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Molecular Medicine


Joseph Kissil, Ph.D.

Department of Molecular Medicine
Florida Campus
Laboratory Website
(561) 228-2170

Scripps Research Joint Appointments

Faculty, Graduate Program

Research Focus

Studies over the past several years have demonstrated that pathways regulating processes such as cell fate decisions and organ size control, during development, also play pivotal roles during tumorigenesis. While many of the individual signal transduction pathways have been outlined, a major ongoing challenge has been to integrate these findings into a comprehensive map of cellular signaling networks. Our lab is studying the signal transduction pathways regulated by small GTP-binding proteins from the Ras and Rac families and how these pathways crosstalk with pathways controlling cell fate and organ size control, such as the Notch, Wnt and Hpo/YAP pathways.


B.Sc., Life Sciences, Ben-Gurion University, Beer-Sheva, Israel, 1993
Ph.D., Molecular Biology, Weizmann Institute of Science, Rehovot, Israel, 1999

Professional Experience

Ph.D. research- Weizmann Institute of Science, 1993-1999
Postdoctoral fellowship - Massachusetts Institute of Technology, 1999-2004

Awards & Professional Activities

1999-2001       "Human Frontier Science Program" Award
2001-2003       NF Foundation "Young Investigator Award"
2003-2004       R.L. Kirchstein National Research Service Award
2010-2012       American Cancer Society Research Scholar Award.
2014                Scripps Florida Outstanding Mentor Award

Selected References

Kota, S., Hou, S., Guerrant, W., Madoux, F., Troutman, S., Fernandez-Vega, V., Alekseeva, N., Madala, N., Scampavia, L., Kissil, J.L.# and Spicer, T.P.# (#corresponding authors). “A novel 3-dimenasional high throughput screening approach identifies inducers of a KRAS selective lethal phenotype”. Oncogene (Published online 10 May) 2018.

Chinthalapudi, K., Mandati, V., Zheng, J., Griffin, P., Kissil, J.L., and Izard, T. “Lipid binding promotes the open conformation, membrane localization and tumor-suppressive activity of neurofibromin 2” Nature Communications 9(1338), 2018.

Moleirinho, S.; Hoxha, S.; Mandati, V.; Curtale, G.; Troutman, S.; Ehmer, U.; Kissil, J.L. "Regulation of localization and function of the transcriptional co-activator YAP by angiomotin." Elife. 2017 May 3;6 pii: e23966. doi: 10.7554/eLife.23966

Troutman, S.; Moleirinho, S.; Kota, S.; Nettles, K.; Fallahi, M.; Johnson, G. and Kissil, J.L. "Crizotinib inhibits NF2-associated schwannoma through inhibition of Focal Adhesion Kinase 1" Oncotarget, 7(34):54515-25, 2016.

Guerrant, W; Kota, S; Troutman, S; Mandati, V; Fallahi, M; Stemmer-Rachamimov, A; Kissil, J.L. "YAP Mediates Tumorigenesis in Neurofibromatosis Type 2 by Promoting Cell Survival and Proliferation through a COX-2-EGFR Signaling Axis". Cancer Research, 2016 May 23

Moleirinho, S.; Guerrant, W.; Kissil, J.L. "The Angiomotins – From discovery to function." FEBS Lett. 2014 Feb 15. pii:S0014-5793(14)00125-2. PMCID: PMC4112001

Yi, C., Shen, Z., Stemmer-Rachamimov, A., Dawany, N., Troutman, S., Showe, L.C., Liu, Q., Shimono, A., Sudol, M., Holmgren, L., Stanger, B.Z. and Kissil, J.L. “Angiomotin-p130 is required for Yap-mediated hepatic epithelial cell expansion and tumorigenesis”. Science Signal. 2013 Sep 3;6(291):ra77

Zhou, C., Troutman, S., Maksimoska, J., Liu, Q., Campbell, D., Marmorstein, R. and Kissil, J.L.FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of NF2-associated schwannomas“.J. Biol. Chem. 288(40):29105-14, 2013.

Licciulli, S., Avila, J.L., Hanlon, L., Troutman, S., Cesaroni, M., Keith, B., Simon, M.C., Pure, E., Radtke, F., Capobianco, A.J. and Kissil, J.L. “Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cells survival via p53”. Cancer Res. 73(19):5974-84, 2013

Chun, Z., Licciulli, S., Avila, J.L., Cho, M., Troutman, S., Jiang, P., Vachani, A., Albelda, S.M. and Kissil, J.L. “Rac1b, a splice form of Rac1, promotes K-ras-induced lung tumorigenesis”. Oncogene 32(7):903-9,  2012.

Yi C, Troutman S, Fera D, Stemmer-Rachamimov A, Avila J, Christian N, Persson NL, Speicher DW, Shimono A, Marmorstein R, Holmgren L and Kissil J.  "A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin’s Regulation of Mitogenic Signaling and Tumor Suppressive Functions" Cancer Cell. 2011 April 19:527-540.

Yi, C. and Kissil, J.L. “Merlin in organ size control and tumorigenesis: Hippo versus EGFR?”. Genes & Dev. 24:1673-80, 2010

Hanlon, L., Avila, J.L., Demarest, R.M., Troutman, S., Allen, M., Ratti, F., Rustgi, A.K., Stanger, B.Z., Radtke, F., Adsay, V., Long, F., Capobianco, A.J. and Kissil, J.L. “Notch1 functions as a tumor suppressor in K-ras-induced pancreatic ductal adenocarcinoma”. Cancer Res. 70: 4280-6, 2010

Santos, A.M., Jung, J., Aziz, N., Kissil, J.L.# and Puré E.# (#Equal contribution). “Targeting the Stroma Cell Protease Fibroblast Activation Protein Inhibits Tumor Growth”. J. Clin. Invest. 119:3613-25, 2009

Yi, C., Wilker, E.W., Yaffe, M.B., Stemmer-Rachamimov, A. and Kissil, J.L. “Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2. Cancer Res. 68:7932-7, 2008

Molecular Medicine Seminar Series
Center for Physiological Proteomics
Department Contacts

CA Faculty

Asahara, Hiroshi
Balch, William E.
Boddy, Michael
Buxbaum, Joel
Catz, Sergio
Conti, Bruno
Cravatt, Benjamin
D'Lima, Darryl
DerMardirossian, Celine
Deryugina, Elena
Elias, Darlene
Encalada, Sandra
Felding, Brunhilde
Fowler, Velia
Friedlander, Martin
Gerace, Larry
Gottesfeld, Joel
Griffin, John
Hanneken, Anne
Heeb, Mary Jo
Henderson, Scott
Hoch, James
Johnson, Eric
Kanaji, Taisuke
Koziol, James
Lamia, Katja
Lazzerini Denchi, Eros
Lipton, Stuart
Loring, Jeanne F.
Loskutoff, David
Lotz, Martin
Makarenkova, Helen P.
Mc Millan, Robert
Miles, Lindsey
Milner, Richard
Modena, Brian
Mosnier, Laurent
Paulson, James C.
Perego, Marta
Petrascheck, Michael
Pollard, Kenneth Michael
Quigley, James P.
Reed, Steven
Roberts, Edward
Rosen, Hugh
Ruggeri, Zaverio
Russell, Paul
Saez, Enrique
Smider, Vaughn
Srinivasan, Supriya
Steinhubl, Steven
Sutcliffe, J.
Tan, Eng
Topol, Eric
Vanderklish, Peter
Vogt, Peter K.
Wiseman, Luke
Wittenberg, Curt
Wolan, Dennis W.
Wu, Peng
Wu, Xiaohua
Yang, Xiang-Lei
Yates III, John

FL Faculty

Bannister, Thomas
Bohn, Laura M.
Cameron, Michael
Duckett, Derek
Gill, Matt
Griffin, Patrick
Hansen, Scott
Joazeiro, Claudio
Kamenecka, Theodore
Kissil, Joseph
Luo, Junli
McDonald, Patricia
Miller, Courtney
Niedernhofer, Laura
Phinney, Donald G.
Robbins, Paul
Scampavia, Louis
Schimmel, Paul
Smith, Roy
Spicer, Timothy

Affiliated Faculty

Cline, Hollis
Kojetin, Douglas
Lairson, Luke
Paegel, Brian
Rumbaugh, Gavin
Shen, Ben
Solt, Laura A
Su, Andrew
Wu, Chunlei
Ye, Li

Adjunct Faculty