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Adrienne Dubin, Ph.D.

Assistant Professor of Neuroscience
Department of Neuroscience
California Campus
Scripps VIVO Scientific Profile
adubin@scripps.edu
(858) 784-7646

Education

Ph.D. (Biology, Neuroscience), University of California, San Diego 1988
B.A. (Biology and Physics (magna cum laude)), Amherst College 1980

Professional Experience

2015-2017 Assistant Professor of Neuroscience, Molecular and Cellular Neuroscience (MCN), The Scripps Research Institute
2014-2015 Senior Staff Scientist, The Scripps Research Institute
2012-2014 Consultant, Transdermal Therapeutics
2005-2014 Staff Scientist, The Scripps Research Institute
2005-2008 Senior Research Associate, The Scripps Research Institute
2003-2005 Principal Scientist and Project Manager, Pain and Related Disorders Team, J&J Pharmaceutical Research & Development, Johnson & Johnson
2001-2003 Principal Scientist and Ion Channel Group Leader, Neuroscience Team, J&J Pharmaceutical Research & Development, Johnson & Johnson
1998-2000 Senior Scientist and Ion Channel Group Leader, Neuroscience Team, J&J Pharmaceutical Research & Development, Johnson & Johnson
1998-1998 Ion Channel consultant/Postdoctoral Fellow, Gene Discovery Team, Johnson & Johnson Pharmaceutical Research and Development, Johnson & Johnson
1997-1998 Assistant Project Scientist, Pharmacology Department, University of California, San Diego
1996-1997 Assistant Project Scientist, Department of Medicine (Cardiology), University of California, San Diego
1993-1994 Assistant Research Professor, Department of Biology, San Diego State University
1992-1993 Postdoctoral Fellow with Dr. Vincent Dionne, Pharmacology, University of California, San Diego
1989-1992 Postdoctoral Fellow with Dr. Richard Aldrich, Neurobiology and Molecular & Cellular Physiology, Stanford University
1988-1989 Postdoctoral Fellow with Dr. Darwin Berg, Biology, University of California, San Diego
1980-1982 Research Assistant with Drs. Torsten Wiesel (Nobel Prize winner in 1981) and Charles Gilbert, Department of Neurobiology, Harvard University
1980-1980 Research Assistant, Health and Safety Division, Oak Ridge National Laboratory
1978-1979 Research Assistant, Biophysics Unit, Lahey Clinic, Lahey Hospital & Medical Center

Selected References

All Publications

Murthy, S. E., Dubin, A. E. & Patapoutian, A. Piezos thrive under pressure: mechanically activated ion channels in health and disease. (2017). Nature Reviews Molecular Cell Biology, 18(12), 771-783.

Syeda, R., Xu, J., Dubin, A. E., Coste, B., Mathur, J., Huynh, T., Matzen, J., Lao, J., Tully, D. C., Engels, I. H., Petrassi, H. M., Schumacher, A. M., et al. Chemical activation of the mechanotransduction channel Piezo1. (2015). eLife, 4, e07369. PMCID: PMC4456433.

Woo, S. H., Ranade, S., Weyer, A. D., Dubin, A. E., Baba, Y., Qiu, Z., Petrus, M., Miyamoto, T., Reddy, K., Lumpkin, E. A., Stucky, C. L., Patapoutian, A. Piezo2 is required for Merkel-cell mechanotransduction. (2014). Nature, 509(7502), 622-626. PMCID: PMC4039622.

Ranade, S. S., Woo, S. H., Dubin, A. E., Moshourab, R. A., Wetzel, C., Petrus, M., Mathur, J., Begay, V., Coste, B., Mainquist, J., Wilson, A. J., Francisco, A. G., et al. Piezo2 is the major transducer of mechanical forces for touch sensation in mice. (2014). Nature, 516(7529), 121-125. PMCID: PMC4380172.

Qiu, Z., Dubin, A. E., Mathur, J., Tu, B., Reddy, K., Miraglia, L. J., Reinhardt, J., Orth, A. P. & Patapoutian, A. SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel. (2014). Cell, 157(2), 447-458. PMCID: PMC4023864.

Dubin, A. E., Schmidt, M., Mathur, J., Petrus, M. J., Xiao, B. L., Coste, B. & Patapoutian, A. Inflammatory signals enhance piezo2-mediated mechanosensitive currents. (2012). Cell Reports, 2(3), 511-517. PMCID: PMC3462303.

Coste, B., Xiao, B. L., Santos, J. S., Syeda, R., Grandl, J., Spencer, K. S., Kim, S. E., Schmidt, M., Mathur, J., Dubin, A. E., Montal, M., Patapoutian, A. Piezo proteins are pore-forming subunits of mechanically activated channels. (2012). Nature, 483(7388), 176-181. PMCID: PMC3297710.

Blasius, A. L., Dubin, A. E., Petrus, M. J., Lim, B. K., Narezkina, A., Criado, J. R., Wills, D. N., Xia, Y., Moresco, E. M. Y., Ehlers, C., Knowlton, K. U., Patapoutian, A., et al. Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype. (2011). Proceedings of the National Academy of Sciences of the United States of America, 108(48), 19413-19418. PMCID: PMC3228463.

Miyamoto, T., Petrus, M. J., Dubin, A. E. & Patapoutian, A. TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin. (2011). Nature Communications, 2, 369. PMCID: PMC3320851.

Dubin, A. E., Herr, D. R. & Chun, J. Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. (2010). Journal of Neuroscience, 30(21), 7300-7309. PMCID: PMC2932640.