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Integrative Structural and Computational Biology

Robyn Stanfield, PhD

Institute Investigator
Department of Integrative Structural and Computational Biology
California Campus
(858) 784-2234

Research Focus

X-ray crystallographic studies of antibody-antigen complexes

My research is focused on x-ray crystallographic studies of antibody-antigen complexes, with an emphasis on antibodies that neutralize the HIV-1 virus. By studying the detailed structures of these complexes we can better understand how antibodies recognize their antigens, and how to design antigens to elicit an effective anti-viral response.


B.S., Chemistry, North Carolina State University, 1980
Ph.D., Chemistry, The University of Texas at Austin, 1986

Selected References

Stanfield RL, Dooley H, Flajnik MF, Wilson IA. Crystal Structure of a Shark Single-Domain Antibody V Region in Complex with Lysozyme. Science. 2004 Aug 19 [Epub ahead of print]

Stanfield RL, Gorny MK, Williams C, Zolla-Pazner S, Wilson IA. Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D. Structure (Camb). 2004 Feb;12(2):193-204.

Stanfield RL, Ghiara JB, Ollmann Saphire E, Profy AT, Wilson IA. Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop. Virology. 2003 Oct 10;315(1):159-73.

Stanfield R, Cabezas E, Satterthwait A, Stura E, Profy A, Wilson I. Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs. Structure Fold Des. 1999 Feb 15;7(2):131-42.