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Christina Sigurdson, D.V.M., Ph.D.

Assistant Professor Adjunct
Department of Immunology and Microbiology
California Campus
Scripps VIVO Scientific Profile
csigurd@scripps.edu
(858) 784-8054

Education

Ph.D., Colorado State University 2001
D.V.M., University of California, Davis 1994
B.S., University of California, Riverside 1990

Professional Experience

2008-2017 Assistant Professor Adjunct, Immunology and Microbial Science (IMS), The Scripps Research Institute

Selected References

All Publications

Kurt, T. D., Bett, C., Fernandez-Borges, N., Joshi-Barr, S., Hornemann, S., Rulicke, T., Castilla, J., Wuthrich, K., Aguzzi, A. & Sigurdson, C. J. Prion transmission prevented by modifying the beta 2-alpha 2 loop structure of host PrP(C). (2014). Journal of Neuroscience, 34(3), 1022-1027. PMCID: PMC3891945.

Bett, C., Kurt, T. D., Lucero, M., Trejo, M., Rozemuller, A. J., Kong, Q. Z., Nilsson, K. P. R., Masliah, E., Oldstone, M. B. & Sigurdson, C. J. Defining the conformational features of anchorless, poorly neuroinvasive prions. (2013). PLoS Pathogens, 9, e1003280. PMCID: PMC3630170.

Bett, C., Joshi-Barr, S., Lucero, M., Trejo, M., Liberski, P., Kelly, J. W., Masliah, E. & Sigurdson, C. J. Biochemical properties of highly neuroinvasive prion strains. (2012). PLoS Pathogens, 8, e1002522. PMCID: PMC3271082.

Sigurdson, C. J., Joshi-Barr, S., Bett, C., Winson, O., Manco, G., Schwarz, P., Rulicke, T., Nilsson, K. P. R., Margalith, I., Raeber, A., Peretz, D., Hornemann, S., et al. Spongiform encephalopathy in transgenic mice expressing a point mutation in the beta 2-alpha 2 loop of the prion protein. (2011). Journal of Neuroscience, 31(39), 13840-13847. PMCID: PMC3205959.

Sigurdson, C. J., Nilsson, K. P. R., Hornemann, S., Manco, G., Fernandez-Borges, N., Schwarz, P., Castilla, J., Wuthrich, K. & Aguzzi, A. A molecular switch controls interspecies prion disease transmission in mice. (2010). Journal of Clinical Investigation, 120(7), 2590-2599. PMCID: PMC2898603.

Sigurdson, C. J., Nilsson, K. P. R., Hornemann, S., Heikenwalder, M., Manco, G., Schwarz, P., Ott, D., Rulicke, T., Liberski, P. P., Julius, C., Falsig, J., Stitz, L., et al. De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis. (2009). Proceedings of the National Academy of Sciences of the United States of America, 106(1), 304-309. PMCID: PMC2629180.

Sigurdson, C. J., Peter, K., Nilsson, R., Hornemann, S., Manco, G., Polymenidou, M., Schwarz, P., Leclerc, M., Hammarstrom, P., Wuthrich, K. & Aguzzi, A. Prion strain discrimination using luminescent conjugated polymers. (2007). Nature Methods, 4(12), 1023-1030.