Scripps Research Joint Appointments

Faculty, Graduate Program

Education

B.S., Chemistry, Case Western Reserve University, 2007
Ph.D., Chemistry , Yale University , 2013

Professional Experience

American Cancer Society Postdoctoral Fellow, The Scripps Research Institute, 2013-2018

Awards & Professional Activities

2017    Aspen Cancer Conference Fellow
2014-2017   American Cancer Society Postdoctoral Fellow
2009    Dox Fellowship in Recognition of Excellence in Academics and Research in Organic Chemistry
2008    T.F. Cooke Award for Teaching Assistant Excellence
2007    Polymer Valley Chemical Undergraduate Research Award
2006    GlaxoSmithKline (GSK) Undergraduate Research Fellowship
2005    Howard Hughes Medical Institute (HHMI) Undergraduate Research Fellowship
2005    Merck Index Award
2005-2007   Case Western Reserve Alumni Scholarship
2003-2007   Full tuition scholarship - Case Western Reserve University

 

Selected References

Parker, C.G.^#; Cravatt, B.F. ^# “Chemistry Takes Center Stage for Identifying Cancer Targetability” Cell, 2018, 173, 815. (^#co-corresponding authors, Preview)

Galmozzi, A.*; Parker, C.G.*, Kok, B. P.; Cravatt, B.F.; Saez, E. “Discovery of Modulators of Adipocyte Physiology Using Fully Functionalized Fragments” Methods Mol Biol, 2018, 1787, 115. (*co-first authors)

Parker, C. G.^#; Kuttruf, C. A.; Galmozzi, A.; Jorgensen, L.; Chein-Hung, Y.; Hermanson, D.H.; Wang, Y.; Perez, M.E.; McKerrall, S.J.; Joslyn, C. J; Duenstl, G.; Felding, J.; Saez, E.; Baran, P.S.^#; Cravatt, B.F^#. “Chemoproteomic Profiling Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs” ACS Cent Sci, 2017, 3, 1276. (^#co-corresponding authors). 

Schonhoft, J.D.*; Monteiro, C.*; Plate, L.; Eisele, Y.S.; Kelly, J.; Boland, D.; Parker, C.G.; Cravatt, B.F.; Berk, J.; Sekijima, Y.; Maurer, M.; Novais, M.; Coelho, T.; Powers, E.T.; Kelly, J.W. “Peptide Probes Detect Misfolded Transthyretin Oligomers in the Plasma of Early Stage Hereditary Amyloidosis Patients” Science Translational Medicine, 2017, 9, eaam7621. (*co-first authors)

Parker, C. G.*^#; Galmozzi, A.*; Wang, W.; Correia, B. E.; Sasaki, K.; Joslyn, C. J.; Kim, A. S.; Cavallaro, C. L.; Lawrence, M.; Johnson, S. R.; Saez, E.^#; Cravatt, B. F.^# “Ligand and target discovery by fragment-based screening in human cells” Cell, 2017, 168, 527-541. (*co-first authors; #co-corresponding authors)

    Featured in News and Analysis in Nature Reviews Drug Discovery, 2017, 16, 225; as a Research Highlight in Nature Protocols, 2017, 225, 52; recommended on F1000prime as being of special significance; highlighted online in Science Translational Medicine: In the Pipeline (3/2/2017) and in Drug Discovery News; TSRI Top 10 Scientific Breakthroughs of 2017.

Parker, C.G.; Dahlgren, M.K.; Li, D.T.; Jawanda, N.; Shoda, T.; Spasov, K.A.; Domaoal, R.A.; Sutton, R.; Anderson, K.S.; Jorgensen, W.L.; Spiegel, D.A. ”Illuminating gp120–Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules,” Chemical Science, 2014, 5, 2311-2317.

Jakobsche, C.E.*; Parker, C.G.* Tao, R.N.; Kolesnikova, M.D.; Spiegel, D.A. “Comparing Activities and Prevalence of Natural Antibody Populations from Human Serum,” ACS Chemical Biology, 2012, 7, 1139-1151. (*co-first authors)

McEnaney, P. J.*; Parker, C.G.*; Zhang, A.X.* Spiegel, D.A. “Antibody-Recruiting Molecules: An Emerging Paradigm for Engaging Immune Function in Treating Human Disease,” ACS Chemical Biology, 2012, 7, 1139-1151. (*co-first authors)

Parker, C.G.; Domaoal, R.A.; Anderson, K.S.; Spiegel, D.A.  “An Antibody-Recruiting Small Molecule That Targets HIV gp120,” J. Am. Chem. Soc., 2009, 131, 16392-16394.

This work was also featured as a spotlight in ACS Chemical Biology, 2009, 4, 975, and was highlighted online by Drug Discovery News, Popular Science, and as ACS Noteworthy Chemistry

Garner, P.; Hu, J.; Parker, C. G.; Youngs, W. J.; Medvetz, D. "The Cu(I) Catalyzed Exo-Selective Asymmetric Multicomponent [C+NC+CC] Coupling Reaction” Tetrahedron Lett, 2007,48 3867.