The Scripps Research Institute - At The Forefront

May 2016

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Focus on:
A Promising Advance in HIV Research

Some people infected with HIV naturally produce antibodies that neutralize many strains of this rapidly mutating virus, and vaccine researchers are searching for ways to induce production of such broadly neutralizing antibodies in everyone.

Now, a team including scientists from The Scripps Research Institute (TSRI) has discovered a precursor cell that can produce broadly neutralizing antibodies exists in most people a breakthrough that could contribute to the creation of an effective vaccine against the virus.

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One of the key authors of the new HIV/AIDS vaccine research study from The Scripps Research Institute, William Schief.






TSRI's groundbreaking research is developing new treatments and cures for devastating diseases, including HIV and diabetes. Please support this life-saving work.


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Key authors of the new study from The Scripps Research Institute included (left to right) Staff Scientist Sunil Kurian, Professor Daniel Salomon and Clinical Scholar Brian Modena.


milestones in medical science:
Can Organ Transplant Rejection Become a Thing of the Past?

Despite advances in organ transplant medicine in recent decades, about half of all kidney transplant patients still lose their organ to rejection within 10 years. These patients must return to dialysis, which is more expensive than a kidney transplant and has higher risks of complications, including death.

Now, a study led by TSRI scientists shows that both early and late kidney rejection, although currently believed by many to be separate diseases, are in fact both due to the same immune rejection process a discovery that could lead to improved therapies.

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Professor Benjamin F. Cravatt (left), here with study co-first author William Parsons.


Other News:
A New Target for Treating Diabetes

A team led by scientists at TSRI and the Salk Institute for Biological Studies has discovered two previously unidentified enzymes that appear to play a role in metabolism and inflammations. These enzymes, which bear little resemblance to any known enzyme class, might someday be targeted with drugs to treat type 2 diabetes and inflammatory disorders.

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Two Scripps Florida Scientists Awarded Alzheimer's Young Investigator Scholarships

Senior Research Associate Bindu Raveendra and Research Associate Supriya Swarnkar, both of the Puthanveettil lab at Scripps Florida, have been awarded Young Investigator Scholarships by the Alzheimer's Drug Discovery Foundation for their promising research to develop new treatments for Alzheimer's and related dementias. Dr. Raveendra is currently screening compound libraries to find activators of axonal transport, which potentially can be used to develop novel therapeutics for memory disorders such as Alzheimer's disease. Dr. Swarnkar is focusing on the role of kinesins in sub-regions of the hippocampus in memory. Congratulations to both of them!



facts & figures

Each year, approximately 2 million people are newly infected with HIV, including approximately 220,000 children.




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