The Scripps Research Institute - At The Forefront

January 2016

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Focus on:
Getting closer to an HIV Vaccine

For more than 30 years, an effective vaccine against HIV has eluded scientists, and more than two million people are still newly infected with the virus each year. In a recent study, scientists at The Scripps Research Institute (TSRI) gained a new weapon in that long fight. They identified four antibodies targeting a specific weak spot on HIV that provided key information for the design of a potential HIV vaccine candidate.

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Authors of the new paper included (left to right) James Voss, Raiees Andrabi, Dennis Burton, Bryan Briney and Chi-Hui Liang.






TSRI's groundbreaking research is finding new ways to treat life-threatening viruses and diseases like HIV and tuberculosis that affect millions across the globe each day. Please support our life-saving work today.


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"We were able to demonstrate that these compounds… show excellent activity against multidrug resistant (MDR) and extensively drug-resistant (XDR) strains," says Associate Professor Kate Carroll.


milestones in medical science:
A New Tool for Fighting Tuberculosis

Tuberculosis has been infecting humans for several millennia, and it is still a major killer, responsible for some 1.5 million deaths each year. Often, it hides inside cells – latent and persistent – waiting to break out. In addition, nearly one-quarter of cases today are multidrug resistant and difficult to treat.

Now, scientists from the Scripps Florida campus, led by TSRI Associate Professor Kate Carroll, have discovered several first-in-class compounds that target these hidden infections and have proven effective in treating drug-resistant strains.

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"We think it is exciting to see that extending lifespan by extending young adulthood can be done at all," says Assistant Professor Michael Petrascheck, here with Senior Research Associate Sunitha Rangaraju.


Other News:
Can Roundworms Show the Key to Slowing the Aging Process?

While medical breakthroughs have successfully extended the human lifespan, most have resulted in a longer period of older age. But now, a team of TSRI scientists has discovered that the antidepressant drug mianserin can increase roundworms' overall lifespan by up to 40 percent by extending the "young adult" period of their lives.

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Take Advantage of Tax-Free IRA Charitable Rollovers Today

The new tax legislation recently signed into law, HR 2029 – dubbed the Protecting Americans from Tax Hikes Act of 2015 – permanently extends previously temporary IRA Charitable Rollovers. The provision allows individuals 70½ or older to make tax-free gifts totaling up to $100,000 directly to TSRI from a traditional IRA account. For more information on this excellent, tax-free way of supporting our life-saving research, click here.



facts & figures

Each year, approximately two million people are newly infected with HIV and 1.2 million die from AIDS-related causes. In 2015, 21 of the 37 million people living with the virus did not have access to lifesaving HIV treatment.




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