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Michael Bollong, Ph.D.

Scripps Fellow
Department of Chemistry
California Campus
mbollong@scripps.edu
(858) 784-9333

Research Focus

Using high throughput chemical screening and downstream target identification experiments, we are focused on using small molecule tools to elucidate the molecular processes governing cellular identity and survival in various human disease states. Current discovery efforts are aimed at identifying compounds which (1) promote adult somatic stem cell self renewal, (2) activate cell survival and detoxification pathways (e.g., NRF1/2, MTF1), and (3) inhibit previously untargeted transcriptional regulators which control cell fate decisions.
We complement these efforts with an additional focus on developing new high throughput and molecular diversity-based methods to accelerate biological discovery. To this end, we are developing platforms for profiling inhibitor-enzyme interactions en masse, deconvoluting the cellular targets for bioactive small molecules and peptides, and leveraging the chemical diversity present in existing chemical libraries as a source of new reactivity for covalent inhibitor design.

Education

B.S., Biochemistry and Cell Biology, University of California, San Diego, 2009
Ph.D., Chemistry, The Scripps Research Institute, 2016