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The Reed Lab

Partial List of Publications by Steven I. Reed

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Tat J, Loriot C, Henze M, Spruck C, Felding BH, Reed SI. CKS protein overexpression renders tumors susceptible to a chemotherapeutic strategy that protects normal tissues. Oncotarget, 2017, 8:114911-114923.
PMID: 29383129 [PubMed]

Teixeira LK, Reed SI. Cyclin E Deregulation and Genomic Instability. Adv Exp Med Biol., 2017, 1042:527-547. doi: 10.1007/978-981-10-6955-0_22.
PMID: 29357072 [PubMed]

Mu R, Tat J, Zamudio R, Zhang Y, Yates JR 3rd, Kumagai A, Dunphy WG, Reed SI. CKS Proteins Promote Checkpoint Recovery by Stimulating Phosphorylation of Treslin. Mol Cell Biol., 2017, vol. 37 no. 20 e00344-17.
28739856 [PubMed]

French ME, Klosowiak JL, Aslanian A, Reed SI, Yates JR 3rd, Hunter T. Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase. J Biol Chem, 2017, 292:10398-10413.
PMID: 28461335 [PubMed]

Teixeira LK and Reed, SI. Cdc6: Skin in the carcinogenesis game. Cell Cycle, 2016, 15: 313.
PMID: 26694635 [PubMed]

Teixeira, LK, Wang X, Li, Y, Ekholm-Reed, S, Wu, X, Reed SI. Cyclin E Deregulation Promotes Loss of Specific Genomic Regions. Curr. Biol., 2015, 25:1327-1333
PMID: 25959964 [PubMed]

Del Rincon SV, Widschwendter M, Sun D, Ekholm-Reed S, Tat J, Teixeira LK, Ellederova Z, Grolieres E, Reed SI, Spruck C. Cks overexpression enhances chemotherapeutic efficacy by overriding DNA damage checkpoints.  Oncogene, 2014,34:1961-1967
PMID: 24858038 [PubMed]

Ekholm-Reed S, Goldberg M, Schlossmacher M, Reed SI. Parkin-Dependent Degradation of Fbw7β Promotes Neuronal Survival by Stabilizing Mcl-1.  Mol Cell Biol., 2013, 33:3627-43.
PMID: 23858059 [PubMed]

Pan YR, Sun M., Wohlschlegel J, Reed SI. Cks1 Enhances Transcription Efficienty at the GAL1 locus by Linking the Paf1 complex to the 19S Proteasome. Eukaryot Cell, 2013, 12:1192-201.
PMID: 23825181 [PubMed]

Teixeira LK, and Reed SI. Ubiquitin Ligases and Cell Cycle Control. Annu Rev Biochem. 2013, 82:387-414.
PMID:2349593 [PubMed]

Bhaskaran N, van Drogen F, Ng HF, Kumar R, Ekholm-Reed S, Peter M, Sangfelt O, Reed SI. Fbw7α and Fbw7γ collaborate to shuttle cyclin E1 into the nucleolus for multiubiquitylation. Mol Cell Biol., 2013, 33:85-97.
PMID: 23109421 [PubMed]

Simmons Kovacs LA, Mayhew MB, Orlando DA, Jin Y, Li Q, Huang C, Reed SI, Mukherjee S, Haase SB. Cyclin-Dependent Kinases Are Regulators and Effectors of Oscillations Driven by a Transcription Factor Network. Mol Cell, 45:669-79.
PMID: 22306294 [PubMed]

Reed SI. Stacking the deck: Putting your Ases where you want them. Cell Cycle, 2011, 10:2625-2626.
PMID:21829101 [PubMed]

Liberal V, Martinsson-Ahlzén HS, Liberal J, Spruck CH, Widschwendter M, McGowan CH, Reed SI. Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins. Proc Natl Acad Sci U S A., 2012, 109:2754-9.
PMID: 21697511 [PubMed]

Liberal V, De Miguel MP, Henze M, Nistal M, Reed SI. Reduced spermatogonial proliferation and decreased fertility in mice overexpressing cyclin E in spermatogonia. Cell Cycle,2010, 9:4222-7.
PMID:20962587 [PubMed]

Chaves S, Baskerville C, Yu V, Reed SI. Cks1, Cdk1, and the 19S proteasome collaborate to regulate gene induction-dependent nucleosome eviction in yeast. Mol Cell Biol., 2010, 30:5284-94.
PMID:20855529 [PubMed]

Chuang LC, Teixeira LK, Wohlschlegel JA, Henze M, Yates JR, Méndez J, Reed SI. Phosphorylation of Mcm2 by Cdc7 promotes pre-replication complex assembly during cell-cycle re-entry. Mol Cell.,2009, 35:206-16.
PMID:19647517 [PubMed]

Martinsson-Ahlzén HS, Liberal V, Grünenfelder B, Chaves SR, Spruck CH, Reed SI. Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells. Mol Cell Biol.,2008, 28:5698-709. 
PMID:18625720 [PubMed]

Baskerville C, Segal M, Reed SI. The protease activity of yeast separase (esp1) is required for anaphase spindle elongation independently of its role in cleavage of cohesin. Genetics, 2008, 178:2361-72.
PMID:18430955 [PubMed]

Sangfelt O, Cepeda D, Malyukova A, van Drogen F, Reed SI. Both SCF(Cdc4alpha) and SCF(Cdc4gamma) are required for cyclin E turnover in cell lines that do not overexpress cyclin E. Cell Cycle, 2008, 7:1075-82.
PMID:18414042 [PubMed]

Reed, SI. Deathproof: new insights on the role of skp2 in tumorigenesis. Cancer Cell, 2008, 13:88-9.
PMID:18242509 [PubMed]

Olson BL, Hock MB, Ekholm-Reed S, Wohlschlegel JA, Dev KK, Kralli A, Reed SI. SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis. Genes Dev,.2008, 22:252-64.
PMID:18198341 [PubMed]

Akhoondi S, Sun D, von der Lehr N, Apostolidou S, Klotz K, Maljukova A, Cepeda D, Fiegl H, Dafou D, Marth C, Mueller-Holzner E, Corcoran M, Dagnell M, Nejad SZ, Nayer BN, Zali MR, Hansson J, Egyhazi S, Petersson F, Sangfelt P, Nordgren H, Grander D, Reed SI, Widschwendter M, Sangfelt O, Spruck C. FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res., 2007, 67:9006-12.
PMID: 17909001 [PubMed]

Egyhazi S, Petersson F, Sangfelt P, Nordgren H, Grander D, Reed SI, Widschwendter M, Sangfelt O, Spruck C. Cancer Res.,2007, 67:9006-12. Erratum in: Cancer Res. 2008 Feb 15;68(4):1245. Dofou, Dimitra [corrected to Dafou, Dimitra].
PMID:17909001 [PubMed]

Keck JM, Summers MK, Tedesco D, Ekholm-Reed S, Chuang LC, Jackson PK, Reed SI. Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1). J Cell Biol.,2007, 178:371-85.
PMID:17664332 [PubMed]

Keller UB, Old JB, Dorsey FC, Nilsson JA, Nilsson L, MacLean KH, Chung L, Yang C, Spruck C, Boyd K, Reed SI, Cleveland JL. Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. EMBO J.,2007, 26:2562-74.
PMID:17464290 [PubMed]

Reed SI. Cooperation between different Cdc4/Fbw7 isoforms may be associated with 2-step inactivation of SCF(Cdc4) targets. Cell Cycle, 2006, 5:1923-4.
PMID:16929178 [PubMed]

Reed SI. The ubiquitin-proteasome pathway in cell cycle control. Results Probl Cell Differ.,2006, 42:147-81.
PMID:16903211 [PubMed]

Spruck C, Sun D, Fiegl H, Marth C, Mueller-Holzner E, Goebel G, Widschwendter M, Reed SI. Detection of low molecular weight derivatives of cyclin E1 is a function of cyclin E1 protein levels in breast cancer. Cancer Res.,2006, 66:7355-60.
PMID:16849587 [PubMed]

van Drogen F, Sangfelt O, Malyukova A, Matskova L, Yeh E, Means AR, Reed SI. Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms. Mol Cell., 2006, 23:37-48.
PMID:16818231 [PubMed]

Smith AP, Henze M, Lee JA, Osborn KG, Keck JM, Tedesco D, Bortner DM, Rosenberg MP, Reed SI. dDeregulated cyclin E promotes p53 loss of heterozygosity and tumorigenesis in the mouse mammary gland. Oncogene, 2006, 25:7245-59. 
PMID:16751806 [PubMed]

Wohlschlegel JA, Johnson ES, Reed SI, Yates JR 3rd. Improved identification of SUMO attachment sites using C-terminal SUMO mutants and tailored protease digestion strategies. J Proteome Res., 2006, 5:761-70.
PMID:16602682 [PubMed]





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