zucca, S., MacMullen, C.M., Dao, M.T., Johnston, C., Iwamoto, H., Blakely, R.D., Davis, R.L., Martemyanov, K.A. (2018) Interrogating the spatiotemporal landscape of neuromodulatory GPCR signaling by real-time imaging of cAMP in intact neurons and circuits. Cell Reports 22, 255-268. PMCID:PMC5761078
Himmelreich, S., Masuho, I., Berry, J.A., MacMullen, C., Skamangas, N.K., Martemyanov, K.A., Davis, R.L. (2017) Dopamine receptor DAMB signals via Gq to mediate forgetting in Drosophila. Cell Reports 21, 2074-2081 PMID: 29166600
Martemyanov, K.A., Sampath, A.P. (2017) The transduction cascade in retinal ON-Bipolar cells: signal processing and disease. Ann Rev Vis Sci. 3, 25-51. PMCID:PMC5778350
Carmon, K.S., Gong, X., Yi, J., Wu, L., Thomas, A., Moore, C.M., Masuho, I., Timson, D.J., Martemyanov, K.A., Liu, Q.J. (2017) LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway. J Biol Chem. 292, 14989-15001. PMCID:PMC5592675
Neuillé, M., Cao, Y., Caplette, R., Guerrero-Given, D., Thomas, C., Kamasawa, N., Sahel, J.A., Hamel, C.P., Audo, I., Picaud, S., Martemyanov, K.A., Zeitz, C. (2017) LRIT3 Differentially affects connectivity and synaptic transmission of cones to ON- and OFF-Bipolar cells. Invest Opthalmol Vis Sci. 58, 1768-1778. PMCID:PMC5374884
Wang, Y., Fehlhaber, K.E., Sarria, I., Cao, Y., Ingram, N.T., Guerrero-Given, D., Throesch, B., Baldwin, K., Kamasawa, N., Ohtsuka, T., Sampath, A.P., Martemyanov, K.A. (2017) The auxiliary calcium channel subunit α2δ4 is required for axonal elaboration, synaptic transmission, and wiring of rod photoreceptors. Neuron 93, 1359-1374. PMCID:PMC5364038
Lohmann, K., Masuho, I., Patil, D.N., Baumann, H., Hebert, E., Steinrücke, S., Trujillano, D., Skamangas, N.K., Dobricic, V., Hüning, I., Gillessen-Kaesbach, G., Westenberger, A., Savic-Pavicevic, D., Münchau, A., Oprea, G., Klein, C., Rolfs, A., Martemyanov, K.A. (2017) Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans. Hum Mol Genet. doi: 10.1093/hmg/ddx018. PMID: 28087732
Aguado, C., Orlandi, C., Fajaro-Serrano, A., Gil-Minguez, M., Martemyanov, K.A., Lujan, R. (2016) Cellular and subcellular localization of the RGS7/Gβ5/R7BP complex in the cerebellar cortex. Front Neuroanat. 10:114. PMCID:PMC5127942
Xie, K., Colgan, L.A., Dao, M.T., Muntean, B.S., Sutton, L.P., Orlandi, C., Boye, S.L., Boye, S.E., Shih, C.C., Li, Y., Xu, B., Smith, R.G., Yasuda, R., Martemyanov, K.A. (2016) NF1 is a direct protein effector essential for opioid signaling to Ras in the striatum. Curr. Biol. 26, 2992-3003. PMCID:PMC5121064
Victoria, N.C., Marron, Fernandez de Velasco, E., Ostrovskaya, O., Metzger, S., Xia, Z., Kotecki, L., Benneyworth, M.A., Zink, A.N., Martemyanov, K.A., Wickman, K. (2016) G protein-gated K+ channel ablation in forebrain pyramidal neurons selectively impairs fear learning. Biol. Psychiatry. 80, 796-806. PMCID:PMC4862939
Shamseldin, H.E., Masuho, I., Alenizi, A., Alyamani, S., Patil, D.N., Ibrahim, N., Martemyanov, K.A., Alkuraya, F.S. (2016) GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition. Genome Biol. 17, 195. PMCID:PMC5037613
Sutton, L.P., Ostrovskaya, O., Dao, M., Xie, K., Orlandi, C., Smith, R., Wee, S., Martemyanov, K.A. (2016) Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum. Biol. Psychiatry. 80, 235-245. PMCID:PMC4753143
Chen, Y., Palczewska, G., Masuho, I., Gao, S., Jin, H., Dong, Z., Gieser, L., Brooks, M.J., Kiser, P.D., Kern, T.S., Martemyanov, K.A., Swaroop, A., Palczewski, K. (2016) Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Sci. Signal. 9(438):ra74. PMCID:PMC4972640
Masuho, I., Fang, M., Geng, C., Zhang, J., Jiang, H., Özgul, R.K., Yılmaz, D.Y., Yalnızoğlu, D., Yüksel, D., Yarrow, A., Myers, A., Burn, S.C., Crotwell, P.L., Padilla-Lopez, S., Dursun, A., Martemyanov, K.A., Kruer, M.C. (2016) Homozygous GNAL mutation associated with familial childhood-onset generalized dystonia. Neurol. Genet. 2(3):e78. PMCID:PMC48666576
Dos Santos, C.O., Masuho, I., da Silva-Júnior, F.P., Barbosa, E.R., Silva, S.M., Borges, V., Ferraz, H.B., Rocha, M.S., Limongi, J.C., Martemyanov, K.A., de Carvalho Aguiar, P. (2016) Screening of GNAL variants in Brazilian patients with isolated dystonia reveals a novel mutation with partial loss of function. J. Neurol. 263, 665-668. PMCID:PMC4828253
Xu, Y., Orlandi, C., Cao, Y., Yang, S., Choi, C.I., Pagadala, V., Birnbaumer, L., Martemyanov, K.A., Vardi, N (2016) The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go. Sci. Rep. 6:20940. PMCID:PMC4756708
Tayou, J., Wang, Q., Jang, G.F., Pronin, A.N., Orlandi, C., Martemyanov, K.A., Crabb, J.W., Slepa,k V.Z. (2016) Regulator of G-protein Signaling 7 (RGS7) can exist in a homo-oligomeric form that is regulated by Gαo and R7-binding protein. J. Biol. Chem. 291, 9133-47. PMCID:PMC4861480
Sarria, I., Orlandi, C., McCall, M.A., Gregg, R.G., Martemyanov, K.A. (2016) Intermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar Neurons. J. Neurosci. 36, 2915-2925. PMCID:PMC4783495
Muntean, B.S., Martemyanov, K.A. (2016) Association with the Plasma Membrane Is Sufficient for Potentiating Catalytic Activity of Regulators of G Protein Signaling (RGS) Proteins of the R7 Subfamily. J. Biol. Chem. 291, 7195-7204. PMCID:PMC4807299
Salaga, M., Storr, M., Martemyanov, K.A., Fichna, J. (2016) RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives. Biosessays 38, 344-354. PMCID:PMC4916644
Masuho, I., Ostrovskaya, O., Kramer, G.M., Jones, C.D., Xie, K., Martemyanov, K.A. (2015 ) Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors. Sci Signal. 8(405):ra123. PMCID:PMC4886239
Xie, K., Masuho, I., Shih, C.C., Cao, Y., Sasaki, K., Lai, C.W., Han, P.L., Ueda, H., Dessauer, C.W., Ehrlich, M.E., Xu, B., Willardson, B.M., Martemyanov, K.A. (2015) Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling. Elife e10451. PMCID:PMC4728126
Cao, Y., Sarria, I., Fehlhaber, K.E., Kamasawa, N., Orlandi, C., James, K.N., Hazen, J.L., Gardner, M.R., Farzan, M., Lee, A., Baker, S., Baldwin, K., Sampath, A.P., Martemyanov, K.A. (2015 )Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision. Neuron 87, 1248-1260. PMCID:PMC4583715
Masuho, .I, Martemyanov, K.A., Lambert, N.A. (2015) Monitoring G Protein Activation in Cells with BRET. Methods Mol.Biol. 1335, 107-113. PMCID:PMC4879496
Neuillé, M., Morgans, C.W., Cao, Y., Orhan, E., Michiels, C., Sahel, J.A., Audo, I., Duvoisin, R.M., Martemyanov, K.A., Zeitz, C. (2015) LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation. Eur. J. Neurosci 42, 1966-1975. PMCID:PMC4733627
Sarria, I., Pahlberg, J., Cao, Y., Kolesnikov, A.V., Kefalov, V.J., Sampath, A.P., Martemyanov, K.A. (2015) Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior. Elife e06358. PMCID:PMC4412108
Orlandi, C., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Martemyanov, K.A. (2015) Orphan Receptor GPR158 is an Allosteric Modulator of Regulator of G Protein Signaling 7 (RGS7) Catalytic Activity with Essential Role in Dictating its Expression and Localization in the Brain. J. Biol. Chemi. 290, 13622-13639. PMCID:PMC4447942
Kumar, K.R., Martemyanov, K.A., Lohmann, K. (2014) GNAL mutations and dystonia--reply. JAMA Neurol. 71(8):1053-4. PMID: 25111209
Martemyanov, K.A. (2014) G protein signaling in the retina and beyond: the cogan lecture.. Invest. Opthalmol. Vis. Sci.55, 8201-07. PMCID:PMC4541486
Ray, T.A., Heath, K.M., Hasan, N., Noel, J.M., Samuels, I.S., Martemyanov, K.A., Peachey, N.S., McCall, M.A., Gregg, R.G. (2014) GPR179 Is Required for High Sensitivity of the mGluR6 Signaling Cascade in Depolarizing Bipolar Cells. J. Neurosci. 34, 6334-43. PMCID:PMC4004817
Ostrovskaya, O., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Wickman, K., Martemyanov, K.A. (2014) RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling. Elife 3:e02053. PMCID:PMC3988575
Kumar, K.R., Lohmann, K., Masuho, I., Miyamoto, R., Ferbert, A., Lohnau, T., Kasten, M., Hagenah, J., Brüggemann, N., Graf, J., Münchau, A., Kostic, V.S., Sue, C.M., Domingo, A.R., Rosales, R.L., Lee, L.V., Freimann, K., Westenberger, A., Mukai, Y., Kawarai, T., Kaj,i R., Klein, C., Martemyanov, K.A., Schmidt, A. (2014) Mutations in GNAL: A Novel Cause of Craniocervical Dystonia. JAMA Neurol. 71(4):490-4. PMCID:PMC4237020
Wydeven, N., Posokhova, E., Xia, Z., Martemyanov, K.A., Wickman, K. (2014) RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate. J. Biol. Chemi.289(4):2440-9. PMCID:PMC3900986
Posokhova, E., NG, D., Opel, A., Masuho, I., Tinker, A., Biesecker, L.G., Wickman, K., Martemyanov, K.A. (2013) Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability. PLoS One 8, e76973 . PMCID:PMD3812209
Orlandi, C., Cao, Y., Martemyanov, K.A. (2013) Orphan Receptor GPR179 Forms Macromolecular Complexes With Components of Metabotropic Signaling Cascade in Retina ON-Bipolar Neurons. Invest. Opthalmol. Vis. Sci. 54, 7153-61. PMCID:PMC3813323
Masuho, I., Xie, K., Martemyanov, K.A. (2013) Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells. J. Biol. Chem. 288, 25129-42. PMCID:PMC3857177
Fajardo-Serrano, A., Wydeven, N., Young, D., Watanabe, M., Shigemoto, R., Martemyanov, K.A., Wickman K., Lujan, R. (2103) Association of Rgs7/Gβ5 complexes with girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons. Hippocampus doi: 10.1002/hipo.22161. PMCID:PMC4060866
Fuchs, T., Saunders-Pullman, R., Masuho, I., San Luciano, M., Raymond, D., Factor, S., Lang, A.E., Liang, T-W, Trosch, R.M., White, S., Ainehsazan, E., Herve, D., Sharma, N., Ehrlich, M.E., Martemyanov, K.A., Bressma, S.B., Ozelius, L.J. (2013) Mutations in GNAL cause primary torsion dystonia. Nat. Genetics 45, 88-92. PMCID:PMC3530620
Xie, K., Masuho, I., Brand, C., Dessauer, C.W., Martemyanov, K.A. (2012) The Complex of G Protein Regulator RGS9-2 and Gβ5 Controls Sensitization and Signaling Kinetics of Type 5 Adenylyl Cyclase in the Striatum. Sci. Signal. 5(239):ra63. PMCID:PMC3580943
Orlandi, C., Posokhova, E., Masuho, I., Ray, T.A., Hasan, N., Gregg, R.G., Martemyanov, K.A. (2012) GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes. J. Cell. Biol. 197:711-719. PMCID:PMC3373406
Cao, Y., Pahlberg, J., Sarria, I., Kamasaw,a N., Sampath, A.P., Martemyanov K.A. (2012) Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons. Proc Natl Acad Sci. USA 109:7905-7910. PMCID:PMC3356620
Xie, K., Ge, S., Collins, V.E., Haynes, C.L, Renner, K.J., Meisel, R.L., Lujan, R., Martemyanov, K.A. (2012) Gβ5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems. Psychoparmacology 219:823-834. PMDID:PMC3260372
Terzi D., Cao Y., Agrimaki I., Martemyanov K.A., Zachariou V. (2012) R7BP Modulates Opiate Analgesia and Tolerance but not Withdrawal. Neuropsychopharmacology 37:1005-1012. PMCID:PMC3280654
Xie K. and Martemyanov K.A. (2011) Control of striatal signaling by g protein regulators. Front. Neuroanat. 5:49. PMCID:PMC3151604
Cao Y., Posokhova E., and Martemyanov K.A. (2011) TRPM1 Forms Complexes with Nyctalopin In Vivo and Accumulates in Postsynaptic Compartment of ON-Bipolar Neurons in mGluR6-Dependent Manner. J. Neurosci.31:11521-11526. PMCID:PMC3164511
Gopalakrishna K.N., Doddapuneni K., Boyd K.K., Masuho I, Martemyanov K.A., and Artemyev N.O. (2011) Interaction of Transducin with Uncoordinated 119 Protein (UNC119): Implications for the model of transducin trafficking in rod photoreceptors. J. Biol. Chem. 286: 28954-289546262. PMCID:PMC3190703
Masuho I., Wakasugi-Masuho H., Posokhova E.N., Patton J.R., and Martemyanov K.A. (2011) Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors. J. Biol. Chem. 286:21806-21813. PMCID:PMC3122235
Posokhova E., Song H., Belcastro M., Higgins L., Bigley L.R., Michaud N.A., Martemyanov K.A., Sokolov M. (2011) Disruption of the chaperonin containing TCP-1 function in rods affects multiple protein networks and arrests outer segment morphogenesis. Mol Cell Proteom. 10, M110.000570 PMCID:PMC3013443
Porter M.Y., Xie K., Pozharski E., Koelle M.R., and Martemyanov K.A. (2010) A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins. J. Biol. Chem. 285: 41100-41112. PMCID:PMC3003408
Posokhova E., Wydeven N., Allen K.L., Wickman K., Martemyanov K.A. (2010) RGS6/Gb5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate. Circ. Res. 107, 1350-1354 PMCID:PMC3014848
Cao Y., Kolesnikov A.V., Masuho I., Kefalov V.J., Martemyanov K.A. (2010) Membrane anchoring subunits specify selective regulation of RGS9/Gb5 GAP complex in photoreceptor neurons. J. Neurosci. 30, 13784-13793. PMCID:PMC2975674
Xie K., Allen K.L., Kourrich S., Colón-Saez J., Thomas, M.J., Wickman K., Martemyanov K.A. (2010) Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling. Nature Neuroscience 13, 661-663 PMCID:PMC2876203
Panicker L.M., Zhang J.H., Posokhova E., Gastinger M.J., Martemyanov K.A., and Simonds W.F. (2010) Nuclear localization of the G protein beta5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein. J. Neurochem. 113: 1101-1112. PMCID:PMC2890294
Posokhova E., Uversky V., Martemyanov K.A. (2010) Proteomic identification of Hsc70 as a mediator of RGS9-2 degradation by in vivo interactome analysis. J. Proteome Res. 9, 1510-1521. PMCID:PMC2890236
Roloff A.M., Anderson G.R., Martemyanov K.A., Thayer S.A. (2010) Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticity. J. Neurosci. 30, 3072-3081. PMCID:PMC2843151
Anderson G.R., Cao Y., Davidson S., Truong H.V., Pravetoni M., Thomas M., Wickman K., Giesler G.J.Jr., Martemyanov K.A. (2010) R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine. Neuropsychopharmacology 35, 1040-1050. PMCID:PMC2887292
Masuho I., Celver J., Kovoor A., and Martemyanov K.A. (2010) Membrane Anchor R9AP Potentiates GTPase-accelerating Protein Activity of RGS11/Gbeta5 Complex and Accelerates Inactivation of the mGluR6-Go Signaling. J. Biol. Chem. 285(7): 4781-4787. PMCID:PMC2836083
Anderson, G.R., Posokhova E., Martemyanov K.A. (2009) The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling. Cell Biochem. Biophys. 54, 33-46. PMCID:PMC2827338
Martemyanov K.A. and Arshavsky V.Y. (2009) Biology and functions of the RGS9 isoforms. In Progress in Molecular Biology and Translational Science (Fisher, R. Ed.), Elsevier volume 86007: 201-273. PMID: 20374717
Cao Y., Masuho I., Okawa H., Xie K, Asami J., Kammermeier P., Furukawa T., Inoue Y., Sampath A.P., Martemyanov K.A. (2009) Retina specific GTPase accelerator RGS11/Gb5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons. J. Neurosci. 29, 9301-9313. PMCID:PMC2731308
Anderson G.R., Lujan R., and Martemyanov K.A. (2009) Changes in striatal signaling induce remodeling of RGS complexes containing Gbeta5 and R7BP subunits. Mol. Cell Biol. 11:3033-3044. PMCID:PMC2682020
Martemyanov K.A., Krispel C.M., Lishko P.V., Burns M.E., and Arshavsky V.Y. (2008) Functional comparison of RGS9 splice isoforms in a living cell. Proc. Natl. Acad. Sci. USA 105:20988-20993. PMCID:PMC2634932
Hooks S., Martemyanov K., and Zachariou, V. (2008) A role of RGS proteins in drug addiction. Biochem. Pharmacol. 75, 76-84. PMID: 17880927
Kim H.J., Martemyanov K.A., and Thayer S.A. (2008) Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death. J. Neurosci. 28:12604-12613 PMCID:PMC2678679
Cao Y., Song H., Okawa H., Sampath A.P., Sokolov M., and Martemyanov K.A. (2008) Targeting of RGS7/G5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP. J. Neurosci. 28: 10443:10449. PMCID:PMC2587022
Anderson G.R., Lujan R., Semenov A., Pravetoni M., Posokhova E.N., Song J.H., Uversky V., Chen C-K., Wickman K., and Martemyanov K.A. (2007) Expression and Localization of RGS9-2/Gbeta5/R7BP Complex In Vivo Is Set by Dynamic Control of Its Constitutive Degradation by Cellular Cysteine Proteases. J. Neurosci. 27:14117-14127. PMID: 18094251
Song J.H., Song H., Wensel T.G., Sokolov M., and Martemyanov K.A. (2007) Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina. Mol. Cell. Neurosci. 35:311-319. PMID:17442586
Anderson G.R., Semenov A., Song J.H., Martemyanov K.A. (2007) The membrane anchor R7BP controls the proteolytic stability of the striatal specific RGS protein, RGS9-2. J. Biol. Chem. 282(7):4772-4781. PMID: 17158100
Song J.H., Waataja J.J., Martemyanov K.A. (2006) Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP. J. Biol. Chem. 281(22):15361-15369. PMID:16574655