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Robyn Leigh Stanfield, Ph.D.

Associate Professor
Department of Integrative Structural and Computational Biology
California Campus
Scripps VIVO Scientific Profile
robyn@scripps.edu
(858) 784-2234

Research Focus

X-ray crystallographic studies of antibody-antigen complexes

My research is focused on x-ray crystallographic studies of antibody-antigen complexes, with an emphasis on antibodies that neutralize the HIV-1 virus. By studying the detailed structures of these complexes we can better understand how antibodies recognize their antigens, and how to design antigens to elicit an effective anti-viral response.

Education

B.S., Chemistry, North Carolina State University, 1980
Ph.D., Chemistry, The University of Texas at Austin, 1986

Professional Experience

1988-2012 Associate Professor, Molecular Biology, The Scripps Research Institute

Selected References

All Publications

Stanfield RL, Dooley H, Flajnik MF, Wilson IA. Crystal Structure of a Shark Single-Domain Antibody V Region in Complex with Lysozyme. Science. 2004 Aug 19 [Epub ahead of print]

Stanfield RL, Gorny MK, Williams C, Zolla-Pazner S, Wilson IA. Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D. Structure (Camb). 2004 Feb;12(2):193-204.

Stanfield RL, Ghiara JB, Ollmann Saphire E, Profy AT, Wilson IA. Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop. Virology. 2003 Oct 10;315(1):159-73.

Stanfield R, Cabezas E, Satterthwait A, Stura E, Profy A, Wilson I. Dual conformations for the HIV-1 gp120 V3 loop in complexes with different neutralizing fabs. Structure Fold Des. 1999 Feb 15;7(2):131-42.