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Integrative Structural and Computational Biology

Chunlei Wu, PhD

Associate Professor
Department of Integrative Structural and Computational Biology
California Campus
Laboratory Website
(858) 784-2111

Scripps Research Joint Appointments

Department of Molecular Medicine
Faculty, Graduate Program

Research Focus

We are currently focusing on applying data science methodology and cloud computing technologies to facilitate biomedical discovery, through the large-scale biological data integration.


Ph.D., Biomathematics and biostatistics, The University of Texas Health Science Center at Houston, 2006

Selected References

Xin J, Afrasiabi C, Lelong S, Adesara J, Tsueng G, Su AI, Wu C. Cross-linking BioThings APIs through JSON-LD to facilitate knowledge exploration. BMC Bioinformatics. 2018 Feb 1;19(1):30.

Xin J, Mark A, Afrasiabi C, Tsueng G, Juchler M, Gopal N, Stupp GS, Putman TE, Ainscough BJ, Griffith OL, Torkamani A, Whetzel PL, Mungall CJ, Mooney SD, Su AI, Wu C. High-performance web services for querying gene and variant annotation. Genome Biol. 2016 May 6;17(1):91.

Liu X, Wu C, Li C, Boerwinkle E. dbNSFP v3.0: A One-Stop Database of Functional Predictions and Annotations for Human Nonsynonymous and Splice-Site SNVs. Hum Mutat. 2016 Mar;37(3):235-41.

Wu C, Jin X, Tsueng G, Afrasiabi C, Su AI. BioGPS: building your own mash-up of gene annotations and expression profiles. Nucleic Acids Res. 2016 Jan 4;44(D1):D313-6.

Wu C
, MacLeod I, Su AI. Su. BioGPS and organizing online, gene-centric information, Nucleic Acids Res, 41(D1):D561-5 2013.

Wu C, Orozco C, Boyer J, Leglise M, Goodale J, Batalov S, Hodge CL, Haase J, Janes J, Huss JW 3rd and 
Su AI (2009) BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol10:R130.

Wu C, Delano DL, Mitro N, Su SV, Janes J, McClurg P, Batalov S, Welch GL, Zhang J, Orth AP, Walker JR, Glynne RJ, Cooke MP, Takahashi JS, Shimomura K, Kohsaka A, Bass J, Saez E, Wiltshire T and Su AI (2008) Gene set enrichment in eQTL data identifies novel annotations and pathway regulators. PLoS Genet, 4:e1000070.

Wu C, Zhao H, Baggerly K, Carta R, Zhang L (2007) Short oligonucleotide probes containing G-stacks display abnormal binding affinity on Affymetrix microarrays. Bioinformatics, 23(19):2566-72.

Wu C, Carta R, Zhang L (2005). Sequence dependence of cross-hybridization on short oligo microarrays. Nucleic Acids Res, 33(9):e84.