The Scripps Research Institute - At The Forefront

August 2014

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TSRI at Center of Ebola Fight

The Ebola virus causes an extremely dangerous disease that currently leads to death in up to 90% of cases. The fast-moving virus is spread through the blood or other bodily fluids of an infected person.

Laboratories at The Scripps Research Institute (TSRI), led by Professor Erica Ollmann Saphire and Assistant Professor Andrew Ward, are investigating antibodies to fight the Ebola virus, including
the three antibodies recently used to treat two Americans infected with the Ebola virus in Liberia. After receiving an experimental antibody cocktail called ZMapp, both patients reportedly showed improved conditions.

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Peter Kuhn

TSRI Professor Erica Ollmann Saphire.

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Marisa Roberto

“The sympathetic nervous system gets turned on during intense exercise, but many had believed it wasn't specific enough to drive specific adaptations in exercised muscle,” says Assistant Professor Michael Conkright.

milestones in medical science:
The Molecular Secret Behind Short, Intense Workouts

In the last few years, researchers and exercise fans have extolled short, intense workouts that last as little as seven minutes a few times a week as something of a metabolic panacea capable of providing greater overall fitness, better blood sugar control and weight reduction.

in a new study, scientists from Scripps Florida confirm that there is something molecularly unique about this intense exercise: the activation of a single protein.

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Srini Subramaniam

A team led by Professor Xiang-Lei Yang (left), shown here with co-author Staff Scientist Yi (Eric) Shi, has discovered a pair of proteins act in concert to regulate the development of blood vessels.

Other News:
The Ying and Yang of Blood Vessel Growth

SerRS (seryl tRNA synthetase) belongs to a family of enzymes that have fundamental, evolutionarily ancient roles in the protein-making machinery of cells.

A TSRI team has discovered that
this enzyme is also involved in a crucial process that regulates the development of blood vessels. The finding could lead to new treatments for disorders involving abnormal blood vessel growth, including common disorders such as diabetic retinopathy and cancer.

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facts & figures

The Ebola virus is named after the Ebola River, where the virus was first recognized in 1976.

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