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Hans Renata, Ph.D.

Assistant Professor
Department of Chemistry
Florida Campus
Laboratory Website
Scripps VIVO Scientific Profile
hrenata@scripps.edu
(561) 228-2672

Scripps Research Joint Appointments

Faculty, Graduate Program

Research Focus

Despite rapid advances in synthetic organic chemistry, many classes of small molecules remain inefficient to access using conventional methods. Enzymatic reactions, on the other hand, offer unparalleled potential for highly selective chemical transformations. By combining the power of directed evolution and advances in microbial genomics, the Renata laboratory aims to develop practical enzymatic solutions for traditionally challenging organic reactions, especially in the realm of C–H functionalization chemistry. The utility of these transformations will be showcased in the concise, scalable synthesis of bioactive natural products and their analogues. After successfully synthesizing these small molecules, we will take advantage of the state-of-the-art HTS operation at Scripps to rapidly assay their pharmacological profiles. Research projects are designed to be highly interdisciplinary, providing students with broad exposure to synthetic organic chemistry, molecular biology, and enzyme engineering to ensure that they are well-equipped for future careers in both academia and industry.

Education

Ph.D. (Chemistry), The Scripps Research Institute, Scripps Graduate Program 2013
B.A. (Chemistry), Columbia University 2008

Professional Experience

2013-2016 Postdoctoral Scholar, California Institute of Technology

Selected References

All Publications

Hernandez, K. E., Renata, H., Lewis, R. D., Kan, S. B. J., Zhang, C., Forte, J., Rozzell, D., McIntosh, J. A. & Arnold, F. H. Highly stereoselective biocatalytic synthesis of key cyclopropane intermediate to ticagrelor. (2016). ACS Catalysis, 6(11), 7810-7813.

Renata, H., Lewis, R. D., Sweredoski, M. J., Moradian, A., Hess, S., Wang, Z. J. & Arnold, F. H. Identification of mechanism-based inactivation in P450-catalyzed cyclopropanation facilitates engineering of improved enzymes. (2016). Journal of the American Chemical Society, 138(38), 12527-12533. PMCID: PMC5042878.

Renata, H., Wang, Z. J. & Arnold, F. H. Expanding the Enzyme Universe: Accessing Non-Natural Reactions by Mechanism-Guided Directed Evolution. (2015). Angewandte Chemie-International Edition, 54(11), 3351-3367.

Renata, H., Zhou, Q., Dunstl, G., Felding, J., Merchant, R. R., Yeh, C. H. & Baran, P. S. Development of a concise synthesis of ouabagenin and hydroxylated corticosteroid analogues. (2015). Journal of the American Chemical Society, 137(3), 1330-1340. PMCID: PMC4353025.

Wang, Z. J., Peck, N. E., Renata, H. & Arnold, F. H. Cytochrome P450-catalyzed insertion of carbenoids into N-H bonds. (2014). Chemical Science, 5(2), 598-601. PMCID: PMC3906682.

Wang, Z. J., Renata, H., Peck, N. E., Farwell, C. C., Coelho, P. S. & Arnold, F. H. Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran. (2014). Angewandte Chemie - International Edition, 53(26), 6810-6813. PMCID: PMC4120663.

Renata, H., Wang, Z. J., Kitto, R. Z. & Arnold, F. H. P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions. (2014). Catalysis Science & Technology, 4(10), 3640-3643. PMCID: PMC4159215.

Renata, H., Zhou, Q. H. & Baran, P. S. Strategic redox relay enables a scalable synthesis of ouabagenin, a bioactive cardenolide. (2013). Science, 339(6115), 59-63. PMCID: PMC4365795.