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M.G. Finn, Ph.D.

Professor Adjunct
Department of Chemistry
California Campus
Laboratory Website
Scripps VIVO Scientific Profile
mgfinn@scripps.edu
(858) 837-3667

Scripps Research Joint Appointments

The Skaggs Institute for Chemical Biology
Center for Integrative Molecular Biosciences
Director, Training Prgm. in Molecular Evolution, Graduate Program

Other Joint Appointments

Editor-in-Chief, ACS Combinatorial Science

Research Focus

Catalysis and Nanotechnology

Our work focuses on three areas: (1) the use of viruses as chemical building blocks for catalysts, materials, pharmaceuticals, and diagnostic agents; (2) the development and applications of highly reliable organic transformations ("click chemistry") to the discovery of biologically active compounds and functional materials; and (3) the use of molecular evolution techniques to develop new enzymes. We engage in many collaborative projects with coworkers at TSRI and elsewhere, and our group is a highly interdisciplinary one.

Education

B.S., Chemistry, California Institute of Technology, 1980
Ph.D., Chemistry, Massachusetts Institute of Technology, 1986

Professional Experience

Postdoc (1986-88) Stanford University (J.P. Collman); NIH postdoctoral fellow, with research on catalytic metalloporphyrin complexes.
University of Virginia (1988-1999) Assistant and Associate Professor; research on organometallic chemistry, synthetic methods, and catalysis.
The Scripps Research Institute (1999-present) Associate and Full Professor.

Awards & Professional Activities

Founding Director, Scripps Predoctoral Training Program in Molecular Evolution
TSRI Academic Advisor for Chemical Biology, 2009-present
TSRI Chemistry Graduate Admissions committee, 1999-present (Chair, 2007-present)
NIH Consortium for Functional Glycomics, Subgroup leader, 2008 – present

Selected References

All Publications

"RNA-Directed Packaging of Enzymes within Virus-Like Particles” Fiedler, J.D.; Brown, S.D.; Lau, J.; Finn, M.G. Angew. Chem. Int. Ed. 2010, 49, 9648-9651.

"Stabilization of Virus-Like Particles with Poly(2-oxazoline)s” Manzenrieder, F.; Luxenhofer, R.; Retzlaff, M.; Jordan, R.; Finn, M.G. Angew. Chem. Int. Ed., 2011, in press.

"Quantitation of Membrane-Bound Protein-Ligand Interactions Using Backscattering Interferometry” Baksh, M.M.; Kussrow, A.; Mileni, M.; Finn, M.G.; Bornhop, D., Nat. Biotechnol., 2011, in press.

"Universal Sensing by Transduction of Antibody Binding using Backscattering Interferometry “ Kussrow, A.; Baksh, M.M.; Bornhop, D.J.; Finn, M.G., ChemBioChem 2010, in press. DOI: 10.1002/cbic.201000671.

"Labeling Live Cells by Copper-Catalyzed Alkyne-Azide Click Chemistry” Hong, V.; Steinmetz, N.F.; Manchester, M.; Finn, M.G. Bioconjugate Chem. 2010, 21, 1912-1916.

"Tailored Ligand Acceleration of the Cu-Catalyzed Azide-Alkyne Cycloaddition Reaction: Practical and Mechanistic Implications” Presolski, S.I.; Hong, Vu.; Cho, S.-H.; Finn, M.G., J. Am. Chem. Soc. 2010, 132, 14570-14576.

"An Unexpected Example of Protein-Templated Click Chemistry” Suzuki, T.; Ota, Y.; Kasuya, Y.; Mutsuga, M.; Kawamura, Y.; Tsumoto, H.; Nakagawa, H.; Finn, M.G.; Miyata, N., Angew. Chem. Int. Ed. 2010, 49, 6817-6820.

"Multivalent Display and Receptor-Mediated Endocytosis of Transferrin on Virus-Like Particles” Banerjee, D.; Liu, A.; Voss, N.R.; Schmid, S.; Finn, M.G. ChemBioChem 2010, 11, 1273-1279.

"Defining Criteria for Oligomannose Immunogens for HIV Using Icosahedral Virus Capsid Scaffolds” Astronomo, R.D.; Kaltgrad, E.; Udit, A.K.; Wang, S.-K.; Doores, K.J.; Huang, C.-Y.; Pantophlet, R.; Paulson, J.C.; Wong, C.-H.; Finn, M.G.; Burton, D.R., Chem. Biol. 2010, 17, 357-370.

"Effects of a Novel Arginine Methyltransferase Inhibitor on T Helper Cell Cytokine Production” Bonham, K.; Lim, Y.-H.; Hill, D.M.; Finn, M.G.; Mowen, K.A. FEBS J. 2010, 277, 2096-2108.

"Glycosylation using Unprotected Alkynyl Donors” Mamidyala, S.K.; Finn, M.G. J. Org. Chem. 2009, 74, 8417-8420.

"Analysis and Optimization of Copper-Catalyzed Azide-Alkyne Cycloaddition for Bioconjugation”  Hong, V.; Presolski, S.I.; Ma, C.; Finn, M.G., Angew. Chem., Int. Ed., 2009, 48, 9879-9883.

"Assembly of Hybrid Bacteriophage Qb Virus-Like Particles” Brown, S.D.; Fiedler, J.D.; Finn, M.G., Biochemistry 2009, 47, 11155-11157.

"Thiol-Selective Fluorogenic Probes for Labeling and Release” Hong, V.; Kislukhin, A.; Finn, M.G. J. Am. Chem. Soc. 2009, 131, 9986-9994.

"Measurement of Monovalent and Polyvalent Carbohydrate-Lectin Binding by Back-Scattering Interferometry” Kussorw, A.; Kaltgrad, E.; Wolfenden, M.L.; Cloninger, M.J.; Finn, M.G.; Bornhop, D.J. Anal. Chem. 2009, 81, 4889-4897.

"Peptide Cyclization and Cyclodimerization by CuI-Mediated Azide-Alkyne Cycloaddition” Jagasia, R.; Holub, J.M.; Bollinger, M.; Kirshenbaum, K.; Finn, M.G. J. Org. Chem. 2009, 74, 2964-2974.

"Heparin Antagonism by Polyvalent Display of Cationic Motifs on Virus-Like Particles” Udit, A.K.; Everett, C.; Gale, A.J.; Kyle, J.R.; Ozkan, M.; Finn, M.G. ChemBioChem, 2009, 10, 503-510.

"Unnatural Amino Acid Incorporation into Virus-Like Particles”  Strable, E.; Prasuhn, D.E., Jr.; Udit, A.K.; Brown, S.; Link, A.J.; Ngo, J.T.; Lander, G.; Quispe, J.; Potter, C.S.; Carragher, B.; Tirrell, D.A.; Finn, M.G. Bioconjugate Chem. 2008, 19, 866-875.

"Plasma Clearance of Bacteriophage Qb Particles as a Function of Surface Charge” Prasuhn, D.E., Jr.; Singh, P.; Strable, E.; Brown, S.; Manchester, M.; Finn, M.G. J. Am. Chem. Soc. 2008, 130, 1328-1334.

"Benzimidazole and Related Ligands for Cu-Catalyzed Azide-Alkyne Cycloaddition” Rodionov, V.O.; Presolski, S.; Gardinier, S.; Lim, Y.-H.; Finn, M.G. J. Am. Chem. Soc. 2007, 129, 12696-12704.

"Ligand-Accelerated Cu-Catalyzed Azide-Alkyne Cycloaddition: a Mechanistic Report” Rodionov, V.O.; Presolski, S.; Díaz, D.D.; Fokin, V.V.; Finn, M.G. J. Am. Chem. Soc. 2007, 129, 12705-12712.