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Derek Duckett, Ph.D.

Associate Professor
Associate Scientific Director I
Department of Molecular Medicine
Florida Campus
Laboratory Website
Scripps VIVO Scientific Profile
ducketdr@scripps.edu
(561) 228-2224

Scripps Research Joint Appointments

Faculty, Graduate Program

Research Focus

Work in our laboratory is aimed at evaluating small molecule kinase inhibitors of biologic and therapeutic interest. We are currently involved in refining a novel class of kinase inhibitors aimed at the therapeutic treatment of human diseases such as Parkinson’s Disease and Cancer. Protein kinases are important components of signal transduction pathways and deregulation of kinase activity can lead to human disease. Kinases have therefore become one of the most important target classes for drug development. Working closely with other disciplines such as chemistry, pharmacology, and drug metabolism, we aim to optimize lead compounds for potency and selectivity while minimizing toxicity to generate candidate molecules with appropriate drug like properties suitable for IND enabling and first time in human studies.

Education

Ph.D. (Biochemistry), The University of Dundee 1990
B.Sc. (Molecular Biology), University of Glasgow 1986

Professional Experience

2015-2017 Associate Professor of Molecular Therapeutics, Molecular Therapeutics, The Scripps Research Institute
2005-2015 Assistant Professor, Molecular Therapeutics, The Scripps Research Institute

Awards & Professional Activities

Member, American Association for Cancer Research

Selected References

All Publications

Therapeutic targeting of casein kinase 1δ in breast cancer. Rosenberg LH, Lafitte M, Quereda V, Grant W, Chen W, Bibian M, Noguchi Y, Fallahi M, Yang C, Chang JC, Roush WR, Cleveland JL, Duckett DR. Sci Transl Med. 2015 Dec 16;7(318):318ra202. doi: 10.1126/scitranslmed.aac8773. PMID: 26676609

Identification of an EGFRvIII-JNK2-HGF/c-Met-Signaling Axis Required for Intercellular Crosstalk and Glioblastoma Multiforme Cell Invasion. Saunders VC, Lafitte M, Adrados I, Quereda V, Feurstein D, Ling Y, Fallahi M, Rosenberg LH, Duckett DR. Mol Pharmacol. 2015 Dec;88(6):962-9. doi: 10.1124/mol.115.097774. Epub 2015 Oct 9. PMID: 26452771

Development of an HTS-Compatible Assay for the Discovery of Ulk1 Inhibitors. Rosenberg LH, Lafitte M, Grant W, Chen W, Cleveland JL, Duckett DR. J Biomol Screen. 2015 Aug;20(7):913-20. doi: 10.1177/1087057115579391. Epub 2015 Apr 7. PMID:25851035 

Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schürer S, Chen W, Nakanishi S, Licht K, Rosenberg LH, Li L, Feng Y, Cameron MD, Duckett DR, Cleveland JL, Roush WR. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80. doi: 10.1016/j.bmcl.2013.05.075. Epub 2013 May 31. PMID: 23787102

Stress-induced nuclear import of apoptosis signal-regulating kinase 1 is mediated by karyopherin α2/β1 heterodimer. Sturchler E, Feurstein D, Chen W, McDonald P, Duckett D. Biochim Biophys Acta. 2013 Mar;1833(3):583-92. doi: 10.1016/j.bbamcr.2012.10.023. Epub 2012 Oct 31. PMID: 23123190

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ. Nature. 2011 Aug 21;477(7364):349-53. doi: 10.1038/nature10368. PMID:21857681