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Gregg Fields, Ph.D.

Professor Adjunct
Department of Chemistry
Florida Campus
Scripps VIVO Scientific Profile
gfields@scripps.edu
(561) 228-2461

Education

Ph.D. (Chemistry), The Florida State University 1988
B.S. (Chemistry), University of Florida 1982
A.A. (Chemistry), Broward Community College 1979

Professional Experience

2010-2014 Vice President of Scientific Affairs, Torrey Pines Institute for Molecular Studies
1997-2008 Professor and Chair, Florida Atlantic University
1995-1997 Associate Professor, University of Minnesota Medical Center, University of Minnesota
1991-1995 Assistant Professor, University of Minnesota Medical Center, University of Minnesota
1988-1991 Postdoctoral Scholar, Pharmaceutical Chemistry, School of Medicine, University of California, San Francisco

Selected References

All Publications

Tagged Karabencheva-Christova, T. G., Christov, C. Z. & Fields, G. B. Collagenolytic matrix metalloproteinase structure-function relationships: insights from molecular dynamics studies. (2017). Structural and Mechanistic Enzymology. 1-24.

Amar, S., Smith, L. & Fields, G. B. Matrix metalloproteinase collagenolysis in health and disease. (2017). Biochimica Et Biophysica Acta-Molecular Cell Research, 1864(11), 1940-1951. PMCID: PMC5605394.

Choi, J. Y., Fuerst, R., Knapinska, A. M., Taylor, A. B., Smith, L., Cao, X., Hart, P. J., Fields, G. B. & Roush, W. R. Structure-based design and synthesis of potent and selective matrix metalloproteinase 13 inhibitors. (2017). Journal of Medicinal Chemistry, 60(13), 5816-5825.

Knapinska, A. M., Estrada, C. A. & Fields, G. B. The roles of matrix metalloproteinases in pancreatic cancer. (2017). Progress in Molecular Biology and Translational Science, 148, 339.

Singh, W., Fields, G. B., Christov, C. Z. & Karabencheva-Christova, T. G. Effects of mutations on structure-function relationships of matrix metalloproteinase-1. (2016). International Journal of Molecular Sciences, 17. PMCID: PMC5085758.

Jiang, J., Taylor, A. B., Choi, J. Y., Hart, P. J., Roush, W. R., Fields, G. B., Hodder, P. S., Minong, D. & Spicer, T. P. Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro. (2014). Journal of Medicinal Chemistry, 57(22), 9598-9611. PMCID: PMC4255739.

Madoux, F., Tredup, C., Scampavia, L., Chase, P. S., Hodder, P. S., Fields, G. B., Becker-Pauly, C., Minond, D. & Spicer, T. P. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β. (2014). Biopolymers, 102(5), 396-406. PMCID: PMC4339026.

Roth, J., Minond, D., Darout, E., Liu, Q., Lauer, J., Hodder, P., Fields, G. B. & Roush, W. R. Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds. (2011). Bioorganic & Medicinal Chemistry Letters, 21(23), 7180-7184. PMCID: PMC3210410.

Lauer-Fields, J. L., Minond, D., Chase, P. S., Baillargeon, P. E., Saldanha, S. A., Stawikowska, R., Hodder, P. & Fields, G. B. High throughput screening of potentially selective mmp-13 exosite inhibitors utilizing a triple-helical fret substrate. (2009). Bioorganic & Medicinal Chemistry, 17(3), 990-1005. PMCID: PMC3298815.

Lauer-Fields, J. L., Chalmers, M. J., Busby, S. A., Minond, D., Griffin, P. R. & Fields, G. B. Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity. (2009). Journal of Biological Chemistry, 284(36), 24017-24024. PMCID: PMC2781996.