Scripps Research Logo

Scott Snyder, Ph.D.

Associate Professor Adjunct
Department of Chemistry
Florida Campus
Laboratory Website
Scripps VIVO Scientific Profile
ssnyder@scripps.edu
(561) 228-2456

Research Focus

For synthetic organic chemistry to reach its full potential as an enabling science, especially in terms of its impact on biomedical and materials research, we must develop the skills not only to prepare any molecule efficiently, on-scale, and in environmentally benign ways, but also to tailor it in any way imaginable so that we can confer upon it whatever new properties we might desire.  Meeting this lofty objective requires complete command over chemoselectivity: the ability to differentiate and controllably functionalize any site within a given molecule. 

Our research program uses the inspiration of Nature’s chemoselective syntheses of tens of thousands of natural products through highly controlled cyclization and functionalization chemistries to provide a sense of our ultimate goal and to identify critical challenges worthy of laboratory execution.  Efforts to date have focused on oligomeric polyphenols, halogenated natural products, stereochemically-dense terpenes, and polycyclic alkaloids, and have afforded several new reagents, strategies, and tactics of broad applicability.

Education

B.A., Chemistry, Williams College, 1999
Ph.D., Chemistry, The Scripps Research Institute, 2004

Professional Experience

2013–Present, Associate Professor, The Scripps Research Institute, Department of Chemistry
2011–2013, Associate Professor, Columbia University, Department of Chemistry
2006–2011, Assistant Professor, Columbia University, Department of Chemistry
2004–2006, NIH Postdoctoral Fellow, Harvard University, Department of Chemistry

Awards & Professional Activities

The Chemical Record Lectureship
ACS Arthur C. Cope Scholar Award
Amgen Young Investigator and New Faculty Awards
DuPont Young Faculty Award
Alfred P. Sloan Research Fellowship
Bristol-Myers Squibb Unrestricted Grant
Cottrell Scholar Award
JSPS Fellowship
Columbia University Presidential Teaching Award
NSF CAREER Award
Eli Lilly New Faculty and Grantee Awards
Camille and Henry Dreyfus New Faculty Award

Selected References

All Publications

T. C. Sherwood, A. H. Trotta, S. A. Snyder.  A Strategy for Complex Dimer Formation When Biomicry Fails: Synthesis of 10 Coccinellid Alkaloids.  J. Am. Chem. Soc. 2014, 136, 9743.

T. H. Jepsen, S. B. Thomas, Y. Lin, C. I. Stathakis, I. de Miguel, S. A. Snyder. Harnessing Quinone Methides: Total Synthesis of (+)-Vaticanol A.  Angew. Chem. Int. Ed. 2014, 53, 6747.

N. E. Wright, S. A. Snyder.  9-Membered Carbocycle Formation: Development of Distinct Friedel-Crafts Cyclizations and Application to a Scalable Total Synthesis of (+)-Caraphenol A.  Angew. Chem. Int. Ed. 2014, 53, 3409.

M. W. Smith, S. A. Snyder. A Concise Synthesis of (+)-Scholarisine A Empowered by a Unique C-H Arylation. J. Am. Chem. Soc. 2013, 135, 12964.

A. M. ElSohly, D. A. Wespe, T. J. Poore, S. A. Snyder. An Efficient Approach to the Securinega Alkaloids Empowered by Cooperative N-Heterocyclic Carbene/Lewis Acid Catalysis. Angew.Chem. Int. Ed. 2013, 52, 5789.

S. A. Snyder, A. P. Brucks, D. S. Treitler, I. Moga.  Concise Synthetic Approaches for the Laurencia Family: Formal Total Syntheses of (±)-Laurefucin and (±)-E- and (±)-Z-Pinnatifidenyne. J. Am. Chem. Soc. 2012, 134, 17714. 

S. A. Snyder, S. B. Thomas, A. C. Mayer, S. P. Breazzano.  Total Syntheses of Hopeanol and Hopeahainol D Empowered by a Chiral Bronsted-acid Induced Pinacol Rearrangement. Angew. Chem. Int. Ed. 2012, 51, 4080.

S.A. Snyder, N. E. Wright, J. J. Pflueger, S. P. Breazzano.  Total Syntheses of Heimiol A, Hopeahainol D, and Constrained Analogues. Angew. Chem. Int. Ed. 2011, 50, 8629.

S. A. Snyder, A. Gollner, M. I. Chiriac. Regioselective Reactions for Programmable Resveratrol Oligomer Synthesis. Nature 2011, 474, 461.

S. A. Snyder, D. A. Wespe, J. M. von Hof. A Concise, Stereocontrolled Total Synthesis of Rippertenol. J. Am. Chem. Soc. 2011, 133, 8850.

S. A Snyder, A. M. ElSohly, F. Kontes. Synthetic and Theoretical Investigations of Myrmicarin Biosynthesis. Angew. Chem. Int. Ed. 2010, 49, 9693.