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Celine DerMardirossian, Ph.D.

Associate Professor of Molecular Medicine
Department of Molecular Medicine
California Campus
Laboratory Website
Scripps VIVO Scientific Profile
dmceline@scripps.edu
(858) 784-8217

Scripps Research Joint Appointments

Assistant Professor of Immunology, Department of Cell and Molecular Biology
Faculty, Graduate Program

Research Focus

My laboratory is interested in understanding the mechanics of signaling components that govern cancer cell movement. During cancer development, cells evade from primary tumor to invade distinct organs, a process called metastasis. During this event, tumor cells must move through tissues which require increased cell motility driven by remodeling of the cytoskeleton, cell-cell contacts and interactions with the extracellular matrix. Cells can switch their movement in response to the microenvironments. Our studies decipher the molecular components and the signaling mechanisms that orchestrate the modes of cancer cell migration in an adaptive response to the surroundings in the hope that this knowledge will ultimately contribute to new therapeutic strategies to treat cancer.

Education

Ph.D., Biology/Biochemistry, University of Paris-Orsay XI, 04/1

Professional Experience

2017-2017 Assistant Professor of Immunology and Microbiology, Immunology and Microbiology, The Scripps Research Institute
2017-2017 Assistant Professor of Molecular Medicine (Joint Appointment), Molecular Medicine, The Scripps Research Institute
1998-2017 Assistant Professor of Immunology, Immunology and Microbial Science (IMS), The Scripps Research Institute

Selected References

All Publications

 Spiering D, Sabouri-Ghomi M, Dagliyan O, DerMardirossian C, Hodgson L, Danuser G, Hahn KM. . (2016) "FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions." Nature Chemical Biology Oct;12(10):802-9. PMID: 27501396

Delorme-Walker V, Seo JY, Gohla A, Fowler B, Bohl B, DerMardirossian C (2015) "Chronophin coordinates cell leading edge dynamics by controlling active cofilin levels." Proc Natl Acad Sci U S A 112: E5150-5159. PMID: 23624884.

Timothy Huang, S Michael, Xu T, Sarkeshik A, Moresco J, Yates JR 3rd, Masliah E, Bokoch GM, DerMardirossian C. (2013) "A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation". Molecular Biology of the Cell, 24, p194-209.

Ritu Pathak, Violaine D. Delorme-Walker, Michael C. Howell, Anthony N. Anselmo, Michael A. White, Gary M. Bokoch and Céline DerMardirossian. (2012) "The Microtubule-associated Rho Activating Factor GEF-H1 interacts with Exocyst complex to regulate Vesicle Traffic". Developmental Cell, 23, p397-411.

Nicolas Taulet, Violaine D. Delorme-Walker and Céline DerMardirossian. (2012) "Reactive Oxygen Species Regulate Protrusion Efficiency by Controlling Actin Dynamics". PlosOne, 7.

Delorme-Walker V., Peterson J., Chernoff J., Waterman C., Danuser G. Bokoch G.M. and DerMardirossian C. (2011) "Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration". Journal of Cell Biology, 7, p1289.

Bielek, H., Anselmo A., and DerMardirossian C. (2009) "Morphological and proliferative abnormalities in renal mesangial cells lacking RhoGDI". Cell Signal, 12, p1974-1983.

Huang* TY, DerMardirossian*C, Bokoch GM. (2007) "Cofilin phosphatases and regulation of actin dynamics". Current Opinion Cell Biology, 18, p26-31.

DerMardirossian C, Rocklin G, Seo J, Bokoch GM. (2006) "Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling". Molecular Biology of the Cell, 17 p4760-4768,

DerMardirossian C, Schnelzer A, Bokoch GM. (2004) "Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase". Molecular Cell; 15: 117-127.