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Adrienne Dubin, Ph.D.

Assistant Professor of Neuroscience
Department of Neuroscience
California Campus
Scripps VIVO Scientific Profile
adubin@scripps.edu
(858) 784-7646

Education

Ph.D. (Biology, Neuroscience), University of California, San Diego 1988
B.A. (Biology and Physics (magna cum laude)), Amherst College 1980

Professional Experience

2015-2017 Assistant Professor of Neuroscience, Molecular and Cellular Neuroscience (MCN), The Scripps Research Institute
2014-2015 Senior Staff Scientist, The Scripps Research Institute
2012-2014 Consultant, Transdermal Therapeutics
2005-2014 Staff Scientist, The Scripps Research Institute
2005-2008 Senior Research Associate, The Scripps Research Institute
2003-2005 Principal Scientist and Project Manager, Pain and Related Disorders Team, J&J Pharmaceutical Research & Development, Johnson & Johnson
2001-2003 Principal Scientist and Ion Channel Group Leader, Neuroscience Team, J&J Pharmaceutical Research & Development, Johnson & Johnson
1998-2000 Senior Scientist and Ion Channel Group Leader, Neuroscience Team, J&J Pharmaceutical Research & Development, Johnson & Johnson
1998-1998 Ion Channel consultant/Postdoctoral Fellow, Gene Discovery Team, Johnson & Johnson Pharmaceutical Research and Development, Johnson & Johnson
1997-1998 Assistant Project Scientist, Pharmacology Department, University of California, San Diego
1996-1997 Assistant Project Scientist, Department of Medicine (Cardiology), University of California, San Diego
1993-1994 Assistant Research Professor, Department of Biology, San Diego State University
1992-1993 Postdoctoral Fellow with Dr. Vincent Dionne, Pharmacology, University of California, San Diego
1989-1992 Postdoctoral Fellow with Dr. Richard Aldrich, Neurobiology and Molecular & Cellular Physiology, Stanford University
1988-1989 Postdoctoral Fellow with Dr. Darwin Berg, Biology, University of California, San Diego
1980-1982 Research Assistant with Drs. Torsten Wiesel (Nobel Prize winner in 1981) and Charles Gilbert, Department of Neurobiology, Harvard University
1980-1980 Research Assistant, Health and Safety Division, Oak Ridge National Laboratory
1978-1979 Research Assistant, Biophysics Unit, Lahey Clinic, Lahey Hospital & Medical Center

Selected References

All Publications

Syeda, R., Xu, J., Dubin, A. E., Coste, B., Mathur, J., Huynh, T., Matzen, J., Lao, J., Tully, D. C., Engels, I. H., Petrassi, H. M., Schumacher, A. M., et al. Chemical activation of the mechanotransduction channel Piezo1. (2015). eLife, 4, e07369. PMCID: PMC4456433.

Woo, S. H., Ranade, S., Weyer, A. D., Dubin, A. E., Baba, Y., Qiu, Z., Petrus, M., Miyamoto, T., Reddy, K., Lumpkin, E. A., Stucky, C. L., Patapoutian, A. Piezo2 is required for Merkel-cell mechanotransduction. (2014). Nature, 509(7502), 622-626. PMCID: PMC4039622.

Ranade, S. S., Woo, S. H., Dubin, A. E., Moshourab, R. A., Wetzel, C., Petrus, M., Mathur, J., Begay, V., Coste, B., Mainquist, J., Wilson, A. J., Francisco, A. G., et al. Piezo2 is the major transducer of mechanical forces for touch sensation in mice. (2014). Nature, 516(7529), 121-125. PMCID: PMC4380172.

Qiu, Z., Dubin, A. E., Mathur, J., Tu, B., Reddy, K., Miraglia, L. J., Reinhardt, J., Orth, A. P. & Patapoutian, A. SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel. (2014). Cell, 157(2), 447-458. PMCID: PMC4023864.

Dubin, A. E., Schmidt, M., Mathur, J., Petrus, M. J., Xiao, B. L., Coste, B. & Patapoutian, A. Inflammatory signals enhance piezo2-mediated mechanosensitive currents. (2012). Cell Reports, 2(3), 511-517. PMCID: PMC3462303.

Coste, B., Xiao, B. L., Santos, J. S., Syeda, R., Grandl, J., Spencer, K. S., Kim, S. E., Schmidt, M., Mathur, J., Dubin, A. E., Montal, M., Patapoutian, A. Piezo proteins are pore-forming subunits of mechanically activated channels. (2012). Nature, 483(7388), 176-181. PMCID: PMC3297710.

Blasius, A. L., Dubin, A. E., Petrus, M. J., Lim, B. K., Narezkina, A., Criado, J. R., Wills, D. N., Xia, Y., Moresco, E. M. Y., Ehlers, C., Knowlton, K. U., Patapoutian, A., et al. Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. (2011). Proceedings of the National Academy of Sciences of the United States of America, 108(48), 19413-19418. PMCID: PMC3228463.

Miyamoto, T., Petrus, M. J., Dubin, A. E. & Patapoutian, A. TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin. (2011). Nature Communications, 2, 369. PMCID: PMC3320851.

Dubin, A. E., Herr, D. R. & Chun, J. Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. (2010). Journal of Neuroscience, 30(21), 7300-7309. PMCID: PMC2932640.

Dubin, A. E. & Patapoutian, A. Nociceptors: The sensors of the pain pathway. (2010). Journal of Clinical Investigation, 120(11), 3760-3772. PMCID: PMC2964977.