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Integrative Structural and Computational Biology

Scott Henderson, PhD

Director, Core Microscopy Facility
Department of Molecular Medicine
California Campus
(858) 784-8163

Scripps Research Joint Appointments

Professor, Department of Integrative Structural and Computational Biology


Ph.D., Zoology / Cell Biology, Western University, 1990

Selected References

Saleh, T., Tyutyunyk-Massey, L., Murray, G. F., Alotaibi, M. R., Kawale, A. S., Elsayed, Z., Henderson, S. C., Yakovlev, V., Elmore, L. W., Toor, A., Harada, H., Reed, J., et al. Tumor cell escape from therapy-induced senescence Biochemical Pharmacology  2019 162:202-212  DOI:10.1016/j.bcp.2018.12.013 PMID:30576620

Mehta, A. P., Supekova, L., Chen, J. H., Pestonjamasp, K., Webster, P., Ko, Y., Henderson, S. C., McDermott, G., Supek, F., Schultz, P. G. Engineering yeast endosymbionts as a step toward the evolution of mitochondria Proceedings of the National Academy of Sciences of the United States of America 2018115:1179611801 DOI:10.1073/pnas.1813143115 PMID:30373839 PMCID:PMC6243291

Xu, X., Zhang, A., Halquist, M. S., Yuan, X., Henderson, S. C., Dewey, W. L., Li, P. L., Li, N. & Zhang, F. Simvastatin promotes NPC1-mediated free cholesterol efflux from lysosomes through CYP7A1/LXRα signalling pathway in oxLDL-loaded macrophages. (2017). Journal of Cellular and Molecular Medicine, 21(2), 364-374. PMCID: PMC5264135.

Baer, M. L., Henderson, S. C. & Colello, R. J. Elucidating the role of injury-induced electric fields (EFs) in regulating the astrocytic response to injury in the mammalian central nervous system. (2015). PLoS One, 10. PMCID: PMC4643040.

Li, W., Mukherjee, A., Wu, J., Zhang, L., Teves, M. E., Li, H., Nambiar, S., Henderson, S. C., Horwitz, A. R., Strauss, J. F. III, Fang, X., Zhang, Z. Sperm associated antigen 6 (SPAG6) regulates fibroblast cell growth, morphology, migration and ciliogenesis. (2015). Scientific Reports, 5. PMCID: PMC4653743.

Gauson, E. J., Windle, B., Donaldson, M. M., Caffarel, M. M., Dornan, E. S., Coleman, N., Herzyk, P., Henderson, S. C., Wang, X. & Morgan, I. M. Regulation of human genome expression and RNA splicing by human papillomavirus 16 E2 protein. (2014). Virology, 468, 10.

Marmarou, C. R., Liang, X., Abidi, N. H., Parveen, S., Taya, K., Henderson, S. C., Young, H. F., Filippidis, A. S. & Baumgarten, C. M. Selective vasopressin-1a receptor antagonist prevents brain edema, reduces astrocytic cell swelling and GFAP, V1aR and AQP4 expression after focal traumatic brain injury. (2014). Brain Research, 1581, 89. PMCID: PMC4240002.

Biggers, J. W., Nguyen, T., Di, X., Gupton, J. T., Henderson, S. C., Emery, S. M., Alotaibi, M., White, K. L., Brown, R., Almenara, J. & Gewirtz, D. A. Autophagy, cell death and sustained senescence arrest in B16/F10 melanoma cells and HCT-116 colon carcinoma cells in response to the novel microtubule poison, JG-03-14. (2013). Cancer Chemotherapy and Pharmacology, 71(2), 441-455.

Pomicter, A. D., DeLoyht, J. M., Hackett, A. R., Purdie, N., Sato-Bigbee, C., Henderson, S. C. & Dupree, J. L. Nfasc155H and MAG are specifically susceptible to detergent extraction in the absence of the myelin sphingolipid sulfatide.. (2013). Neurochemical Research, 38(12), 2490-2502. PMCID: PMC4917001.

Teves, M. E., Zhang, Z., Costanzo, R. M., Henderson, S. C., Corwin, F. D., Zweit, J., Sundaresan, G., Subler, M., Salloum, F. N., Rubin, B. K. & Strauss, J. F. III Sperm-associated antigen-17 gene is essential for motile cilia function and neonatal survival. (2013). American Journal of Respiratory Cell and Molecular Biology, 48(6), 765-772. PMCID: PMC3727877.

Wang, Y., Zankovs, D. P., Jiang, M., Zhang, M., Henderson, S. C. & Tseng, G. N. [Ca2+]i elevation and oxidative stress induce KCNQ1 protein translocation from the cytosol to the cell surface and increase slow delayed rectifier (IKs) in cardiac myocytes. (2013). Journal of Biological Chemistry, 288(49), 35358-35371. PMCID: PMC3853284.

Bristol, M. L., Di, X., Beckman, M. J., Wilson, E. N., Henderson, S. C., Maiti, A., Fan, Z. & Gewirtz, D. A. Dual functions of autophagy in the response of breast tumor cells to radiation: Cytoprotective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D-3. (2012). Autophagy, 8(5), 739-753. PMCID: PMC3378418.