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Elena Deryugina, Ph.D.

Assistant Professor of CMB
Department of Molecular Medicine
California Campus
Scripps VIVO Scientific Profile
(858) 784-7187

Professional Experience

2014-2017 Assistant Professor of CMB, Cell and Molecular Biology (CMB), The Scripps Research Institute
2004-2014 Staff Scientist, Cell Biology, The Scripps Research Institute
2003-2004 Scientific Associate, Vascular Biology
2002-2003 Research Assistant Professor, Sanford Burnham Prebys Medical Discovery Institute
1999-2002 Research Scientist, Sanford Burnham Prebys Medical Discovery Institute
1997-1999 Assistant Staff Scientist, La Jolla Institute for Experimental Medicine
1993-1996 Research Scientist, La Jolla Institute for Experimental Medicine
1991-1993 Invited Research Scientist, Medical Biology Institute
1988-1991 Senior Research Scientist, The Institute of Experimental Hematology, National Hematological Scientific Center (Moscow, Russia)
1984-1987 Research Scientist, Laboratory for Physiology of Hematopoiesis, The Institute of Experimental Hematology, National Hematological Scientific Center (Moscow, Russia)

Selected References

All Publications

Deryugina, E. I. & Kiosses, W. B. Intratumoral cancer cell intravasation can occur independent of invasion into the adjacent stroma. (2017). Cell Reports, 19(3), 601-616.

Vandooren, J., Born, B., Solomonov, I., Zajac, E., Saldova, R., Senske, M., Ugarte-Berzal, E., Martens, E., Van den Steen, P. E., Van Damme, J., Garcia-Pardo, A., Froeyen, M., et al. Circular trimers of gelatinase B/matrix metalloproteinase-9 constitute a distinct population of functional enzyme molecules differentially regulated by tissue inhibitor of metalloproteinases-1. (2015). Biochemical Journal, 465, 259. PMCID: PMC4399976.

Minder, P., Zajac, E., Quigley, J. P. & Deryugina, E. EGFR regulates the development and microarchitecture of intratumoral angiogenic vasculature capable of sustaining cancer cell intravasation. (2015). Neoplasia, 17(8), 634-649. PMCID: PMC4674488.

Deryugina, E. I. & Quigley, J. P. Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature. (2015). Matrix Biology, 44-46, 94. PMCID: PMC5079283.

Hodgson, M. C., Deryugina, E. I., Suarez, E., Lopez, S. M., Lin, D., Xue, H., Gorlov, I. P., Wang, Y. & Agoulnik, I. U. INPP4B suppresses prostate cancer cell invasion. (2014). Cell Communication and Signaling, 12, 61. PMCID: PMC4181726.

Casar, B., Rimann, I., Kato, H., Shattil, S. J., Quigley, J. P. & Deryugina, E. I. In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated beta1 integrin and induction of FAK/PI3K/Akt motility signaling. (2014). Oncogene, 33(2), 255-268. PMCID: PMC3931462.

Deryugina, E. I., Zajac, E., Juncker-Jensen, A., Kupriyanova, T. A., Welter, L. & Quigley, J. P. Tissue-infiltrating neutrophils constitute the major in vivo source of angiogenesis-inducing MMP-9 in the tumor microenvironment. (2014). Neoplasia, 16(10), 771-788. PMCID: PMC4212255.

Zajac, E., Schweighofer, B., Kupriyanova, T. A., Juncker-Jensen, A., Minder, P., Quigley, J. P. & Deryugina, E. I. Angiogenic capacity of M1-and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9. (2013). Blood, 122(25), 4054-4067. PMCID: PMC3862278.

Juncker-Jensen, A., Deryugina, E. I., Rimann, I., Zajac, E., Kupriyanova, T. A., Engelholm, L. H. & Quigley, J. P. Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination. (2013). Cancer Research, 73(14), 4196-4211. PMCID: PMC3754905.

Casar, B., He, Y., Iconomou, M., Hooper, J. D., Quigley, J. P. & Deryugina, E. I. Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells. (2012). Oncogene, 31(35), 3924-3938. PMCID: PMC4350937.