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Molecular Medicine


Brian Modena, M.D.

Assistant Professor of Molecular Medicine
Assistant Professor of Scripps Translational Science Institute
Department of Molecular Medicine
California Campus
(858) 784-2036

Scripps Research Joint Appointments

Assistant Professor, Scripps Translational Science Institute
Assistant Professor, Department of Molecular Medicine
Faculty, Graduate Program

Other Joint Appointments

Scripps Health

Research Focus

Brian Modena, M.D., M.Sc. is a physician & researcher with trained expertise in Allergy-Immunology. He completed a 2-year Allergy-Immunology clinical fellowship with a focus on treating severe asthma patients at the University of Pittsburgh, a hub for the NIH-funded Severe Asthma Research Program. He obtained a M.Sc. in Clinical & Translational Research at the Scripps Research Institute (TSRI) with a focus in Genomics and Translational research, and joined STSI and TSRI as a joint Assistant Professor in 2016. He serves as a clinical preceptor to medical students and Allergy-Immunology fellows by maintaining a faculty appointment in the Scripps Health Allergy-Immunology Division.

His research interest involves the use of mRNA gene expression, epigenetic methylation changes, genetic variation, microbiome changes (‘dysbiosis’) and utilization of new health monitoring technologies to improve biological and clinical understanding of clinical disease, particularly in patients with severe asthma and organ transplantation. 




B.S., Mechanical Engineering, Virginia Polytechnic Institute & State University, 2000
M.D., Medicine, West Virginia University School of Medicine, 2006
M.Sc., Clinical & Translational Research, The Scripps Research Institute, 2016

Professional Experience

Mechanical Engineering, Virginia Polytechnic Institute & State University

Medicine, West Virginia University School of Medicine  

Internal Medicine, Scripps Clinic & Green Hospital

Internal Medicine, Scripps Clinic & Green Hospital 

Clinical Fellowship 
Allergy & Immunology, University of Pittsburgh

Masters in Science
Clinical & Translational Reserach, The Scripps Research Institute

Awards & Professional Activities

2016 Chairman’s Award of Research Excellence, Scripps Health, San Diego, CA
2015 "Going the Extra Mile" Teaching Award, University of California San Diego
2015 The Scripps Translational Science Institute’s KL2 Scholar Pilot Award
2014 Scripps Health Pilot Award 
2014 The Scripps Translational Science Institute’s KL2 Scholar Pilot Award           
2014 KL2 Clinical Scholar Program Scholarship
2014 Winner of American Academy of Allergy, Asthma, and Immunology National Conference Abstract Competition

Selected References

Modena, Brian D; Eugene R Bleecker; William W Busse; Serpil C. Erzurum; Benjamin M Gaston; Nizar N. Jarjour; Deborah A Meyers; Jadranka Milosevic; John R Tedrow; Wei Wu; Naftali Kaminski; Sally E Wenzel; Gene Expression Correlated to Severe Asthma Characteristics Reveals Heterogeneous Mechanisms of Severe Disease. In Press, Published online December 16, 2016. American Journal of Respiratory and Critical Care Medicine (AJRCCM).

Modena B, Tedrow J, Milosevic J, Bleecker E, Meyers D, Wu W, Bar-Joseph Z, Erzurum S, Gaston B, Busse W, Jarjour N, Kaminski N & Wenzel S. (2014). Gene Expression in Relation to Exhaled NO Identifies Novel Asthma Phenotypes with Unique Biomolecular Pathways. American Journal of Respiratory and Critical Care Medicine (AJRCCM). Vol. 190, No. 12 (2014), pp. 1363-1372. doi: 10.1164/rccm.201406-1099OC.

Modena Brian, Sunil M Kurian, Lillian W Gaber, Jill Waalen, Terri Gelbart, Tony S Mondala, Steven R Head, Suzanne Papp, Raymond Heilman, John J Friedewald, Stuart Flechner, Christopher L Marsh, Randall S. Sung, Hamid Shidban, Laurence Chan, Michael M Abecassis, Daniel R Salomon. (2016). Gene Expression in Biopsies of Acute Rejection and Interstitial Fibrosis/Tubular Atrophy Reveals Highly Shared Mechanisms that Correlate with Worse Long-term Outcomes.  American Journal of Transplantation (AJT). March 15, 2016. 

Modena, Brian D Rachel Milam, Frank Harrison, Jennifer A Cheeseman, Michael M Abecassis, John Friedewald, Allan D. Kirk, Daniel R Salomon. Changes in urinary microbiome populations correlate in kidney transplants with interstitial fibrosis and tubular atrophy documented in early surveillance biopsies. Sept 6, 2016. American Journal of Transplantation (AJT)

Modena, Brian D, Sally E Wenzel. Consistency of T2 Gene Signatures in Severe Asthma: Key to Effective Treatments or Merely the Tip of the Iceberg? In Press. 2016. American Journal of Respiratory and Critical Care Medicine (AJRCCM).

Modena, Brian, Kristen M Dazy, Andrew White Emerging Concepts: mast cell involvement in allergic diseases (2016). Translational Research. Feb 24, 2016

Cook K, Modena B, Wineinger N, Woessner, K, Simon R, White A. Use of a Composite Symptom Score during Challenge in Patients with Suspected Aspirin-Exacerbated Respiratory Disease. In Press (2017). Annals of Allergy, Asthma & Immunology.

Cook K, Modena B, Simon R. Improvement in Asthma Control Using a Minimally Burdensome and Proactive Smartphone Application. The Journal of Allergy and Clinical Immunology (JACI): In Practice. Jul-Aug;4(4):730-737.e1. doi: 10.1016/j.jaip.2016.03.005 (2016). 

Molecular Medicine Seminar Series
Center for Physiological Proteomics
Department Contacts

CA Faculty

Asahara, Hiroshi
Balch, William E.
Boddy, Michael
Buxbaum, Joel
Catz, Sergio
Conti, Bruno
Cravatt, Benjamin
D'Lima, Darryl
DerMardirossian, Celine
Deryugina, Elena
Elias, Darlene
Encalada, Sandra
Felding, Brunhilde
Fowler, Velia
Friedlander, Martin
Gerace, Larry
Gottesfeld, Joel
Griffin, John
Hanneken, Anne
Heeb, Mary Jo
Henderson, Scott
Hoch, James
Johnson, Eric
Kanaji, Taisuke
Koziol, James
Lamia, Katja
Lazzerini Denchi, Eros
Lipton, Stuart
Loring, Jeanne F.
Loskutoff, David
Lotz, Martin
Makarenkova, Helen P.
Mc Millan, Robert
Miles, Lindsey
Milner, Richard
Modena, Brian
Mosnier, Laurent
Nicholson, Laura
Paulson, James C.
Perego, Marta
Petrascheck, Michael
Pollard, Kenneth Michael
Quigley, James P.
Reed, Steven
Roberts, Edward
Rosen, Hugh
Ruggeri, Zaverio
Russell, Paul
Saez, Enrique
Smider, Vaughn
Srinivasan, Supriya
Steinhubl, Steven
Sutcliffe, J.
Tan, Eng
Topol, Eric
Vanderklish, Peter
Vogt, Peter K.
Wiseman, Luke
Wittenberg, Curt
Wolan, Dennis W.
Wu, Peng
Wu, Xiaohua
Yang, Xiang-Lei
Yates III, John

FL Faculty

Bannister, Thomas
Bohn, Laura M.
Cameron, Michael
Duckett, Derek
Gill, Matt
Griffin, Patrick
Hansen, Scott
Joazeiro, Claudio
Kamenecka, Theodore
Kissil, Joseph
Luo, Junli
McDonald, Patricia
Miller, Courtney
Niedernhofer, Laura
Phinney, Donald G.
Robbins, Paul
Scampavia, Louis
Schimmel, Paul
Smith, Roy
Spicer, Timothy

Affiliated Faculty

Cline, Hollis
Kojetin, Douglas
Lairson, Luke
Paegel, Brian
Rumbaugh, Gavin
Shen, Ben
Solt, Laura A
Su, Andrew
Wu, Chunlei
Ye, Li

Adjunct Faculty