The Scripps Research Institute - At The Forefront

February 2016

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Focus on:
Stopping Breast Cancer in its Tracks

Targeted cancer therapies customized to act only on specific tumor cells allow doctors to stop tumor growth while causing little or no harm to normal cells. While many types of breast cancer can be treated this way, others still cannot.

Now, scientists from Scripps Florida have identified a compound that may serve as a new approach for treating certain breast cancers.

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Scripps Florida's Associate Professor Derek Duckett led the collaborative study.






TSRI's collaborative approach to research is resulting in groundbreaking new treatments for diseases like breast cancer and diabetes, which affect millions each day. Please support this life-saving work.


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Assistant Professor Patricia McDonald led the new study with Institute Professor Richard Lerner.


milestones in medical science:
How Lizard Venom is Helping Treat Diabetes

Scientists at The Scripps Research Institute (TSRI) have discovered a new anti-diabetes compound by altering molecules based on a small protein, Exendin-4, which was originally found in the venom of Gila Monster lizards.

The finding may lead to a new type of treatment for diabetes. And, just as importantly, it demonstrates the potential of a new drug discovery technique, known as autocrine selection, to help researchers quickly find drug candidates that activate cellular receptors in desired ways.

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Authors of the new paper included TSRI Associate Professor Ashok Deniz (right) and Research Associate Priya Banerjee.


Other News:
How One "Transformer" Protein Causes Cancer

When it mutates, a protein known for mysteriously transforming into two distinct forms has been shown to interfere with cells' normal tumor-suppressing skills and to contribute to cancers including non-Hodgkin lymphoma and acute myelogenous leukemia.

A new study led by scientists from TSRI and St. Jude Children's Research Hospital reveals the mechanism through which the protein twists and morphs into different structures – a discovery that could lead to new cancer therapies.

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Three TSRI Breakthroughs Among Top Stories of 2015

Three exciting research discoveries made by TSRI scientists were featured on several lists of the top stories of 2015. The development of a powerful anti-HIV drug candidate is included in a National Institutes of Health list of the year's most notable advances. Another study demonstrating that the immune system can be primed to block HIV was included among the San Diego Union-Tribune's top local stories. And finally, a study showing the potential to selectively erase addiction-associated memories in people with methamphetamine dependency was highlighted by The Huffington Post. Congratulations to all the TSRI scientists working on these important projects!



facts & figures

Approximately 1 in 8 U.S. women will develop invasive breast cancer over the course of their lifetimes, and approximately 40,000 die from the disease each year.




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