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Integrative Structural and Computational Biology

Kendall Nettles, PhD

Scripps Research Affiliate
Department of Integrative Structural and Computational Biology
Florida Campus
Laboratory Website
(561) 228-3209

Scripps Research Joint Appointments

Faculty, Graduate Program


Ph.D., Cancer Biology, The University of Chicago, 2003
B.A., Psychology, Colgate University, 1990

Awards & Professional Activities

Best Thesis, 2003. The Committee on Cancer Biology, The University of Chicago Elaine Erhman Award for Research in Cancer Biology, 2002. Awarded yearly to a senior graduate Student at the University of Chicago

Selected References

Nettles KW, Bruning JB, Gil G, Nowak J, Sharma SK, Hahm JB, Kulp K, Hochberg RB, Zhou H, Katzenellenbogen JA, Katzenellenbogen BS, Kim Y, Joachmiak A, Greene GL. NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses. Nat Chem Biol. 2008 4(4):241-7.

Nettles KW, Gil G, Nowak J, Metivier R, Sharma VB, Greene GL. CBP is a dosage dependent regulator of NFkB suppression by the estrogen receptor.Molecular Endocrinology, 2008, 22(2): 263-7

Bruning JB, Chalmers, MJ, Prasad S, Busby SA, Kamenecka TM, He Y, Nettles KW, Griffin PR. Partial Agonists Activate PPARα Using a Helix 12 Independent Mechanism. Structure, 2007 15(10):1258-7

Zhou HB, Nettles KW, Bruning JB, Kim Y, Joachimiak A, Sharma S, Carlson KE, Stossi F, Katzenellenbogen BS, Greene GL, Katzenellenbogen JA. Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands. Chem Biol. 2007 Jun;14(6):659-69.