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Shane Crotty, Ph.D.

Professor Adjunct
Department of Immunology and Microbiology
California Campus
Scripps VIVO Scientific Profile
(858) 784-8104


Ph.D. (Biochemistry and Molecular Biology), University of California, San Francisco 2001
B.S. (Biology), Massachusetts Institute of Technology 1996
B.S. (Writing), Massachusetts Institute of Technology 1996

Professional Experience

2015-2017 Professor Adjunct, Immunology and Microbial Science (IMS), The Scripps Research Institute
2009-2014 Associate Professor, La Jolla Institute for Allergy and Immunology
2004-2010 Assistant Professor Adjunct, Department of Medicine, University of California, San Diego
2003-2009 Assistant Professor, La Jolla Institute for Allergy and Immunology
2001-2003 Postdoctoral Fellow in Immunology, Emory University
1995-1996 Research Technician, Massachusetts Institute of Technology

Selected References

All Publications

Pauthner, M., Havenar-Daughton, C., Sok, D., Nkolola, J. P., Bastidas, R., Boopathy, A. V., Carnathan, D. G., Chandrashekar, A., Cirelli, K. M., Cottrell, C. A., Eroshkin, A. M., Guenaga, J., et al. Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches. (2017). Immunity, 46(6), 1073-1088. PMCID: PMC5483234.

Kulp, D. W., Steichen, J. M., Pauthner, M., Hu, X., Schiffner, T., Liguori, A., Cottrell, C. A., Havenar-Daughton, C., Ozorowski, G., Georgeson, E., Kalyuzhniy, O., Willis, J. R., et al. Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding. (2017). Nature Communications, 8. PMCID: PMC5698488.

Havenar-Daughton, C., Lee, J. H. & Crotty, S. Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem. (2017). Immunological Reviews, 275(1), 49-61.

Havenar-Daughton, C., Carnathan, D. G., Torrents de la Peña, A., Pauthner, M., Briney, B., Reiss, S. M., Wood, J. S., Kaushik, K., van Gils, M. J., Rosales, S. L., van der Woude, P., Locci, M., et al. Direct probing of germinal center responses reveals immunological features and bottlenecks for neutralizing antibody responses to HIV Env trimer. (2016). Cell Reports, 17(9), 2195-2209. PMCID: PMC5142765.

Crotty, S. & Pipkin, M. E. In vivo RNAi screens: concepts and applications. (2015). Trends in Immunology, 36(5), 315-322. PMCID: PMC4810674.

Hu, J. K., Crampton, J. C., Cupo, A., Ketas, T., van Gils, M. J., Sliepen, K., de Taeye, S. W., Sok, D., Ozorowski, G., Deresa, I., Stanfield, R., Ward, A. B., et al. Murine antibody responses to cleaved soluble HIV-1 envelope trimers are highly restricted in specificity. (2015). Journal of Virology, 89(20), 10383-10398. PMCID: PMC4580201.

Martinez, G. J., Pereira, R. M., Aijo, T., Kim, E. Y., Marangoni, F., Pipkin, M. E., Togher, S., Heissmeyer, V., Zhang, Y. C., Crotty, S., Lamperti, E. D., Ansel, K. M., et al. The transcription factor NFAT promotes exhaustion of activated CD8(+) T cells. (2015). Immunity, 42(2), 265-278. PMCID: PMC4346317.

Chen, R., Belanger, S., Frederick, M. A., Li, B., Johnston, R. J., Xiao, N., Liu, Y. C., Sharma, S., Peters, B., Rao, A., Crotty, S., Pipkin, M. E. In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation. (2014). Immunity, 41(2), 325-338. PMCID: PMC4160313.

Matho, M. H., de Val, N., Miller, G. M., Brown, J., Schlossman, A., Meng, X., Crotty, S., Peters, B., Xiang, Y., Hsieh-Wilson, L. C., Ward, A. B., Zajonc, D. M. Murine anti-vaccinia virus D8 antibodies target different epitopes and differ in their ability to block D8 binding to CS-E. (2014). PLoS Pathogens, 10. PMCID: PMC4256255.

Wang, H., Geng, J., Wen, X., Bi, E., Kossenkov, A. V., Wolf, A. I., Tas, J., Choi, Y. S., Takata, H., Day, T. J., Chang, L. Y., Sprout, S. L., et al. The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells. (2014). Nature Immunology, 15(7), 667-675. PMCID: PMC4142638.