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Molecular Medicine


Scott Hansen, Ph.D.

Associate Professor
Department of Molecular Medicine
Florida Campus
Laboratory Website
(561) 228-2415

Scripps Research Joint Appointments

Department of Neuroscience
Faculty, Graduate Program

Research Focus

Membrane proteins, and ion channels in particular, are important molecular switches that control nerve cell activity in the brain.  Ion channels are drug targets for the treatment of brain afflictions including addiction, pain, depression, and loss of consciousness. My lab employs electrophysiology, pharmacology, and membrane protein crystallography to understand lipid-gated ion channel  and develop receptor-selective compounds for the treatment of neurological disease.

My research is uniquely situated at the interface of ion channel regulation and lipid signaling. Recent findings, including my own, suggest that lipids gate ion channels by chemical means analogous to classical agonists or neurotransmitters. The number of ion channels inhibited or activated by lipids is extensive; they include the Kir, Kv, hERG, Slo, K2P, CNG, ENaC, TRP, P2X, nAChR, and GABA channels. We are developing the tools to answer important biophysical questions about lipid gating of ion channels.

A position is available to study the molecular mechanism of mechanosensation. Individuals, who are interested in joining the lab, please email Scott Hansen. Postdoc applicants with experinence in ion channel electrophysiology, or pharmacology are particularly encouraged to apply. 

Professional Experience

Ph.D. University of California, San Diego 2005

Awards & Professional Activities

NIH Director's New Innovator Award, DP2 (2013)
Postdoctoral Fellowship (2007-2011) Howard Hughes Medical Institute
Martin D. Kamen Award (2006), best doctoral thesis; University of California, San Diego
Young Scientist Travel Award (2006) American Society of Pharmacology and Experimental Therapeutics
Dissertation Fellowship (2003-2005) Tobacco Related Disease Research Program

Selected References

Cabanos C, Wang M, Han X, Hansen SB (2017) A Soluble Fluorescent Binding Assay Reveals PIP 2 Antagonism of TREK-1 Channels. Cell Rep 20(6):1287–1294.

E. Nicholas Peteresen, Hae-Wng Chung, Arman Nayebosadri, and Scott B. Hansen "Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D" Nature Commun. 2016 Dec (7) 13873; doi: 10.1038/ncomms13873. PubMed PMID: 27976674

Hansen SB “Lipid Agonism; the PIP2 Paradigm of ligand gated ion channels” Biochim Biophys Acta 2015 May 1851 (5): 620-628. 

Hansen SB, Xiao Tao, Roderick MacKinnon “Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2” Nature 2011, 477:495-98

Hansen SB, Wang, HL, Taylor P, and Sine SM “An Ion-Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance. J Biol Chem. 2008 Dec 26:283(52):36066-70

Hansen SB and Taylor P “Galanthamine and Non-competitive Inhibitor Binding to ACh-binding Protein: Evidence for a Binding Site on Non-a-subunit Interfaces of Heteromeric Neuronal Nicotinic Receptors” J. Mol. Biol. 2007 June 369, 895-901 

Gao F, Mer G, Tonelli M, Hansen SB, Burghart TP, Taylor P, Sine SM. “Solution NMR of Acetycholine Binding Protein Reveals ACh-mediated Conformational Change of the C-loop” Mol Pharmacol. 2006 Oct 70(4): 1230-5

Bourne Y, Talley TT, Hansen SB, Taylor P and Marchot P “Crystal structure of a Cbtx-AChBP complex reveals essential interaction between snake a-neurotoxins and nicotinic receptors” Embo J 2005, 24: 1512-22

Hibbs RE, Johnson DA, Shi J, Hansen SB, and Taylor P “Structural Dynamics of the a-Neurotoxin-Acetylcholine Binding Protein Complex: Hydrodynamic and Fluorescence Anisotropy Decay Analyses” Biochemistry 2005, 44:16602-11

Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P, and Bourne Y “Structures of Aplysia AChBP complexes with agonists and antagonists reveal distinctive binding interfaces and conformations” Embo J 2005, 24:3635-46

Gao F, Bren N, Burghardt TP, Hansen SB, Henchman RH, Taylor P, McCammon JA, Sine SM. “Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence” J Biol Chem. 2005 Mar 4;280(9):8443-51

Bouzat C, Gumilar F, Spitzmaul G, Wang HL, Rayes D, Hansen SB, Taylor P, and Sine SM “Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel” Nature 2004 Aug 19:430:896-900

Hansen SB, Talley TT, Radic Z, and Taylor P. “Structural and ligand recognition characteristics of an acetylcholine binding protein from Aplysia californica” J Biol Chem. 2004 Jun 4:279(23):24197-202

Gao F, Bern N, Little A, Wang HL, Hansen SB, Talley TT, Taylor P, and Sine SM. “Curariform antagonists bind in different orientations to acetylcholine-binding protein” J Biol Chem. 2003 Jun 20;278(25):23020-6.

Hansen SB, Radic Z, Talley TT, Molles BE, Deerinck T, Tsigelny I, and Taylor P. “Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein” J Biol Chem. 2002 Nov 1;277(44):41299-302.

Issued Patents

Hansen SB, Radic Z, and Taylor P “Methods for identifying agents that modulate LGIC receptor activity.” United States Patent 7947466. 24 May 2011

Hansen SB, Hansen AS "Methods for identifying molecules that modulate lipid binding sites of ion channels" United States Patent 8669065. 11 March 2014 


New Innovator Award 2013

Pubmed Citations

Neuroscience page

Press release, Appointment

Faculty of 1000

Webvision: notable paper

Google Scholar

Molecular Medicine Seminar Series
Center for Physiological Proteomics
Department Contacts

CA Faculty

Asahara, Hiroshi
Balch, William E.
Boddy, Michael
Buxbaum, Joel
Catz, Sergio
Conti, Bruno
Cravatt, Benjamin
D'Lima, Darryl
DerMardirossian, Celine
Deryugina, Elena
Elias, Darlene
Encalada, Sandra
Felding, Brunhilde
Fowler, Velia
Friedlander, Martin
Gerace, Larry
Gottesfeld, Joel
Griffin, John
Hanneken, Anne
Heeb, Mary Jo
Henderson, Scott
Hoch, James
Johnson, Eric
Kanaji, Taisuke
Koziol, James
Lamia, Katja
Lipton, Stuart
Loring, Jeanne F.
Loskutoff, David
Lotz, Martin
Makarenkova, Helen P.
Mc Millan, Robert
Miles, Lindsey
Milner, Richard
Modena, Brian
Mosnier, Laurent
Nicholson, Laura
Paulson, James C.
Perego, Marta
Petrascheck, Michael
Pollard, Kenneth Michael
Quigley, James P.
Reed, Steven
Roberts, Edward
Rosen, Hugh
Ruggeri, Zaverio
Russell, Paul
Saez, Enrique
Smider, Vaughn
Srinivasan, Supriya
Steinhubl, Steven
Sutcliffe, J.
Tan, Eng
Topol, Eric
Vanderklish, Peter
Vogt, Peter K.
Wiseman, Luke
Wittenberg, Curt
Wolan, Dennis W.
Wu, Peng
Wu, Xiaohua
Yang, Xiang-Lei
Yates III, John

FL Faculty

Bannister, Thomas
Bohn, Laura M.
Cameron, Michael
Duckett, Derek
Gill, Matt
Griffin, Patrick
Hansen, Scott
Joazeiro, Claudio
Kamenecka, Theodore
Kissil, Joseph
Luo, Junli
McDonald, Patricia
Miller, Courtney
Niedernhofer, Laura
Phinney, Donald G.
Robbins, Paul
Scampavia, Louis
Schimmel, Paul
Smith, Roy
Spicer, Timothy

Affiliated Faculty

Cline, Hollis
Kojetin, Douglas
Lairson, Luke
Paegel, Brian
Rumbaugh, Gavin
Shen, Ben
Solt, Laura A
Su, Andrew
Wu, Chunlei
Ye, Li

Adjunct Faculty